| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Santos Rosa C et al. | Antihistaminic and antieicosanoid effects of oleanolic and ursolic acid fraction from Helichrysum picardii. | 2007 | Pharmazie | pmid:17663195 |
| Choi BM et al. | Cyclic adenosine monophosphate inhibits ursolic acid-induced apoptosis via activation of protein kinase A in human leukaemic HL-60 cells. | 2000 | Pharmacol. Toxicol. | pmid:10728914 |
| Ahmad SF et al. | Amelioration of adjuvant-induced arthritis by ursolic acid through altered Th1/Th2 cytokine production. | 2006 | Pharmacol. Res. | pmid:16406805 |
| Lee SU et al. | Anabolic activity of ursolic acid in bone: Stimulating osteoblast differentiation in vitro and inducing new bone formation in vivo. | 2008 Nov-Dec | Pharmacol. Res. | pmid:18822379 |
| Nabekura T et al. | Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals. | 2010 | Pharmacol. Res. | pmid:19944162 |
| Colla AR et al. | Serotonergic and noradrenergic systems are implicated in the antidepressant-like effect of ursolic acid in mice. | 2014 | Pharmacol. Biochem. Behav. | pmid:24887451 |
| Machado DG et al. | Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: evidence for the involvement of the dopaminergic system. | 2012 | Pharmacol. Biochem. Behav. | pmid:22940588 |
| Verano J et al. | Ursolic acid from Agastache mexicana aerial parts produces antinociceptive activity involving TRPV1 receptors, cGMP and a serotonergic synergism. | 2013 | Pharmacol. Biochem. Behav. | pmid:23932918 |
| Park JH et al. | Inhibition of Wnt/β-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells. | 2013 | Pharmacol Rep | pmid:24399733 |
| Saravanan R and Pugalendi V | Impact of ursolic acid on chronic ethanol-induced oxidative stress in the rat heart. | 2006 Jan-Feb | Pharmacol Rep | pmid:16531629 |
| Venkateswara Rao G et al. | Chemical constituents and biological studies of Origanum vulgare Linn. | 2011 | Pharmacognosy Res | pmid:21772760 |
| Lahon K and Das S | Hepatoprotective activity of Ocimum sanctum alcoholic leaf extract against paracetamol-induced liver damage in Albino rats. | 2011 | Pharmacognosy Res | pmid:21731390 |
| Annegowda HV et al. | Influence of sonication on the phenolic content and antioxidant activity of Terminalia catappa L. leaves. | 2010 | Pharmacognosy Res | pmid:21713141 |
| Annan K et al. | Acaricidal effect of an isolate from Hoslundia opposita vahl against Amblyomma variegatum (Acari: Ixodidae). | 2011 | Pharmacognosy Res | pmid:22022167 |
| Singh M et al. | Anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. leaves. | 2010 | Pharmacognosy Res | pmid:21713140 |
| Prajapati MS et al. | Leucas aspera: A review. | 2010 | Pharmacogn Rev | pmid:22228946 |
| Perera PK and Li Y | Functional herbal food ingredients used in type 2 diabetes mellitus. | 2012 | Pharmacogn Rev | pmid:22654403 |
| Ali M and Chaudhary N | Ficus hispida Linn.: A review of its pharmacognostic and ethnomedicinal properties. | 2011 | Pharmacogn Rev | pmid:22096323 |
| Conserva LM and Ferreira JC | Borreria and Spermacoce species (Rubiaceae): A review of their ethnomedicinal properties, chemical constituents, and biological activities. | 2012 | Pharmacogn Rev | pmid:22654404 |
| Beg S et al. | Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives. | 2011 | Pharmacogn Rev | pmid:22279370 |
| Aslan M et al. | Effect of Gentiana olivieri on experimental epilepsy models. | 2011 | Pharmacogn Mag | pmid:22262939 |
| Ahmed MK | 2012 - Another successful new year for Pharmacogn Mag. | 2012 | Pharmacogn Mag | pmid:22438655 |
| Tang XH et al. | Preservation on calcium homeostasis is involved in mitochondrial protection of Limonium sinense against liver damage in mice. | 2010 | Pharmacogn Mag | pmid:20931078 |
| Tian S et al. | Determination of oleanolic acid and ursolic acid contents in Ziziphora clinopodioides Lam. by HPLC method. | 2010 | Pharmacogn Mag | pmid:20668577 |
| Anand P et al. | Cancer is a preventable disease that requires major lifestyle changes. | 2008 | Pharm. Res. | pmid:18626751 |
| González-Chávez MM et al. | Anti-inflammatory activity of standardized dichloromethane extract of Salvia connivens on macrophages stimulated by LPS. | 2017 | Pharm Biol | pmid:28347190 |
| Jin YR et al. | Ursolic acid enhances mouse liver regeneration after partial hepatectomy. | 2012 | Pharm Biol | pmid:22136205 |
| Chen Y et al. | Changes in bioactive components related to the harvest time from the spicas of Prunella vulgaris. | 2012 | Pharm Biol | pmid:22686260 |
| Cunha WR et al. | Evaluation of the antibacterial activity of the methylene chloride extract of Miconia ligustroides, isolated triterpene acids, and ursolic acid derivatives. | 2010 | Pharm Biol | pmid:20645834 |
| BRIESKORN CH and KESKIN M | [Triterpenes in the bark, peel and leaf of Punica granatum L. 5. Knowledge of biochemistry of triterpenes]. | 1954 | Pharm Acta Helv | pmid:13236480 |
| Innocente AM et al. | Anti-Trichomonas vaginalis activity from triterpenoid derivatives. | 2014 | Parasitol. Res. | pmid:24880238 |
| Ferreira Dda S et al. | Trypanocidal activity and acute toxicity assessment of triterpene acids. | 2010 | Parasitol. Res. | pmid:20140451 |
| Yamamoto ES et al. | Treatment with triterpenic fraction purified from Baccharis uncinella leaves inhibits Leishmania (Leishmania) amazonensis spreading and improves Th1 immune response in infected mice. | 2014 | Parasitol. Res. | pmid:24173812 |
| Passero LF et al. | Anti-leishmanial effects of purified compounds from aerial parts of Baccharis uncinella C. DC. (Asteraceae). | 2011 | Parasitol. Res. | pmid:20886232 |
| Cho J et al. | Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. | 2015 | Oncotarget | pmid:26513295 |
| Xiang L et al. | A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis. | 2015 | Oncotarget | pmid:25823660 |
| Achiwa Y et al. | Ursolic acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial cancer SNG-II cells. | 2005 | Oncol. Rep. | pmid:15583801 |
| Achiwa Y et al. | Molecular mechanism of ursolic acid induced apoptosis in poorly differentiated endometrial cancer HEC108 cells. | 2005 | Oncol. Rep. | pmid:16012738 |
| Duval RE et al. | Differential involvement of mitochondria during ursolic acid-induced apoptotic process in HaCaT and M4Beu cells. | 2008 | Oncol. Rep. | pmid:18097588 |
| Li J et al. | Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-κB pathways. | 2012 | Oncol. Rep. | pmid:22641480 |
| Dai Z et al. | Pomegranate extract inhibits the proliferation and viability of MMTV-Wnt-1 mouse mammary cancer stem cells in vitro. | 2010 | Oncol. Rep. | pmid:20811693 |
| Cha HJ et al. | Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells. | 1998 | Oncogene | pmid:9488041 |
| Matsumoto RL et al. | Effects of maté tea intake on ex vivo LDL peroxidation induced by three different pathways. | 2009 | Nutrients | pmid:22253965 |
| Kim MJ et al. | Effects of freeze-dried cranberry powder on serum lipids and inflammatory markers in lipopolysaccharide treated rats fed an atherogenic diet. | 2011 | Nutr Res Pract | pmid:22125677 |
| Banihani S et al. | Pomegranate and type 2 diabetes. | 2013 | Nutr Res | pmid:23684435 |
| De Angel RE et al. | Antitumor effects of ursolic acid in a mouse model of postmenopausal breast cancer. | 2010 | Nutr Cancer | pmid:21058195 |
| Achiwa Y et al. | Effect of ursolic acid on MAPK in cyclin D1 signaling and RING-type E3 ligase (SCF E3s) in two endometrial cancer cell lines. | 2013 | Nutr Cancer | pmid:24083669 |
| Sung B et al. | Cancer cell signaling pathways targeted by spice-derived nutraceuticals. | 2012 | Nutr Cancer | pmid:22149093 |
| Shih YH et al. | Ursolic acid protects hippocampal neurons against kainate-induced excitotoxicity in rats. | 2004 | Neurosci. Lett. | pmid:15193771 |
| Yealland G et al. | Rescue of mitochondrial function in parkin-mutant fibroblasts using drug loaded PMPC-PDPA polymersomes and tubular polymersomes. | 2016 | Neurosci. Lett. | pmid:27412236 |