| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim HI et al. | Inhibition of estrogen signaling through depletion of estrogen receptor alpha by ursolic acid and betulinic acid from Prunella vulgaris var. lilacina. | 2014 | Biochem. Biophys. Res. Commun. | pmid:25088993 |
| Tang Q et al. | Mitochondrial translocation of cofilin-1 promotes apoptosis of gastric cancer BGC-823 cells induced by ursolic acid. | 2014 | Tumour Biol. | pmid:24197982 |
| Chen J et al. | A new synthetic ursolic acid derivative IUA with anti-tumor efficacy against osteosarcoma cells via inhibition of JNK signaling pathway. | 2014 | Cell. Physiol. Biochem. | pmid:25171517 |
| Song J et al. | Development and characterisation of ursolic acid nanocrystals without stabiliser having improved dissolution rate and in vitro anticancer activity. | 2014 | AAPS PharmSciTech | pmid:24022345 |
| Wu P et al. | Effects of ursolic acid derivatives on Caco-2 cells and their alleviating role in streptozocin-induced type 2 diabetic rats. | 2014 | Molecules | pmid:25153871 |
| Baek SY et al. | Ursolic acid ameliorates autoimmune arthritis via suppression of Th17 and B cell differentiation. | 2014 | Acta Pharmacol. Sin. | pmid:25087995 |
| Qin N et al. | RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus biofilm inhibition by ursolic acid and resveratrol. | 2014 | Sci Rep | pmid:24970710 |
| Micota B et al. | Leonurus cardiaca L. herb--a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis. | 2014 | Acta Biochim. Pol. | pmid:24918490 |
| Colla AR et al. | Serotonergic and noradrenergic systems are implicated in the antidepressant-like effect of ursolic acid in mice. | 2014 | Pharmacol. Biochem. Behav. | pmid:24887451 |
| Fu HJ et al. | Tryptophan hydroxylase 1 (Tph-1)-targeted bone anabolic agents for osteoporosis. | 2014 | J. Med. Chem. | pmid:24844139 |
| Li Y et al. | Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and suppression of ERK1/2 MAPK in HeLa cells. | 2014 | J. Pharmacol. Sci. | pmid:24881958 |
| Shen S et al. | Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress. | 2014 | Chem. Biol. Interact. | pmid:24802810 |
| Lee J et al. | Effects of ursolic acid on glucose metabolism, the polyol pathway and dyslipidemia in non-obese type 2 diabetic mice. | 2014 | Indian J. Exp. Biol. | pmid:25059036 |
| Chun J et al. | Ursolic acid inhibits nuclear factor-κB signaling in intestinal epithelial cells and macrophages, and attenuates experimental colitis in mice. | 2014 | Life Sci. | pmid:24992474 |
| Ma D et al. | Crucial role of heme oxygenase-1 in the sensitivity of acute myeloid leukemia cell line Kasumi-1 to ursolic acid. | 2014 | Anticancer Drugs | pmid:24413389 |
| Innocente AM et al. | Anti-Trichomonas vaginalis activity from triterpenoid derivatives. | 2014 | Parasitol. Res. | pmid:24880238 |
| Yang Y et al. | Ursolic acid prevents endoplasmic reticulum stress-mediated apoptosis induced by heat stress in mouse cardiac myocytes. | 2014 | J. Mol. Cell. Cardiol. | pmid:24389342 |
| Déciga-Campos M et al. | Isobolographic analysis of the antinociceptive interaction between ursolic acid and diclofenac or tramadol in mice. | 2014 | Planta Med. | pmid:24431012 |
| Lee YH et al. | Ursolic acid differentially modulates apoptosis in skin melanoma and retinal pigment epithelial cells exposed to UV-VIS broadband radiation. | 2014 | Apoptosis | pmid:24375173 |
| Yoon JH et al. | p-Coumaric acid and ursolic acid from Corni fructus attenuated β-amyloid(25-35)-induced toxicity through regulation of the NF-κB signaling pathway in PC12 cells. | 2014 | J. Agric. Food Chem. | pmid:24815946 |
| Fabri RL et al. | Chromatographic fingerprint analysis and effects of the medicinal plant species Mitracarpus frigidus on adult Schistosoma mansoni worms. | 2014 | Biomed Res Int | pmid:24901000 |
| Zhang W et al. | Review on anti-tumor effect of triterpene acid compounds. | 2014 | J Cancer Res Ther | pmid:25207885 |
| Zhao CH et al. | Inhibition of human enterovirus 71 replication by pentacyclic triterpenes and their novel synthetic derivatives. | 2014 | Chem. Pharm. Bull. | pmid:25087628 |
| Soica C et al. | The synergistic biologic activity of oleanolic and ursolic acids in complex with hydroxypropyl-γ-cyclodextrin. | 2014 | Molecules | pmid:24747649 |
| Kurek A et al. | The effect of oleanolic and ursolic acids on the hemolytic properties and biofilm formation of Listeria monocytogenes. | 2014 | Pol. J. Microbiol. | pmid:25033658 |
| Nowak R et al. | HPTLC-densitometry determination of triterpenic acids in Origanum vulgare, Rosmarinus officinalis and Syzygium aromaticum. | 2013 May-Jun | Acta Pol Pharm | pmid:23757931 |
| Xue YM et al. | [Determination of ursolic acid of Sambucus adnata]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:24010309 |
| Mazumder K et al. | Cytotoxic activity of ursolic acid derivatives obtained by isolation and oxidative derivatization. | 2013 | Molecules | pmid:23896618 |
| Ogasawara R et al. | Ursolic acid stimulates mTORC1 signaling after resistance exercise in rat skeletal muscle. | 2013 | Am. J. Physiol. Endocrinol. Metab. | pmid:23900420 |
| Lin J et al. | Ursolic acid promotes colorectal cancer cell apoptosis and inhibits cell proliferation via modulation of multiple signaling pathways. | 2013 | Int. J. Oncol. | pmid:23900560 |
| Yang JJ et al. | [Study on the effect of ursolic acid (UA) on the myocardial fibrosis of experimental diabetic mice]. | 2013 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:24175562 |
| Kong L et al. | Oleanolic acid and ursolic acid: novel hepatitis C virus antivirals that inhibit NS5B activity. | 2013 | Antiviral Res. | pmid:23422646 |
| Nam H and Kim MM | Ursolic acid induces apoptosis of SW480 cells via p53 activation. | 2013 | Food Chem. Toxicol. | pmid:24071474 |
| Lin J et al. | Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways. | 2013 | Int. J. Oncol. | pmid:24042330 |
| Saraswati S et al. | Ursolic acid inhibits tumor angiogenesis and induces apoptosis through mitochondrial-dependent pathway in Ehrlich ascites carcinoma tumor. | 2013 | Chem. Biol. Interact. | pmid:24051192 |
| Wang W et al. | Ursolic acid inhibits the growth of colon cancer-initiating cells by targeting STAT3. | 2013 | Anticancer Res. | pmid:24122993 |
| Feng L et al. | Inhibition of human neutrophil elastase by pentacyclic triterpenes. | 2013 | PLoS ONE | pmid:24376583 |
| Gai L et al. | Ursolic acid induces apoptosis via Akt/NF-κB signaling suppression in T24 human bladder cancer cells. | 2013 | Mol Med Rep | pmid:23483134 |
| Park JH et al. | Inhibition of Wnt/β-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells. | 2013 | Pharmacol Rep | pmid:24399733 |
| do Nascimento PG et al. | Antibacterial and antioxidant activities of ursolic acid and derivatives. | 2013 | Molecules | pmid:24451251 |
| Wan LS et al. | Two new chiratane-type triterpenoids from Swertia kouitchensis. | 2013 | Molecules | pmid:23873389 |
| Nguyen PH et al. | Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity. | 2013 | J. Nat. Prod. | pmid:24224843 |
| Chen Y et al. | Optimisation of potassium chloride nutrition for proper growth, physiological development and bioactive component production in Prunella vulgaris L. | 2013 | PLoS ONE | pmid:23874390 |
| Wang YL et al. | Effects of artesunate and ursolic acid on hyperlipidemia and its complications in rabbit. | 2013 | Eur J Pharm Sci | pmid:23954455 |
| Achiwa Y et al. | Effect of ursolic acid on MAPK in cyclin D1 signaling and RING-type E3 ligase (SCF E3s) in two endometrial cancer cell lines. | 2013 | Nutr Cancer | pmid:24083669 |
| Wang ZW et al. | α-Glucosidase inhibitory triterpenoids from the stem barks of Uncaria laevigata. | 2013 | Fitoterapia | pmid:23856092 |
| da Silva Ferreira D et al. | In vivo activity of ursolic and oleanolic acids during the acute phase of Trypanosoma cruzi infection. | 2013 | Exp. Parasitol. | pmid:23648663 |
| Banihani S et al. | Pomegranate and type 2 diabetes. | 2013 | Nutr Res | pmid:23684435 |
| Wu L et al. | Processing technology investigation of loquat (Eriobotrya japonica) leaf by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry combined with chemometrics. | 2013 | PLoS ONE | pmid:23667702 |
| Zhai B et al. | Antimalarial evaluation of the chemical constituents of hairy root culture of Bixa orellana L. | 2013 | Molecules | pmid:24406786 |
| Çulhaoğlu B et al. | Bioactive constituents of Salvia chrysophylla Stapf. | 2013 | Nat. Prod. Res. | pmid:23126495 |
| Kowalczyk MC et al. | Effects of combined phytochemicals on skin tumorigenesis in SENCAR mice. | 2013 | Int. J. Oncol. | pmid:23835587 |
| Kim SH et al. | Ursolic acid, a potential PPARγ agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthma. | 2013 | Eur. J. Pharmacol. | pmid:23201068 |
| Zheng QY et al. | Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells. | 2013 | Cell. Signal. | pmid:23000344 |
| Junco JJ et al. | Resveratrol and P-glycoprotein inhibitors enhance the anti-skin cancer effects of ursolic acid. | 2013 | Mol. Cancer Res. | pmid:24072817 |
| Zhang P et al. | Ursolic acid inhibits acid sphingomyelinase in intestinal cells. | 2013 | Phytother Res | pmid:22511398 |
| Yu F et al. | Functional characterization of amyrin synthase involved in ursolic acid biosynthesis in Catharanthus roseus leaf epidermis. | 2013 | Phytochemistry | pmid:22652241 |
| Jiménez-Arellanes A et al. | Ursolic and oleanolic acids as antimicrobial and immunomodulatory compounds for tuberculosis treatment. | 2013 | BMC Complement Altern Med | pmid:24098949 |
| Rao AR et al. | In vitro and in vivo inhibitory activities of four Indian medicinal plant extracts and their major components on rat aldose reductase and generation of advanced glycation endproducts. | 2013 | Phytother Res | pmid:22826152 |
| Fu SB et al. | Biotransformation of ursolic acid by Syncephalastrum racemosum CGMCC 3.2500 and anti-HCV activity. | 2013 | Fitoterapia | pmid:23425601 |
| Verma SC et al. | Microwave-assisted extraction and rapid isolation of ursolic acid from the leaves of Eucalyptus × hybrida Maiden and its quantification using HPLC-diode array technique. | 2013 | J Sep Sci | pmid:23471897 |
| Shanmugam MK et al. | Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies. | 2013 | Biochem. Pharmacol. | pmid:23499879 |
| Rashid S et al. | Synthesis and biological evaluation of ursolic acid-triazolyl derivatives as potential anti-cancer agents. | 2013 | Eur J Med Chem | pmid:23811086 |
| Shin SW and Park JW | Ursolic acid sensitizes prostate cancer cells to TRAIL-mediated apoptosis. | 2013 | Biochim. Biophys. Acta | pmid:23247106 |
| da Silva GN et al. | Two series of new semisynthetic triterpene derivatives: differences in anti-malarial activity, cytotoxicity and mechanism of action. | 2013 | Malar. J. | pmid:23497003 |
| Chen X et al. | Ursolic acid attenuates lipopolysaccharide-induced acute lung injury in a mouse model. | 2013 | Immunotherapy | pmid:23256797 |
| Li L et al. | Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice. | 2013 | Brain Res. | pmid:23276496 |
| Son HS et al. | Activation of AMP-activated protein kinase and phosphorylation of glycogen synthase kinase3 β mediate ursolic acid induced apoptosis in HepG2 liver cancer cells. | 2013 | Phytother Res | pmid:23325562 |
| Zhu Z et al. | A phase I pharmacokinetic study of ursolic acid nanoliposomes in healthy volunteers and patients with advanced solid tumors. | 2013 | Int J Nanomedicine | pmid:23319864 |
| Saifudin A et al. | Sesquiterpenes from the rhizomes of Curcuma heyneana. | 2013 | J. Nat. Prod. | pmid:23387824 |
| Zhang H et al. | Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2). | 2013 | Int J Pharm | pmid:23194884 |
| Dorota W et al. | Effect of asiatic and ursolic acids on morphology, hydrophobicity, and adhesion of UPECs to uroepithelial cells. | 2013 | Folia Microbiol. (Praha) | pmid:23132656 |
| Wang XH et al. | Evaluation of toxicity and single-dose pharmacokinetics of intravenous ursolic acid liposomes in healthy adult volunteers and patients with advanced solid tumors. | 2013 | Expert Opin Drug Metab Toxicol | pmid:23134084 |
| Liu K et al. | Ursolic acid inhibits epithelial-mesenchymal transition by suppressing the expression of astrocyte-elevated gene-1 in human nonsmall cell lung cancer A549 cells. | 2013 | Anticancer Drugs | pmid:23511428 |
| Wu DM et al. | Ursolic acid improves domoic acid-induced cognitive deficits in mice. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23707761 |
| Caligiani A et al. | A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients. | 2013 | Food Chem | pmid:23122121 |
| Shih WL et al. | Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model. | 2013 | Mol. Carcinog. | pmid:22549898 |
| Leng S et al. | Ursolic acid promotes cancer cell death by inducing Atg5-dependent autophagy. | 2013 | Int. J. Cancer | pmid:23737395 |
| Wang J et al. | Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells. | 2013 | PLoS ONE | pmid:23737956 |
| Zhao C et al. | Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells. | 2013 | Autophagy | pmid:23182854 |
| He Y et al. | Ursolic acid inhibits adipogenesis in 3T3-L1 adipocytes through LKB1/AMPK pathway. | 2013 | PLoS ONE | pmid:23922935 |
| Caldeira de Araújo Lopes S et al. | Preparation, physicochemical characterization, and cell viability evaluation of long-circulating and pH-sensitive liposomes containing ursolic acid. | 2013 | Biomed Res Int | pmid:23984367 |
| Brandão GC et al. | Chemistry and Antiviral Activity of Arrabidaea pulchra (Bignoniaceae). | 2013 | Molecules | pmid:23959197 |
| Zhang ZF et al. | Two new ursolic acid saponins from Morina nepalensis var. alba Hand-Mazz. | 2013 | Nat. Prod. Res. | pmid:23962075 |
| Yu ZL and Zeng WC | Antioxidant, antibrowning, and cytoprotective activities of Ligustrum robustum (Rxob.) Blume extract. | 2013 | J. Food Sci. | pmid:23924383 |
| Verano J et al. | Ursolic acid from Agastache mexicana aerial parts produces antinociceptive activity involving TRPV1 receptors, cGMP and a serotonergic synergism. | 2013 | Pharmacol. Biochem. Behav. | pmid:23932918 |
| Lee YH et al. | Modulation of photochemical damage in normal and malignant cells by naturally occurring compounds. | 2012 Nov-Dec | Photochem. Photobiol. | pmid:22486439 |
| Yang YC et al. | Optimisation of an ultrasound-assisted extraction followed by RP-HPLC separation for the simultaneous determination of oleanolic acid, ursolic acid and oridonin content in Rabdosia rubescens. | 2012 Nov-Dec | Phytochem Anal | pmid:22706975 |
| Peixoto MP et al. | LC-UV assay method and UPLC/Q-TOF-MS characterisation of saponins from Ilex paraguariensis A. St. Hil. (mate) unripe fruits. | 2012 Jul-Aug | Phytochem Anal | pmid:22105927 |
| Adotey JP et al. | A Review of the Ethnobotany and Pharmacological Importance of Alstonia boonei De Wild (Apocynaceae). | 2012 | ISRN Pharmacol | pmid:22900200 |
| Fu S et al. | Anti-inflammatory effects of active constituents extracted from Chinese medicinal herbs against Propionibacterium acnes. | 2012 | Nat. Prod. Res. | pmid:21999396 |
| Khan AW et al. | Phytochemical analysis and Enzyme Inhibition Assay of Aerva javanica for Ulcer. | 2012 | Chem Cent J | pmid:22849857 |
| Pai PG et al. | Nephroprotective effect of ursolic Acid in a murine model of gentamicin-induced renal damage. | 2012 | ISRN Pharmacol | pmid:22811930 |
| Mullié C et al. | Differences in anti-malarial activity of 4-aminoalcohol quinoline enantiomers and investigation of the presumed underlying mechanism of action. | 2012 | Malar. J. | pmid:22401346 |
| Wang J et al. | Ursolic acid inhibits proliferation and induces apoptosis in human glioblastoma cell lines U251 by suppressing TGF-β1/miR-21/PDCD4 pathway. | 2012 | Basic Clin. Pharmacol. Toxicol. | pmid:22353043 |
| Checker R et al. | Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-AT. | 2012 | PLoS ONE | pmid:22363615 |
| Chen Y et al. | Changes in bioactive components related to the harvest time from the spicas of Prunella vulgaris. | 2012 | Pharm Biol | pmid:22686260 |
| Manguro LO et al. | Triterpene saponins of Maesa lanceolata stem wood. | 2012 | J Asian Nat Prod Res | pmid:23098176 |
| Zhou BJ et al. | [The quality standard study on Hugan qingzhi tablets]. | 2012 | Zhong Yao Cai | pmid:23019914 |
| de Oliveira Eloy J et al. | Solid dispersion of ursolic acid in Gelucire 50/13: a strategy to enhance drug release and trypanocidal activity. | 2012 | AAPS PharmSciTech | pmid:23070562 |