| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Khaliq S et al. | Phytochemical investigation of Perovskia abrotanoides. | 2007 | Planta Med. | pmid:17315312 |
| Lin YL et al. | [Study on fingerprint spectrum of loquat leaf by HPLC]. | 2007 | Zhong Yao Cai | pmid:18300490 |
| Saimaru H et al. | Production of triterpene acids by cell suspension cultures of Olea europaea. | 2007 | Chem. Pharm. Bull. | pmid:17473469 |
| Moghaddam FM et al. | Chemical Constituents of Dichloromethane Extract of Cultivated Satureja khuzistanica. | 2007 | Evid Based Complement Alternat Med | pmid:17342246 |
| Tatsuzaki J et al. | Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents. | 2007 | Bioorg. Med. Chem. | pmid:17591444 |
| Ko KM and Leung HY | Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. | 2007 | Chin Med | pmid:17386115 |
| Tuntiwachwuttikul P et al. | Constituents of the leaves of Holarrhena pubescens. | 2007 | Fitoterapia | pmid:17329039 |
| Lu J et al. | Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. | 2007 | Biochem. Pharmacol. | pmid:17692828 |
| Wapling J et al. | Targeting human immunodeficiency virus type 1 assembly, maturation and budding. | 2007 | Drug Target Insights | pmid:21901072 |
| Dufour D et al. | Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius. | 2007 | J Ethnopharmacol | pmid:17156957 |
| Jovel EM et al. | Bioactivity-guided isolation of the active compounds from Rosa nutkana and quantitative analysis of ascorbic acid by HPLC. | 2007 | Can. J. Physiol. Pharmacol. | pmid:18066132 |
| Jung SH et al. | Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator. | 2007 | Biochem. J. | pmid:17201692 |
| Pathak AK et al. | Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. | 2007 | Mol. Cancer Res. | pmid:17855663 |
| Wu JY et al. | [Chemical constituents of the non-alkaloid fraction of Uncaria macrophylla]. | 2007 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:17355944 |
| Gao X et al. | Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling. | 2007 | J. Neurooncol. | pmid:17361329 |
| Zhou C et al. | Determination of oleanolic acid, ursolic acid and amygdalin in the flower of Eriobotrya japonica Lindl. by HPLC. | 2007 | Biomed. Chromatogr. | pmid:17385800 |
| Rosas LV et al. | In vitro evaluation of the cytotoxic and trypanocidal activities of Ampelozizyphus amazonicus (Rhamnaceae). | 2007 | Braz. J. Med. Biol. Res. | pmid:17464428 |
| Kress CL et al. | Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma. | 2007 | PLoS ONE | pmid:17593960 |
| Huang L et al. | Use of liquid chromatography-atmospheric pressure chemical ionization-ion trap mass spectrometry for identification of oleanolic acid and ursolic acid in Anoectochilus roxburghii (wall.) Lindl. | 2007 | J Mass Spectrom | pmid:17535010 |
| Ogawa S et al. | Oxyfunctionalization products of terpenoids with dimethyldioxirane and their biological activity. | 2007 | Chem. Pharm. Bull. | pmid:17268097 |
| Vareed SK et al. | Lipid peroxidation, cyclooxygenase enzyme and tumor cell proliferation inhibitory compounds in Cornus kousa fruits. | 2007 | Phytomedicine | pmid:17084606 |
| Wójciak-Kosior M | Separation and determination of closely related triterpenic acids by high performance thin-layer chromatography after iodine derivatization. | 2007 | J Pharm Biomed Anal | pmid:17587531 |
| Yin MC and Chan KC | Nonenzymatic antioxidative and antiglycative effects of oleanolic acid and ursolic acid. | 2007 | J. Agric. Food Chem. | pmid:17658830 |
| Santos Rosa C et al. | Antihistaminic and antieicosanoid effects of oleanolic and ursolic acid fraction from Helichrysum picardii. | 2007 | Pharmazie | pmid:17663195 |
| Chen JC et al. | Inhibition of Escherichia coli heat-labile enterotoxin-induced diarrhea by Chaenomeles speciosa. | 2007 | J Ethnopharmacol | pmid:17624704 |
| Heo HJ et al. | Carbenoxolone and triterpenoids inhibited mucin secretion from airway epithelial cells. | 2007 | Phytother Res | pmid:17262888 |
| Kowalski R | Studies of selected plant raw materials as alternative sources of triterpenes of oleanolic and ursolic acid types. | 2007 | J. Agric. Food Chem. | pmid:17263457 |
| Senthil S et al. | Isomers (oleanolic and ursolic acids) differ in their protective effect against isoproterenol-induced myocardial ischemia in rats. | 2007 | Int. J. Cardiol. | pmid:17052790 |
| Yang P et al. | Determination of free isomeric oleanolic acid and ursolic acid in Pterocephalus hookeri by capillary zone electrophoresis. | 2007 | J Pharm Biomed Anal | pmid:17141445 |
| Szakiel A and Mroczek A | Distribution of triterpene acids and their derivatives in organs of cowberry (Vaccinium vitis-idaea L.) plant. | 2007 | Acta Biochim. Pol. | pmid:17968438 |
| Ali MS et al. | Ursolic acid: a potent inhibitor of superoxides produced in the cellular system. | 2007 | Phytother Res | pmid:17295383 |
| Kassi E et al. | Ursolic acid, a naturally occurring triterpenoid, demonstrates anticancer activity on human prostate cancer cells. | 2007 | J. Cancer Res. Clin. Oncol. | pmid:17516089 |
| Oh CJ et al. | Ursolic acid regulates high glucose-induced apoptosis. | 2007 | Free Radic. Res. | pmid:17516235 |
| Li YL et al. | [Studies on chemical constituents from Serissa serissoides]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17583202 |
| Sun M et al. | [Experimental study on treating hyperlipidemic fatty liver with Taizhi'an capsule]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17583205 |
| Nangia-Makker P et al. | Inhibition of breast tumor growth and angiogenesis by a medicinal herb: Ocimum gratissimum. | 2007 | Int. J. Cancer | pmid:17437270 |
| Lim SW et al. | Simultaneous effect of ursolic acid and oleanolic acid on epidermal permeability barrier function and epidermal keratinocyte differentiation via peroxisome proliferator-activated receptor-alpha. | 2007 | J. Dermatol. | pmid:17727365 |
| Vidya SM et al. | Evaluation of hepatoprotective activity of Clerodendrum serratum L. | 2007 | Indian J. Exp. Biol. | pmid:17585689 |
| Nataraju A et al. | Group IIA secretory PLA2 inhibition by ursolic acid: a potent anti-inflammatory molecule. | 2007 | Curr Top Med Chem | pmid:17456043 |
| Steinkamp-Fenske K et al. | Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells. | 2007 | Atherosclerosis | pmid:17481637 |
| Huang L et al. | [Studies on chemical constituents of Patrinia villosa]. | 2007 | Zhong Yao Cai | pmid:17674792 |
| Liu XS and Jiang J | Induction of apoptosis and regulation of the MAPK pathway by ursolic acid in human leukemia K562 cells. | 2007 | Planta Med. | pmid:17764066 |
| Tang LY et al. | [Studies on chemical constituents of Sambucus adnata]. | 2007 | Zhong Yao Cai | pmid:17727059 |
| Yim EK et al. | Antiproliferative and antiviral mechanisms of ursolic acid and dexamethasone in cervical carcinoma cell lines. | 2006 Nov-Dec | Int. J. Gynecol. Cancer | pmid:17177841 |
| Jedinák A et al. | Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalis. | 2006 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:17294686 |
| Saravanan R and Pugalendi V | Impact of ursolic acid on chronic ethanol-induced oxidative stress in the rat heart. | 2006 Jan-Feb | Pharmacol Rep | pmid:16531629 |
| Pozo M et al. | Ursolic acid inhibits neointima formation in the rat carotid artery injury model. | 2006 | Atherosclerosis | pmid:15922347 |
| Lee HK et al. | Phytocomponents of triterpenoids, oleanolic acid and ursolic acid, regulated differently the processing of epidermal keratinocytes via PPAR-alpha pathway. | 2006 | Exp. Dermatol. | pmid:16364033 |
| Jang DS et al. | Beccaridiol, an unusual 28-nortriterpenoid from the leaves of Diplectria beccariana. | 2006 | Phytochemistry | pmid:16426647 |
| Sagar SM et al. | Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 2. | 2006 | Curr Oncol | pmid:17576449 |