| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hollósy F et al. | Activation of caspase-3 protease during the process of ursolic acid and its derivative-induced apoptosis. | 2001 Sep-Oct | Anticancer Res. | pmid:11848513 |
| Andersson D et al. | Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase. | 2003 Jul-Aug | Anticancer Res. | pmid:12926069 |
| Garg AK et al. | Chemosensitization and radiosensitization of tumors by plant polyphenols. | Antioxid. Redox Signal. | pmid:16356126 | |
| Kong L et al. | Oleanolic acid and ursolic acid: novel hepatitis C virus antivirals that inhibit NS5B activity. | 2013 | Antiviral Res. | pmid:23422646 |
| Chiang LC et al. | Antiviral activity of Plantago major extracts and related compounds in vitro. | 2002 | Antiviral Res. | pmid:12076751 |
| Kurek A et al. | Oleanolic acid and ursolic acid affect peptidoglycan metabolism in Listeria monocytogenes. | 2010 | Antonie Van Leeuwenhoek | pmid:19894138 |
| Lee YH et al. | Ursolic acid differentially modulates apoptosis in skin melanoma and retinal pigment epithelial cells exposed to UV-VIS broadband radiation. | 2014 | Apoptosis | pmid:24375173 |
| Ren D et al. | Differential gene expression for investigation of Escherichia coli biofilm inhibition by plant extract ursolic acid. | 2005 | Appl. Environ. Microbiol. | pmid:16000817 |
| SCHINDLER H and HERB M | [Chemistry of Ilex aquifolium L. I. Isolation of ursolic acid and rutin from leaves]. | 1955 | Arch Pharm Ber Dtsch Pharm Ges | pmid:13303362 |
| BRIESKORN CH and EBERHARDT KH | [Oxytriterpenic acids of sage oil. 9. Constituents of Salvia officinalis L..]. | 1953 | Arch Pharm Ber Dtsch Pharm Ges | pmid:13081104 |
| Both DM et al. | Liposome-encapsulated ursolic acid increases ceramides and collagen in human skin cells. | 2002 | Arch. Dermatol. Res. | pmid:11876525 |
| Lee S et al. | Phytochemical constituents from the fruits of Acanthopanax sessiliflorus. | 2002 | Arch. Pharm. Res. | pmid:12135097 |
| Kim J et al. | Anti-lipase and lipolytic activities of ursolic acid isolated from the roots of Actinidia arguta. | 2009 | Arch. Pharm. Res. | pmid:19641878 |
| Jo Y et al. | Jacaranone and related compounds from the fresh fruits of Ternstroemia japonica and their antioxidative activity. | 2005 | Arch. Pharm. Res. | pmid:16178411 |
| Moon HK et al. | Protection of peroxynitrite-induced DNA damage by dietary antioxidants. | 2006 | Arch. Pharm. Res. | pmid:16596994 |
| Kim DW et al. | Growth inhibitory activities of kalopanaxsaponins A and I against human pathogenic fungi. | 1998 | Arch. Pharm. Res. | pmid:9868538 |
| Paik KJ et al. | Induction of differentiation of the cultured rat mammary epithelial cells by triterpene acids. | 1998 | Arch. Pharm. Res. | pmid:9875466 |
| Zhang P et al. | Antibacterial constituents from fruit bodies of ascomyce Bulgaria inquinans. | 2005 | Arch. Pharm. Res. | pmid:16178412 |
| Wu B et al. | Ursolic acid-induced apoptosis in K562 cells involving upregulation of PTEN gene expression and inactivation of the PI3K/Akt pathway. | 2012 | Arch. Pharm. Res. | pmid:22477202 |
| Xiang M et al. | Attenuation of aortic injury by ursolic acid through RAGE-Nox-NFκB pathway in streptozocin-induced diabetic rats. | 2012 | Arch. Pharm. Res. | pmid:22644855 |
| Tapondjou LA et al. | In vivo anti-nociceptive and anti-inflammatory effect of the two triterpenes, ursolic acid and 23-hydroxyursolic acid, from Cussonia bancoensis. | 2003 | Arch. Pharm. Res. | pmid:12643591 |
| Kim KH et al. | Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells. | 2011 | Arch. Pharm. Res. | pmid:21910059 |
| Min BS et al. | Cytotoxic triterpenes from Crataegus pinnatifida. | 2000 | Arch. Pharm. Res. | pmid:10836742 |
| Zheng MS et al. | Chemical constituents of Melandrium firmum Rohrbach and their anti-inflammatory activity. | 2008 | Arch. Pharm. Res. | pmid:18409044 |
| Cipak L et al. | Dual activity of triterpenoids: apoptotic versus antidifferentiation effects. | 2006 | Arch. Toxicol. | pmid:16496127 |
| Liang W et al. | Ursolic acid attenuates beta-amyloid-induced memory impairment in mice. | 2016 | Arq Neuropsiquiatr | pmid:27332074 |
| Elliott S et al. | The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes. | 2003 | Arthritis Res. Ther. | pmid:12932292 |
| Patel DK et al. | Pedalium murex Linn.: an overview of its phytopharmacological aspects. | 2011 | Asian Pac J Trop Med | pmid:21967701 |
| Li R et al. | Ursolic acid promotes apoptosis of SGC-7901 gastric cancer cells through ROCK/PTEN mediated mitochondrial translocation of cofilin-1. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25520072 |
| Mooi LY et al. | Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22799301 |
| Gayathri R et al. | Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats. | 2009 | Asian Pac. J. Cancer Prev. | pmid:20104993 |
| Messner B et al. | Ursolic acid causes DNA-damage, p53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo. | 2011 | Atherosclerosis | pmid:21703625 |
| Pozo M et al. | Ursolic acid inhibits neointima formation in the rat carotid artery injury model. | 2006 | Atherosclerosis | pmid:15922347 |
| Ullevig SL et al. | Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis. | 2011 | Atherosclerosis | pmid:21752377 |
| Tannock LR | Ursolic acid effect on atherosclerosis: apples and apples, or apples and oranges? | 2011 | Atherosclerosis | pmid:21993411 |
| Steinkamp-Fenske K et al. | Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells. | 2007 | Atherosclerosis | pmid:17481637 |
| Zhao C et al. | Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells. | 2013 | Autophagy | pmid:23182854 |
| Wang J et al. | Ursolic acid inhibits proliferation and induces apoptosis in human glioblastoma cell lines U251 by suppressing TGF-β1/miR-21/PDCD4 pathway. | 2012 | Basic Clin. Pharmacol. Toxicol. | pmid:22353043 |
| Xue PF et al. | [Studies on the chemical constituents from Potentilla multifida L]. | 2004 | Beijing Da Xue Xue Bao | pmid:14970881 |
| Kim HI et al. | Inhibition of estrogen signaling through depletion of estrogen receptor alpha by ursolic acid and betulinic acid from Prunella vulgaris var. lilacina. | 2014 | Biochem. Biophys. Res. Commun. | pmid:25088993 |
| Cárdenas C et al. | Effects of ursolic acid on different steps of the angiogenic process. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15219842 |
| Quéré L et al. | Triterpenes as potential dimerization inhibitors of HIV-1 protease. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8967903 |
| Tang X et al. | Inhibition by [corrected] ursolic acid of [corrected] calcium-induced mitochondrial permeability transition and release of two proapoptotic proteins. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16188235 |
| Kiran MS et al. | Modulation of angiogenic factors by ursolic acid. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18448068 |
| Liu Y et al. | Evaluation of inhibition of fatty acid synthase by ursolic acid: positive cooperation mechanism. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20074555 |
| Zheng QY et al. | Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22387548 |
| Ying QL et al. | Inhibition of human leucocyte elastase by ursolic acid. Evidence for a binding site for pentacyclic triterpenes. | 1991 | Biochem. J. | pmid:1859379 |
| Jung SH et al. | Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator. | 2007 | Biochem. J. | pmid:17201692 |
| Tan GT et al. | Natural-product inhibitors of human DNA ligase I. | 1996 | Biochem. J. | pmid:8615799 |
| Shanmugam MK et al. | Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies. | 2013 | Biochem. Pharmacol. | pmid:23499879 |