MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with ursolic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Li BX et al. | [Ursolic acid activates chloride channels and decreases cell volume in poorly differentiated nasopharyngeal carcinoma cells]. | 2012 | Sheng Li Xue Bao | pmid:23258331 |
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Wang JS et al. | Ursolic acid induces apoptosis by suppressing the expression of FoxM1 in MCF-7 human breast cancer cells. | 2012 | Med. Oncol. | pmid:21191671 |
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Shin IS et al. | Ursolic acid reduces prostate size and dihydrotestosterone level in a rat model of benign prostatic hyperplasia. | 2012 | Food Chem. Toxicol. | pmid:22266360 |
Kalani K et al. | Pharmacophore, QSAR, and ADME based semisynthesis and in vitro evaluation of ursolic acid analogs for anticancer activity. | 2012 | J Mol Model | pmid:22271093 |
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Choi YH et al. | Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22940448 |
He X et al. | In vitro and in vivo antimammary tumor activities and mechanisms of the apple total triterpenoids. | 2012 | J. Agric. Food Chem. | pmid:22924395 |
Machado DG et al. | Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: evidence for the involvement of the dopaminergic system. | 2012 | Pharmacol. Biochem. Behav. | pmid:22940588 |
Kazmi I et al. | Antiepileptic potential of ursolic acid stearoyl glucoside by GABA receptor stimulation. | 2012 | CNS Neurosci Ther | pmid:22943148 |
Leal AS et al. | Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells. | 2012 | Bioorg. Med. Chem. | pmid:22959527 |
Hong SY et al. | Protective effects of the key compounds isolated from Corni fructus against β-amyloid-induced neurotoxicity in PC12 cells. | 2012 | Molecules | pmid:22964500 |
Zhong Y et al. | Preparation and evaluation of liposome-encapsulated codrug LMX. | 2012 | Int J Pharm | pmid:22981689 |
Rodrigues MR et al. | Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice. | 2012 | J Ethnopharmacol | pmid:22154965 |
Shin SW et al. | Autophagy inhibition enhances ursolic acid-induced apoptosis in PC3 cells. | 2012 | Biochim. Biophys. Acta | pmid:22178132 |
Berrington D and Lall N | Anticancer Activity of Certain Herbs and Spices on the Cervical Epithelial Carcinoma (HeLa) Cell Line. | 2012 | Evid Based Complement Alternat Med | pmid:22649474 |
Koh SJ et al. | Sensitization of ionizing radiation-induced apoptosis by ursolic acid. | 2012 | Free Radic. Res. | pmid:22239065 |
Bei WJ et al. | Lipid-regulating effect of traditional chinese medicine: mechanisms of actions. | 2012 | Evid Based Complement Alternat Med | pmid:22611438 |
Kunkel SD et al. | Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease. | 2012 | PLoS ONE | pmid:22745735 |
Pai PG et al. | Nephroprotective effect of ursolic Acid in a murine model of gentamicin-induced renal damage. | 2012 | ISRN Pharmacol | pmid:22811930 |
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Song YH et al. | Ursolic acid from Oldenlandia diffusa induces apoptosis via activation of caspases and phosphorylation of glycogen synthase kinase 3 beta in SK-OV-3 ovarian cancer cells. | 2012 | Biol. Pharm. Bull. | pmid:22791147 |
Massaoka MH et al. | Jacaranone induces apoptosis in melanoma cells via ROS-mediated downregulation of Akt and p38 MAPK activation and displays antitumor activity in vivo. | 2012 | PLoS ONE | pmid:22701695 |
Gu G et al. | Oldenlandia diffusa extracts exert antiproliferative and apoptotic effects on human breast cancer cells through ERα/Sp1-mediated p53 activation. | 2012 | J. Cell. Physiol. | pmid:22213398 |
Wilkinson K and El Khoury J | Microglial scavenger receptors and their roles in the pathogenesis of Alzheimer's disease. | 2012 | Int J Alzheimers Dis | pmid:22666621 |
Ma T et al. | Human papillomavirus type 18 E6 and E7 genes integrate into human hepatoma derived cell line Hep G2. | 2012 | PLoS ONE | pmid:22655088 |
Debprasad C et al. | Inhibition of NO(2), PGE(2), TNF-α, and iNOS EXpression by Shorea robusta L.: An Ethnomedicine Used for Anti-Inflammatory and Analgesic Activity. | 2012 | Evid Based Complement Alternat Med | pmid:22649472 |
Huang FX et al. | Microbial transformation of ursolic acid by Syncephalastrum racemosum (Cohn) Schroter AS 3.264. | 2012 | Phytochemistry | pmid:22800913 |
Meynial-Denis D et al. | New Strategies to Fight against Sarcopenia at Old Age. | 2012 | J Aging Res | pmid:22619719 |
Lu J et al. | Quality Difference Study of Six Varieties of Ganoderma lucidum with Different Origins. | 2012 | Front Pharmacol | pmid:22509164 |
Leal AS et al. | Semisynthetic ursolic acid fluorolactone derivatives inhibit growth with induction of p21(waf1) and induce apoptosis with upregulation of NOXA and downregulation of c-FLIP in cancer cells. | 2012 | ChemMedChem | pmid:22807348 |
Lan YH et al. | Activations of Both Extrinsic and Intrinsic Pathways in HCT 116 Human Colorectal Cancer Cells Contribute to Apoptosis through p53-Mediated ATM/Fas Signaling by Emilia sonchifolia Extract, a Folklore Medicinal Plant. | 2012 | Evid Based Complement Alternat Med | pmid:22474491 |
Wu B et al. | Ursolic acid-induced apoptosis in K562 cells involving upregulation of PTEN gene expression and inactivation of the PI3K/Akt pathway. | 2012 | Arch. Pharm. Res. | pmid:22477202 |
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Abstracts of the 6th cachexia conference, milan, Italy, december 8-10, 2011 (part 2). | 2012 | J Cachexia Sarcopenia Muscle | pmid:22460563 | |
Shanmugam MK et al. | Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways. | 2012 | PLoS ONE | pmid:22427843 |
Mooi LY et al. | Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22799301 |
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Feldman M et al. | Cranberry proanthocyanidins inhibit the adherence properties of Candida albicans and cytokine secretion by oral epithelial cells. | 2012 | BMC Complement Altern Med | pmid:22248145 |
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Kazmi I et al. | Anti-diabetic potential of ursolic acid stearoyl glucoside: a new triterpenic gycosidic ester from Lantana camara. | 2012 | Fitoterapia | pmid:22051701 |
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Lv YY et al. | Ursolic acid suppresses IL-6 induced C-reactive protein expression in HepG2 and protects HUVECs from injury induced by CRP. | 2012 | Eur J Pharm Sci | pmid:22108347 |
Zheng QY et al. | Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22387548 |
Jin YR et al. | Ursolic acid enhances mouse liver regeneration after partial hepatectomy. | 2012 | Pharm Biol | pmid:22136205 |
Gao J et al. | Facile synthesis of triterpenoid saponins bearing β-Glu/Gal-(1→3)-β-GluA methyl ester and their cytotoxic activities. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22406153 |
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Liu W et al. | Ursolic acid inhibits cigarette smoke extract-induced human bronchial epithelial cell injury and prevents development of lung cancer. | 2012 | Molecules | pmid:22858837 |
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Prasad S et al. | Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine. | 2012 | Clin. Cancer Res. | pmid:22832932 |
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