| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
Total
1
Lycopene
Lycopene is a lipid of Prenol Lipids (PR) class. Lycopene is associated with abnormalities such as Consumption-archaic term for TB, Chronic disease, Dehydration, furuncle and Cardiovascular Diseases. The involved functions are known as Cell Differentiation process, Signal Transduction, Biochemical Pathway, Mutation and IGF-1 Signaling Pathway. Lycopene often locates in Body tissue, Hepatic, Blood, Adipose tissue and Structure of parenchyma of lung. The associated genes with Lycopene are EPB41L2 gene, VEGFB gene, P4HTM gene, FATE1 gene and SLC33A1 gene. The related lipids are Micelles, Liposomes, Total cholesterol, Steroids and apo-10'-lycopenoic acid. The related experimental models are Mouse Model, Knock-out, Cancer Model, Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Lycopene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lycopene?
Lycopene is suspected in Chronic disease, Cardiovascular Diseases, Atherosclerosis, Congenital contractural arachnodactyly, Myocardial Infarction, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lycopene
PubChem Associated disorders and diseases
What pathways are associated with Lycopene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lycopene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Lycopene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Lycopene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Lycopene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Lycopene?
Cancer Model
Cancer Model are used in the study 'Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis.' (Imaida K et al., 2001), Cancer Model are used in the study 'Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention.' (Chen L et al., 2001), Cancer Model are used in the study 'Re: Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets.' (Limpens J et al., 2004), Cancer Model are used in the study 'Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells.' (Liu X et al., 2008) and Cancer Model are used in the study 'Can smoke-exposed ferrets be utilized to unravel the mechanisms of action of lycopene?' (Wang XD, 2005).
Knock-out
Knock-out are used in the study 'Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.' (Ip BC et al., 2014), Knock-out are used in the study 'In silico identification of gene amplification targets for improvement of lycopene production.' (Choi HS et al., 2010) and Knock-out are used in the study 'Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models.' (Stice CP et al., 2015).
Mouse Model
Mouse Model are used in the study 'Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature.' (Giovannucci E, 1999), Mouse Model are used in the study 'Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women.' (Watzl B et al., 2000) and Mouse Model are used in the study 'Executive summary report.' (Davis CD et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Lycopene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Slifka KA et al. | A survey of serum and dietary carotenoids in captive wild animals. | 1999 | J. Nutr. | pmid:10024616 |
| Tucker KL et al. | Carotenoid intakes, assessed by dietary questionnaire, are associated with plasma carotenoid concentrations in an elderly population. | 1999 | J. Nutr. | pmid:10024624 |
| Giovannucci E | Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. | 1999 | J. Natl. Cancer Inst. | pmid:10050865 |
| Suganuma H and Inakuma T | Protective effect of dietary tomato against endothelial dysfunction in hypercholesterolemic mice. | 1999 | Biosci. Biotechnol. Biochem. | pmid:10052125 |
| McEligot AJ et al. | Comparison of serum carotenoid responses between women consuming vegetable juice and women consuming raw or cooked vegetables. | 1999 | Cancer Epidemiol. Biomarkers Prev. | pmid:10090300 |
| Gann PH et al. | Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis. | 1999 | Cancer Res. | pmid:10096552 |
| Poulsen HE et al. | Oxidative DNA damage in vivo: relationship to age, plasma antioxidants, drug metabolism, glutathione-S-transferase activity and urinary creatinine excretion. | 1998 | Free Radic. Res. | pmid:10098460 |
| Miura Y et al. | Production of lycopene by the food yeast, Candida utilis that does not naturally synthesize carotenoid. | 1998 Apr 20-May 5 | Biotechnol. Bioeng. | pmid:10191407 |
| Lowe GM et al. | Lycopene and beta-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses. | 1999 | Free Radic. Res. | pmid:10193582 |
| Riso P et al. | Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage? | 1999 | Am. J. Clin. Nutr. | pmid:10197573 |
| Mayne ST et al. | Plasma lycopene concentrations in humans are determined by lycopene intake, plasma cholesterol concentrations and selected demographic factors. | 1999 | J. Nutr. | pmid:10203560 |
| Ronen G et al. | Regulation of carotenoid biosynthesis during tomato fruit development: expression of the gene for lycopene epsilon-cyclase is down-regulated during ripening and is elevated in the mutant Delta. | 1999 | Plant J. | pmid:10205893 |
| Hasselwander O et al. | HDL composition and HDL antioxidant capacity in patients on regular haemodialysis. | 1999 | Atherosclerosis | pmid:10208487 |
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| Harker M and Bramley PM | Expression of prokaryotic 1-deoxy-D-xylulose-5-phosphatases in Escherichia coli increases carotenoid and ubiquinone biosynthesis. | 1999 | FEBS Lett. | pmid:10217421 |
| Amir H et al. | Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells. | 1999 | Nutr Cancer | pmid:10227052 |
| Hendriks HF et al. | Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects. | 1999 | Eur J Clin Nutr | pmid:10334658 |
| Müller H et al. | Plasma concentrations of carotenoids in healthy volunteers after intervention with carotenoid-rich foods. | 1999 | Eur J Nutr | pmid:10338686 |
| Boileau AC et al. | Cis-lycopene is more bioavailable than trans-lycopene in vitro and in vivo in lymph-cannulated ferrets. | 1999 | J. Nutr. | pmid:10356083 |
| Mayne ST and Cartmel B | Antioxidant vitamin supplementation and lipid peroxidation in smokers. | 1999 | Am. J. Clin. Nutr. | pmid:10357756 |
| Oshima S et al. | Absorption and distribution of lycopene in rat colon. | 1999 | J. Nutr. Sci. Vitaminol. | pmid:10360247 |
| Safety assessment and potential health benefits of food components based on selected scientific criteria. ILSI North America Technical Committee on Food Components for Health Promotion. | 1999 | Crit Rev Food Sci Nutr | pmid:10367185 | |
| Rao AV et al. | Serum and tissue lycopene and biomarkers of oxidation in prostate cancer patients: a case-control study. | 1999 | Nutr Cancer | pmid:10368811 |
| Hecht SS et al. | Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. | 1999 | Cancer Lett. | pmid:10374832 |
| Dugas TR et al. | Dietary supplementation with beta-carotene, but not with lycopene, inhibits endothelial cell-mediated oxidation of low-density lipoprotein. | 1999 | Free Radic. Biol. Med. | pmid:10381195 |
| Grant WB | An ecologic study of dietary links to prostate cancer. | 1999 | Altern Med Rev | pmid:10383480 |
| Verdoes JC et al. | Cloning and characterization of the astaxanthin biosynthetic gene encoding phytoene desaturase of Xanthophyllomyces dendrorhous. | 1999 | Biotechnol. Bioeng. | pmid:10397832 |
| Yamamoto Y and Yamashita S | Plasma ubiquinone to ubiquinol ratio in patients with hepatitis, cirrhosis, and hepatoma, and in patients treated with percutaneous transluminal coronary reperfusion. | 1999 | Biofactors | pmid:10416036 |
| Handelman GJ et al. | Lutein and zeaxanthin concentrations in plasma after dietary supplementation with egg yolk. | 1999 | Am. J. Clin. Nutr. | pmid:10426702 |
| Zackheim HS | Re: Tomatoes, tomato-based products, lycopene, and prostate cancer: review of the epidemiologic literature. | 1999 | J. Natl. Cancer Inst. | pmid:10433624 |
| Jewell C and O'Brien NM | Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat. | 1999 | Br. J. Nutr. | pmid:10434850 |
| Deshpande A and Sonar S | Bacterioopsin-triggered retinal biosynthesis is inhibited by bacteriorhodopsin formation in Halobacterium salinarium. | 1999 | J. Biol. Chem. | pmid:10438533 |
| Sutherland WH et al. | Supplementation with tomato juice increases plasma lycopene but does not alter susceptibility to oxidation of low-density lipoproteins from renal transplant recipients. | 1999 | Clin. Nephrol. | pmid:10442493 |
| Böhm V and Bitsch R | Intestinal absorption of lycopene from different matrices and interactions to other carotenoids, the lipid status, and the antioxidant capacity of human plasma. | 1999 | Eur J Nutr | pmid:10443333 |
| Fleshner NE and Klotz LH | Diet, androgens, oxidative stress and prostate cancer susceptibility. | 1998-1999 | Cancer Metastasis Rev. | pmid:10453275 |
| Tsubono Y et al. | Plasma antioxidant vitamins and carotenoids in five Japanese populations with varied mortality from gastric cancer. | 1999 | Nutr Cancer | pmid:10453442 |
| Arimochi H et al. | Effects of beta-glucuronidase-deficient and lycopene-producing Escherichia coli strains on formation of azoxymethane-induced aberrant crypt foci in the rat colon. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10462473 |
| Tatsuzawa H et al. | Singlet oxygen ((1)Delta(g)O(2)) as the principal oxidant in myeloperoxidase-mediated bacterial killing in neutrophil phagosome. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10471379 |
| Breitenbach J et al. | Catalytic properties of an expressed and purified higher plant type zeta-carotene desaturase from Capsicum annuum. | 1999 | Eur. J. Biochem. | pmid:10491195 |
| Sengupta A and Das S | The anti-carcinogenic role of lycopene, abundantly present in tomato. | 1999 | Eur. J. Cancer Prev. | pmid:10493308 |
| Paetau I et al. | Carotenoids in human buccal mucosa cells after 4 wk of supplementation with tomato juice or lycopene supplements. | 1999 | Am. J. Clin. Nutr. | pmid:10500017 |
| Leal M et al. | Effect of lycopene on lipid peroxidation and glutathione-dependent enzymes induced by T-2 toxin in vivo. | 1999 | Toxicol. Lett. | pmid:10514025 |
| Clinton SK | The dietary antioxidant network and prostate carcinoma. | 1999 | Cancer | pmid:10547532 |
| Mezzetti A et al. | Increased systemic oxidative stress after elective endarterectomy: relation to vascular healing and remodeling. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10559008 |
| Riedl J et al. | Some dietary fibers reduce the absorption of carotenoids in women. | 1999 | J. Nutr. | pmid:10573545 |
| Cohen LA et al. | Effect of dietary lycopene on N-methylnitrosourea-induced mammary tumorigenesis. | 1999 | Nutr Cancer | pmid:10578482 |
| Klipstein-Grobusch K et al. | Serum carotenoids and atherosclerosis. The Rotterdam Study. | 2000 | Atherosclerosis | pmid:10580170 |
| Xu X et al. | Solubilization and stabilization of carotenoids using micelles: delivery of lycopene to cells in culture. | 1999 | Lipids | pmid:10580330 |
| Wright AJ et al. | Beta-carotene and lycopene, but not lutein, supplementation changes the plasma fatty acid profile of healthy male non-smokers. | 1999 | J. Lab. Clin. Med. | pmid:10595786 |
| Perugini C et al. | Distribution of lipid-soluble antioxidants in lipoproteins from healthy subjects. I. Correlation with plasma antioxidant levels and composition of lipoproteins. | 2000 | Pharmacol. Res. | pmid:10600270 |
| Perugini C et al. | Distribution of lipid-soluble antioxidants in lipoproteins from healthy subjects. II. Effects of in vivo supplementation with alpha-tocopherol. | 2000 | Pharmacol. Res. | pmid:10600271 |
| Pollack A et al. | Cataract development in sand and galactosemic rats fed a natural tomato extract. | 1999 | J. Agric. Food Chem. | pmid:10606583 |
| Kawchak DA et al. | Longitudinal analysis shows serum carotenoid concentrations are low in children with cystic fibrosis. | 1999 | J Am Diet Assoc | pmid:10608954 |
| Siems WG et al. | Lycopene and beta-carotene decompose more rapidly than lutein and zeaxanthin upon exposure to various pro-oxidants in vitro. | 1999 | Biofactors | pmid:10609870 |
| Ito Y et al. | A study on serum carotenoid levels in breast cancer patients of Indian women in Chennai (Madras), India. | 1999 | J Epidemiol | pmid:10616263 |
| Stahl W et al. | Stimulation of gap junctional communication: comparison of acyclo-retinoic acid and lycopene. | 2000 | Arch. Biochem. Biophys. | pmid:10620348 |
| Panasenko OM et al. | Interaction of peroxynitrite with carotenoids in human low density lipoproteins. | 2000 | Arch. Biochem. Biophys. | pmid:10620353 |
| Holloway DE et al. | Isomerization of dietary lycopene during assimilation and transport in plasma. | 2000 | Free Radic. Res. | pmid:10625221 |
| Ye X et al. | Engineering the provitamin A (beta-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. | 2000 | Science | pmid:10634784 |
| Grant WB | Calcium, lycopene, vitamin D and prostate cancer. | 2000 | Prostate | pmid:10639196 |
| Kristal AR and Cohen JH | Invited commentary: tomatoes, lycopene, and prostate cancer. How strong is the evidence? | 2000 | Am. J. Epidemiol. | pmid:10645814 |
| Slattery ML et al. | Carotenoids and colon cancer. | 2000 | Am. J. Clin. Nutr. | pmid:10648274 |
| Shi J and Le Maguer M | Lycopene in tomatoes: chemical and physical properties affected by food processing. | 2000 | Crit Rev Food Sci Nutr | pmid:10674200 |
| Ronco A et al. | Vegetables, fruits, and related nutrients and risk of breast cancer: a case-control study in Uruguay. | 1999 | Nutr Cancer | pmid:10693163 |
| Rock E et al. | The effect of copper supplementation on red blood cell oxidizability and plasma antioxidants in middle-aged healthy volunteers. | 2000 | Free Radic. Biol. Med. | pmid:10699742 |
| Porrini M and Riso P | Lymphocyte lycopene concentration and DNA protection from oxidative damage is increased in women after a short period of tomato consumption. | 2000 | J. Nutr. | pmid:10720168 |
| Gossage C et al. | Effect of beta-carotene supplementation and lactation on carotenoid metabolism and mitogenic T lymphocyte proliferation. | 2000 | Am. J. Clin. Nutr. | pmid:10731502 |
| Kurtzweil P | Joint program pools food research resources. | 2000 Jan-Feb | FDA Consum | pmid:10732498 |
| Pellegrini N et al. | Tomato consumption does not affect the total antioxidant capacity of plasma. | 2000 | Nutrition | pmid:10758362 |
| Kozuki Y et al. | Inhibitory effects of carotenoids on the invasion of rat ascites hepatoma cells in culture. | 2000 | Cancer Lett. | pmid:10766430 |
| Karg E et al. | Diminished blood levels of reduced glutathione and alpha-tocopherol in two triosephosphate isomerase-deficient brothers. | 2000 | Blood Cells Mol. Dis. | pmid:10772880 |
| Hoffmann J et al. | Dietary fiber reduces the antioxidative effect of a carotenoid and alpha-tocopherol mixture on LDL oxidation ex vivo in humans. | 1999 | Eur J Nutr | pmid:10784384 |
| Goodman GE | Prevention of lung cancer. | 2000 | Crit. Rev. Oncol. Hematol. | pmid:10789492 |
| Karas M et al. | Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells. | 2000 | Nutr Cancer | pmid:10798222 |
| Roodenburg AJ et al. | Amount of fat in the diet affects bioavailability of lutein esters but not of alpha-carotene, beta-carotene, and vitamin E in humans. | 2000 | Am. J. Clin. Nutr. | pmid:10799382 |
| van het Hof KH et al. | Carotenoid bioavailability in humans from tomatoes processed in different ways determined from the carotenoid response in the triglyceride-rich lipoprotein fraction of plasma after a single consumption and in plasma after four days of consumption. | 2000 | J. Nutr. | pmid:10801917 |
| Ferreira AL et al. | Tissue distribution of lycopene in ferrets and rats after lycopene supplementation. | 2000 | J. Nutr. | pmid:10801927 |
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| Alba R et al. | Fruit-localized phytochromes regulate lycopene accumulation independently of ethylene production in tomato. | 2000 | Plant Physiol. | pmid:10806253 |
| Breinholt V et al. | Dose-response effects of lycopene on selected drug-metabolizing and antioxidant enzymes in the rat. | 2000 | Cancer Lett. | pmid:10806309 |
| Arias R et al. | Correlation of lycopene measured by HPLC with the L, a, b color readings of a hydroponic tomato and the relationship of maturity with color and lycopene content. | 2000 | J. Agric. Food Chem. | pmid:10820081 |
| Voutilainen S et al. | Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study. | 2000 | Eur J Clin Nutr | pmid:10822291 |
| Boileau TW et al. | Tissue lycopene concentrations and isomer patterns are affected by androgen status and dietary lycopene concentration in male F344 rats. | 2000 | J. Nutr. | pmid:10827218 |
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| Upritchard JE et al. | Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. | 2000 | Diabetes Care | pmid:10840987 |
| Martin KR et al. | The effect of carotenoids on the expression of cell surface adhesion molecules and binding of monocytes to human aortic endothelial cells. | 2000 | Atherosclerosis | pmid:10856518 |
| Longnecker MP et al. | Dietary intake of calcium, magnesium and antioxidants in relation to risk of amyotrophic lateral sclerosis. | 2000 Jul-Aug | Neuroepidemiology | pmid:10859501 |
| Lin S et al. | Localization of carotenoids in plasma low-density lipoproteins studied by surface-enhanced resonance Raman spectroscopy. | 2000 | Biopolymers | pmid:10861389 |
| Watzl B et al. | Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women. | 2000 | J. Nutr. | pmid:10867042 |
| Bramley PM | Is lycopene beneficial to human health? | 2000 | Phytochemistry | pmid:10870177 |
| Carroll YL et al. | Lipoprotein carotenoid profiles and the susceptibility of low density lipoprotein to oxidative modification in healthy elderly volunteers. | 2000 | Eur J Clin Nutr | pmid:10878653 |
| Abushita AA et al. | Change in carotenoids and antioxidant vitamins in tomato as a function of varietal and technological factors. | 2000 | J. Agric. Food Chem. | pmid:10888501 |
| De Stefani E et al. | Tomatoes, tomato-rich foods, lycopene and cancer of the upper aerodigestive tract: a case-control in Uruguay. | 2000 | Oral Oncol. | pmid:10889919 |
| Casso D et al. | Correlates of serum lycopene in older women. | 2000 | Nutr Cancer | pmid:10890026 |
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