MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with ursolic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Podder B et al. | Ursolic Acid Activates Intracellular Killing Effect of Macrophages During Mycobacterium tuberculosis Infection. | 2015 | J. Microbiol. Biotechnol. | pmid:25406534 |
Castro AJ et al. | The mechanism of action of ursolic acid as insulin secretagogue and insulinomimetic is mediated by cross-talk between calcium and kinases to regulate glucose balance. | 2015 | Biochim. Biophys. Acta | pmid:25312987 |
Junco JJ et al. | Ursolic acid and resveratrol synergize with chloroquine to reduce melanoma cell viability. | 2015 | Melanoma Res. | pmid:25647735 |
Broniatowski M et al. | Studies of the interactions of ursane-type bioactive terpenes with the model of Escherichia coli inner membrane-Langmuir monolayer approach. | 2015 | Biochim. Biophys. Acta | pmid:25450351 |
Gao R et al. | Simultaneous determination of oleanolic acid, ursolic acid, quercetin and apigenin in Swertia mussotii Franch by capillary zone electrophoresis with running buffer modifier. | 2015 | Biomed. Chromatogr. | pmid:25042239 |
López-GarcÃa S et al. | Macrophage Activation by Ursolic and Oleanolic Acids during Mycobacterial Infection. | 2015 | Molecules | pmid:26287131 |
Park SN et al. | Oleanolic acid and ursolic acid inhibit peptidoglycan biosynthesis in Streptococcus mutans UA159. | 2015 | Braz. J. Microbiol. | pmid:26273281 |
Nelson AT et al. | Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties. | 2015 | Bioorg. Med. Chem. Lett. | pmid:26259803 |
Cho J et al. | Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate. | 2015 | Cancer Prev Res (Phila) | pmid:26100520 |
Flores-Bocanegra L et al. | α-Glucosidase Inhibitors from Vauquelinia corymbosa. | 2015 | Molecules | pmid:26307962 |
Cho J et al. | Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. | 2015 | Oncotarget | pmid:26513295 |
Woźniak Šet al. | Ursolic Acid--A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities. | 2015 | Molecules | pmid:26610440 |
Kim SH et al. | Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells. | 2015 | Sci Rep | pmid:26412148 |
Wu P et al. | Synthesis and Evaluation of Novel Triterpene Analogues of Ursolic Acid as Potential Antidiabetic Agent. | 2015 | PLoS ONE | pmid:26406581 |
Wu J et al. | Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells. | 2015 | J. Exp. Clin. Cancer Res. | pmid:26362062 |
He W et al. | A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver. | 2015 | Drug Des Devel Ther | pmid:26347199 |
Ebert SM et al. | Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. | 2015 | J. Biol. Chem. | pmid:26338703 |
Yang Y et al. | Enhancement of Radiation Effects by Ursolic Acid in BGC-823 Human Adenocarcinoma Gastric Cancer Cell Line. | 2015 | PLoS ONE | pmid:26177078 |
Aguiriano-Moser V et al. | Ursolic acid from Trailliaedoxa gracilis induces apoptosis in medullary thyroid carcinoma cells. | 2015 | Mol Med Rep | pmid:26151624 |
Tan X et al. | Transcriptome analysis of the biofilm formed by methicillin-susceptible Staphylococcus aureus. | 2015 | Sci Rep | pmid:26149474 |