| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cui HZ et al. | Ursolic acid increases the secretion of atrial natriuretic peptide in isolated perfused beating rabbit atria. | 2011 | Eur. J. Pharmacol. | pmid:21122803 |
| Kunkel SD et al. | mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass. | 2011 | Cell Metab. | pmid:21641545 |
| Skariyachan S et al. | Computer aided screening and evaluation of herbal therapeutics against MRSA infections. | 2011 | Bioinformation | pmid:22125390 |
| Liobikas J et al. | Uncoupling and antioxidant effects of ursolic acid in isolated rat heart mitochondria. | 2011 | J. Nat. Prod. | pmid:21648406 |
| Lu J et al. | Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice. | 2011 | Brain Behav. Immun. | pmid:21708244 |
| Messner B et al. | Ursolic acid causes DNA-damage, p53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo. | 2011 | Atherosclerosis | pmid:21703625 |
| Sun LP et al. | Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors. | 2011 | Eur J Med Chem | pmid:21680062 |
| Bai KK et al. | Synthesis of [3β-acetoxy-urs-12-en-28-oyl]-1-monoglyceride and investigation on its anti tumor effects against BGC-823. | 2011 | Bioorg. Med. Chem. | pmid:21664827 |
| Deoda RS et al. | Gastroprotective Effect of Rubia cordifolia Linn. on Aspirin Plus Pylorus-Ligated Ulcer. | 2011 | Evid Based Complement Alternat Med | pmid:21423635 |
| Liu Y et al. | Ursolic acid promotes robust tolerance to cardiac allografts in mice. | 2011 | Clin. Exp. Immunol. | pmid:21391985 |
| Sultana N | Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product. | 2011 | J Enzyme Inhib Med Chem | pmid:21417964 |
| Shanmugam MK et al. | Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model. | 2011 | Int. J. Cancer | pmid:21480220 |
| Wang YJ et al. | Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways. | 2011 | Neurobiol Learn Mem | pmid:21496491 |
| Huang CY et al. | Inhibition of cell proliferation, invasion and migration by ursolic acid in human lung cancer cell lines. | 2011 | Toxicol In Vitro | pmid:21539908 |
| Sporn MB et al. | New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. | 2011 | J. Nat. Prod. | pmid:21309592 |
| Fukushima EO et al. | CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis. | 2011 | Plant Cell Physiol. | pmid:22039103 |
| Ali M and Chaudhary N | Ficus hispida Linn.: A review of its pharmacognostic and ethnomedicinal properties. | 2011 | Pharmacogn Rev | pmid:22096323 |
| Roth M et al. | Isolation of modulators of the liver-specific organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae). | 2011 | J. Pharmacol. Exp. Ther. | pmid:21846839 |
| Chiou JF et al. | A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging. | 2011 | Evid Based Complement Alternat Med | pmid:21785640 |
| Kikuchi T et al. | 3-O-(E)-p-coumaroyl tormentic acid from Eriobotrya japonica leaves induces caspase-dependent apoptotic cell death in human leukemia cell line. | 2011 | Chem. Pharm. Bull. | pmid:21372421 |
| Xu XY et al. | Two new triterpenoid glycosides from the leaves of Anthocephalus chinensis. | 2011 | J Asian Nat Prod Res | pmid:21985583 |
| Wang C et al. | Determination of oleanolic and ursolic acid in Chinese herbs using HPLC and γ-CD as mobile phase modifier. | 2011 | J Sep Sci | pmid:21994210 |
| Ullevig SL et al. | Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis. | 2011 | Atherosclerosis | pmid:21752377 |
| Walch SG et al. | Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea). | 2011 | Front Pharmacol | pmid:22194722 |
| Venkateswara Rao G et al. | Chemical constituents and biological studies of Origanum vulgare Linn. | 2011 | Pharmacognosy Res | pmid:21772760 |
| Tan W et al. | Anti-cancer natural products isolated from chinese medicinal herbs. | 2011 | Chin Med | pmid:21777476 |
| Samadi N et al. | Comparative antibacterial efficacy of endemic satureja khuzistanica jamzad essential oil, sodium hypochlorite and chlorhexidine gluconate solutions as root canal irrigations. | 2011 | Dent Res J (Isfahan) | pmid:22132012 |
| Yau Hsiung W and Abdul Kadir H | Leea indica Ethyl Acetate Fraction Induces Growth-Inhibitory Effect in Various Cancer Cell Lines and Apoptosis in Ca Ski Human Cervical Epidermoid Carcinoma Cells. | 2011 | Evid Based Complement Alternat Med | pmid:21423690 |
| Pieroni LG et al. | Antioxidant activity and total phenols from the methanolic extract of Miconia albicans (Sw.) Triana leaves. | 2011 | Molecules | pmid:22075573 |
| Rasoanaivo P et al. | Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. | 2011 | Malar. J. | pmid:21411015 |
| Wang X et al. | Antifungal metabolites from the roots of Diospyros virginiana by overpressure layer chromatography. | 2011 | Chem. Biodivers. | pmid:22162171 |
| Arbab AS et al. | MRI to assess chemoprevention in transgenic adenocarcinoma of mouse prostate (TRAMP). | 2011 | BMC Med Imaging | pmid:22165848 |
| Lúcio KA et al. | Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo. | 2011 | PLoS ONE | pmid:22174843 |
| Jia Y et al. | Ursolic acid is a PPAR-α agonist that regulates hepatic lipid metabolism. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21855333 |
| Yao L et al. | Protective effects of polysaccharides from soybean meal against X-ray radiation induced damage in mouse spleen lymphocytes. | 2011 | Int J Mol Sci | pmid:22174652 |
| Kim MJ et al. | Effects of freeze-dried cranberry powder on serum lipids and inflammatory markers in lipopolysaccharide treated rats fed an atherogenic diet. | 2011 | Nutr Res Pract | pmid:22125677 |
| Schwaiger S et al. | Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.). | 2011 | J Ethnopharmacol | pmid:21040770 |
| Kondo M et al. | Ursolic acid and its esters: occurrence in cranberries and other Vaccinium fruit and effects on matrix metalloproteinase activity in DU145 prostate tumor cells. | 2011 | J. Sci. Food Agric. | pmid:21351105 |
| Kavitha CV et al. | Asiatic acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture models. | 2011 | PLoS ONE | pmid:21826202 |
| Ansarullah S et al. | Influence of Oreocnide integrifolia (Gaud.) Miq on IRS-1, Akt and Glut-4 in Fat-Fed C57BL/6J Type 2 Diabetes Mouse Model. | 2011 | Evid Based Complement Alternat Med | pmid:21785636 |
| Lahon K and Das S | Hepatoprotective activity of Ocimum sanctum alcoholic leaf extract against paracetamol-induced liver damage in Albino rats. | 2011 | Pharmacognosy Res | pmid:21731390 |
| Kiran MS et al. | Changes in expression of VE-cadherin and MMPs in endothelial cells: Implications for angiogenesis. | 2011 | pmid:21349163 | |
| Peixoto JA et al. | Antileishmanial activity of the hydroalcoholic extract of Miconia langsdorffii, isolated compounds, and semi-synthetic derivatives. | 2011 | Molecules | pmid:21343887 |
| Kuete V et al. | Antimicrobial activities of the methanol extract, fractions and compounds from Ficus polita Vahl. (Moraceae). | 2011 | BMC Complement Altern Med | pmid:21269424 |
| Kaur M and Goel RK | Anti-Convulsant Activity of Boerhaavia diffusa: Plausible Role of Calcium Channel Antagonism. | 2011 | Evid Based Complement Alternat Med | pmid:19948752 |
| Szuster-Ciesielska A et al. | Betulin and betulinic acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS), cytokine (TNF-α, TGF-β) production and by influencing intracellular signaling. | 2011 | Toxicology | pmid:21172400 |
| Passero LF et al. | Anti-leishmanial effects of purified compounds from aerial parts of Baccharis uncinella C. DC. (Asteraceae). | 2011 | Parasitol. Res. | pmid:20886232 |
| Yang ZG et al. | Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells. | 2011 | Molecules | pmid:21772233 |
| Wu HY et al. | Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid. | 2011 | J. Agric. Food Chem. | pmid:21314126 |
| Grudniak AM et al. | Oleanolic and ursolic acids influence affect the expression of the cysteine regulon and the stress response in Escherichia coli. | 2011 | Curr. Microbiol. | pmid:21221969 |
| Yamaguchi H et al. | Ligand-receptor interaction between triterpenoids and the 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) enzyme predicts their toxic effects against tumorigenic r/m HM-SFME-1 cells. | 2011 | J. Biol. Chem. | pmid:21880714 |
| Cárdenas C et al. | Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. | 2011 | PLoS ONE | pmid:21858104 |
| Lin CC et al. | Antiangiogenic potential of three triterpenic acids in human liver cancer cells. | 2011 | J. Agric. Food Chem. | pmid:21175131 |
| Lee HZ et al. | Clarification of the phenotypic characteristics and anti-tumor activity of Hedyotis diffusa. | 2011 | Am. J. Chin. Med. | pmid:21213409 |
| Bishayee A et al. | Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer. | 2011 | Front Biosci (Landmark Ed) | pmid:21196213 |
| Assob JC et al. | Antimicrobial and toxicological activities of five medicinal plant species from Cameroon traditional medicine. | 2011 | BMC Complement Altern Med | pmid:21867554 |
| Zhou C et al. | Herbaceous peony (Paeonia lactiflora Pall.) as an alternative source of oleanolic and ursolic acids. | 2011 | Int J Mol Sci | pmid:21340006 |
| Gasnier C et al. | Defined plant extracts can protect human cells against combined xenobiotic effects. | 2011 | J Occup Med Toxicol | pmid:21251308 |
| Chen RJ et al. | Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+ -ATPase. | 2010 | Acta Pharmacol. Sin. | pmid:20523340 |
| Zhou Y et al. | Ursolic acid inhibits early lesions of diabetic nephropathy. | 2010 | Int. J. Mol. Med. | pmid:20818497 |
| Fang X et al. | Optimization of microwave-assisted extraction followed by RP-HPLC for the simultaneous determination of oleanolic acid and ursolic acid in the fruits of Chaenomeles sinensis. | 2010 | J Sep Sci | pmid:20183824 |
| Yu YX et al. | Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway. | 2010 | Chin. Med. J. | pmid:20819578 |
| Ibarra A et al. | Effects of chronic administration of Melissa officinalis L. extract on anxiety-like reactivity and on circadian and exploratory activities in mice. | 2010 | Phytomedicine | pmid:20171069 |
| Akak CM et al. | New coumarin glycosides from the leaves of Diospyros crassiflora (Hiern). | 2010 | Fitoterapia | pmid:20580922 |
| Nabekura T | Overcoming multidrug resistance in human cancer cells by natural compounds. | 2010 | Toxins (Basel) | pmid:22069634 |
| Lee J et al. | Ursolic acid ameliorates thymic atrophy and hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice. | 2010 | Chem. Biol. Interact. | pmid:20869956 |
| Yu LB et al. | [Inhibitive effect of ursolic acid on the invasion and metastasis of ovarian carcinoma cells HO-8910PM]. | 2010 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:21265099 |
| Kwon SH et al. | Apoptotic action of ursolic acid isolated from Corni fructus in RC-58T/h/SA#4 primary human prostate cancer cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20943386 |
| Song FL et al. | Total phenolic contents and antioxidant capacities of selected chinese medicinal plants. | 2010 | Int J Mol Sci | pmid:20640157 |
| Kazakova OB et al. | Betulin and ursolic acid synthetic derivatives as inhibitors of Papilloma virus. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20558062 |
| Lee MS and Thuong PT | Stimulation of glucose uptake by triterpenoids from Weigela subsessilis. | 2010 | Phytother Res | pmid:19548274 |
| Yeh CT et al. | Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling. | 2010 | Mol Nutr Food Res | pmid:20352621 |
| Li Y et al. | Enhancement of chemotherapeutic agent-induced apoptosis by inhibition of NF-kappaB using ursolic acid. | 2010 | Int. J. Cancer | pmid:19908232 |
| Jang SM et al. | Inhibitory effects of ursolic acid on hepatic polyol pathway and glucose production in streptozotocin-induced diabetic mice. | 2010 | Metab. Clin. Exp. | pmid:19846180 |
| Li J et al. | A new dilactone from the seeds of Gaultheria yunnanensis. | 2010 | Fitoterapia | pmid:19628028 |
| Bibi N et al. | In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20542692 |
| Kanjoormana M and Kuttan G | Antiangiogenic activity of ursolic acid. | 2010 | Integr Cancer Ther | pmid:20462855 |
| Jung TY et al. | Ursolic acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFN-gamma by CD4+ naïve T cells. | 2010 | Eur. J. Pharmacol. | pmid:20599915 |
| Ibarra A et al. | Importance of extract standardization and in vitro/ex vivo assay selection for the evaluation of antioxidant activity of botanicals: a case study on three Rosmarinus officinalis L. extracts. | 2010 | J Med Food | pmid:20626255 |
| Yang L et al. | Ursolic acid induces doxorubicin-resistant HepG2 cell death via the release of apoptosis-inducing factor. | 2010 | Cancer Lett. | pmid:20630652 |
| Yadav VR et al. | Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. | 2010 | Toxins (Basel) | pmid:22069560 |
| Meng Y et al. | Synthesis and in vitro cytotoxicity of novel ursolic acid derivatives. | 2010 | Molecules | pmid:20657424 |
| Bankeu JJ et al. | Ceramide and Cerebroside from the stem bark of Ficus mucuso (Moraceae). | 2010 | Chem. Pharm. Bull. | pmid:21139276 |
| Li Y et al. | Ursolic acid stimulates lipolysis in primary-cultured rat adipocytes. | 2010 | Mol Nutr Food Res | pmid:20521271 |
| Mandukhail SU et al. | Studies on antidyslipidemic effects of Morinda citrifolia (Noni) fruit, leaves and root extracts. | 2010 | Lipids Health Dis | pmid:20727145 |
| Xia N et al. | Prunella vulgaris L. Upregulates eNOS expression in human endothelial cells. | 2010 | Am. J. Chin. Med. | pmid:20503475 |
| Zhang Y et al. | Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro. | 2010 | Mol. Carcinog. | pmid:20146252 |
| Wu B et al. | [Apoptosis of jurkat cells induced by ursolic acid and its mechanism]. | 2010 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:20137120 |
| Bertoni BW et al. | Genetic diversity in natural populations of Jacaranda decurrens Cham. determined using RAPD and AFLP markers. | 2010 | Genet. Mol. Biol. | pmid:21637428 |
| Gui C et al. | Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. | 2010 | Curr Chem Genomics | pmid:20448812 |
| Zhou C et al. | Variation of oleanolic and ursolic acid in the flesh of persimmon fruit among different cultivars. | 2010 | Molecules | pmid:20877245 |
| Azevedo MF et al. | Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3. | 2010 | Phytother Res | pmid:20127879 |
| Shyu MH et al. | Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP. | 2010 | J. Agric. Food Chem. | pmid:20415421 |
| Yu Z et al. | Gas phase isomeric differentiation of oleanolic and ursolic acids associated with heptakis-(2,6-di-O-methyl)-beta-cyclodextrin by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. | 2010 | J Mass Spectrom | pmid:20306522 |
| Takada K et al. | Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-α-induced E-selectin expression by cultured umbilical vein endothelial cells. | 2010 | Phytomedicine | pmid:20579861 |
| Shen D et al. | LC-MS method for the simultaneous quantitation of the anti-inflammatory constituents in oregano (Origanum species). | 2010 | J. Agric. Food Chem. | pmid:20496910 |
| Ko CH et al. | Osteoprotective effects of Fructus Ligustri Lucidi aqueous extract in aged ovariectomized rats. | 2010 | Chin Med | pmid:21114821 |
| Feng L et al. | Combination of active components enhances the efficacy of Prunella in prevention and treatment of lung cancer. | 2010 | Molecules | pmid:21060297 |
| Tang XH et al. | Preservation on calcium homeostasis is involved in mitochondrial protection of Limonium sinense against liver damage in mice. | 2010 | Pharmacogn Mag | pmid:20931078 |
| Tian S et al. | Determination of oleanolic acid and ursolic acid contents in Ziziphora clinopodioides Lam. by HPLC method. | 2010 | Pharmacogn Mag | pmid:20668577 |