| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ding YJ et al. | Nephroprotective role of resveratrol and ursolic Acid in aristolochic Acid intoxicated zebrafish. | 2015 | Toxins (Basel) | pmid:25590276 |
| Podder B et al. | Ursolic Acid Activates Intracellular Killing Effect of Macrophages During Mycobacterium tuberculosis Infection. | 2015 | J. Microbiol. Biotechnol. | pmid:25406534 |
| Castro AJ et al. | The mechanism of action of ursolic acid as insulin secretagogue and insulinomimetic is mediated by cross-talk between calcium and kinases to regulate glucose balance. | 2015 | Biochim. Biophys. Acta | pmid:25312987 |
| Junco JJ et al. | Ursolic acid and resveratrol synergize with chloroquine to reduce melanoma cell viability. | 2015 | Melanoma Res. | pmid:25647735 |
| Broniatowski M et al. | Studies of the interactions of ursane-type bioactive terpenes with the model of Escherichia coli inner membrane-Langmuir monolayer approach. | 2015 | Biochim. Biophys. Acta | pmid:25450351 |
| Gao R et al. | Simultaneous determination of oleanolic acid, ursolic acid, quercetin and apigenin in Swertia mussotii Franch by capillary zone electrophoresis with running buffer modifier. | 2015 | Biomed. Chromatogr. | pmid:25042239 |
| Yamamoto ES et al. | The Effect of Ursolic Acid on Leishmania (Leishmania) amazonensis Is Related to Programed Cell Death and Presents Therapeutic Potential in Experimental Cutaneous Leishmaniasis. | 2015 | PLoS ONE | pmid:26674781 |
| López-GarcÃa S et al. | Macrophage Activation by Ursolic and Oleanolic Acids during Mycobacterial Infection. | 2015 | Molecules | pmid:26287131 |
| Park SN et al. | Oleanolic acid and ursolic acid inhibit peptidoglycan biosynthesis in Streptococcus mutans UA159. | 2015 | Braz. J. Microbiol. | pmid:26273281 |
| Nelson AT et al. | Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties. | 2015 | Bioorg. Med. Chem. Lett. | pmid:26259803 |
| Cho J et al. | Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate. | 2015 | Cancer Prev Res (Phila) | pmid:26100520 |
| Flores-Bocanegra L et al. | α-Glucosidase Inhibitors from Vauquelinia corymbosa. | 2015 | Molecules | pmid:26307962 |
| Cho J et al. | Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. | 2015 | Oncotarget | pmid:26513295 |
| Lin H et al. | Targeting Th17 Cells with Small Molecules and Small Interference RNA. | 2015 | Mediators Inflamm. | pmid:26792955 |
| Woźniak Šet al. | Ursolic Acid--A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities. | 2015 | Molecules | pmid:26610440 |
| Kim SH et al. | Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells. | 2015 | Sci Rep | pmid:26412148 |
| Wu P et al. | Synthesis and Evaluation of Novel Triterpene Analogues of Ursolic Acid as Potential Antidiabetic Agent. | 2015 | PLoS ONE | pmid:26406581 |
| Wu J et al. | Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells. | 2015 | J. Exp. Clin. Cancer Res. | pmid:26362062 |
| He W et al. | A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver. | 2015 | Drug Des Devel Ther | pmid:26347199 |
| Ebert SM et al. | Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. | 2015 | J. Biol. Chem. | pmid:26338703 |
| Yang Y et al. | Enhancement of Radiation Effects by Ursolic Acid in BGC-823 Human Adenocarcinoma Gastric Cancer Cell Line. | 2015 | PLoS ONE | pmid:26177078 |
| Qin N et al. | RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus biofilm inhibition by ursolic acid and resveratrol. | 2014 | Sci Rep | pmid:24970710 |
| Micota B et al. | Leonurus cardiaca L. herb--a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis. | 2014 | Acta Biochim. Pol. | pmid:24918490 |
| Colla AR et al. | Serotonergic and noradrenergic systems are implicated in the antidepressant-like effect of ursolic acid in mice. | 2014 | Pharmacol. Biochem. Behav. | pmid:24887451 |
| Fu HJ et al. | Tryptophan hydroxylase 1 (Tph-1)-targeted bone anabolic agents for osteoporosis. | 2014 | J. Med. Chem. | pmid:24844139 |
| Li Y et al. | Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and suppression of ERK1/2 MAPK in HeLa cells. | 2014 | J. Pharmacol. Sci. | pmid:24881958 |
| Shen S et al. | Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress. | 2014 | Chem. Biol. Interact. | pmid:24802810 |
| Ou X et al. | Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome. | 2014 | PLoS ONE | pmid:24740400 |
| Lee J et al. | Effects of ursolic acid on glucose metabolism, the polyol pathway and dyslipidemia in non-obese type 2 diabetic mice. | 2014 | Indian J. Exp. Biol. | pmid:25059036 |
| Hua WJ et al. | The influence of herbal medicine ursolic acid on the uptake of rosuvastatin mediated by OATP1B1*1a and *5. | 2014 | Eur J Drug Metab Pharmacokinet | pmid:24736980 |
| Chun J et al. | Ursolic acid inhibits nuclear factor-κB signaling in intestinal epithelial cells and macrophages, and attenuates experimental colitis in mice. | 2014 | Life Sci. | pmid:24992474 |
| Ullevig SL et al. | Ursolic acid protects monocytes against metabolic stress-induced priming and dysfunction by preventing the induction of Nox4. | 2014 | Redox Biol | pmid:24494201 |
| Peng W et al. | Bioavailability and activity of natural food additive triterpenoids as influenced by protein. | 2014 | J. Agric. Food Chem. | pmid:24548018 |
| Ma D et al. | Crucial role of heme oxygenase-1 in the sensitivity of acute myeloid leukemia cell line Kasumi-1 to ursolic acid. | 2014 | Anticancer Drugs | pmid:24413389 |
| Wang J et al. | Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis. | 2014 | Sci Rep | pmid:25833312 |
| Innocente AM et al. | Anti-Trichomonas vaginalis activity from triterpenoid derivatives. | 2014 | Parasitol. Res. | pmid:24880238 |
| Yang Y et al. | Ursolic acid prevents endoplasmic reticulum stress-mediated apoptosis induced by heat stress in mouse cardiac myocytes. | 2014 | J. Mol. Cell. Cardiol. | pmid:24389342 |
| Zang LL et al. | Research progress of ursolic acid's anti-tumor actions. | 2014 | Chin J Integr Med | pmid:24374755 |
| Xue C et al. | Powerful protection against renal ischemia reperfusion injury by T cell-specific NF-κB inhibition. | 2014 | Transplantation | pmid:24398854 |
| Han YY et al. | Oleanolic acid and ursolic acid inhibit proliferation in transformed rat hepatic oval cells. | 2014 | World J. Gastroenterol. | pmid:24574810 |
| Wang CM et al. | The role of pentacyclic triterpenoids in the allelopathic effects of Alstonia scholaris. | 2014 | J. Chem. Ecol. | pmid:24390624 |
| Yang G et al. | In vitro and in vivo antitumor effects of folate-targeted ursolic acid stealth liposome. | 2014 | J. Agric. Food Chem. | pmid:24528163 |
| Deng L et al. | Ursolic acid induces U937 cells differentiation by PI3K/Akt pathway activation. | 2014 | Chin J Nat Med | pmid:24484591 |
| Fabri RL et al. | Chromatographic fingerprint analysis and effects of the medicinal plant species Mitracarpus frigidus on adult Schistosoma mansoni worms. | 2014 | Biomed Res Int | pmid:24901000 |
| Liu L et al. | Inhibition of HepG2 cell proliferation by ursolic acid and polysaccharides via the downregulation of cyclooxygenase-2. | 2014 | Mol Med Rep | pmid:24638056 |
| Fabri RL et al. | Anti-inflammatory and antioxidative effects of the methanolic extract of the aerial parts of Mitracarpus frigidus in established animal models. | 2014 | J. Pharm. Pharmacol. | pmid:24350832 |
| Lopes SC et al. | Ursolic acid incorporation does not prevent the formation of a non-lamellar phase in pH-sensitive and long-circulating liposomes. | 2014 | Langmuir | pmid:25490253 |
| Yamamoto ES et al. | Treatment with triterpenic fraction purified from Baccharis uncinella leaves inhibits Leishmania (Leishmania) amazonensis spreading and improves Th1 immune response in infected mice. | 2014 | Parasitol. Res. | pmid:24173812 |
| Soica C et al. | The synergistic biologic activity of oleanolic and ursolic acids in complex with hydroxypropyl-γ-cyclodextrin. | 2014 | Molecules | pmid:24747649 |
| Siewert B et al. | The chemical and biological potential of C ring modified triterpenoids. | 2014 | Eur J Med Chem | pmid:24361521 |