| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
Total
1
Lycopene
Lycopene is a lipid of Prenol Lipids (PR) class. Lycopene is associated with abnormalities such as Consumption-archaic term for TB, Chronic disease, Dehydration, furuncle and Cardiovascular Diseases. The involved functions are known as Cell Differentiation process, Signal Transduction, Biochemical Pathway, Mutation and IGF-1 Signaling Pathway. Lycopene often locates in Body tissue, Hepatic, Blood, Adipose tissue and Structure of parenchyma of lung. The associated genes with Lycopene are EPB41L2 gene, VEGFB gene, P4HTM gene, FATE1 gene and SLC33A1 gene. The related lipids are Micelles, Liposomes, Total cholesterol, Steroids and apo-10'-lycopenoic acid. The related experimental models are Mouse Model, Knock-out, Cancer Model, Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Lycopene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lycopene?
Lycopene is suspected in Chronic disease, Cardiovascular Diseases, Atherosclerosis, Congenital contractural arachnodactyly, Myocardial Infarction, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lycopene
PubChem Associated disorders and diseases
What pathways are associated with Lycopene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lycopene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Lycopene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Lycopene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Lycopene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Lycopene?
Cancer Model
Cancer Model are used in the study 'Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis.' (Imaida K et al., 2001), Cancer Model are used in the study 'Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention.' (Chen L et al., 2001), Cancer Model are used in the study 'Re: Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets.' (Limpens J et al., 2004), Cancer Model are used in the study 'Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells.' (Liu X et al., 2008) and Cancer Model are used in the study 'Can smoke-exposed ferrets be utilized to unravel the mechanisms of action of lycopene?' (Wang XD, 2005).
Knock-out
Knock-out are used in the study 'Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.' (Ip BC et al., 2014), Knock-out are used in the study 'In silico identification of gene amplification targets for improvement of lycopene production.' (Choi HS et al., 2010) and Knock-out are used in the study 'Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models.' (Stice CP et al., 2015).
Mouse Model
Mouse Model are used in the study 'Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature.' (Giovannucci E, 1999), Mouse Model are used in the study 'Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women.' (Watzl B et al., 2000) and Mouse Model are used in the study 'Executive summary report.' (Davis CD et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Lycopene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Slifka KA et al. | A survey of serum and dietary carotenoids in captive wild animals. | 1999 | J. Nutr. | pmid:10024616 |
| Tucker KL et al. | Carotenoid intakes, assessed by dietary questionnaire, are associated with plasma carotenoid concentrations in an elderly population. | 1999 | J. Nutr. | pmid:10024624 |
| Giovannucci E | Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. | 1999 | J. Natl. Cancer Inst. | pmid:10050865 |
| Suganuma H and Inakuma T | Protective effect of dietary tomato against endothelial dysfunction in hypercholesterolemic mice. | 1999 | Biosci. Biotechnol. Biochem. | pmid:10052125 |
| McEligot AJ et al. | Comparison of serum carotenoid responses between women consuming vegetable juice and women consuming raw or cooked vegetables. | 1999 | Cancer Epidemiol. Biomarkers Prev. | pmid:10090300 |
| Gann PH et al. | Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis. | 1999 | Cancer Res. | pmid:10096552 |
| Poulsen HE et al. | Oxidative DNA damage in vivo: relationship to age, plasma antioxidants, drug metabolism, glutathione-S-transferase activity and urinary creatinine excretion. | 1998 | Free Radic. Res. | pmid:10098460 |
| Miura Y et al. | Production of lycopene by the food yeast, Candida utilis that does not naturally synthesize carotenoid. | 1998 Apr 20-May 5 | Biotechnol. Bioeng. | pmid:10191407 |
| Lowe GM et al. | Lycopene and beta-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses. | 1999 | Free Radic. Res. | pmid:10193582 |
| Riso P et al. | Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage? | 1999 | Am. J. Clin. Nutr. | pmid:10197573 |
| Mayne ST et al. | Plasma lycopene concentrations in humans are determined by lycopene intake, plasma cholesterol concentrations and selected demographic factors. | 1999 | J. Nutr. | pmid:10203560 |
| Ronen G et al. | Regulation of carotenoid biosynthesis during tomato fruit development: expression of the gene for lycopene epsilon-cyclase is down-regulated during ripening and is elevated in the mutant Delta. | 1999 | Plant J. | pmid:10205893 |
| Hasselwander O et al. | HDL composition and HDL antioxidant capacity in patients on regular haemodialysis. | 1999 | Atherosclerosis | pmid:10208487 |
| Faure H et al. | [Carotenoids: 1. Metabolism and physiology]. | 1999 Mar-Apr | Ann. Biol. Clin. (Paris) | pmid:10210743 |
| Harker M and Bramley PM | Expression of prokaryotic 1-deoxy-D-xylulose-5-phosphatases in Escherichia coli increases carotenoid and ubiquinone biosynthesis. | 1999 | FEBS Lett. | pmid:10217421 |
| Amir H et al. | Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells. | 1999 | Nutr Cancer | pmid:10227052 |
| Hendriks HF et al. | Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects. | 1999 | Eur J Clin Nutr | pmid:10334658 |
| Müller H et al. | Plasma concentrations of carotenoids in healthy volunteers after intervention with carotenoid-rich foods. | 1999 | Eur J Nutr | pmid:10338686 |
| Boileau AC et al. | Cis-lycopene is more bioavailable than trans-lycopene in vitro and in vivo in lymph-cannulated ferrets. | 1999 | J. Nutr. | pmid:10356083 |
| Mayne ST and Cartmel B | Antioxidant vitamin supplementation and lipid peroxidation in smokers. | 1999 | Am. J. Clin. Nutr. | pmid:10357756 |
| Oshima S et al. | Absorption and distribution of lycopene in rat colon. | 1999 | J. Nutr. Sci. Vitaminol. | pmid:10360247 |
| Safety assessment and potential health benefits of food components based on selected scientific criteria. ILSI North America Technical Committee on Food Components for Health Promotion. | 1999 | Crit Rev Food Sci Nutr | pmid:10367185 | |
| Rao AV et al. | Serum and tissue lycopene and biomarkers of oxidation in prostate cancer patients: a case-control study. | 1999 | Nutr Cancer | pmid:10368811 |
| Hecht SS et al. | Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. | 1999 | Cancer Lett. | pmid:10374832 |
| Dugas TR et al. | Dietary supplementation with beta-carotene, but not with lycopene, inhibits endothelial cell-mediated oxidation of low-density lipoprotein. | 1999 | Free Radic. Biol. Med. | pmid:10381195 |
| Grant WB | An ecologic study of dietary links to prostate cancer. | 1999 | Altern Med Rev | pmid:10383480 |
| Verdoes JC et al. | Cloning and characterization of the astaxanthin biosynthetic gene encoding phytoene desaturase of Xanthophyllomyces dendrorhous. | 1999 | Biotechnol. Bioeng. | pmid:10397832 |
| Yamamoto Y and Yamashita S | Plasma ubiquinone to ubiquinol ratio in patients with hepatitis, cirrhosis, and hepatoma, and in patients treated with percutaneous transluminal coronary reperfusion. | 1999 | Biofactors | pmid:10416036 |
| Handelman GJ et al. | Lutein and zeaxanthin concentrations in plasma after dietary supplementation with egg yolk. | 1999 | Am. J. Clin. Nutr. | pmid:10426702 |
| Zackheim HS | Re: Tomatoes, tomato-based products, lycopene, and prostate cancer: review of the epidemiologic literature. | 1999 | J. Natl. Cancer Inst. | pmid:10433624 |
| Jewell C and O'Brien NM | Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat. | 1999 | Br. J. Nutr. | pmid:10434850 |
| Deshpande A and Sonar S | Bacterioopsin-triggered retinal biosynthesis is inhibited by bacteriorhodopsin formation in Halobacterium salinarium. | 1999 | J. Biol. Chem. | pmid:10438533 |
| Sutherland WH et al. | Supplementation with tomato juice increases plasma lycopene but does not alter susceptibility to oxidation of low-density lipoproteins from renal transplant recipients. | 1999 | Clin. Nephrol. | pmid:10442493 |
| Böhm V and Bitsch R | Intestinal absorption of lycopene from different matrices and interactions to other carotenoids, the lipid status, and the antioxidant capacity of human plasma. | 1999 | Eur J Nutr | pmid:10443333 |
| Fleshner NE and Klotz LH | Diet, androgens, oxidative stress and prostate cancer susceptibility. | 1998-1999 | Cancer Metastasis Rev. | pmid:10453275 |
| Tsubono Y et al. | Plasma antioxidant vitamins and carotenoids in five Japanese populations with varied mortality from gastric cancer. | 1999 | Nutr Cancer | pmid:10453442 |
| Arimochi H et al. | Effects of beta-glucuronidase-deficient and lycopene-producing Escherichia coli strains on formation of azoxymethane-induced aberrant crypt foci in the rat colon. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10462473 |
| Tatsuzawa H et al. | Singlet oxygen ((1)Delta(g)O(2)) as the principal oxidant in myeloperoxidase-mediated bacterial killing in neutrophil phagosome. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10471379 |
| Breitenbach J et al. | Catalytic properties of an expressed and purified higher plant type zeta-carotene desaturase from Capsicum annuum. | 1999 | Eur. J. Biochem. | pmid:10491195 |
| Sengupta A and Das S | The anti-carcinogenic role of lycopene, abundantly present in tomato. | 1999 | Eur. J. Cancer Prev. | pmid:10493308 |
| Paetau I et al. | Carotenoids in human buccal mucosa cells after 4 wk of supplementation with tomato juice or lycopene supplements. | 1999 | Am. J. Clin. Nutr. | pmid:10500017 |
| Leal M et al. | Effect of lycopene on lipid peroxidation and glutathione-dependent enzymes induced by T-2 toxin in vivo. | 1999 | Toxicol. Lett. | pmid:10514025 |
| Clinton SK | The dietary antioxidant network and prostate carcinoma. | 1999 | Cancer | pmid:10547532 |
| Mezzetti A et al. | Increased systemic oxidative stress after elective endarterectomy: relation to vascular healing and remodeling. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10559008 |
| Riedl J et al. | Some dietary fibers reduce the absorption of carotenoids in women. | 1999 | J. Nutr. | pmid:10573545 |
| Cohen LA et al. | Effect of dietary lycopene on N-methylnitrosourea-induced mammary tumorigenesis. | 1999 | Nutr Cancer | pmid:10578482 |
| Klipstein-Grobusch K et al. | Serum carotenoids and atherosclerosis. The Rotterdam Study. | 2000 | Atherosclerosis | pmid:10580170 |
| Xu X et al. | Solubilization and stabilization of carotenoids using micelles: delivery of lycopene to cells in culture. | 1999 | Lipids | pmid:10580330 |
| Wright AJ et al. | Beta-carotene and lycopene, but not lutein, supplementation changes the plasma fatty acid profile of healthy male non-smokers. | 1999 | J. Lab. Clin. Med. | pmid:10595786 |