| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chang CL et al. | Phytochemical characteristics, free radical scavenging activities, and neuroprotection of five medicinal plant extracts. | 2012 | Evid Based Complement Alternat Med | pmid:21845204 |
| Roth M et al. | Isolation of modulators of the liver-specific organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae). | 2011 | J. Pharmacol. Exp. Ther. | pmid:21846839 |
| Jia Y et al. | Ursolic acid is a PPAR-α agonist that regulates hepatic lipid metabolism. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21855333 |
| Cárdenas C et al. | Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. | 2011 | PLoS ONE | pmid:21858104 |
| Rivero-Chan BE et al. | Rapid access to ketones related to oleanolic and ursolic acids. | 2012 | Nat. Prod. Res. | pmid:21859373 |
| Assob JC et al. | Antimicrobial and toxicological activities of five medicinal plant species from Cameroon traditional medicine. | 2011 | BMC Complement Altern Med | pmid:21867554 |
| Yamaguchi H et al. | Ligand-receptor interaction between triterpenoids and the 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) enzyme predicts their toxic effects against tumorigenic r/m HM-SFME-1 cells. | 2011 | J. Biol. Chem. | pmid:21880714 |
| Fu SB et al. | Biotransformation of ursolic acid by an endophytic fungus from medicinal plant Huperzia serrata. | 2011 | Chem. Pharm. Bull. | pmid:21881267 |
| Bitencourt MA et al. | Aqueous and methanolic extracts of Caulerpa mexicana suppress cell migration and ear edema induced by inflammatory agents. | 2011 | Mar Drugs | pmid:21892348 |
| Wapling J et al. | Targeting human immunodeficiency virus type 1 assembly, maturation and budding. | 2007 | Drug Target Insights | pmid:21901072 |
| Kim KH et al. | Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells. | 2011 | Arch. Pharm. Res. | pmid:21910059 |
| pmid:21919561 | ||||
| Jilani K et al. | Triggering of erythrocyte cell membrane scrambling by ursolic acid. | 2011 | J. Nat. Prod. | pmid:21923134 |
| pmid:21936626 | ||||
| pmid:21939747 | ||||
| Gao N et al. | Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti-leukaemic activity in nude mice through the PKB pathway. | 2012 | Br. J. Pharmacol. | pmid:21950524 |
| Xia EQ et al. | Microwave-assisted extraction of oleanolic acid and ursolic acid from Ligustrum lucidum Ait. | 2011 | Int J Mol Sci | pmid:21954361 |
| pmid:21955093 | ||||
| Patel DK et al. | Pedalium murex Linn.: an overview of its phytopharmacological aspects. | 2011 | Asian Pac J Trop Med | pmid:21967701 |
| Saxena RC et al. | Efficacy of an Extract of Ocimum tenuiflorum (OciBest) in the Management of General Stress: A Double-Blind, Placebo-Controlled Study. | 2012 | Evid Based Complement Alternat Med | pmid:21977056 |
| Xu XY et al. | Two new triterpenoid glycosides from the leaves of Anthocephalus chinensis. | 2011 | J Asian Nat Prod Res | pmid:21985583 |
| Tannock LR | Ursolic acid effect on atherosclerosis: apples and apples, or apples and oranges? | 2011 | Atherosclerosis | pmid:21993411 |
| Zeng G et al. | Ursolic acid inhibits T-cell activation through modulating nuclear factor-κ B signaling. | 2012 | Chin J Integr Med | pmid:21994027 |
| Wang C et al. | Determination of oleanolic and ursolic acid in Chinese herbs using HPLC and γ-CD as mobile phase modifier. | 2011 | J Sep Sci | pmid:21994210 |
| Fu S et al. | Anti-inflammatory effects of active constituents extracted from Chinese medicinal herbs against Propionibacterium acnes. | 2012 | Nat. Prod. Res. | pmid:21999396 |
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| Kazmi I et al. | Anti-diabetic potential of ursolic acid stearoyl glucoside: a new triterpenic gycosidic ester from Lantana camara. | 2012 | Fitoterapia | pmid:22051701 |
| pmid:22062354 | ||||
| Silva LL et al. | Effects of Lecythis pisonis Camb. (Lecythidaceae) in a mouse model of pruritus. | 2012 | J Ethnopharmacol | pmid:22063727 |
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| Uygur B and Wu WS | SLUG promotes prostate cancer cell migration and invasion via CXCR4/CXCL12 axis. | 2011 | Mol. Cancer | pmid:22074556 |
| Pieroni LG et al. | Antioxidant activity and total phenols from the methanolic extract of Miconia albicans (Sw.) Triana leaves. | 2011 | Molecules | pmid:22075573 |
| Hwang JS et al. | Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22079762 |
| Zhong Y et al. | Synthesis, stability and pharmacological evaluation of a novel codrug consisting of lamivudine and ursolic acid. | 2012 | Eur J Pharm Sci | pmid:22085635 |
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| Lv YY et al. | Ursolic acid suppresses IL-6 induced C-reactive protein expression in HepG2 and protects HUVECs from injury induced by CRP. | 2012 | Eur J Pharm Sci | pmid:22108347 |
| Shewale VD et al. | Anti-Inflammatory Activity of Delonix regia (Boj. Ex. Hook). | 2012 | Adv Pharmacol Sci | pmid:22110490 |