| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Skariyachan S et al. | Computer aided screening and evaluation of herbal therapeutics against MRSA infections. | 2011 | Bioinformation | pmid:22125390 |
| Lu J et al. | Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice. | 2011 | Brain Behav. Immun. | pmid:21708244 |
| Saaby L et al. | Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.). | 2011 | Phytother Res | pmid:20632303 |
| Messner B et al. | Ursolic acid causes DNA-damage, p53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo. | 2011 | Atherosclerosis | pmid:21703625 |
| Sun LP et al. | Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors. | 2011 | Eur J Med Chem | pmid:21680062 |
| Bai KK et al. | Synthesis of [3β-acetoxy-urs-12-en-28-oyl]-1-monoglyceride and investigation on its anti tumor effects against BGC-823. | 2011 | Bioorg. Med. Chem. | pmid:21664827 |
| Liu Y et al. | Ursolic acid promotes robust tolerance to cardiac allografts in mice. | 2011 | Clin. Exp. Immunol. | pmid:21391985 |
| Sultana N | Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product. | 2011 | J Enzyme Inhib Med Chem | pmid:21417964 |
| Shanmugam MK et al. | Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model. | 2011 | Int. J. Cancer | pmid:21480220 |
| Wen KC et al. | Inhibitory Effects of Terminalia catappa on UVB-Induced Photodamage in Fibroblast Cell Line. | 2011 | Evid Based Complement Alternat Med | pmid:20981325 |
| Wang YJ et al. | Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways. | 2011 | Neurobiol Learn Mem | pmid:21496491 |
| Huang CY et al. | Inhibition of cell proliferation, invasion and migration by ursolic acid in human lung cancer cell lines. | 2011 | Toxicol In Vitro | pmid:21539908 |
| Shao JW et al. | In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives. | 2011 | Eur J Med Chem | pmid:21514015 |
| Arora R et al. | Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud. | 2011 | Evid Based Complement Alternat Med | pmid:20976081 |
| Shanmugam MK et al. | Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. | 2011 | J. Mol. Med. | pmid:21465181 |
| Zhang T et al. | Ursolic acid induces HL60 monocytic differentiation and upregulates C/EBPβ expression by ERK pathway activation. | 2011 | Anticancer Drugs | pmid:20948428 |
| Sonnet P and Mullié C | In vitro antimalarial activity of ICL670: a further proof of the correlation between inhibition of β-hematin formation and of peroxidative degradation of hemin. | 2011 | Exp. Parasitol. | pmid:21295029 |
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| Chiou JF et al. | A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging. | 2011 | Evid Based Complement Alternat Med | pmid:21785640 |
| Chung PY et al. | Synergistic antimicrobial activity between pentacyclic triterpenoids and antibiotics against Staphylococcus aureus strains. | 2011 | Ann. Clin. Microbiol. Antimicrob. | pmid:21658242 |
| Shan JZ et al. | Proliferation-inhibiting and apoptosis-inducing effects of ursolic acid and oleanolic acid on multi-drug resistance cancer cells in vitro. | 2011 | Chin J Integr Med | pmid:21826595 |
| Xu XY et al. | Two new triterpenoid glycosides from the leaves of Anthocephalus chinensis. | 2011 | J Asian Nat Prod Res | pmid:21985583 |
| Wang C et al. | Determination of oleanolic and ursolic acid in Chinese herbs using HPLC and γ-CD as mobile phase modifier. | 2011 | J Sep Sci | pmid:21994210 |
| Ullevig SL et al. | Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis. | 2011 | Atherosclerosis | pmid:21752377 |
| Lin Y et al. | Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters. | 2011 | Evid Based Complement Alternat Med | pmid:19228775 |
| Venkateswara Rao G et al. | Chemical constituents and biological studies of Origanum vulgare Linn. | 2011 | Pharmacognosy Res | pmid:21772760 |
| Tan W et al. | Anti-cancer natural products isolated from chinese medicinal herbs. | 2011 | Chin Med | pmid:21777476 |
| Samadi N et al. | Comparative antibacterial efficacy of endemic satureja khuzistanica jamzad essential oil, sodium hypochlorite and chlorhexidine gluconate solutions as root canal irrigations. | 2011 | Dent Res J (Isfahan) | pmid:22132012 |
| Pieroni LG et al. | Antioxidant activity and total phenols from the methanolic extract of Miconia albicans (Sw.) Triana leaves. | 2011 | Molecules | pmid:22075573 |
| Wang X et al. | Antifungal metabolites from the roots of Diospyros virginiana by overpressure layer chromatography. | 2011 | Chem. Biodivers. | pmid:22162171 |
| Arbab AS et al. | MRI to assess chemoprevention in transgenic adenocarcinoma of mouse prostate (TRAMP). | 2011 | BMC Med Imaging | pmid:22165848 |
| Jia Y et al. | Ursolic acid is a PPAR-α agonist that regulates hepatic lipid metabolism. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21855333 |
| Odonne G et al. | Antileishmanial sesquiterpene lactones from Pseudelephantopus spicatus, a traditional remedy from the Chayahuita Amerindians (Peru). Part III. | 2011 | J Ethnopharmacol | pmid:21771652 |
| Kim MJ et al. | Effects of freeze-dried cranberry powder on serum lipids and inflammatory markers in lipopolysaccharide treated rats fed an atherogenic diet. | 2011 | Nutr Res Pract | pmid:22125677 |
| Uygur B and Wu WS | SLUG promotes prostate cancer cell migration and invasion via CXCR4/CXCL12 axis. | 2011 | Mol. Cancer | pmid:22074556 |
| Schwaiger S et al. | Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.). | 2011 | J Ethnopharmacol | pmid:21040770 |
| Kondo M et al. | Ursolic acid and its esters: occurrence in cranberries and other Vaccinium fruit and effects on matrix metalloproteinase activity in DU145 prostate tumor cells. | 2011 | J. Sci. Food Agric. | pmid:21351105 |
| Zhang HE et al. | [Optimization of supercritical fluid extraction of ursolic acid from follum eriobotryae by response surface methodology]. | 2011 | Zhong Yao Cai | pmid:22372151 |
| Ansarullah S et al. | Influence of Oreocnide integrifolia (Gaud.) Miq on IRS-1, Akt and Glut-4 in Fat-Fed C57BL/6J Type 2 Diabetes Mouse Model. | 2011 | Evid Based Complement Alternat Med | pmid:21785636 |
| Lahon K and Das S | Hepatoprotective activity of Ocimum sanctum alcoholic leaf extract against paracetamol-induced liver damage in Albino rats. | 2011 | Pharmacognosy Res | pmid:21731390 |
| Mohan L et al. | Evaluation of the Anxiolytic Activity of NR-ANX-C (a Polyherbal Formulation) in Ethanol Withdrawal-Induced Anxiety Behavior in Rats. | 2011 | Evid Based Complement Alternat Med | pmid:20953426 |
| Qiang Z et al. | Permeability of rosmarinic acid in Prunella vulgaris and ursolic acid in Salvia officinalis extracts across Caco-2 cell monolayers. | 2011 | J Ethnopharmacol | pmid:21798330 |
| Meng YQ et al. | [Synthesis and anti-tumor activity of ursolic acid derivatives]. | 2011 | Yao Xue Xue Bao | pmid:21800543 |
| Kuete V et al. | Antimicrobial activities of the methanol extract, fractions and compounds from Ficus polita Vahl. (Moraceae). | 2011 | BMC Complement Altern Med | pmid:21269424 |
| Wang O et al. | Anticancer activity of 2α, 3α, 19β, 23β-Tetrahydroxyurs-12-en-28-oic acid (THA), a novel triterpenoid isolated from Sinojackia sarcocarpa. | 2011 | PLoS ONE | pmid:21695177 |
| Kaur M and Goel RK | Anti-Convulsant Activity of Boerhaavia diffusa: Plausible Role of Calcium Channel Antagonism. | 2011 | Evid Based Complement Alternat Med | pmid:19948752 |
| Fu SB et al. | Multihydroxylation of ursolic acid by Pestalotiopsis microspora isolated from the medicinal plant Huperzia serrata. | 2011 | Fitoterapia | pmid:21767617 |
| Passero LF et al. | Anti-leishmanial effects of purified compounds from aerial parts of Baccharis uncinella C. DC. (Asteraceae). | 2011 | Parasitol. Res. | pmid:20886232 |
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| Akiyama M | The roles of ABCA12 in keratinocyte differentiation and lipid barrier formation in the epidermis. | 2011 | Dermatoendocrinol | pmid:21695020 |
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| Gasnier C et al. | Defined plant extracts can protect human cells against combined xenobiotic effects. | 2011 | J Occup Med Toxicol | pmid:21251308 |
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| Chen RJ et al. | Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+ -ATPase. | 2010 | Acta Pharmacol. Sin. | pmid:20523340 |
| Hsu CL et al. | Antioxidant and anti-inflammatory effects of Orthosiphon aristatus and its bioactive compounds. | 2010 | J. Agric. Food Chem. | pmid:20095565 |
| Wang P et al. | Synthesis and cytotoxic activity of the N-acetylglucosamine-bearing triterpenoid saponins. | 2010 | Carbohydr. Res. | pmid:20116049 |
| Zhou Y et al. | Ursolic acid inhibits early lesions of diabetic nephropathy. | 2010 | Int. J. Mol. Med. | pmid:20818497 |
| Fang X et al. | Optimization of microwave-assisted extraction followed by RP-HPLC for the simultaneous determination of oleanolic acid and ursolic acid in the fruits of Chaenomeles sinensis. | 2010 | J Sep Sci | pmid:20183824 |
| Yu YX et al. | Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway. | 2010 | Chin. Med. J. | pmid:20819578 |
| Lee AW et al. | Ursolic acid induces allograft inflammatory factor-1 expression via a nitric oxide-related mechanism and increases neovascularization. | 2010 | J. Agric. Food Chem. | pmid:21070071 |
| Ibarra A et al. | Effects of chronic administration of Melissa officinalis L. extract on anxiety-like reactivity and on circadian and exploratory activities in mice. | 2010 | Phytomedicine | pmid:20171069 |
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| De Angel RE et al. | Antitumor effects of ursolic acid in a mouse model of postmenopausal breast cancer. | 2010 | Nutr Cancer | pmid:21058195 |
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| Kwon SH et al. | Apoptotic action of ursolic acid isolated from Corni fructus in RC-58T/h/SA#4 primary human prostate cancer cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20943386 |
| Lan K et al. | Simple quality assessment approach for herbal extracts using high performance liquid chromatography-UV based metabolomics platform. | 2010 | J Chromatogr A | pmid:20045112 |
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| Lee JY et al. | Effects of hydroxy pentacyclic triterpene acids from Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea pigs. | 2010 | Biol. Pharm. Bull. | pmid:20118545 |
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| Kanjoormana M and Kuttan G | Antiangiogenic activity of ursolic acid. | 2010 | Integr Cancer Ther | pmid:20462855 |
| Jung TY et al. | Ursolic acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFN-gamma by CD4+ naïve T cells. | 2010 | Eur. J. Pharmacol. | pmid:20599915 |
| Ibarra A et al. | Importance of extract standardization and in vitro/ex vivo assay selection for the evaluation of antioxidant activity of botanicals: a case study on three Rosmarinus officinalis L. extracts. | 2010 | J Med Food | pmid:20626255 |
| Yang L et al. | Ursolic acid induces doxorubicin-resistant HepG2 cell death via the release of apoptosis-inducing factor. | 2010 | Cancer Lett. | pmid:20630652 |
| Meng Y et al. | Synthesis and in vitro cytotoxicity of novel ursolic acid derivatives. | 2010 | Molecules | pmid:20657424 |
| Li Y et al. | Ursolic acid stimulates lipolysis in primary-cultured rat adipocytes. | 2010 | Mol Nutr Food Res | pmid:20521271 |
| Mandukhail SU et al. | Studies on antidyslipidemic effects of Morinda citrifolia (Noni) fruit, leaves and root extracts. | 2010 | Lipids Health Dis | pmid:20727145 |
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| Zhang Y et al. | Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro. | 2010 | Mol. Carcinog. | pmid:20146252 |
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| Rollinger JM et al. | 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. | 2010 | Bioorg. Med. Chem. | pmid:20100662 |
| Zhang YX et al. | Ursolic acid overcomes Bcl-2-mediated resistance to apoptosis in prostate cancer cells involving activation of JNK-induced Bcl-2 phosphorylation and degradation. | 2010 | J. Cell. Biochem. | pmid:20052671 |
| Bertoni BW et al. | Genetic diversity in natural populations of Jacaranda decurrens Cham. determined using RAPD and AFLP markers. | 2010 | Genet. Mol. Biol. | pmid:21637428 |
| Gui C et al. | Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. | 2010 | Curr Chem Genomics | pmid:20448812 |
| Yang EJ et al. | Acanthopanax koreanum fruit waste inhibits lipopolysaccharide-induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages. | 2010 | J. Biomed. Biotechnol. | pmid:20368786 |
| Zhou C et al. | Variation of oleanolic and ursolic acid in the flesh of persimmon fruit among different cultivars. | 2010 | Molecules | pmid:20877245 |
| Azevedo MF et al. | Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3. | 2010 | Phytother Res | pmid:20127879 |
| Kaur G et al. | Exploring the potential effect of Ocimum sanctum in vincristine-induced neuropathic pain in rats. | 2010 | J Brachial Plex Peripher Nerve Inj | pmid:20181005 |
| Shyu MH et al. | Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP. | 2010 | J. Agric. Food Chem. | pmid:20415421 |
| Yu Z et al. | Gas phase isomeric differentiation of oleanolic and ursolic acids associated with heptakis-(2,6-di-O-methyl)-beta-cyclodextrin by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. | 2010 | J Mass Spectrom | pmid:20306522 |
| Shen D et al. | LC-MS method for the simultaneous quantitation of the anti-inflammatory constituents in oregano (Origanum species). | 2010 | J. Agric. Food Chem. | pmid:20496910 |
| Tang XH et al. | Preservation on calcium homeostasis is involved in mitochondrial protection of Limonium sinense against liver damage in mice. | 2010 | Pharmacogn Mag | pmid:20931078 |
| Tian S et al. | Determination of oleanolic acid and ursolic acid contents in Ziziphora clinopodioides Lam. by HPLC method. | 2010 | Pharmacogn Mag | pmid:20668577 |