MeSH term | MeSH ID | Detail |
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Adenocarcinoma | D000230 | 166 associated lipids |
Lycopene is a lipid of Prenol Lipids (PR) class. Lycopene is associated with abnormalities such as Consumption-archaic term for TB, Chronic disease, Dehydration, furuncle and Cardiovascular Diseases. The involved functions are known as Cell Differentiation process, Signal Transduction, Biochemical Pathway, Mutation and IGF-1 Signaling Pathway. Lycopene often locates in Body tissue, Hepatic, Blood, Adipose tissue and Structure of parenchyma of lung. The associated genes with Lycopene are EPB41L2 gene, VEGFB gene, P4HTM gene, FATE1 gene and SLC33A1 gene. The related lipids are Micelles, Liposomes, Total cholesterol, Steroids and apo-10'-lycopenoic acid. The related experimental models are Mouse Model, Knock-out, Cancer Model, Transgenic Model and Xenograft Model.
To understand associated biological information of Lycopene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Lycopene is suspected in Chronic disease, Cardiovascular Diseases, Atherosclerosis, Congenital contractural arachnodactyly, Myocardial Infarction, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Lycopene
MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis.' (Imaida K et al., 2001), Cancer Model are used in the study 'Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention.' (Chen L et al., 2001), Cancer Model are used in the study 'Re: Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets.' (Limpens J et al., 2004), Cancer Model are used in the study 'Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells.' (Liu X et al., 2008) and Cancer Model are used in the study 'Can smoke-exposed ferrets be utilized to unravel the mechanisms of action of lycopene?' (Wang XD, 2005).
Knock-out are used in the study 'Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.' (Ip BC et al., 2014), Knock-out are used in the study 'In silico identification of gene amplification targets for improvement of lycopene production.' (Choi HS et al., 2010) and Knock-out are used in the study 'Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models.' (Stice CP et al., 2015).
Mouse Model are used in the study 'Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature.' (Giovannucci E, 1999), Mouse Model are used in the study 'Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women.' (Watzl B et al., 2000) and Mouse Model are used in the study 'Executive summary report.' (Davis CD et al., 2005).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Slifka KA et al. | A survey of serum and dietary carotenoids in captive wild animals. | 1999 | J. Nutr. | pmid:10024616 |
Tucker KL et al. | Carotenoid intakes, assessed by dietary questionnaire, are associated with plasma carotenoid concentrations in an elderly population. | 1999 | J. Nutr. | pmid:10024624 |
Giovannucci E | Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. | 1999 | J. Natl. Cancer Inst. | pmid:10050865 |
Suganuma H and Inakuma T | Protective effect of dietary tomato against endothelial dysfunction in hypercholesterolemic mice. | 1999 | Biosci. Biotechnol. Biochem. | pmid:10052125 |
McEligot AJ et al. | Comparison of serum carotenoid responses between women consuming vegetable juice and women consuming raw or cooked vegetables. | 1999 | Cancer Epidemiol. Biomarkers Prev. | pmid:10090300 |
Gann PH et al. | Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis. | 1999 | Cancer Res. | pmid:10096552 |
Poulsen HE et al. | Oxidative DNA damage in vivo: relationship to age, plasma antioxidants, drug metabolism, glutathione-S-transferase activity and urinary creatinine excretion. | 1998 | Free Radic. Res. | pmid:10098460 |
Miura Y et al. | Production of lycopene by the food yeast, Candida utilis that does not naturally synthesize carotenoid. | 1998 Apr 20-May 5 | Biotechnol. Bioeng. | pmid:10191407 |
Lowe GM et al. | Lycopene and beta-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses. | 1999 | Free Radic. Res. | pmid:10193582 |
Riso P et al. | Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage? | 1999 | Am. J. Clin. Nutr. | pmid:10197573 |
Mayne ST et al. | Plasma lycopene concentrations in humans are determined by lycopene intake, plasma cholesterol concentrations and selected demographic factors. | 1999 | J. Nutr. | pmid:10203560 |
Ronen G et al. | Regulation of carotenoid biosynthesis during tomato fruit development: expression of the gene for lycopene epsilon-cyclase is down-regulated during ripening and is elevated in the mutant Delta. | 1999 | Plant J. | pmid:10205893 |
Hasselwander O et al. | HDL composition and HDL antioxidant capacity in patients on regular haemodialysis. | 1999 | Atherosclerosis | pmid:10208487 |
Faure H et al. | [Carotenoids: 1. Metabolism and physiology]. | 1999 Mar-Apr | Ann. Biol. Clin. (Paris) | pmid:10210743 |
Harker M and Bramley PM | Expression of prokaryotic 1-deoxy-D-xylulose-5-phosphatases in Escherichia coli increases carotenoid and ubiquinone biosynthesis. | 1999 | FEBS Lett. | pmid:10217421 |
Amir H et al. | Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells. | 1999 | Nutr Cancer | pmid:10227052 |
Hendriks HF et al. | Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects. | 1999 | Eur J Clin Nutr | pmid:10334658 |
Müller H et al. | Plasma concentrations of carotenoids in healthy volunteers after intervention with carotenoid-rich foods. | 1999 | Eur J Nutr | pmid:10338686 |
Boileau AC et al. | Cis-lycopene is more bioavailable than trans-lycopene in vitro and in vivo in lymph-cannulated ferrets. | 1999 | J. Nutr. | pmid:10356083 |