| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Stiti N and Hartmann MA | Nonsterol Triterpenoids as Major Constituents of Olea europaea. | 2012 | J Lipids | pmid:22523691 |
| Liu M et al. | Chemical constituents of the ethyl acetate extract of Belamcanda chinensis (L.) DC roots and their antitumor activities. | 2012 | Molecules | pmid:22627971 |
| Wang JS et al. | Ursolic acid induces apoptosis by suppressing the expression of FoxM1 in MCF-7 human breast cancer cells. | 2012 | Med. Oncol. | pmid:21191671 |
| Gohari AR et al. | Evaluation of the cytotoxicity of Satureja spicigera and its main compounds. | 2012 | ScientificWorldJournal | pmid:22623883 |
| Mobasheri A et al. | Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health. | 2012 | Int J Mol Sci | pmid:22605974 |
| Hua WJ et al. | Transepithelial transport of rosuvastatin and effect of ursolic acid on its transport in Caco-2 monolayers. | 2012 | Eur J Drug Metab Pharmacokinet | pmid:22562361 |
| Limami Y et al. | The P2Y2/Src/p38/COX-2 pathway is involved in the resistance to ursolic acid-induced apoptosis in colorectal and prostate cancer cells. | 2012 | Biochimie | pmid:22521508 |
| Bag P et al. | Anti-herpes virus activities of bioactive fraction and isolated pure constituent of Mallotus peltatus: an ethnomedicine from Andaman Islands. | 2012 | Virol. J. | pmid:22624581 |
| Teixeira T et al. | Molluscicidal activity of crude water and hexane extracts of Hypericum species to snails (Radix peregra). | 2012 | Environ. Toxicol. Chem. | pmid:22170085 |
| He X et al. | In vitro and in vivo antimammary tumor activities and mechanisms of the apple total triterpenoids. | 2012 | J. Agric. Food Chem. | pmid:22924395 |
| Rodrigues MR et al. | Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice. | 2012 | J Ethnopharmacol | pmid:22154965 |
| Bei WJ et al. | Lipid-regulating effect of traditional chinese medicine: mechanisms of actions. | 2012 | Evid Based Complement Alternat Med | pmid:22611438 |
| Debprasad C et al. | Inhibition of NO(2), PGE(2), TNF-α, and iNOS EXpression by Shorea robusta L.: An Ethnomedicine Used for Anti-Inflammatory and Analgesic Activity. | 2012 | Evid Based Complement Alternat Med | pmid:22649472 |
| Meynial-Denis D et al. | New Strategies to Fight against Sarcopenia at Old Age. | 2012 | J Aging Res | pmid:22619719 |
| Sung B et al. | Cancer cell signaling pathways targeted by spice-derived nutraceuticals. | 2012 | Nutr Cancer | pmid:22149093 |
| Li J et al. | Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-κB pathways. | 2012 | Oncol. Rep. | pmid:22641480 |
| Xiang M et al. | Attenuation of aortic injury by ursolic acid through RAGE-Nox-NFκB pathway in streptozocin-induced diabetic rats. | 2012 | Arch. Pharm. Res. | pmid:22644855 |
| Chang CL and Lin CS | Phytochemical Composition, Antioxidant Activity, and Neuroprotective Effect of Terminalia chebula Retzius Extracts. | 2012 | Evid Based Complement Alternat Med | pmid:21754945 |
| Lv YY et al. | Ursolic acid suppresses IL-6 induced C-reactive protein expression in HepG2 and protects HUVECs from injury induced by CRP. | 2012 | Eur J Pharm Sci | pmid:22108347 |
| Jin YR et al. | Ursolic acid enhances mouse liver regeneration after partial hepatectomy. | 2012 | Pharm Biol | pmid:22136205 |
| Hwang JS et al. | Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22079762 |
| Saaby L and Nielsen CH | Triterpene acids from rose hip powder inhibit self-antigen- and LPS-induced cytokine production and CD4⺠T-cell proliferation in human mononuclear cell cultures. | 2012 | Phytother Res | pmid:22170858 |
| Zhong Y et al. | Synthesis, stability and pharmacological evaluation of a novel codrug consisting of lamivudine and ursolic acid. | 2012 | Eur J Pharm Sci | pmid:22085635 |
| Katsargyris A et al. | Cranberry as promising natural source of potential anticancer agents: current evidence and future perspectives. | 2012 | Anticancer Agents Med Chem | pmid:22043998 |
| Xia EQ et al. | Ultrasound-assisted extraction of oleanolic acid and ursolic acid from Ligustrum lucidum Ait. | 2012 | Ultrason Sonochem | pmid:22197019 |
| Maurya A et al. | QSAR, docking and in vivo studies for immunomodulatory activity of isolated triterpenoids from Eucalyptus tereticornis and Gentiana kurroo. | 2012 | Eur J Pharm Sci | pmid:22659375 |
| Lee EH et al. | Inhibitory effect of ursolic acid derivatives on recombinant human aldose reductase. | 2011 Sep-Oct | Bioorg. Khim. | pmid:22332359 |
| Cui HZ et al. | Ursolic acid increases the secretion of atrial natriuretic peptide in isolated perfused beating rabbit atria. | 2011 | Eur. J. Pharmacol. | pmid:21122803 |
| Kunkel SD et al. | mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass. | 2011 | Cell Metab. | pmid:21641545 |
| Skariyachan S et al. | Computer aided screening and evaluation of herbal therapeutics against MRSA infections. | 2011 | Bioinformation | pmid:22125390 |
| Liobikas J et al. | Uncoupling and antioxidant effects of ursolic acid in isolated rat heart mitochondria. | 2011 | J. Nat. Prod. | pmid:21648406 |
| Saaby L et al. | Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.). | 2011 | Phytother Res | pmid:20632303 |
| Ali M and Chaudhary N | Ficus hispida Linn.: A review of its pharmacognostic and ethnomedicinal properties. | 2011 | Pharmacogn Rev | pmid:22096323 |
| Xu XY et al. | Two new triterpenoid glycosides from the leaves of Anthocephalus chinensis. | 2011 | J Asian Nat Prod Res | pmid:21985583 |
| Wang C et al. | Determination of oleanolic and ursolic acid in Chinese herbs using HPLC and γ-CD as mobile phase modifier. | 2011 | J Sep Sci | pmid:21994210 |
| Ullevig SL et al. | Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis. | 2011 | Atherosclerosis | pmid:21752377 |
| Zhang XH and Zhu X | [The newest progress of the pharmacology of prunol]. | 2011 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:22013813 |
| Tannock LR | Ursolic acid effect on atherosclerosis: apples and apples, or apples and oranges? | 2011 | Atherosclerosis | pmid:21993411 |
| Pieroni LG et al. | Antioxidant activity and total phenols from the methanolic extract of Miconia albicans (Sw.) Triana leaves. | 2011 | Molecules | pmid:22075573 |
| Uygur B and Wu WS | SLUG promotes prostate cancer cell migration and invasion via CXCR4/CXCL12 axis. | 2011 | Mol. Cancer | pmid:22074556 |
| Zhang HE et al. | [Optimization of supercritical fluid extraction of ursolic acid from follum eriobotryae by response surface methodology]. | 2011 | Zhong Yao Cai | pmid:22372151 |
| Lahon K and Das S | Hepatoprotective activity of Ocimum sanctum alcoholic leaf extract against paracetamol-induced liver damage in Albino rats. | 2011 | Pharmacognosy Res | pmid:21731390 |
| Meng YQ et al. | [Synthesis and anti-tumor activity of ursolic acid derivatives]. | 2011 | Yao Xue Xue Bao | pmid:21800543 |
| Fu SB et al. | Multihydroxylation of ursolic acid by Pestalotiopsis microspora isolated from the medicinal plant Huperzia serrata. | 2011 | Fitoterapia | pmid:21767617 |
| Chen Y et al. | [Preparation and transdermal diffusion of ursolic acid ethosomes]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21809568 |
| Wilkinson K et al. | A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36. | 2011 | J. Biol. Chem. | pmid:21835916 |
| Fu SB et al. | Biotransformation of ursolic acid by an endophytic fungus from medicinal plant Huperzia serrata. | 2011 | Chem. Pharm. Bull. | pmid:21881267 |
| Kim KH et al. | Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells. | 2011 | Arch. Pharm. Res. | pmid:21910059 |
| Dutra RC et al. | Preventive and therapeutic euphol treatment attenuates experimental colitis in mice. | 2011 | PLoS ONE | pmid:22073270 |
| Bishayee A et al. | Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer. | 2011 | Front Biosci (Landmark Ed) | pmid:21196213 |