Lycopene

Lycopene is a lipid of Prenol Lipids (PR) class. Lycopene is associated with abnormalities such as Consumption-archaic term for TB, Chronic disease, Dehydration, furuncle and Cardiovascular Diseases. The involved functions are known as Cell Differentiation process, Signal Transduction, Biochemical Pathway, Mutation and IGF-1 Signaling Pathway. Lycopene often locates in Body tissue, Hepatic, Blood, Adipose tissue and Structure of parenchyma of lung. The associated genes with Lycopene are EPB41L2 gene, VEGFB gene, P4HTM gene, FATE1 gene and SLC33A1 gene. The related lipids are Micelles, Liposomes, Total cholesterol, Steroids and apo-10'-lycopenoic acid. The related experimental models are Mouse Model, Knock-out, Cancer Model, Transgenic Model and Xenograft Model.

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Introduction

To understand associated biological information of Lycopene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Lycopene?

Lycopene is suspected in Chronic disease, Cardiovascular Diseases, Atherosclerosis, Congenital contractural arachnodactyly, Myocardial Infarction, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Lycopene

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Lycopene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Lycopene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Lycopene?


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What lipids are associated with Lycopene?

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What genes are associated with Lycopene?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Lycopene?

Cancer Model

Cancer Model are used in the study 'Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis.' (Imaida K et al., 2001), Cancer Model are used in the study 'Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention.' (Chen L et al., 2001), Cancer Model are used in the study 'Re: Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets.' (Limpens J et al., 2004), Cancer Model are used in the study 'Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells.' (Liu X et al., 2008) and Cancer Model are used in the study 'Can smoke-exposed ferrets be utilized to unravel the mechanisms of action of lycopene?' (Wang XD, 2005).

Knock-out

Knock-out are used in the study 'Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.' (Ip BC et al., 2014), Knock-out are used in the study 'In silico identification of gene amplification targets for improvement of lycopene production.' (Choi HS et al., 2010) and Knock-out are used in the study 'Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models.' (Stice CP et al., 2015).

Mouse Model

Mouse Model are used in the study 'Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature.' (Giovannucci E, 1999), Mouse Model are used in the study 'Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women.' (Watzl B et al., 2000) and Mouse Model are used in the study 'Executive summary report.' (Davis CD et al., 2005).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Lycopene

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Authors Title Published Journal PubMed Link
Boeira SP et al. Lycopene protects against acute zearalenone-induced oxidative, endocrine, inflammatory and reproductive damages in male mice. 2015 Chem. Biol. Interact. pmid:25682699
Vallverdú-Queralt A et al. Carotenoid profile of tomato sauces: effect of cooking time and content of extra virgin olive oil. 2015 Int J Mol Sci pmid:25927580
Huang RF et al. Inhibition of colon cancer cell growth by nanoemulsion carrying gold nanoparticles and lycopene. 2015 Int J Nanomedicine pmid:25914533
Giri AK et al. Effect of lycopene against gastroesophageal reflux disease in experimental animals. 2015 BMC Complement Altern Med pmid:25888837
Eliassen AH et al. Plasma carotenoids and risk of breast cancer over 20 y of follow-up. 2015 Am. J. Clin. Nutr. pmid:25877493
Cuperus JT et al. A tetO Toolkit To Alter Expression of Genes in Saccharomyces cerevisiae. 2015 ACS Synth Biol pmid:25742460
Sołtysiak P and Folwarczna J [Effects of lycopene on the skeletal system]. 2015 Postepy Hig Med Dosw (Online) pmid:25720611
Bucak MN et al. Lycopene and resveratrol improve post-thaw bull sperm parameters: sperm motility, mitochondrial activity and DNA integrity. 2015 Andrologia pmid:24909239
Lasekan J et al. Soy protein-based infant formulas with supplemental fructooligosaccharides: gastrointestinal tolerance and hydration status in newborn infants. 2015 Nutrients pmid:25912040
Cicero AF and Colletti A Nutraceuticals and Blood Pressure Control: Results from Clinical Trials and Meta-Analyses. 2015 High Blood Press Cardiovasc Prev pmid:25788027