| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Miyazawa M et al. | Suppression of the SOS-inducing activity of mutagenic heterocyclic amine, Trp-P-1, by triterpenoid from Uncaria sinensis in the Salmonella typhimurium TA1535/pSK1002 Umu test. | 2005 | J. Agric. Food Chem. | pmid:15769173 |
| Achiwa Y et al. | Ursolic acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial cancer SNG-II cells. | 2005 | Oncol. Rep. | pmid:15583801 |
| Wang P et al. | Synthesis of two bidesmosidic ursolic acid saponins bearing a 2,3-branched trisaccharide residue. | 2005 | Carbohydr. Res. | pmid:16043158 |
| Usia T et al. | Cytochrome P450 2D6 (CYP2D6) inhibitory constituents of Catharanthus roseus. | 2005 | Biol. Pharm. Bull. | pmid:15930738 |
| Zhang W et al. | [Experimental study on MCF-7 cell apoptosis induced by ursolic acid]. | 2005 | Zhong Yao Cai | pmid:16104504 |
| Chávez IO et al. | Cytotoxic activity and effect on nitric oxide production of tirucallane-type triterpenes. | 2005 | J. Pharm. Pharmacol. | pmid:16105229 |
| Jeong HG et al. | Involvement of cytokines in the hepatic expression of metallothionein by ursolic acid. | 2005 | Toxicol. Lett. | pmid:15649620 |
| Jo Y et al. | Jacaranone and related compounds from the fresh fruits of Ternstroemia japonica and their antioxidative activity. | 2005 | Arch. Pharm. Res. | pmid:16178411 |
| Tang X et al. | Inhibition by [corrected] ursolic acid of [corrected] calcium-induced mitochondrial permeability transition and release of two proapoptotic proteins. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16188235 |
| Ikeda Y et al. | Ursolic acid promotes the release of macrophage migration inhibitory factor via ERK2 activation in resting mouse macrophages. | 2005 | Biochem. Pharmacol. | pmid:16188240 |
| Wang B et al. | [Studies on the chemical constituents from herb of Rhodobryum roseum]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16124603 |
| Liu Z et al. | [Study on the extracting of ursolic acid by uniform design]. | 2005 | Zhong Yao Cai | pmid:16131040 |
| Urech K et al. | Apoptosis inducing activity of viscin, a lipophilic extract from Viscum album L. | 2005 | J. Pharm. Pharmacol. | pmid:15638998 |
| Zhang G et al. | Determination of oleanolic acid and ursolic acid in cornel by cyclodextrin-modified micellar electrokinetic chromatography. | 2005 | Biomed. Chromatogr. | pmid:15654724 |
| Fu L et al. | Three new triterpenes from Nerium oleander and biological activity of the isolated compounds. | 2005 | J. Nat. Prod. | pmid:15730243 |
| Harmand PO et al. | Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and caspase-3 activation in M4Beu melanoma cells. | 2005 | Int. J. Cancer | pmid:15523687 |
| Xiang W et al. | Four new prenylated isoflavonoids in Tadehagi triquetrum. | 2005 | J. Agric. Food Chem. | pmid:15656660 |
| Miceli N et al. | Anti-inflammatory activity of extract and fractions from Nepeta sibthorpii Bentham. | 2005 | J Ethnopharmacol | pmid:15707763 |
| Das B et al. | A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma. | 2005 | Cancer Res. | pmid:16103078 |
| Yoshida M et al. | Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica. | 2005 | Biol. Pharm. Bull. | pmid:15635187 |
| Tokar M and Klimek B | Isolation and identification of biologically active compounds from Forsythia viridissima flowers. | 2004 May-Jun | Acta Pol Pharm | pmid:15481244 |
| Hsu YL et al. | Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells. | 2004 | Life Sci. | pmid:15350828 |
| Basappa M et al. | Novel delta2-isoxazolines as group II phospholipase A2 inhibitors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15203142 |
| Shih YH et al. | Ursolic acid protects hippocampal neurons against kainate-induced excitotoxicity in rats. | 2004 | Neurosci. Lett. | pmid:15193771 |
| Cárdenas C et al. | Effects of ursolic acid on different steps of the angiogenic process. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15219842 |
| Murakami S et al. | Ursolic acid, an antagonist for transforming growth factor (TGF)-beta1. | 2004 | FEBS Lett. | pmid:15147868 |
| León F et al. | Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells. | 2004 | J. Nat. Prod. | pmid:15620242 |
| Qi SH et al. | Constituents of Carapa guianensis Aubl. (Meliaceae). | 2004 | Pharmazie | pmid:15248467 |
| Gao J et al. | Hepatoprotective activity of Terminalia catappa L. leaves and its two triterpenoids. | 2004 | J. Pharm. Pharmacol. | pmid:15525453 |
| Taketa AT et al. | Triterpenoids from Brazilian Ilex species and their in vitro antitrypanosomal activity. | 2004 | J. Nat. Prod. | pmid:15497942 |
| Saeidnia S et al. | Two new monoterpene glycosides and trypanocidal terpenoids from Dracocephalum kotschyi. | 2004 | Chem. Pharm. Bull. | pmid:15467247 |
| Cao S et al. | Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest. | 2004 | J. Nat. Prod. | pmid:15217279 |
| Gu JQ et al. | Antitubercular constituents of Valeriana laxiflora. | 2004 | Planta Med. | pmid:15229801 |
| Dallavalle S et al. | A new 3,4-seco-lupane derivative from Lasianthus gardneri. | 2004 | J. Nat. Prod. | pmid:15165165 |
| Kim KA et al. | Inhibition of cytochrome P450 activities by oleanolic acid and ursolic acid in human liver microsomes. | 2004 | Life Sci. | pmid:15043991 |
| Shin KM et al. | In vitro anti-inflammatory activity of 23-hydroxyursolic acid isolated from Cussonia bancoensis in murine macrophage RAW 264.7 cells. | 2004 | Planta Med. | pmid:15386188 |
| Ragasa CY et al. | New cycloartenol esters from Ixora coccinea. | 2004 | Nat. Prod. Res. | pmid:15214483 |
| Mallavadhani UV et al. | Antimicrobial activity of some pentacyclic triterpenes and their synthesized 3-O-lipophilic chains. | 2004 | Biol. Pharm. Bull. | pmid:15467198 |
| Skopinski P et al. | Suppression of angiogenic activity of sera from diabetic patients with non-proliferative retinopathy by compounds of herbal origin and sulindac sulfone. | 2004 | Int. J. Mol. Med. | pmid:15375605 |
| Somova LI et al. | Cardiotonic and antidysrhythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol. | 2004 | Phytomedicine | pmid:15070161 |
| Park JH et al. | Antiinflammatory activity of Synurus deltoides. | 2004 | Phytother Res | pmid:15597310 |
| Chang CI et al. | Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines. | 2004 | J. Nat. Prod. | pmid:14738395 |
| Lee CJ et al. | Effects of ursolic acid, betulin and sulfur-containing compounds on mucin release from airway goblet cells. | 2004 | Planta Med. | pmid:15643543 |
| Bérangère C et al. | Rapid analysis of triterpenic acids by liquid chromatography using porous graphitic carbon and evaporative light scattering detection. | 2004 | J Sep Sci | pmid:15352713 |
| Nguyen QC et al. | New 3-O-acyl betulinic acids from Strychnos vanprukii Craib. | 2004 | J. Nat. Prod. | pmid:15217281 |
| Li Y and Ohizumi Y | Search for constituents with neurotrophic factor-potentiating activity from the medicinal plants of paraguay and Thailand. | 2004 | Yakugaku Zasshi | pmid:15235225 |
| Neurath AR et al. | Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide. | 2004 | BMC Infect. Dis. | pmid:15485580 |
| Xue PF et al. | [Studies on the chemical constituents from Potentilla multifida L]. | 2004 | Beijing Da Xue Xue Bao | pmid:14970881 |
| Chaturvedula VS et al. | A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase beta lyase. | 2004 | J. Nat. Prod. | pmid:15165161 |
| Nakamura N | [Inhibitory effects of some traditional medicines on proliferation of HIV-1 and its protease]. | 2004 | Yakugaku Zasshi | pmid:15297721 |