| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chang CW et al. | Analgesic and Anti-Inflammatory Activities of Methanol Extract of Cissus repens in Mice. | 2012 | Evid Based Complement Alternat Med | pmid:22991570 |
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| RodrÃguez-Berriguete G et al. | MAP Kinases and Prostate Cancer. | 2012 | J Signal Transduct | pmid:22046506 |
| Adotey JP et al. | A Review of the Ethnobotany and Pharmacological Importance of Alstonia boonei De Wild (Apocynaceae). | 2012 | ISRN Pharmacol | pmid:22900200 |
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| Kurek A et al. | Modulation of antibiotic resistance in bacterial pathogens by oleanolic acid and ursolic acid. | 2012 | Phytomedicine | pmid:22341643 |
| Zeller I et al. | Inhibition of cell surface expression of endothelial adhesion molecules by ursolic acid prevents intimal hyperplasia of venous bypass grafts in rats. | 2012 | Eur J Cardiothorac Surg | pmid:22551965 |
| Fu S et al. | Anti-inflammatory effects of active constituents extracted from Chinese medicinal herbs against Propionibacterium acnes. | 2012 | Nat. Prod. Res. | pmid:21999396 |
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| Wang J et al. | Ursolic acid inhibits proliferation and induces apoptosis in human glioblastoma cell lines U251 by suppressing TGF-β1/miR-21/PDCD4 pathway. | 2012 | Basic Clin. Pharmacol. Toxicol. | pmid:22353043 |
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| Wen KC et al. | Inhibitory Effects of Terminalia catappa on UVB-Induced Photodamage in Fibroblast Cell Line. | 2011 | Evid Based Complement Alternat Med | pmid:20981325 |
| Wang YJ et al. | Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways. | 2011 | Neurobiol Learn Mem | pmid:21496491 |
| Huang CY et al. | Inhibition of cell proliferation, invasion and migration by ursolic acid in human lung cancer cell lines. | 2011 | Toxicol In Vitro | pmid:21539908 |
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| Zhang T et al. | Ursolic acid induces HL60 monocytic differentiation and upregulates C/EBPβ expression by ERK pathway activation. | 2011 | Anticancer Drugs | pmid:20948428 |
| Sonnet P and Mullié C | In vitro antimalarial activity of ICL670: a further proof of the correlation between inhibition of β-hematin formation and of peroxidative degradation of hemin. | 2011 | Exp. Parasitol. | pmid:21295029 |
| Chen Q et al. | Development of a liquid chromatography-mass spectrometry method for the determination of ursolic acid in rat plasma and tissue: application to the pharmacokinetic and tissue distribution study. | 2011 | Anal Bioanal Chem | pmid:21249342 |
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| Limami Y et al. | HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death. | 2011 | Biochimie | pmid:21251952 |
| Patel DK et al. | Pedalium murex Linn.: an overview of its phytopharmacological aspects. | 2011 | Asian Pac J Trop Med | pmid:21967701 |
| Prasad S et al. | Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK. | 2011 | J. Biol. Chem. | pmid:21156789 |
| Fukushima EO et al. | CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis. | 2011 | Plant Cell Physiol. | pmid:22039103 |
| Wang X et al. | Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells. | 2011 | J. Hepatol. | pmid:21168456 |
| Xia Y et al. | Quantitation of ursolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry and its pharmacokinetic study. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21169069 |
| Xu T et al. | Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. | 2011 | J. Biol. Chem. | pmid:21566134 |
| Filocamo A et al. | Norfloxacin and ursolic acid: in vitro association and postantibiotic effect against Staphylococcus aureus. | 2011 | Lett. Appl. Microbiol. | pmid:21609344 |
| Rao VS et al. | Ursolic acid, a pentacyclic triterpene from Sambucus australis, prevents abdominal adiposity in mice fed a high-fat diet. | 2011 | J Med Food | pmid:21612453 |
| Pinon A et al. | A novel form of melanoma apoptosis resistance: melanogenesis up-regulation in apoptotic B16-F0 cells delays ursolic acid-triggered cell death. | 2011 | Exp. Cell Res. | pmid:21565187 |
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| Shan JZ et al. | Proliferation-inhibiting and apoptosis-inducing effects of ursolic acid and oleanolic acid on multi-drug resistance cancer cells in vitro. | 2011 | Chin J Integr Med | pmid:21826595 |
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