MeSH term | MeSH ID | Detail |
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Adenocarcinoma | D000230 | 166 associated lipids |
Lycopene is a lipid of Prenol Lipids (PR) class. Lycopene is associated with abnormalities such as Consumption-archaic term for TB, Chronic disease, Dehydration, furuncle and Cardiovascular Diseases. The involved functions are known as Cell Differentiation process, Signal Transduction, Biochemical Pathway, Mutation and IGF-1 Signaling Pathway. Lycopene often locates in Body tissue, Hepatic, Blood, Adipose tissue and Structure of parenchyma of lung. The associated genes with Lycopene are EPB41L2 gene, VEGFB gene, P4HTM gene, FATE1 gene and SLC33A1 gene. The related lipids are Micelles, Liposomes, Total cholesterol, Steroids and apo-10'-lycopenoic acid. The related experimental models are Mouse Model, Knock-out, Cancer Model, Transgenic Model and Xenograft Model.
To understand associated biological information of Lycopene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Lycopene is suspected in Chronic disease, Cardiovascular Diseases, Atherosclerosis, Congenital contractural arachnodactyly, Myocardial Infarction, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Lycopene
MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis.' (Imaida K et al., 2001), Cancer Model are used in the study 'Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention.' (Chen L et al., 2001), Cancer Model are used in the study 'Re: Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets.' (Limpens J et al., 2004), Cancer Model are used in the study 'Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells.' (Liu X et al., 2008) and Cancer Model are used in the study 'Can smoke-exposed ferrets be utilized to unravel the mechanisms of action of lycopene?' (Wang XD, 2005).
Knock-out are used in the study 'Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.' (Ip BC et al., 2014), Knock-out are used in the study 'In silico identification of gene amplification targets for improvement of lycopene production.' (Choi HS et al., 2010) and Knock-out are used in the study 'Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models.' (Stice CP et al., 2015).
Mouse Model are used in the study 'Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature.' (Giovannucci E, 1999), Mouse Model are used in the study 'Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women.' (Watzl B et al., 2000) and Mouse Model are used in the study 'Executive summary report.' (Davis CD et al., 2005).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sengupta A and Das S | The anti-carcinogenic role of lycopene, abundantly present in tomato. | 1999 | Eur. J. Cancer Prev. | pmid:10493308 |
Paetau I et al. | Carotenoids in human buccal mucosa cells after 4 wk of supplementation with tomato juice or lycopene supplements. | 1999 | Am. J. Clin. Nutr. | pmid:10500017 |
Leal M et al. | Effect of lycopene on lipid peroxidation and glutathione-dependent enzymes induced by T-2 toxin in vivo. | 1999 | Toxicol. Lett. | pmid:10514025 |
Clinton SK | The dietary antioxidant network and prostate carcinoma. | 1999 | Cancer | pmid:10547532 |
Mezzetti A et al. | Increased systemic oxidative stress after elective endarterectomy: relation to vascular healing and remodeling. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10559008 |
Riedl J et al. | Some dietary fibers reduce the absorption of carotenoids in women. | 1999 | J. Nutr. | pmid:10573545 |
Cohen LA et al. | Effect of dietary lycopene on N-methylnitrosourea-induced mammary tumorigenesis. | 1999 | Nutr Cancer | pmid:10578482 |
Klipstein-Grobusch K et al. | Serum carotenoids and atherosclerosis. The Rotterdam Study. | 2000 | Atherosclerosis | pmid:10580170 |
Xu X et al. | Solubilization and stabilization of carotenoids using micelles: delivery of lycopene to cells in culture. | 1999 | Lipids | pmid:10580330 |
Wright AJ et al. | Beta-carotene and lycopene, but not lutein, supplementation changes the plasma fatty acid profile of healthy male non-smokers. | 1999 | J. Lab. Clin. Med. | pmid:10595786 |
Perugini C et al. | Distribution of lipid-soluble antioxidants in lipoproteins from healthy subjects. I. Correlation with plasma antioxidant levels and composition of lipoproteins. | 2000 | Pharmacol. Res. | pmid:10600270 |
Perugini C et al. | Distribution of lipid-soluble antioxidants in lipoproteins from healthy subjects. II. Effects of in vivo supplementation with alpha-tocopherol. | 2000 | Pharmacol. Res. | pmid:10600271 |
Pollack A et al. | Cataract development in sand and galactosemic rats fed a natural tomato extract. | 1999 | J. Agric. Food Chem. | pmid:10606583 |
Kawchak DA et al. | Longitudinal analysis shows serum carotenoid concentrations are low in children with cystic fibrosis. | 1999 | J Am Diet Assoc | pmid:10608954 |
Siems WG et al. | Lycopene and beta-carotene decompose more rapidly than lutein and zeaxanthin upon exposure to various pro-oxidants in vitro. | 1999 | Biofactors | pmid:10609870 |
Ito Y et al. | A study on serum carotenoid levels in breast cancer patients of Indian women in Chennai (Madras), India. | 1999 | J Epidemiol | pmid:10616263 |
Stahl W et al. | Stimulation of gap junctional communication: comparison of acyclo-retinoic acid and lycopene. | 2000 | Arch. Biochem. Biophys. | pmid:10620348 |
Panasenko OM et al. | Interaction of peroxynitrite with carotenoids in human low density lipoproteins. | 2000 | Arch. Biochem. Biophys. | pmid:10620353 |
Holloway DE et al. | Isomerization of dietary lycopene during assimilation and transport in plasma. | 2000 | Free Radic. Res. | pmid:10625221 |
Ye X et al. | Engineering the provitamin A (beta-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. | 2000 | Science | pmid:10634784 |