| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
Total
1
Lycopene
Lycopene is a lipid of Prenol Lipids (PR) class. Lycopene is associated with abnormalities such as Consumption-archaic term for TB, Chronic disease, Dehydration, furuncle and Cardiovascular Diseases. The involved functions are known as Cell Differentiation process, Signal Transduction, Biochemical Pathway, Mutation and IGF-1 Signaling Pathway. Lycopene often locates in Body tissue, Hepatic, Blood, Adipose tissue and Structure of parenchyma of lung. The associated genes with Lycopene are EPB41L2 gene, VEGFB gene, P4HTM gene, FATE1 gene and SLC33A1 gene. The related lipids are Micelles, Liposomes, Total cholesterol, Steroids and apo-10'-lycopenoic acid. The related experimental models are Mouse Model, Knock-out, Cancer Model, Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Lycopene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lycopene?
Lycopene is suspected in Chronic disease, Cardiovascular Diseases, Atherosclerosis, Congenital contractural arachnodactyly, Myocardial Infarction, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lycopene
PubChem Associated disorders and diseases
What pathways are associated with Lycopene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lycopene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Lycopene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Lycopene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Lycopene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Lycopene?
Cancer Model
Cancer Model are used in the study 'Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis.' (Imaida K et al., 2001), Cancer Model are used in the study 'Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention.' (Chen L et al., 2001), Cancer Model are used in the study 'Re: Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets.' (Limpens J et al., 2004), Cancer Model are used in the study 'Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells.' (Liu X et al., 2008) and Cancer Model are used in the study 'Can smoke-exposed ferrets be utilized to unravel the mechanisms of action of lycopene?' (Wang XD, 2005).
Knock-out
Knock-out are used in the study 'Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.' (Ip BC et al., 2014), Knock-out are used in the study 'In silico identification of gene amplification targets for improvement of lycopene production.' (Choi HS et al., 2010) and Knock-out are used in the study 'Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models.' (Stice CP et al., 2015).
Mouse Model
Mouse Model are used in the study 'Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature.' (Giovannucci E, 1999), Mouse Model are used in the study 'Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women.' (Watzl B et al., 2000) and Mouse Model are used in the study 'Executive summary report.' (Davis CD et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Lycopene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hughes DA et al. | Effects of lycopene and lutein supplementation on the expression of functionally associated surface molecules on blood monocytes from healthy male nonsmokers. | 2000 | J. Infect. Dis. | pmid:10944479 |
| Davies J | Tomatoes and health. | 2000 | J R Soc Promot Health | pmid:10944878 |
| Yamaguchi LF et al. | Lycopene entrapped in human albumin protects 2'-deoxyguanosine against singlet oxygen damage. | 1999 | Arch Latinoam Nutr | pmid:10971838 |
| Goldstein MR | Effects of dietary phytosterols on cholesterol metabolism and atherosclerosis. | 2000 | Am. J. Med. | pmid:10991743 |
| Heber D | Colorful cancer prevention: alpha-carotene, lycopene, and lung cancer. | 2000 | Am. J. Clin. Nutr. | pmid:11010928 |
| Michaud DS et al. | Intake of specific carotenoids and risk of lung cancer in 2 prospective US cohorts. | 2000 | Am. J. Clin. Nutr. | pmid:11010942 |
| Agarwal S and Rao AV | Tomato lycopene and its role in human health and chronic diseases. | 2000 | CMAJ | pmid:11022591 |
| Rao AV and Agarwal S | Role of antioxidant lycopene in cancer and heart disease. | 2000 | J Am Coll Nutr | pmid:11022869 |
| Chopra M et al. | Influence of increased fruit and vegetable intake on plasma and lipoprotein carotenoids and LDL oxidation in smokers and nonsmokers. | 2000 | Clin. Chem. | pmid:11067818 |
| Rosati C et al. | Metabolic engineering of beta-carotene and lycopene content in tomato fruit. | 2000 | Plant J. | pmid:11069713 |
| De Stefani E et al. | Dietary carotenoids and risk of gastric cancer: a case-control study in Uruguay. | 2000 | Eur. J. Cancer Prev. | pmid:11075886 |
| Lee A et al. | Consumption of tomato products with olive oil but not sunflower oil increases the antioxidant activity of plasma. | 2000 | Free Radic. Biol. Med. | pmid:11084294 |
| Baysal T et al. | Supercritical CO(2) extraction of beta-carotene and lycopene from tomato paste waste. | 2000 | J. Agric. Food Chem. | pmid:11087510 |
| Matos HR et al. | Protective effect of lycopene on lipid peroxidation and oxidative DNA damage in cell culture. | 2000 | Arch. Biochem. Biophys. | pmid:11097176 |
| Rissanen T et al. | Low plasma lycopene concentration is associated with increased intima-media thickness of the carotid artery wall. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:11116071 |
| Neuman I et al. | Reduction of exercise-induced asthma oxidative stress by lycopene, a natural antioxidant. | 2000 | Allergy | pmid:11117277 |
| Jones KL et al. | Low-copy plasmids can perform as well as or better than high-copy plasmids for metabolic engineering of bacteria. | 2000 | Metab. Eng. | pmid:11120644 |
| Yeh S and Hu M | Antioxidant and pro-oxidant effects of lycopene in comparison with beta-carotene on oxidant-induced damage in Hs68 cells. | 2000 | J. Nutr. Biochem. | pmid:11137891 |
| Guttenplan JB et al. | Effects of a lycopene-rich diet on spontaneous and benzo[a]pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse. | 2001 | Cancer Lett. | pmid:11166909 |
| Farmer WR and Liao JC | Precursor balancing for metabolic engineering of lycopene production in Escherichia coli. | 2001 Jan-Feb | Biotechnol. Prog. | pmid:11170480 |
| Biacs PA and Daood HG | Lipoxygenase-catalysed degradation of carotenoids from tomato in the presence of antioxidant vitamins. | 2000 | Biochem. Soc. Trans. | pmid:11171227 |
| Grolier P et al. | Age-related changes in plasma lycopene concentrations, but not in vitamin E, are associated with fat mass. | 2000 | Br. J. Nutr. | pmid:11177185 |
| Shi J and Le Maguer M | Lycopene in tomatoes: chemical and physical properties affected by food processing. | 2000 | Crit. Rev. Biotechnol. | pmid:11192026 |
| La Placa M et al. | Lycopenaemia. | 2000 | J Eur Acad Dermatol Venereol | pmid:11204525 |
| Wei W et al. | Association of smoking with serum and dietary levels of antioxidants in adults: NHANES III, 1988-1994. | 2001 | Am J Public Health | pmid:11211635 |
| Can tomatoes fight oral cancer? | 2001 | J Am Dent Assoc | pmid:11217586 | |
| Chesnokova NB et al. | [Experimental validation of licopin-containing drug tomatol use in combined therapy of patients with diabetic retinopathy]. | 2000 Sep-Oct | Vestn Oftalmol | pmid:11221377 |
| Fuhrman B et al. | Lycopene synergistically inhibits LDL oxidation in combination with vitamin E, glabridin, rosmarinic acid, carnosic acid, or garlic. | 2000 | Antioxid. Redox Signal. | pmid:11229363 |
| Nishino H et al. | Cancer prevention by natural carotenoids. | 2000 | Biofactors | pmid:11237205 |
| Kim DJ et al. | Chemoprevention of lung cancer by lycopene. | 2000 | Biofactors | pmid:11237207 |
| Imaida K et al. | Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis. | 2001 | Carcinogenesis | pmid:11238188 |
| Schoonover LL | Oxidative stress and the role of antioxidants in cardiovascular risk reduction. | 2001 | Prog Cardiovasc Nurs | pmid:11252875 |
| Saada Helen N and Azab Khaled S | Role of lycopene in recovery of radiation induced injury to mammalian cellular organelles. | 2001 | Pharmazie | pmid:11265592 |
| Kim SJ et al. | Formation of cleavage products by autoxidation of lycopene. | 2001 | Lipids | pmid:11269700 |
| Kiefer C et al. | Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. | 2001 | J. Biol. Chem. | pmid:11278918 |
| Fleshner NE and Kucuk O | Antioxidant dietary supplements: Rationale and current status as chemopreventive agents for prostate cancer. | 2001 | Urology | pmid:11295603 |
| Djuric Z and Powell LC | Antioxidant capacity of lycopene-containing foods. | 2001 | Int J Food Sci Nutr | pmid:11303462 |
| Canfield LM et al. | Red palm oil in the maternal diet increases provitamin A carotenoids in breastmilk and serum of the mother-infant dyad. | 2001 | Eur J Nutr | pmid:11315503 |
| de la Taille A et al. | [Cancer of the prostate: influence of nutritional factors. Vitamins, antioxidants and trace elements]. | 2001 | Presse Med | pmid:11317936 |
| Stahl W et al. | Dietary tomato paste protects against ultraviolet light-induced erythema in humans. | 2001 | J. Nutr. | pmid:11340098 |
| Record IR et al. | Changes in plasma antioxidant status following consumption of diets high or low in fruit and vegetables or following dietary supplementation with an antioxidant mixture. | 2001 | Br. J. Nutr. | pmid:11348560 |
| O'Neill ME et al. | A European carotenoid database to assess carotenoid intakes and its use in a five-country comparative study. | 2001 | Br. J. Nutr. | pmid:11348565 |
| Mortensen A et al. | The interaction of dietary carotenoids with radical species. | 2001 | Arch. Biochem. Biophys. | pmid:11361009 |
| Young AJ and Lowe GM | Antioxidant and prooxidant properties of carotenoids. | 2001 | Arch. Biochem. Biophys. | pmid:11361018 |
| Boileau TW et al. | Testosterone and food restriction modulate hepatic lycopene isomer concentrations in male F344 rats. | 2001 | J. Nutr. | pmid:11385062 |
| Mucci LA et al. | Are dietary influences on the risk of prostate cancer mediated through the insulin-like growth factor system? | 2001 | BJU Int. | pmid:11412218 |
| Nahum A et al. | Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27(Kip1) in the cyclin E-cdk2 complexes. | 2001 | Oncogene | pmid:11423993 |
| Rissanen TH et al. | Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. | 2001 | Br. J. Nutr. | pmid:11430780 |
| Krubasik P et al. | Expression and functional analysis of a gene cluster involved in the synthesis of decaprenoxanthin reveals the mechanisms for C50 carotenoid formation. | 2001 | Eur. J. Biochem. | pmid:11432736 |
| Ben-Dor A et al. | Effects of acyclo-retinoic acid and lycopene on activation of the retinoic acid receptor and proliferation of mammary cancer cells. | 2001 | Arch. Biochem. Biophys. | pmid:11437362 |