MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with ursolic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Zhang H et al. | Efficient delivery of ursolic acid by poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles for inhibiting the growth of hepatocellular carcinoma in vitro and in vivo. | 2015 | Int J Nanomedicine | pmid:25792825 |
Lu X et al. | Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Akt/mTOR suppression. | 2015 | PLoS ONE | pmid:25689721 |
Chen H et al. | Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agents. | 2015 | Eur J Med Chem | pmid:25617694 |
Ding YJ et al. | Nephroprotective role of resveratrol and ursolic Acid in aristolochic Acid intoxicated zebrafish. | 2015 | Toxins (Basel) | pmid:25590276 |
Yamamoto ES et al. | The Effect of Ursolic Acid on Leishmania (Leishmania) amazonensis Is Related to Programed Cell Death and Presents Therapeutic Potential in Experimental Cutaneous Leishmaniasis. | 2015 | PLoS ONE | pmid:26674781 |
Broniatowski M et al. | Grazing incidence diffraction studies of the interactions between ursane-type antimicrobial triterpenes and bacterial anionic phospholipids. | 2015 | Colloids Surf B Biointerfaces | pmid:25805152 |
LÅ‘rincz A et al. | Effects of ursolic acid on the structural and morphological behaviours of dipalmitoyl lecithin vesicles. | 2015 | Biochim. Biophys. Acta | pmid:25620772 |
Hu Z et al. | Ursolic acid improves survival and attenuates lung injury in septic rats induced by cecal ligation and puncture. | 2015 | J. Surg. Res. | pmid:25454976 |
Lin H et al. | Targeting Th17 Cells with Small Molecules and Small Interference RNA. | 2015 | Mediators Inflamm. | pmid:26792955 |
Xiang L et al. | A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis. | 2015 | Oncotarget | pmid:25823660 |
Adams CM et al. | Use of mRNA expression signatures to discover small molecule inhibitors of skeletal muscle atrophy. | 2015 | Curr Opin Clin Nutr Metab Care | pmid:25807353 |
Kalani K et al. | In vitro, in silico and in vivo studies of ursolic acid as an anti-filarial agent. | 2014 | PLoS ONE | pmid:25375886 |
Hwang TL et al. | Ursolic acid inhibits superoxide production in activated neutrophils and attenuates trauma-hemorrhage shock-induced organ injury in rats. | 2014 | PLoS ONE | pmid:25360589 |
He Y et al. | Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes. | 2014 | PLoS ONE | pmid:25329874 |
Xue C et al. | Powerful protection against renal ischemia reperfusion injury by T cell-specific NF-κB inhibition. | 2014 | Transplantation | pmid:24398854 |
Wang CM et al. | The role of pentacyclic triterpenoids in the allelopathic effects of Alstonia scholaris. | 2014 | J. Chem. Ecol. | pmid:24390624 |
Yang G et al. | In vitro and in vivo antitumor effects of folate-targeted ursolic acid stealth liposome. | 2014 | J. Agric. Food Chem. | pmid:24528163 |
Deng L et al. | Ursolic acid induces U937 cells differentiation by PI3K/Akt pathway activation. | 2014 | Chin J Nat Med | pmid:24484591 |
Li S et al. | Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease rats. | 2014 | PLoS ONE | pmid:24489777 |
Lu CC et al. | Ursolic acid triggers nonprogrammed death (necrosis) in human glioblastoma multiforme DBTRG-05MG cells through MPT pore opening and ATP decline. | 2014 | Mol Nutr Food Res | pmid:25131308 |