MeSH term | MeSH ID | Detail |
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Adenocarcinoma | D000230 | 166 associated lipids |
Lycopene is a lipid of Prenol Lipids (PR) class. Lycopene is associated with abnormalities such as Consumption-archaic term for TB, Chronic disease, Dehydration, furuncle and Cardiovascular Diseases. The involved functions are known as Cell Differentiation process, Signal Transduction, Biochemical Pathway, Mutation and IGF-1 Signaling Pathway. Lycopene often locates in Body tissue, Hepatic, Blood, Adipose tissue and Structure of parenchyma of lung. The associated genes with Lycopene are EPB41L2 gene, VEGFB gene, P4HTM gene, FATE1 gene and SLC33A1 gene. The related lipids are Micelles, Liposomes, Total cholesterol, Steroids and apo-10'-lycopenoic acid. The related experimental models are Mouse Model, Knock-out, Cancer Model, Transgenic Model and Xenograft Model.
To understand associated biological information of Lycopene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Lycopene is suspected in Chronic disease, Cardiovascular Diseases, Atherosclerosis, Congenital contractural arachnodactyly, Myocardial Infarction, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Lycopene
MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis.' (Imaida K et al., 2001), Cancer Model are used in the study 'Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention.' (Chen L et al., 2001), Cancer Model are used in the study 'Re: Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets.' (Limpens J et al., 2004), Cancer Model are used in the study 'Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells.' (Liu X et al., 2008) and Cancer Model are used in the study 'Can smoke-exposed ferrets be utilized to unravel the mechanisms of action of lycopene?' (Wang XD, 2005).
Knock-out are used in the study 'Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.' (Ip BC et al., 2014), Knock-out are used in the study 'In silico identification of gene amplification targets for improvement of lycopene production.' (Choi HS et al., 2010) and Knock-out are used in the study 'Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models.' (Stice CP et al., 2015).
Mouse Model are used in the study 'Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature.' (Giovannucci E, 1999), Mouse Model are used in the study 'Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women.' (Watzl B et al., 2000) and Mouse Model are used in the study 'Executive summary report.' (Davis CD et al., 2005).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Barros PP et al. | Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats. | 2017 | Acta Cir Bras | pmid:28403343 |
Morgia G et al. | Survivin and NAIP in Human Benign Prostatic Hyperplasia: Protective Role of the Association of Serenoa repens, Lycopene and Selenium from the Randomized Clinical Study. | 2017 | Int J Mol Sci | pmid:28327526 |
Yamamoto Y et al. | The effects of tomato juice on male infertility. | 2017 | Asia Pac J Clin Nutr | pmid:28049263 |
Dueñas-GarcÃa IE et al. | Lycopene, resveratrol, vitamin C and FeSO increase damage produced by pro-oxidant carcinogen 4-nitroquinoline-1-oxide in Drosophila melanogaster: Xenobiotic metabolism implications. | 2017 | Food Chem. Toxicol. | pmid:28202360 |
Jeon S et al. | Effect of Carotenoid Supplemented Formula on Carotenoid Bioaccumulation in Tissues of Infant Rhesus Macaques: A Pilot Study Focused on Lutein. | 2017 | Nutrients | pmid:28075370 |
Ding S et al. | EcoSynther: A Customized Platform To Explore the Biosynthetic Potential in E. coli. | 2017 | ACS Chem. Biol. | pmid:28952720 |
Zhang XF et al. | Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3). | 2017 | Int J Nanomedicine | pmid:29075115 |
Li W et al. | Self-assembly of green tea catechin derivatives in nanoparticles for oral lycopene delivery. | 2017 | J Control Release | pmid:28077264 |
Assis RP et al. | Combined Effects of Curcumin and Lycopene or Bixin in Yoghurt on Inhibition of LDL Oxidation and Increases in HDL and Paraoxonase Levels in Streptozotocin-Diabetic Rats. | 2017 | Int J Mol Sci | pmid:28333071 |
Ellis AC et al. | Modulating Oxidative Stress and Inflammation in Elders: The MOXIE Study. | 2016 Oct-Dec | J Nutr Gerontol Geriatr | pmid:27897608 |
Göncü T et al. | Anti-inflammatory effect of lycopene on endotoxin-induced uveitis in rats. | 2016 Nov-Dec | Arq Bras Oftalmol | pmid:28076559 |
Sawardekar SB et al. | Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: An in vitro study. | 2016 Jan-Feb | Indian J Pharmacol | pmid:26997718 |
Ooe E et al. | Analysis and characterization of anthocyanins and carotenoids in Japanese blue tomato. | 2016 | Biosci. Biotechnol. Biochem. | pmid:26443075 |
Zhou S et al. | INHIBITORY EFFECT OF LYCOPENE AGAINST THE GROWTH OF HUMAN GASTRIC CANCER CELLS. | 2016 | Afr J Tradit Complement Altern Med | pmid:28852735 |
He Y et al. | Lycopene Ameliorates Transplant Arteriosclerosis in Vascular Allograft Transplantation by Regulating the NO/cGMP Pathways and Rho-Associated Kinases Expression. | 2016 | Oxid Med Cell Longev | pmid:28050227 |
Jiang W et al. | Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat. | 2016 | World J. Gastroenterol. | pmid:28028366 |
Wang RH et al. | Transcriptome Analysis Provides a Preliminary Regulation Route of the Ethylene Signal Transduction Component, SlEIN2, during Tomato Ripening. | 2016 | PLoS ONE | pmid:27973616 |
Yildiz M and Sandikci M | Changes in rat ovary with experimentally induced diabetes and the effects of lycopene on those changes. | 2016 | Rom J Morphol Embryol | pmid:27833962 |
Cai T et al. | Serenoa repens associated with selenium and lycopene extract and bromelain and methylsulfonylmethane extract are able to improve the efficacy of levofloxacin in chronic bacterial prostatitis patients. | 2016 | Arch Ital Urol Androl | pmid:27711089 |
Zhou YE et al. | Plasma Lycopene Is Associated with Pizza and Pasta Consumption in Middle-Aged and Older African American and White Adults in the Southeastern USA in a Cross-Sectional Study. | 2016 | PLoS ONE | pmid:27583358 |
Ye M et al. | Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma. | 2016 | Mol Med Rep | pmid:27510325 |
Gong X et al. | Mitochondrial β-Carotene 9',10' Oxygenase Modulates Prostate Cancer Growth via NF-κB Inhibition: A Lycopene-Independent Function. | 2016 | Mol. Cancer Res. | pmid:27406826 |
Zhang Q et al. | Effect of lycopene on the blood-spinal cord barrier after spinal cord injury in mice. | 2016 | Biosci Trends | pmid:27357536 |
Chen Y et al. | Lycopene overproduction in Saccharomyces cerevisiae through combining pathway engineering with host engineering. | 2016 | Microb. Cell Fact. | pmid:27329233 |
Bae JM | Reinterpretation of the results of a pooled analysis of dietary carotenoid intake and breast cancer risk by using the interval collapsing method. | 2016 | Epidemiol Health | pmid:27283141 |
Antwi SO et al. | Carotenoid intake and adipose tissue carotenoid levels in relation to prostate cancer aggressiveness among African-American and European-American men in the North Carolina-Louisiana prostate cancer project (PCaP). | 2016 | Prostate | pmid:27271547 |
Pandurangaiah S et al. | Differential expression of carotenoid biosynthetic pathway genes in two contrasting tomato genotypes for lycopene content. | 2016 | J. Biosci. | pmid:27240986 |
Aizawa K et al. | Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation. | 2016 | Int. J. Cancer | pmid:27116542 |
Mohan V et al. | Neofunctionalization of Chromoplast Specific Lycopene Beta Cyclase Gene (CYC-B) in Tomato Clade. | 2016 | PLoS ONE | pmid:27070417 |
Feng C et al. | Lycopene protects human SH‑SY5Y neuroblastoma cells against hydrogen peroxide‑induced death via inhibition of oxidative stress and mitochondria‑associated apoptotic pathways. | 2016 | Mol Med Rep | pmid:27035331 |
BaÅŸ H and Pandir D | Protective Effects of Lycopene on Furan-treated Diabetic and Non-diabetic Rat Lung. | 2016 | Biomed. Environ. Sci. | pmid:27003172 |
Tong C et al. | Intravenous Administration of Lycopene, a Tomato Extract, Protects against Myocardial Ischemia-Reperfusion Injury. | 2016 | Nutrients | pmid:26950150 |
Hackshaw-McGeagh L et al. | Prostate cancer - evidence of exercise and nutrition trial (PrEvENT): study protocol for a randomised controlled feasibility trial. | 2016 | Trials | pmid:26948468 |
Kataria Y et al. | Retinoid and carotenoid status in serum and liver among patients at high-risk for liver cancer. | 2016 | BMC Gastroenterol | pmid:26927700 |
van Die MD et al. | Phytotherapeutic interventions in the management of biochemically recurrent prostate cancer: a systematic review of randomised trials. | 2016 | BJU Int. | pmid:26898239 |
Petyaev IM | Lycopene Deficiency in Ageing and Cardiovascular Disease. | 2016 | Oxid Med Cell Longev | pmid:26881023 |
D'Adamo CR et al. | A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations. | 2016 | Nutrients | pmid:26861389 |
Wang Y et al. | Lycopene, tomato products and prostate cancer-specific mortality among men diagnosed with nonmetastatic prostate cancer in the Cancer Prevention Study II Nutrition Cohort. | 2016 | Int. J. Cancer | pmid:26830232 |
Sharma A et al. | Potential biological efficacy of Pinus plant species against oxidative, inflammatory and microbial disorders. | 2016 | BMC Complement Altern Med | pmid:26822870 |
Graff RE et al. | Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression. | 2016 | Am. J. Clin. Nutr. | pmid:26817504 |
Ascenso A et al. | The Effect of Lycopene Preexposure on UV-B-Irradiated Human Keratinocytes. | 2016 | Oxid Med Cell Longev | pmid:26664697 |
Nordström T et al. | Associations between circulating carotenoids, genomic instability and the risk of high-grade prostate cancer. | 2016 | Prostate | pmid:26585352 |
Liu TY and Chen SB | Sarcandra glabra combined with lycopene protect rats from lipopolysaccharide induced acute lung injury via reducing inflammatory response. | 2016 | Biomed. Pharmacother. | pmid:27631138 |
Godsey J and Grundmann O | Review of Various Herbal Supplements as Complementary Treatments for Oral Cancer. | 2016 | J Diet Suppl | pmid:26863913 |
Boehm F et al. | A dramatic effect of oxygen on protection of human cells against γ-radiation by lycopene. | 2016 | FEBS Lett. | pmid:26991327 |
Janse VAN Rensburg A and Wenhold F | Validity and Reliability of Field Resonance Raman Spectroscopy for Assessing Carotenoid Status. | 2016 | J. Nutr. Sci. Vitaminol. | pmid:27928118 |
Stuetz W et al. | Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35-74 Years) General Population: A Cross-Sectional Study in Six European Countries. | 2016 | Nutrients | pmid:27706032 |
GÅ‚Ä…bska D et al. | Lycopene, Lutein and Zeaxanthin May Reduce Faecal Blood, Mucus and Pus but not Abdominal Pain in Individuals with Ulcerative Colitis. | 2016 | Nutrients | pmid:27706028 |
Mumford SL et al. | Serum Antioxidants Are Associated with Serum Reproductive Hormones and Ovulation among Healthy Women. | 2016 | J. Nutr. | pmid:26581679 |
Cunja V et al. | Fresh from the Ornamental Garden: Hips of Selected Rose Cultivars Rich in Phytonutrients. | 2016 | J. Food Sci. | pmid:26773854 |
Piña-Zentella RM et al. | Lycopene Improves Diet-Mediated Recuperation in Rat Model of Nonalcoholic Fatty Liver Disease. | 2016 | J Med Food | pmid:27214602 |
Moran NE et al. | Absorption and Distribution Kinetics of the 13C-Labeled Tomato Carotenoid Phytoene in Healthy Adults. | 2016 | J. Nutr. | pmid:26674763 |
Biddle MJ et al. | Lycopene dietary intervention: a pilot study in patients with heart failure. | 2015 May-Jun | J Cardiovasc Nurs | pmid:24651682 |
Goel S and Ahmed J | A comparative study on efficacy of different treatment modalities of oral submucous fibrosis evaluated by clinical staging in population of Southern Rajasthan. | 2015 Jan-Mar | J Cancer Res Ther | pmid:25879347 |
Colmán-MartÃnez M et al. | A New Method to Simultaneously Quantify the Antioxidants: Carotenes, Xanthophylls, and Vitamin A in Human Plasma. | 2015 | Oxid Med Cell Longev | pmid:26697143 |
Boeira SP et al. | Lycopene protects against acute zearalenone-induced oxidative, endocrine, inflammatory and reproductive damages in male mice. | 2015 | Chem. Biol. Interact. | pmid:25682699 |
Bongers M et al. | Systems analysis of methylerythritol-phosphate pathway flux in E. coli: insights into the role of oxidative stress and the validity of lycopene as an isoprenoid reporter metabolite. | 2015 | Microb. Cell Fact. | pmid:26610700 |
Moran NE et al. | Compartmental and noncompartmental modeling of ¹³C-lycopene absorption, isomerization, and distribution kinetics in healthy adults. | 2015 | Am. J. Clin. Nutr. | pmid:26561629 |
Key TJ et al. | Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies. | 2015 | Am. J. Clin. Nutr. | pmid:26447150 |
Gann PH et al. | A Phase II Randomized Trial of Lycopene-Rich Tomato Extract Among Men with High-Grade Prostatic Intraepithelial Neoplasia. | 2015 | Nutr Cancer | pmid:26422197 |
Wang Y et al. | Effect of Carotene and Lycopene on the Risk of Prostate Cancer: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies. | 2015 | PLoS ONE | pmid:26372549 |
Oguz E et al. | Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats. | 2015 | Asian Pac. J. Cancer Prev. | pmid:26320496 |
Xu J et al. | Lycopene Protects against Hypoxia/Reoxygenation Injury by Alleviating ER Stress Induced Apoptosis in Neonatal Mouse Cardiomyocytes. | 2015 | PLoS ONE | pmid:26291709 |
Chen P et al. | Lycopene and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis. | 2015 | Medicine (Baltimore) | pmid:26287411 |
Seo YB et al. | Molecular Cloning and Co-Expression of Phytoene Synthase Gene from Kocuria gwangalliensis in Escherichia coli. | 2015 | J. Microbiol. Biotechnol. | pmid:26215267 |
Watstein DM et al. | Precise metabolic engineering of carotenoid biosynthesis in Escherichia coli towards a low-cost biosensor. | 2015 | Metab. Eng. | pmid:26141149 |
Guest J et al. | Lycopene Pretreatment Ameliorates Acute Ethanol Induced NAD(+) Depletion in Human Astroglial Cells. | 2015 | Oxid Med Cell Longev | pmid:26075038 |
Vallverdú-Queralt A et al. | Carotenoid profile of tomato sauces: effect of cooking time and content of extra virgin olive oil. | 2015 | Int J Mol Sci | pmid:25927580 |
Huang RF et al. | Inhibition of colon cancer cell growth by nanoemulsion carrying gold nanoparticles and lycopene. | 2015 | Int J Nanomedicine | pmid:25914533 |
Giri AK et al. | Effect of lycopene against gastroesophageal reflux disease in experimental animals. | 2015 | BMC Complement Altern Med | pmid:25888837 |
Eliassen AH et al. | Plasma carotenoids and risk of breast cancer over 20 y of follow-up. | 2015 | Am. J. Clin. Nutr. | pmid:25877493 |
Cuperus JT et al. | A tetO Toolkit To Alter Expression of Genes in Saccharomyces cerevisiae. | 2015 | ACS Synth Biol | pmid:25742460 |
Sołtysiak P and Folwarczna J | [Effects of lycopene on the skeletal system]. | 2015 | Postepy Hig Med Dosw (Online) | pmid:25720611 |
Yang Y et al. | Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica. | 2015 | J. Bacteriol. | pmid:25712483 |
Sommerburg O et al. | Supplementation with red palm oil increases β-carotene and vitamin A blood levels in patients with cystic fibrosis. | 2015 | Mediators Inflamm. | pmid:25688177 |
Ip BC et al. | Lycopene and apo-10'-lycopenoic acid have differential mechanisms of protection against hepatic steatosis in β-carotene-9',10'-oxygenase knockout male mice. | 2015 | J. Nutr. | pmid:25644347 |
Zubair N et al. | Genetic variation predicts serum lycopene concentrations in a multiethnic population of postmenopausal women. | 2015 | J. Nutr. | pmid:25644336 |
Iwasaki M et al. | Comparison of plasma levels of nutrient-related biomarkers among Japanese populations in Tokyo, Japan, São Paulo, Brazil, and Hawaii, USA. | 2015 | Eur. J. Cancer Prev. | pmid:25633435 |
Sahin K et al. | Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model. | 2015 | Arch. Biochem. Biophys. | pmid:25602702 |
Stice CP et al. | Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models. | 2015 | Arch. Biochem. Biophys. | pmid:25592162 |
Dai C et al. | Lycopene attenuates colistin-induced nephrotoxicity in mice via activation of the Nrf2/HO-1 pathway. | 2015 | Antimicrob. Agents Chemother. | pmid:25385104 |
Sun Q et al. | Melatonin promotes ripening and improves quality of tomato fruit during postharvest life. | 2015 | J. Exp. Bot. | pmid:25147270 |
Filipcikova R et al. | Lycopene improves the distorted ratio between AA/DHA in the seminal plasma of infertile males and increases the likelihood of successful pregnancy. | 2015 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:23446211 |
Bucak MN et al. | Lycopene and resveratrol improve post-thaw bull sperm parameters: sperm motility, mitochondrial activity and DNA integrity. | 2015 | Andrologia | pmid:24909239 |
Dourado GK et al. | Chemopreventive Actions of Blond and Red-Fleshed Sweet Orange Juice on the Loucy Leukemia Cell Line. | 2015 | Asian Pac. J. Cancer Prev. | pmid:26434864 |
Maggio M et al. | Relationship between Carotenoids, Retinol, and Estradiol Levels in Older Women. | 2015 | Nutrients | pmid:26251919 |
Kim JE et al. | Effects of egg consumption on carotenoid absorption from co-consumed, raw vegetables. | 2015 | Am. J. Clin. Nutr. | pmid:26016861 |
Lasekan J et al. | Soy protein-based infant formulas with supplemental fructooligosaccharides: gastrointestinal tolerance and hydration status in newborn infants. | 2015 | Nutrients | pmid:25912040 |
Golley RK et al. | A dietary guideline adherence score is positively associated with dietary biomarkers but not lipid profile in healthy children. | 2015 | J. Nutr. | pmid:25527667 |
Ho WJ et al. | Antioxidant micronutrients and the risk of renal cell carcinoma in the Women's Health Initiative cohort. | 2015 | Cancer | pmid:25302685 |
Cooperstone JL et al. | Enhanced bioavailability of lycopene when consumed as cis-isomers from tangerine compared to red tomato juice, a randomized, cross-over clinical trial. | 2015 | Mol Nutr Food Res | pmid:25620547 |
Cicero AF and Colletti A | Nutraceuticals and Blood Pressure Control: Results from Clinical Trials and Meta-Analyses. | 2015 | High Blood Press Cardiovasc Prev | pmid:25788027 |
Pakrashi T and Oehninger S | Lycopene and male infertility: do we know enough? | 2014 May-Jun | Asian J. Androl. | pmid:24713839 |
Durairajanayagam D et al. | Lycopene and male infertility. | 2014 May-Jun | Asian J. Androl. | pmid:24675655 |
Wang HB et al. | Improved beta-carotene and lycopene production by Blakeslea trispora with ultrasonic treatment in submerged fermentation. | 2014 May-Jun | Z. Naturforsch., C, J. Biosci. | pmid:25069162 |
Socaci SA et al. | Chemometric discrimination of different tomato cultivars based on their volatile fingerprint in relation to lycopene and total phenolics content. | 2014 Mar-Apr | Phytochem Anal | pmid:24259292 |
Burton-Freeman B and Sesso HD | Whole food versus supplement: comparing the clinical evidence of tomato intake and lycopene supplementation on cardiovascular risk factors. | 2014 | Adv Nutr | pmid:25469376 |
Kujawska M et al. | Antioxidant effect of lycopene-enriched tomato paste on N-nitrosodiethylamine-induced oxidative stress in rats. | 2014 | J. Physiol. Biochem. | pmid:25387411 |
Schweiggert RM et al. | Carotenoids are more bioavailable from papaya than from tomato and carrot in humans: a randomised cross-over study. | 2014 | Br. J. Nutr. | pmid:23931131 |
Renju GL et al. | Effect of lycopene from Chlorella marina on high cholesterol-induced oxidative damage and inflammation in rats. | 2014 | Inflammopharmacology | pmid:23887896 |