Lycopene

Lycopene is a lipid of Prenol Lipids (PR) class. Lycopene is associated with abnormalities such as Consumption-archaic term for TB, Chronic disease, Dehydration, furuncle and Cardiovascular Diseases. The involved functions are known as Cell Differentiation process, Signal Transduction, Biochemical Pathway, Mutation and IGF-1 Signaling Pathway. Lycopene often locates in Body tissue, Hepatic, Blood, Adipose tissue and Structure of parenchyma of lung. The associated genes with Lycopene are EPB41L2 gene, VEGFB gene, P4HTM gene, FATE1 gene and SLC33A1 gene. The related lipids are Micelles, Liposomes, Total cholesterol, Steroids and apo-10'-lycopenoic acid. The related experimental models are Mouse Model, Knock-out, Cancer Model, Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Lycopene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Lycopene?

Lycopene is suspected in Chronic disease, Cardiovascular Diseases, Atherosclerosis, Congenital contractural arachnodactyly, Myocardial Infarction, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Lycopene

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Lycopene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Lycopene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Lycopene?


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What lipids are associated with Lycopene?

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What genes are associated with Lycopene?

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What common seen animal models are associated with Lycopene?

Cancer Model

Cancer Model are used in the study 'Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis.' (Imaida K et al., 2001), Cancer Model are used in the study 'Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention.' (Chen L et al., 2001), Cancer Model are used in the study 'Re: Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets.' (Limpens J et al., 2004), Cancer Model are used in the study 'Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells.' (Liu X et al., 2008) and Cancer Model are used in the study 'Can smoke-exposed ferrets be utilized to unravel the mechanisms of action of lycopene?' (Wang XD, 2005).

Knock-out

Knock-out are used in the study 'Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.' (Ip BC et al., 2014), Knock-out are used in the study 'In silico identification of gene amplification targets for improvement of lycopene production.' (Choi HS et al., 2010) and Knock-out are used in the study 'Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models.' (Stice CP et al., 2015).

Mouse Model

Mouse Model are used in the study 'Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature.' (Giovannucci E, 1999), Mouse Model are used in the study 'Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women.' (Watzl B et al., 2000) and Mouse Model are used in the study 'Executive summary report.' (Davis CD et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Lycopene

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Authors Title Published Journal PubMed Link
Barros PP et al. Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats. 2017 Acta Cir Bras pmid:28403343
Morgia G et al. Survivin and NAIP in Human Benign Prostatic Hyperplasia: Protective Role of the Association of Serenoa repens, Lycopene and Selenium from the Randomized Clinical Study. 2017 Int J Mol Sci pmid:28327526
Yamamoto Y et al. The effects of tomato juice on male infertility. 2017 Asia Pac J Clin Nutr pmid:28049263
Dueñas-García IE et al. Lycopene, resveratrol, vitamin C and FeSO increase damage produced by pro-oxidant carcinogen 4-nitroquinoline-1-oxide in Drosophila melanogaster: Xenobiotic metabolism implications. 2017 Food Chem. Toxicol. pmid:28202360
Jeon S et al. Effect of Carotenoid Supplemented Formula on Carotenoid Bioaccumulation in Tissues of Infant Rhesus Macaques: A Pilot Study Focused on Lutein. 2017 Nutrients pmid:28075370
Ding S et al. EcoSynther: A Customized Platform To Explore the Biosynthetic Potential in E. coli. 2017 ACS Chem. Biol. pmid:28952720
Zhang XF et al. Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3). 2017 Int J Nanomedicine pmid:29075115
Li W et al. Self-assembly of green tea catechin derivatives in nanoparticles for oral lycopene delivery. 2017 J Control Release pmid:28077264
Assis RP et al. Combined Effects of Curcumin and Lycopene or Bixin in Yoghurt on Inhibition of LDL Oxidation and Increases in HDL and Paraoxonase Levels in Streptozotocin-Diabetic Rats. 2017 Int J Mol Sci pmid:28333071
Ellis AC et al. Modulating Oxidative Stress and Inflammation in Elders: The MOXIE Study. 2016 Oct-Dec J Nutr Gerontol Geriatr pmid:27897608
Göncü T et al. Anti-inflammatory effect of lycopene on endotoxin-induced uveitis in rats. 2016 Nov-Dec Arq Bras Oftalmol pmid:28076559
Sawardekar SB et al. Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: An in vitro study. 2016 Jan-Feb Indian J Pharmacol pmid:26997718
Ooe E et al. Analysis and characterization of anthocyanins and carotenoids in Japanese blue tomato. 2016 Biosci. Biotechnol. Biochem. pmid:26443075
Zhou S et al. INHIBITORY EFFECT OF LYCOPENE AGAINST THE GROWTH OF HUMAN GASTRIC CANCER CELLS. 2016 Afr J Tradit Complement Altern Med pmid:28852735
He Y et al. Lycopene Ameliorates Transplant Arteriosclerosis in Vascular Allograft Transplantation by Regulating the NO/cGMP Pathways and Rho-Associated Kinases Expression. 2016 Oxid Med Cell Longev pmid:28050227
Jiang W et al. Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat. 2016 World J. Gastroenterol. pmid:28028366
Wang RH et al. Transcriptome Analysis Provides a Preliminary Regulation Route of the Ethylene Signal Transduction Component, SlEIN2, during Tomato Ripening. 2016 PLoS ONE pmid:27973616
Yildiz M and Sandikci M Changes in rat ovary with experimentally induced diabetes and the effects of lycopene on those changes. 2016 Rom J Morphol Embryol pmid:27833962
Cai T et al. Serenoa repens associated with selenium and lycopene extract and bromelain and methylsulfonylmethane extract are able to improve the efficacy of levofloxacin in chronic bacterial prostatitis patients. 2016 Arch Ital Urol Androl pmid:27711089
Zhou YE et al. Plasma Lycopene Is Associated with Pizza and Pasta Consumption in Middle-Aged and Older African American and White Adults in the Southeastern USA in a Cross-Sectional Study. 2016 PLoS ONE pmid:27583358
Ye M et al. Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma. 2016 Mol Med Rep pmid:27510325
Gong X et al. Mitochondrial β-Carotene 9',10' Oxygenase Modulates Prostate Cancer Growth via NF-κB Inhibition: A Lycopene-Independent Function. 2016 Mol. Cancer Res. pmid:27406826
Zhang Q et al. Effect of lycopene on the blood-spinal cord barrier after spinal cord injury in mice. 2016 Biosci Trends pmid:27357536
Chen Y et al. Lycopene overproduction in Saccharomyces cerevisiae through combining pathway engineering with host engineering. 2016 Microb. Cell Fact. pmid:27329233
Bae JM Reinterpretation of the results of a pooled analysis of dietary carotenoid intake and breast cancer risk by using the interval collapsing method. 2016 Epidemiol Health pmid:27283141
Antwi SO et al. Carotenoid intake and adipose tissue carotenoid levels in relation to prostate cancer aggressiveness among African-American and European-American men in the North Carolina-Louisiana prostate cancer project (PCaP). 2016 Prostate pmid:27271547
Pandurangaiah S et al. Differential expression of carotenoid biosynthetic pathway genes in two contrasting tomato genotypes for lycopene content. 2016 J. Biosci. pmid:27240986
Aizawa K et al. Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation. 2016 Int. J. Cancer pmid:27116542
Mohan V et al. Neofunctionalization of Chromoplast Specific Lycopene Beta Cyclase Gene (CYC-B) in Tomato Clade. 2016 PLoS ONE pmid:27070417
Feng C et al. Lycopene protects human SH‑SY5Y neuroblastoma cells against hydrogen peroxide‑induced death via inhibition of oxidative stress and mitochondria‑associated apoptotic pathways. 2016 Mol Med Rep pmid:27035331
BaÅŸ H and Pandir D Protective Effects of Lycopene on Furan-treated Diabetic and Non-diabetic Rat Lung. 2016 Biomed. Environ. Sci. pmid:27003172
Tong C et al. Intravenous Administration of Lycopene, a Tomato Extract, Protects against Myocardial Ischemia-Reperfusion Injury. 2016 Nutrients pmid:26950150
Hackshaw-McGeagh L et al. Prostate cancer - evidence of exercise and nutrition trial (PrEvENT): study protocol for a randomised controlled feasibility trial. 2016 Trials pmid:26948468
Kataria Y et al. Retinoid and carotenoid status in serum and liver among patients at high-risk for liver cancer. 2016 BMC Gastroenterol pmid:26927700
van Die MD et al. Phytotherapeutic interventions in the management of biochemically recurrent prostate cancer: a systematic review of randomised trials. 2016 BJU Int. pmid:26898239
Petyaev IM Lycopene Deficiency in Ageing and Cardiovascular Disease. 2016 Oxid Med Cell Longev pmid:26881023
D'Adamo CR et al. A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations. 2016 Nutrients pmid:26861389
Wang Y et al. Lycopene, tomato products and prostate cancer-specific mortality among men diagnosed with nonmetastatic prostate cancer in the Cancer Prevention Study II Nutrition Cohort. 2016 Int. J. Cancer pmid:26830232
Sharma A et al. Potential biological efficacy of Pinus plant species against oxidative, inflammatory and microbial disorders. 2016 BMC Complement Altern Med pmid:26822870
Graff RE et al. Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression. 2016 Am. J. Clin. Nutr. pmid:26817504
Ascenso A et al. The Effect of Lycopene Preexposure on UV-B-Irradiated Human Keratinocytes. 2016 Oxid Med Cell Longev pmid:26664697
Nordström T et al. Associations between circulating carotenoids, genomic instability and the risk of high-grade prostate cancer. 2016 Prostate pmid:26585352
Liu TY and Chen SB Sarcandra glabra combined with lycopene protect rats from lipopolysaccharide induced acute lung injury via reducing inflammatory response. 2016 Biomed. Pharmacother. pmid:27631138
Godsey J and Grundmann O Review of Various Herbal Supplements as Complementary Treatments for Oral Cancer. 2016 J Diet Suppl pmid:26863913
Boehm F et al. A dramatic effect of oxygen on protection of human cells against γ-radiation by lycopene. 2016 FEBS Lett. pmid:26991327
Janse VAN Rensburg A and Wenhold F Validity and Reliability of Field Resonance Raman Spectroscopy for Assessing Carotenoid Status. 2016 J. Nutr. Sci. Vitaminol. pmid:27928118
Stuetz W et al. Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35-74 Years) General Population: A Cross-Sectional Study in Six European Countries. 2016 Nutrients pmid:27706032
GÅ‚Ä…bska D et al. Lycopene, Lutein and Zeaxanthin May Reduce Faecal Blood, Mucus and Pus but not Abdominal Pain in Individuals with Ulcerative Colitis. 2016 Nutrients pmid:27706028
Mumford SL et al. Serum Antioxidants Are Associated with Serum Reproductive Hormones and Ovulation among Healthy Women. 2016 J. Nutr. pmid:26581679
Cunja V et al. Fresh from the Ornamental Garden: Hips of Selected Rose Cultivars Rich in Phytonutrients. 2016 J. Food Sci. pmid:26773854
Piña-Zentella RM et al. Lycopene Improves Diet-Mediated Recuperation in Rat Model of Nonalcoholic Fatty Liver Disease. 2016 J Med Food pmid:27214602
Moran NE et al. Absorption and Distribution Kinetics of the 13C-Labeled Tomato Carotenoid Phytoene in Healthy Adults. 2016 J. Nutr. pmid:26674763
Biddle MJ et al. Lycopene dietary intervention: a pilot study in patients with heart failure. 2015 May-Jun J Cardiovasc Nurs pmid:24651682
Goel S and Ahmed J A comparative study on efficacy of different treatment modalities of oral submucous fibrosis evaluated by clinical staging in population of Southern Rajasthan. 2015 Jan-Mar J Cancer Res Ther pmid:25879347
Colmán-Martínez M et al. A New Method to Simultaneously Quantify the Antioxidants: Carotenes, Xanthophylls, and Vitamin A in Human Plasma. 2015 Oxid Med Cell Longev pmid:26697143
Boeira SP et al. Lycopene protects against acute zearalenone-induced oxidative, endocrine, inflammatory and reproductive damages in male mice. 2015 Chem. Biol. Interact. pmid:25682699
Bongers M et al. Systems analysis of methylerythritol-phosphate pathway flux in E. coli: insights into the role of oxidative stress and the validity of lycopene as an isoprenoid reporter metabolite. 2015 Microb. Cell Fact. pmid:26610700
Moran NE et al. Compartmental and noncompartmental modeling of ¹³C-lycopene absorption, isomerization, and distribution kinetics in healthy adults. 2015 Am. J. Clin. Nutr. pmid:26561629
Key TJ et al. Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies. 2015 Am. J. Clin. Nutr. pmid:26447150
Gann PH et al. A Phase II Randomized Trial of Lycopene-Rich Tomato Extract Among Men with High-Grade Prostatic Intraepithelial Neoplasia. 2015 Nutr Cancer pmid:26422197
Wang Y et al. Effect of Carotene and Lycopene on the Risk of Prostate Cancer: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies. 2015 PLoS ONE pmid:26372549
Oguz E et al. Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats. 2015 Asian Pac. J. Cancer Prev. pmid:26320496
Xu J et al. Lycopene Protects against Hypoxia/Reoxygenation Injury by Alleviating ER Stress Induced Apoptosis in Neonatal Mouse Cardiomyocytes. 2015 PLoS ONE pmid:26291709
Chen P et al. Lycopene and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis. 2015 Medicine (Baltimore) pmid:26287411
Seo YB et al. Molecular Cloning and Co-Expression of Phytoene Synthase Gene from Kocuria gwangalliensis in Escherichia coli. 2015 J. Microbiol. Biotechnol. pmid:26215267
Watstein DM et al. Precise metabolic engineering of carotenoid biosynthesis in Escherichia coli towards a low-cost biosensor. 2015 Metab. Eng. pmid:26141149
Guest J et al. Lycopene Pretreatment Ameliorates Acute Ethanol Induced NAD(+) Depletion in Human Astroglial Cells. 2015 Oxid Med Cell Longev pmid:26075038
Vallverdú-Queralt A et al. Carotenoid profile of tomato sauces: effect of cooking time and content of extra virgin olive oil. 2015 Int J Mol Sci pmid:25927580
Huang RF et al. Inhibition of colon cancer cell growth by nanoemulsion carrying gold nanoparticles and lycopene. 2015 Int J Nanomedicine pmid:25914533
Giri AK et al. Effect of lycopene against gastroesophageal reflux disease in experimental animals. 2015 BMC Complement Altern Med pmid:25888837
Eliassen AH et al. Plasma carotenoids and risk of breast cancer over 20 y of follow-up. 2015 Am. J. Clin. Nutr. pmid:25877493
Cuperus JT et al. A tetO Toolkit To Alter Expression of Genes in Saccharomyces cerevisiae. 2015 ACS Synth Biol pmid:25742460
Sołtysiak P and Folwarczna J [Effects of lycopene on the skeletal system]. 2015 Postepy Hig Med Dosw (Online) pmid:25720611
Yang Y et al. Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica. 2015 J. Bacteriol. pmid:25712483
Sommerburg O et al. Supplementation with red palm oil increases β-carotene and vitamin A blood levels in patients with cystic fibrosis. 2015 Mediators Inflamm. pmid:25688177
Ip BC et al. Lycopene and apo-10'-lycopenoic acid have differential mechanisms of protection against hepatic steatosis in β-carotene-9',10'-oxygenase knockout male mice. 2015 J. Nutr. pmid:25644347
Zubair N et al. Genetic variation predicts serum lycopene concentrations in a multiethnic population of postmenopausal women. 2015 J. Nutr. pmid:25644336
Iwasaki M et al. Comparison of plasma levels of nutrient-related biomarkers among Japanese populations in Tokyo, Japan, São Paulo, Brazil, and Hawaii, USA. 2015 Eur. J. Cancer Prev. pmid:25633435
Sahin K et al. Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model. 2015 Arch. Biochem. Biophys. pmid:25602702
Stice CP et al. Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models. 2015 Arch. Biochem. Biophys. pmid:25592162
Dai C et al. Lycopene attenuates colistin-induced nephrotoxicity in mice via activation of the Nrf2/HO-1 pathway. 2015 Antimicrob. Agents Chemother. pmid:25385104
Sun Q et al. Melatonin promotes ripening and improves quality of tomato fruit during postharvest life. 2015 J. Exp. Bot. pmid:25147270
Filipcikova R et al. Lycopene improves the distorted ratio between AA/DHA in the seminal plasma of infertile males and increases the likelihood of successful pregnancy. 2015 Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub pmid:23446211
Bucak MN et al. Lycopene and resveratrol improve post-thaw bull sperm parameters: sperm motility, mitochondrial activity and DNA integrity. 2015 Andrologia pmid:24909239
Dourado GK et al. Chemopreventive Actions of Blond and Red-Fleshed Sweet Orange Juice on the Loucy Leukemia Cell Line. 2015 Asian Pac. J. Cancer Prev. pmid:26434864
Maggio M et al. Relationship between Carotenoids, Retinol, and Estradiol Levels in Older Women. 2015 Nutrients pmid:26251919
Kim JE et al. Effects of egg consumption on carotenoid absorption from co-consumed, raw vegetables. 2015 Am. J. Clin. Nutr. pmid:26016861
Lasekan J et al. Soy protein-based infant formulas with supplemental fructooligosaccharides: gastrointestinal tolerance and hydration status in newborn infants. 2015 Nutrients pmid:25912040
Golley RK et al. A dietary guideline adherence score is positively associated with dietary biomarkers but not lipid profile in healthy children. 2015 J. Nutr. pmid:25527667
Ho WJ et al. Antioxidant micronutrients and the risk of renal cell carcinoma in the Women's Health Initiative cohort. 2015 Cancer pmid:25302685
Cooperstone JL et al. Enhanced bioavailability of lycopene when consumed as cis-isomers from tangerine compared to red tomato juice, a randomized, cross-over clinical trial. 2015 Mol Nutr Food Res pmid:25620547
Cicero AF and Colletti A Nutraceuticals and Blood Pressure Control: Results from Clinical Trials and Meta-Analyses. 2015 High Blood Press Cardiovasc Prev pmid:25788027
Pakrashi T and Oehninger S Lycopene and male infertility: do we know enough? 2014 May-Jun Asian J. Androl. pmid:24713839
Durairajanayagam D et al. Lycopene and male infertility. 2014 May-Jun Asian J. Androl. pmid:24675655
Wang HB et al. Improved beta-carotene and lycopene production by Blakeslea trispora with ultrasonic treatment in submerged fermentation. 2014 May-Jun Z. Naturforsch., C, J. Biosci. pmid:25069162
Socaci SA et al. Chemometric discrimination of different tomato cultivars based on their volatile fingerprint in relation to lycopene and total phenolics content. 2014 Mar-Apr Phytochem Anal pmid:24259292
Burton-Freeman B and Sesso HD Whole food versus supplement: comparing the clinical evidence of tomato intake and lycopene supplementation on cardiovascular risk factors. 2014 Adv Nutr pmid:25469376
Kujawska M et al. Antioxidant effect of lycopene-enriched tomato paste on N-nitrosodiethylamine-induced oxidative stress in rats. 2014 J. Physiol. Biochem. pmid:25387411
Schweiggert RM et al. Carotenoids are more bioavailable from papaya than from tomato and carrot in humans: a randomised cross-over study. 2014 Br. J. Nutr. pmid:23931131
Renju GL et al. Effect of lycopene from Chlorella marina on high cholesterol-induced oxidative damage and inflammation in rats. 2014 Inflammopharmacology pmid:23887896