| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shyu MH et al. | Hsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CCl(4) via inhibition of hepatic stellate cells activation. | 2008 | Food Chem. Toxicol. | pmid:18929613 |
| Shin IS et al. | Ursolic acid reduces prostate size and dihydrotestosterone level in a rat model of benign prostatic hyperplasia. | 2012 | Food Chem. Toxicol. | pmid:22266360 |
| Radhiga T et al. | Effect of ursolic acid on cardiac marker enzymes, lipid profile and macroscopic enzyme mapping assay in isoproterenol-induced myocardial ischemic rats. | 2012 | Food Chem. Toxicol. | pmid:22898613 |
| Murakami A and Ohnishi K | Target molecules of food phytochemicals: food science bound for the next dimension. | 2012 | Food Funct | pmid:22377900 |
| Koh SJ et al. | Sensitization of ionizing radiation-induced apoptosis by ursolic acid. | 2012 | Free Radic. Res. | pmid:22239065 |
| Oh CJ et al. | Ursolic acid regulates high glucose-induced apoptosis. | 2007 | Free Radic. Res. | pmid:17516235 |
| Bishayee A et al. | Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer. | 2011 | Front Biosci (Landmark Ed) | pmid:21196213 |
| Multhoff G and Radons J | Radiation, inflammation, and immune responses in cancer. | 2012 | Front Oncol | pmid:22675673 |
| Walch SG et al. | Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea). | 2011 | Front Pharmacol | pmid:22194722 |
| Lu J et al. | Quality Difference Study of Six Varieties of Ganoderma lucidum with Different Origins. | 2012 | Front Pharmacol | pmid:22509164 |
| Chung MI et al. | Studies on the constituents of Formosan gentianaceous plants. Part VII. Constituents of Swertia randaiensis Hayata and pharmacological activity of norswertianolin. | 1986 | Gaoxiong Yi Xue Ke Xue Za Zhi | pmid:3482877 |
| Sundaresan A et al. | Ursolic acid and rosiglitazone combination alleviates metabolic syndrome in high fat diet fed C57BL/6J mice. | 2012 | Gen. Physiol. Biophys. | pmid:23047945 |
| Bertoni BW et al. | Genetic diversity in natural populations of Jacaranda decurrens Cham. determined using RAPD and AFLP markers. | 2010 | Genet. Mol. Biol. | pmid:21637428 |
| Gao YS et al. | Inhibitory effect of ursolic acid and oleanolic acid from Eriobotrya fragrans on A549 cell viability in vivo. | 2016 | Genet. Mol. Res. | pmid:27323036 |
| Gu BP et al. | [Comparative study of the spectral characteristics of ursolic acid between laser Raman spectra and IR spectrum]. | 2002 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:12914177 |
| Yarosh DB et al. | Liposomal ursolic acid (merotaine) increases ceramides and collagen in human skin. | 2000 | Horm. Res. | pmid:11595826 |
| Raphael TJ and Kuttan G | Effect of naturally occurring triterpenoids ursolic acid and glycyrrhizic acid on the cell-mediated immune responses of metastatic tumor-bearing animals. | 2008 | Immunopharmacol Immunotoxicol | pmid:18569082 |
| Chen X et al. | Ursolic acid attenuates lipopolysaccharide-induced acute lung injury in a mouse model. | 2013 | Immunotherapy | pmid:23256797 |
| Purnima A et al. | Antiinflammatory, Analgesic and Antipyretic Activities of Mimusops elengi Linn. | 2010 | Indian J Pharm Sci | pmid:21218059 |
| Ghosh P et al. | Triterpenoids from Psidium guajava with Biocidal Activity. | 2010 | Indian J Pharm Sci | pmid:21218065 |
| Pavithra PS et al. | Antibacterial and antioxidant activity of methanol extract of Evolvulus nummularius. | 2009 | Indian J Pharmacol | pmid:20177496 |
| Ashok P et al. | Antiurolithiatic and antioxidant activity of Mimusops elengi on ethylene glycol-induced urolithiasis in rats. | 2010 | Indian J Pharmacol | pmid:21189910 |
| Hamza M et al. | In vitro effectiveness of triterpenoids and their synergistic effect with antibiotics against Staphylococcus aureus strains. | 2016 Nov-Dec | Indian J Pharmacol | pmid:28066112 |
| Anusha M et al. | Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats. | 2011 | Indian J Pharmacol | pmid:22022001 |
| Lee J et al. | Effects of ursolic acid on glucose metabolism, the polyol pathway and dyslipidemia in non-obese type 2 diabetic mice. | 2014 | Indian J. Exp. Biol. | pmid:25059036 |
| Vidya SM et al. | Evaluation of hepatoprotective activity of Clerodendrum serratum L. | 2007 | Indian J. Exp. Biol. | pmid:17585689 |
| Wojnicz D et al. | Pentacyclic triterpenes combined with ciprofloxacin help to eradicate the biofilm formed in vitro by Escherichia coli. | 2015 | Indian J. Med. Res. | pmid:25963496 |
| Huang Y et al. | Effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf on inflammatory cytokine and mediator induction from alveolar macrophages of chronic bronchitic rats. | 2007 | Inflamm. Res. | pmid:17431744 |
| Wilkinson K and El Khoury J | Microglial scavenger receptors and their roles in the pathogenesis of Alzheimer's disease. | 2012 | Int J Alzheimers Dis | pmid:22666621 |
| Yu SG et al. | Ursolic acid derivative ameliorates streptozotocin-induced diabestic bone deleterious effects in mice. | 2015 | Int J Clin Exp Pathol | pmid:26097549 |
| Lin RX et al. | Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells. | 2015 | Int J Clin Exp Pathol | pmid:25973027 |
| Smit N et al. | The hunt for natural skin whitening agents. | 2009 | Int J Mol Sci | pmid:20054473 |
| Song FL et al. | Total phenolic contents and antioxidant capacities of selected chinese medicinal plants. | 2010 | Int J Mol Sci | pmid:20640157 |
| Mobasheri A et al. | Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health. | 2012 | Int J Mol Sci | pmid:22605974 |
| Ni Q et al. | Seasonal variations of the antioxidant composition in ground bamboo Sasa argenteastriatus leaves. | 2012 | Int J Mol Sci | pmid:22408451 |
| Xia EQ et al. | Microwave-assisted extraction of oleanolic acid and ursolic acid from Ligustrum lucidum Ait. | 2011 | Int J Mol Sci | pmid:21954361 |
| Yao L et al. | Protective effects of polysaccharides from soybean meal against X-ray radiation induced damage in mouse spleen lymphocytes. | 2011 | Int J Mol Sci | pmid:22174652 |
| Yang JD et al. | Lysis of Microcystis aeruginosa with extracts from Chinese medicinal herbs. | 2009 | Int J Mol Sci | pmid:19865537 |
| Abdullah NH et al. | Hyaluronidase Inhibitory Activity of Pentacylic Triterpenoids from Prismatomeris tetrandra (Roxb.) K. Schum: Isolation, Synthesis and QSAR Study. | 2016 | Int J Mol Sci | pmid:26907251 |
| Zhou C et al. | Flavonoids, phenolics, and antioxidant capacity in the flower of Eriobotrya japonica Lindl. | 2011 | Int J Mol Sci | pmid:21686159 |
| Zhou C et al. | Herbaceous peony (Paeonia lactiflora Pall.) as an alternative source of oleanolic and ursolic acids. | 2011 | Int J Mol Sci | pmid:21340006 |
| Zhang H et al. | Efficient delivery of ursolic acid by poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles for inhibiting the growth of hepatocellular carcinoma in vitro and in vivo. | 2015 | Int J Nanomedicine | pmid:25792825 |
| Zhu Z et al. | A phase I pharmacokinetic study of ursolic acid nanoliposomes in healthy volunteers and patients with advanced solid tumors. | 2013 | Int J Nanomedicine | pmid:23319864 |
| Jesus JA et al. | Therapeutic effect of ursolic acid in experimental visceral leishmaniasis. | 2017 | Int J Parasitol Drugs Drug Resist | pmid:27984757 |
| Zhong Y et al. | Preparation and evaluation of liposome-encapsulated codrug LMX. | 2012 | Int J Pharm | pmid:22981689 |
| Zhang H et al. | Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2). | 2013 | Int J Pharm | pmid:23194884 |
| Jang SM et al. | Ursolic acid enhances the cellular immune system and pancreatic beta-cell function in streptozotocin-induced diabetic mice fed a high-fat diet. | 2009 | Int. Immunopharmacol. | pmid:19013541 |
| Manu KA and Kuttan G | Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells. | 2008 | Int. Immunopharmacol. | pmid:18486908 |
| Sohn EJ et al. | Blockage of epithelial to mesenchymal transition and upregulation of let 7b are critically involved in ursolic acid induced apoptosis in malignant mesothelioma cell. | 2016 | Int. J. Biol. Sci. | pmid:28090191 |
| Shanmugam MK et al. | Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model. | 2011 | Int. J. Cancer | pmid:21480220 |