| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim HI et al. | Inhibition of estrogen signaling through depletion of estrogen receptor alpha by ursolic acid and betulinic acid from Prunella vulgaris var. lilacina. | 2014 | Biochem. Biophys. Res. Commun. | pmid:25088993 |
| Tang Q et al. | Mitochondrial translocation of cofilin-1 promotes apoptosis of gastric cancer BGC-823 cells induced by ursolic acid. | 2014 | Tumour Biol. | pmid:24197982 |
| Chen J et al. | A new synthetic ursolic acid derivative IUA with anti-tumor efficacy against osteosarcoma cells via inhibition of JNK signaling pathway. | 2014 | Cell. Physiol. Biochem. | pmid:25171517 |
| Song J et al. | Development and characterisation of ursolic acid nanocrystals without stabiliser having improved dissolution rate and in vitro anticancer activity. | 2014 | AAPS PharmSciTech | pmid:24022345 |
| Wu P et al. | Effects of ursolic acid derivatives on Caco-2 cells and their alleviating role in streptozocin-induced type 2 diabetic rats. | 2014 | Molecules | pmid:25153871 |
| Baek SY et al. | Ursolic acid ameliorates autoimmune arthritis via suppression of Th17 and B cell differentiation. | 2014 | Acta Pharmacol. Sin. | pmid:25087995 |
| Qin N et al. | RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus biofilm inhibition by ursolic acid and resveratrol. | 2014 | Sci Rep | pmid:24970710 |
| Micota B et al. | Leonurus cardiaca L. herb--a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis. | 2014 | Acta Biochim. Pol. | pmid:24918490 |
| Colla AR et al. | Serotonergic and noradrenergic systems are implicated in the antidepressant-like effect of ursolic acid in mice. | 2014 | Pharmacol. Biochem. Behav. | pmid:24887451 |
| Fu HJ et al. | Tryptophan hydroxylase 1 (Tph-1)-targeted bone anabolic agents for osteoporosis. | 2014 | J. Med. Chem. | pmid:24844139 |
| Li Y et al. | Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and suppression of ERK1/2 MAPK in HeLa cells. | 2014 | J. Pharmacol. Sci. | pmid:24881958 |
| Shen S et al. | Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress. | 2014 | Chem. Biol. Interact. | pmid:24802810 |
| Lee J et al. | Effects of ursolic acid on glucose metabolism, the polyol pathway and dyslipidemia in non-obese type 2 diabetic mice. | 2014 | Indian J. Exp. Biol. | pmid:25059036 |
| Chun J et al. | Ursolic acid inhibits nuclear factor-κB signaling in intestinal epithelial cells and macrophages, and attenuates experimental colitis in mice. | 2014 | Life Sci. | pmid:24992474 |
| Ma D et al. | Crucial role of heme oxygenase-1 in the sensitivity of acute myeloid leukemia cell line Kasumi-1 to ursolic acid. | 2014 | Anticancer Drugs | pmid:24413389 |
| Innocente AM et al. | Anti-Trichomonas vaginalis activity from triterpenoid derivatives. | 2014 | Parasitol. Res. | pmid:24880238 |
| Yang Y et al. | Ursolic acid prevents endoplasmic reticulum stress-mediated apoptosis induced by heat stress in mouse cardiac myocytes. | 2014 | J. Mol. Cell. Cardiol. | pmid:24389342 |
| Déciga-Campos M et al. | Isobolographic analysis of the antinociceptive interaction between ursolic acid and diclofenac or tramadol in mice. | 2014 | Planta Med. | pmid:24431012 |
| Lee YH et al. | Ursolic acid differentially modulates apoptosis in skin melanoma and retinal pigment epithelial cells exposed to UV-VIS broadband radiation. | 2014 | Apoptosis | pmid:24375173 |
| Yoon JH et al. | p-Coumaric acid and ursolic acid from Corni fructus attenuated β-amyloid(25-35)-induced toxicity through regulation of the NF-κB signaling pathway in PC12 cells. | 2014 | J. Agric. Food Chem. | pmid:24815946 |
| Fabri RL et al. | Chromatographic fingerprint analysis and effects of the medicinal plant species Mitracarpus frigidus on adult Schistosoma mansoni worms. | 2014 | Biomed Res Int | pmid:24901000 |
| Zhang W et al. | Review on anti-tumor effect of triterpene acid compounds. | 2014 | J Cancer Res Ther | pmid:25207885 |
| Zhao CH et al. | Inhibition of human enterovirus 71 replication by pentacyclic triterpenes and their novel synthetic derivatives. | 2014 | Chem. Pharm. Bull. | pmid:25087628 |
| Soica C et al. | The synergistic biologic activity of oleanolic and ursolic acids in complex with hydroxypropyl-γ-cyclodextrin. | 2014 | Molecules | pmid:24747649 |
| Kurek A et al. | The effect of oleanolic and ursolic acids on the hemolytic properties and biofilm formation of Listeria monocytogenes. | 2014 | Pol. J. Microbiol. | pmid:25033658 |
| Nowak R et al. | HPTLC-densitometry determination of triterpenic acids in Origanum vulgare, Rosmarinus officinalis and Syzygium aromaticum. | 2013 May-Jun | Acta Pol Pharm | pmid:23757931 |
| Feng L et al. | Inhibition of human neutrophil elastase by pentacyclic triterpenes. | 2013 | PLoS ONE | pmid:24376583 |
| Gai L et al. | Ursolic acid induces apoptosis via Akt/NF-κB signaling suppression in T24 human bladder cancer cells. | 2013 | Mol Med Rep | pmid:23483134 |
| Park JH et al. | Inhibition of Wnt/β-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells. | 2013 | Pharmacol Rep | pmid:24399733 |
| do Nascimento PG et al. | Antibacterial and antioxidant activities of ursolic acid and derivatives. | 2013 | Molecules | pmid:24451251 |
| Wan LS et al. | Two new chiratane-type triterpenoids from Swertia kouitchensis. | 2013 | Molecules | pmid:23873389 |
| Nguyen PH et al. | Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity. | 2013 | J. Nat. Prod. | pmid:24224843 |
| Chen Y et al. | Optimisation of potassium chloride nutrition for proper growth, physiological development and bioactive component production in Prunella vulgaris L. | 2013 | PLoS ONE | pmid:23874390 |
| Wang ZW et al. | α-Glucosidase inhibitory triterpenoids from the stem barks of Uncaria laevigata. | 2013 | Fitoterapia | pmid:23856092 |
| da Silva Ferreira D et al. | In vivo activity of ursolic and oleanolic acids during the acute phase of Trypanosoma cruzi infection. | 2013 | Exp. Parasitol. | pmid:23648663 |
| Banihani S et al. | Pomegranate and type 2 diabetes. | 2013 | Nutr Res | pmid:23684435 |
| Wu L et al. | Processing technology investigation of loquat (Eriobotrya japonica) leaf by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry combined with chemometrics. | 2013 | PLoS ONE | pmid:23667702 |
| Zheng QY et al. | Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells. | 2013 | Cell. Signal. | pmid:23000344 |
| Junco JJ et al. | Resveratrol and P-glycoprotein inhibitors enhance the anti-skin cancer effects of ursolic acid. | 2013 | Mol. Cancer Res. | pmid:24072817 |
| Jiménez-Arellanes A et al. | Ursolic and oleanolic acids as antimicrobial and immunomodulatory compounds for tuberculosis treatment. | 2013 | BMC Complement Altern Med | pmid:24098949 |
| Rao AR et al. | In vitro and in vivo inhibitory activities of four Indian medicinal plant extracts and their major components on rat aldose reductase and generation of advanced glycation endproducts. | 2013 | Phytother Res | pmid:22826152 |
| Fu SB et al. | Biotransformation of ursolic acid by Syncephalastrum racemosum CGMCC 3.2500 and anti-HCV activity. | 2013 | Fitoterapia | pmid:23425601 |
| Liu K et al. | Ursolic acid inhibits epithelial-mesenchymal transition by suppressing the expression of astrocyte-elevated gene-1 in human nonsmall cell lung cancer A549 cells. | 2013 | Anticancer Drugs | pmid:23511428 |
| Wu DM et al. | Ursolic acid improves domoic acid-induced cognitive deficits in mice. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23707761 |
| Leng S et al. | Ursolic acid promotes cancer cell death by inducing Atg5-dependent autophagy. | 2013 | Int. J. Cancer | pmid:23737395 |
| Wang J et al. | Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells. | 2013 | PLoS ONE | pmid:23737956 |
| Zhao C et al. | Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells. | 2013 | Autophagy | pmid:23182854 |
| He Y et al. | Ursolic acid inhibits adipogenesis in 3T3-L1 adipocytes through LKB1/AMPK pathway. | 2013 | PLoS ONE | pmid:23922935 |
| Caldeira de Araújo Lopes S et al. | Preparation, physicochemical characterization, and cell viability evaluation of long-circulating and pH-sensitive liposomes containing ursolic acid. | 2013 | Biomed Res Int | pmid:23984367 |
| Brandão GC et al. | Chemistry and Antiviral Activity of Arrabidaea pulchra (Bignoniaceae). | 2013 | Molecules | pmid:23959197 |