| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
Total
1
Lycopene
Lycopene is a lipid of Prenol Lipids (PR) class. Lycopene is associated with abnormalities such as Consumption-archaic term for TB, Chronic disease, Dehydration, furuncle and Cardiovascular Diseases. The involved functions are known as Cell Differentiation process, Signal Transduction, Biochemical Pathway, Mutation and IGF-1 Signaling Pathway. Lycopene often locates in Body tissue, Hepatic, Blood, Adipose tissue and Structure of parenchyma of lung. The associated genes with Lycopene are EPB41L2 gene, VEGFB gene, P4HTM gene, FATE1 gene and SLC33A1 gene. The related lipids are Micelles, Liposomes, Total cholesterol, Steroids and apo-10'-lycopenoic acid. The related experimental models are Mouse Model, Knock-out, Cancer Model, Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Lycopene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lycopene?
Lycopene is suspected in Chronic disease, Cardiovascular Diseases, Atherosclerosis, Congenital contractural arachnodactyly, Myocardial Infarction, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lycopene
PubChem Associated disorders and diseases
What pathways are associated with Lycopene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lycopene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Lycopene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Lycopene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Lycopene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Lycopene?
Cancer Model
Cancer Model are used in the study 'Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis.' (Imaida K et al., 2001), Cancer Model are used in the study 'Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention.' (Chen L et al., 2001), Cancer Model are used in the study 'Re: Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets.' (Limpens J et al., 2004), Cancer Model are used in the study 'Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells.' (Liu X et al., 2008) and Cancer Model are used in the study 'Can smoke-exposed ferrets be utilized to unravel the mechanisms of action of lycopene?' (Wang XD, 2005).
Knock-out
Knock-out are used in the study 'Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.' (Ip BC et al., 2014), Knock-out are used in the study 'In silico identification of gene amplification targets for improvement of lycopene production.' (Choi HS et al., 2010) and Knock-out are used in the study 'Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models.' (Stice CP et al., 2015).
Mouse Model
Mouse Model are used in the study 'Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature.' (Giovannucci E, 1999), Mouse Model are used in the study 'Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women.' (Watzl B et al., 2000) and Mouse Model are used in the study 'Executive summary report.' (Davis CD et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Lycopene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sundelin SP and Nilsson SE | Lipofuscin-formation in retinal pigment epithelial cells is reduced by antioxidants. | 2001 | Free Radic. Biol. Med. | pmid:11440833 |
| Lu QY et al. | Inverse associations between plasma lycopene and other carotenoids and prostate cancer. | 2001 | Cancer Epidemiol. Biomarkers Prev. | pmid:11440960 |
| Fedtke C et al. | Mode of action of new diethylamines in lycopene cyclase inhibition and in photosystem II turnover. | 2001 | Pest Manag. Sci. | pmid:11455658 |
| Matlaga BR et al. | Response of hormone refractory prostate cancer to lycopene. | 2001 | J. Urol. | pmid:11458084 |
| Schmitz-Dräger BJ et al. | Nutrition and prostate cancer. | 2001 | Urol. Int. | pmid:11464107 |
| Wendland BE et al. | Lipid peroxidation and plasma antioxidant micronutrients in Crohn disease. | 2001 | Am. J. Clin. Nutr. | pmid:11470730 |
| Watzl B and Rechkemmer G | Validity of dietary assessment. | 2001 | Am. J. Clin. Nutr. | pmid:11470737 |
| Corridan BM et al. | Low-dose supplementation with lycopene or beta-carotene does not enhance cell-mediated immunity in healthy free-living elderly humans. | 2001 | Eur J Clin Nutr | pmid:11477460 |
| Heber D et al. | Role of tomatoes, tomato products and lycopene in cancer prevention. | 2001 | Adv. Exp. Med. Biol. | pmid:11480673 |
| Burri BJ et al. | Serum carotenoid depletion follows first-order kinetics in healthy adult women fed naturally low carotenoid diets. | 2001 | J. Nutr. | pmid:11481400 |
| Kucuk O et al. | Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. | 2001 | Cancer Epidemiol. Biomarkers Prev. | pmid:11489752 |
| Mure K and Rossman TG | Reduction of spontaneous mutagenesis in mismatch repair-deficient and proficient cells by dietary antioxidants. | 2001 | Mutat. Res. | pmid:11506802 |
| Metzger A et al. | Antioxidant status and acute malaria in children in Kampala, Uganda. | 2001 | Am. J. Trop. Med. Hyg. | pmid:11508384 |
| Takeoka GR et al. | Processing effects on lycopene content and antioxidant activity of tomatoes. | 2001 | J. Agric. Food Chem. | pmid:11513653 |
| Hultén K et al. | Carotenoids, alpha-tocopherols, and retinol in plasma and breast cancer risk in northern Sweden. | 2001 | Cancer Causes Control | pmid:11519761 |
| Fraser PD et al. | Effect of the Cnr mutation on carotenoid formation during tomato fruit ripening. | 2001 | Phytochemistry | pmid:11524116 |
| DePrimo SE et al. | Prevention of prostate cancer. | 2001 | Hematol. Oncol. Clin. North Am. | pmid:11525290 |
| Palan PR et al. | Placental and serum levels of carotenoids in preeclampsia. | 2001 | Obstet Gynecol | pmid:11530129 |
| Ferruzzi MG et al. | Analysis of lycopene geometrical isomers in biological microsamples by liquid chromatography with coulometric array detection. | 2001 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11530988 |
| Arias R et al. | Quality comparison of hydroponic tomatoes (Lycopersicon esculentum) ripened on and off vine. | 2000 | J. Food Sci. | pmid:11543432 |
| Pollack A et al. | Inhibitory effect of lycopene on cataract development in galactosemic rats. | 1996-1997 | Metab Pediatr Syst Ophthalmol (1985) | pmid:11548783 |
| Chen G and Djuric Z | Carotenoids are degraded by free radicals but do not affect lipid peroxidation in unilamellar liposomes under different oxygen tensions. | 2001 | FEBS Lett. | pmid:11557059 |
| Maruyama C et al. | Effects of tomato juice consumption on plasma and lipoprotein carotenoid concentrations and the susceptibility of low density lipoprotein to oxidative modification. | 2001 | J. Nutr. Sci. Vitaminol. | pmid:11575576 |
| Watanabe S et al. | Effects of lycopene and Sho-saiko-to on hepatocarcinogenesis in a rat model of spontaneous liver cancer. | 2001 | Nutr Cancer | pmid:11588908 |
| Wei Y et al. | Application of analytical and preparative high-speed counter-current chromatography for separation of lycopene from crude extract of tomato paste. | 2001 | J Chromatogr A | pmid:11594399 |
| Cramer DW et al. | Carotenoids, antioxidants and ovarian cancer risk in pre- and postmenopausal women. | 2001 | Int. J. Cancer | pmid:11668487 |
| Harada J et al. | Phytoene desaturase, CrtI, of the purple photosynthetic bacterium, Rubrivivax gelatinosus, produces both neurosporene and lycopene. | 2001 | Plant Cell Physiol. | pmid:11673627 |
| Yeh SL and Hu ML | Induction of oxidative DNA damage in human foreskin fibroblast Hs68 cells by oxidized beta-Carotene and lycopene. | 2001 | Free Radic. Res. | pmid:11697201 |
| Ishida BK et al. | A simple, rapid method for HPLC analysis of lycopene isomers. | 2001 May-Jun | Phytochem Anal | pmid:11705025 |
| Lewinsohn E et al. | Enhanced levels of the aroma and flavor compound S-linalool by metabolic engineering of the terpenoid pathway in tomato fruits. | 2001 | Plant Physiol. | pmid:11706204 |
| Grassmann J et al. | Antioxidative effects of lemon oil and its components on copper induced oxidation of low density lipoprotein. | 2001 | Arzneimittelforschung | pmid:11715632 |
| Breitenbach J et al. | Gene sll0033 from Synechocystis 6803 encodes a carotene isomerase involved in the biosynthesis of all-E lycopene. | 2001 Sep-Oct | Z. Naturforsch., C, J. Biosci. | pmid:11724407 |
| Bhuvaneswari V et al. | Chemopreventive efficacy of lycopene on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. | 2001 | Fitoterapia | pmid:11731111 |
| McQuillan BM et al. | Antioxidant vitamins and the risk of carotid atherosclerosis. The Perth Carotid Ultrasound Disease Assessment study (CUDAS). | 2001 | J. Am. Coll. Cardiol. | pmid:11738275 |
| Böhm F et al. | Dietary uptake of lycopene protects human cells from singlet oxygen and nitrogen dioxide - ROS components from cigarette smoke. | 2001 | J. Photochem. Photobiol. B, Biol. | pmid:11744404 |
| Kabagambe EK et al. | Application of the method of triads to evaluate the performance of food frequency questionnaires and biomarkers as indicators of long-term dietary intake. | 2001 | Am. J. Epidemiol. | pmid:11744518 |
| Matos HR et al. | Lycopene inhibits DNA damage and liver necrosis in rats treated with ferric nitrilotriacetate. | 2001 | Arch. Biochem. Biophys. | pmid:11747294 |
| Chen L et al. | Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention. | 2001 | J. Natl. Cancer Inst. | pmid:11752012 |
| Böhm V et al. | Trolox equivalent antioxidant capacity of different geometrical isomers of alpha-carotene, beta-carotene, lycopene, and zeaxanthin. | 2002 | J. Agric. Food Chem. | pmid:11754571 |
| Nara E et al. | Acyclic carotenoids and their oxidation mixtures inhibit the growth of HL-60 human promyelocytic leukemia cells. | 2001 | Nutr Cancer | pmid:11759292 |
| Breitenbach J et al. | Chromatographic performance on a C30-bonded stationary phase of monohydroxycarotenoids with variable chain length or degree of desaturation and of lycopene isomers synthesized by various carotene desaturases. | 2001 | J Chromatogr A | pmid:11761006 |
| Masamoto K et al. | Identification of a gene required for cis-to-trans carotene isomerization in carotenogenesis of the cyanobacterium Synechocystis sp. PCC 6803. | 2001 | Plant Cell Physiol. | pmid:11773533 |
| Kucuk O and Wood DP | Re: Response of hormone refractory prostate cancer to lycopene. | 2002 | J. Urol. | pmid:11792944 |
| Böhm F et al. | Antioxidant inhibition of porphyrin-induced cellular phototoxicity. | 2001 | J. Photochem. Photobiol. B, Biol. | pmid:11809377 |
| Reifen R et al. | Lycopene supplementation attenuates the inflammatory status of colitis in a rat model. | 2001 | Int J Vitam Nutr Res | pmid:11840838 |
| Tyssandier V et al. | Vegetable-borne lutein, lycopene, and beta-carotene compete for incorporation into chylomicrons, with no adverse effect on the medium-term (3-wk) plasma status of carotenoids in humans. | 2002 | Am. J. Clin. Nutr. | pmid:11864859 |
| Gianetti J et al. | Inverse association between carotid intima-media thickness and the antioxidant lycopene in atherosclerosis. | 2002 | Am. Heart J. | pmid:11868053 |
| Giovannucci E et al. | A prospective study of tomato products, lycopene, and prostate cancer risk. | 2002 | J. Natl. Cancer Inst. | pmid:11880478 |
| Richelle M et al. | A food-based formulation provides lycopene with the same bioavailability to humans as that from tomato paste. | 2002 | J. Nutr. | pmid:11880563 |
| Eckardt NA | Tangerine dreams: cloning of carotenoid isomerase from Arabidopsis and tomato. | 2002 | Plant Cell | pmid:11884674 |