| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shanmugam MK et al. | Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model. | 2011 | Int. J. Cancer | pmid:21480220 |
| Li Y et al. | Enhancement of chemotherapeutic agent-induced apoptosis by inhibition of NF-kappaB using ursolic acid. | 2010 | Int. J. Cancer | pmid:19908232 |
| Baek JH et al. | Intracellular Ca2+ release mediates ursolic acid-induced apoptosis in human leukemic HL-60 cells. | 1997 | Int. J. Cancer | pmid:9398053 |
| Harmand PO et al. | Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and caspase-3 activation in M4Beu melanoma cells. | 2005 | Int. J. Cancer | pmid:15523687 |
| Nangia-Makker P et al. | Inhibition of breast tumor growth and angiogenesis by a medicinal herb: Ocimum gratissimum. | 2007 | Int. J. Cancer | pmid:17437270 |
| Kim DK et al. | Apoptotic activity of ursolic acid may correlate with the inhibition of initiation of DNA replication. | 2000 | Int. J. Cancer | pmid:10925354 |
| Senthil S et al. | Isomers (oleanolic and ursolic acids) differ in their protective effect against isoproterenol-induced myocardial ischemia in rats. | 2007 | Int. J. Cardiol. | pmid:17052790 |
| Yim EK et al. | Antiproliferative and antiviral mechanisms of ursolic acid and dexamethasone in cervical carcinoma cell lines. | 2006 Nov-Dec | Int. J. Gynecol. Cancer | pmid:17177841 |
| Zhou Y et al. | Ursolic acid inhibits early lesions of diabetic nephropathy. | 2010 | Int. J. Mol. Med. | pmid:20818497 |
| Skopinski P et al. | Suppression of angiogenic activity of sera from diabetic patients with non-proliferative retinopathy by compounds of herbal origin and sulindac sulfone. | 2004 | Int. J. Mol. Med. | pmid:15375605 |
| Lin J et al. | Ursolic acid promotes colorectal cancer cell apoptosis and inhibits cell proliferation via modulation of multiple signaling pathways. | 2013 | Int. J. Oncol. | pmid:23900560 |
| Lin J et al. | Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways. | 2013 | Int. J. Oncol. | pmid:24042330 |
| Kowalczyk MC et al. | Effects of combined phytochemicals on skin tumorigenesis in SENCAR mice. | 2013 | Int. J. Oncol. | pmid:23835587 |
| Harmand PO et al. | Ursolic acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells. | 2003 | Int. J. Oncol. | pmid:12792782 |
| Choi YH et al. | Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human prostate epithelial cells. | 2000 | Int. J. Oncol. | pmid:10938399 |
| Kanjoormana M and Kuttan G | Antiangiogenic activity of ursolic acid. | 2010 | Integr Cancer Ther | pmid:20462855 |
| Adotey JP et al. | A Review of the Ethnobotany and Pharmacological Importance of Alstonia boonei De Wild (Apocynaceae). | 2012 | ISRN Pharmacol | pmid:22900200 |
| Pai PG et al. | Nephroprotective effect of ursolic Acid in a murine model of gentamicin-induced renal damage. | 2012 | ISRN Pharmacol | pmid:22811930 |
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| KING NM et al. | A note on the isolation of ursolic acid from Verbena stricta, Vent. | 1950 | J Am Pharm Assoc Am Pharm Assoc | pmid:14778784 |
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