| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
Total
1
Lycopene
Lycopene is a lipid of Prenol Lipids (PR) class. Lycopene is associated with abnormalities such as Consumption-archaic term for TB, Chronic disease, Dehydration, furuncle and Cardiovascular Diseases. The involved functions are known as Cell Differentiation process, Signal Transduction, Biochemical Pathway, Mutation and IGF-1 Signaling Pathway. Lycopene often locates in Body tissue, Hepatic, Blood, Adipose tissue and Structure of parenchyma of lung. The associated genes with Lycopene are EPB41L2 gene, VEGFB gene, P4HTM gene, FATE1 gene and SLC33A1 gene. The related lipids are Micelles, Liposomes, Total cholesterol, Steroids and apo-10'-lycopenoic acid. The related experimental models are Mouse Model, Knock-out, Cancer Model, Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Lycopene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lycopene?
Lycopene is suspected in Chronic disease, Cardiovascular Diseases, Atherosclerosis, Congenital contractural arachnodactyly, Myocardial Infarction, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lycopene
PubChem Associated disorders and diseases
What pathways are associated with Lycopene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lycopene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Lycopene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Lycopene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Lycopene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Lycopene?
Cancer Model
Cancer Model are used in the study 'Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis.' (Imaida K et al., 2001), Cancer Model are used in the study 'Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention.' (Chen L et al., 2001), Cancer Model are used in the study 'Re: Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets.' (Limpens J et al., 2004), Cancer Model are used in the study 'Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells.' (Liu X et al., 2008) and Cancer Model are used in the study 'Can smoke-exposed ferrets be utilized to unravel the mechanisms of action of lycopene?' (Wang XD, 2005).
Knock-out
Knock-out are used in the study 'Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.' (Ip BC et al., 2014), Knock-out are used in the study 'In silico identification of gene amplification targets for improvement of lycopene production.' (Choi HS et al., 2010) and Knock-out are used in the study 'Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models.' (Stice CP et al., 2015).
Mouse Model
Mouse Model are used in the study 'Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature.' (Giovannucci E, 1999), Mouse Model are used in the study 'Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women.' (Watzl B et al., 2000) and Mouse Model are used in the study 'Executive summary report.' (Davis CD et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Lycopene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Barros PP et al. | Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats. | 2017 | Acta Cir Bras | pmid:28403343 |
| Morgia G et al. | Survivin and NAIP in Human Benign Prostatic Hyperplasia: Protective Role of the Association of Serenoa repens, Lycopene and Selenium from the Randomized Clinical Study. | 2017 | Int J Mol Sci | pmid:28327526 |
| Yamamoto Y et al. | The effects of tomato juice on male infertility. | 2017 | Asia Pac J Clin Nutr | pmid:28049263 |
| Dueñas-GarcÃa IE et al. | Lycopene, resveratrol, vitamin C and FeSO increase damage produced by pro-oxidant carcinogen 4-nitroquinoline-1-oxide in Drosophila melanogaster: Xenobiotic metabolism implications. | 2017 | Food Chem. Toxicol. | pmid:28202360 |
| Jeon S et al. | Effect of Carotenoid Supplemented Formula on Carotenoid Bioaccumulation in Tissues of Infant Rhesus Macaques: A Pilot Study Focused on Lutein. | 2017 | Nutrients | pmid:28075370 |
| Ding S et al. | EcoSynther: A Customized Platform To Explore the Biosynthetic Potential in E. coli. | 2017 | ACS Chem. Biol. | pmid:28952720 |
| Zhang XF et al. | Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3). | 2017 | Int J Nanomedicine | pmid:29075115 |
| Li W et al. | Self-assembly of green tea catechin derivatives in nanoparticles for oral lycopene delivery. | 2017 | J Control Release | pmid:28077264 |
| Assis RP et al. | Combined Effects of Curcumin and Lycopene or Bixin in Yoghurt on Inhibition of LDL Oxidation and Increases in HDL and Paraoxonase Levels in Streptozotocin-Diabetic Rats. | 2017 | Int J Mol Sci | pmid:28333071 |
| Ellis AC et al. | Modulating Oxidative Stress and Inflammation in Elders: The MOXIE Study. | 2016 Oct-Dec | J Nutr Gerontol Geriatr | pmid:27897608 |
| Göncü T et al. | Anti-inflammatory effect of lycopene on endotoxin-induced uveitis in rats. | 2016 Nov-Dec | Arq Bras Oftalmol | pmid:28076559 |
| Sawardekar SB et al. | Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: An in vitro study. | 2016 Jan-Feb | Indian J Pharmacol | pmid:26997718 |
| Ooe E et al. | Analysis and characterization of anthocyanins and carotenoids in Japanese blue tomato. | 2016 | Biosci. Biotechnol. Biochem. | pmid:26443075 |
| Zhou S et al. | INHIBITORY EFFECT OF LYCOPENE AGAINST THE GROWTH OF HUMAN GASTRIC CANCER CELLS. | 2016 | Afr J Tradit Complement Altern Med | pmid:28852735 |
| He Y et al. | Lycopene Ameliorates Transplant Arteriosclerosis in Vascular Allograft Transplantation by Regulating the NO/cGMP Pathways and Rho-Associated Kinases Expression. | 2016 | Oxid Med Cell Longev | pmid:28050227 |
| Jiang W et al. | Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat. | 2016 | World J. Gastroenterol. | pmid:28028366 |
| Wang RH et al. | Transcriptome Analysis Provides a Preliminary Regulation Route of the Ethylene Signal Transduction Component, SlEIN2, during Tomato Ripening. | 2016 | PLoS ONE | pmid:27973616 |
| Yildiz M and Sandikci M | Changes in rat ovary with experimentally induced diabetes and the effects of lycopene on those changes. | 2016 | Rom J Morphol Embryol | pmid:27833962 |
| Cai T et al. | Serenoa repens associated with selenium and lycopene extract and bromelain and methylsulfonylmethane extract are able to improve the efficacy of levofloxacin in chronic bacterial prostatitis patients. | 2016 | Arch Ital Urol Androl | pmid:27711089 |
| Zhou YE et al. | Plasma Lycopene Is Associated with Pizza and Pasta Consumption in Middle-Aged and Older African American and White Adults in the Southeastern USA in a Cross-Sectional Study. | 2016 | PLoS ONE | pmid:27583358 |
| Ye M et al. | Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma. | 2016 | Mol Med Rep | pmid:27510325 |
| Gong X et al. | Mitochondrial β-Carotene 9',10' Oxygenase Modulates Prostate Cancer Growth via NF-κB Inhibition: A Lycopene-Independent Function. | 2016 | Mol. Cancer Res. | pmid:27406826 |
| Zhang Q et al. | Effect of lycopene on the blood-spinal cord barrier after spinal cord injury in mice. | 2016 | Biosci Trends | pmid:27357536 |
| Chen Y et al. | Lycopene overproduction in Saccharomyces cerevisiae through combining pathway engineering with host engineering. | 2016 | Microb. Cell Fact. | pmid:27329233 |
| Bae JM | Reinterpretation of the results of a pooled analysis of dietary carotenoid intake and breast cancer risk by using the interval collapsing method. | 2016 | Epidemiol Health | pmid:27283141 |
| Antwi SO et al. | Carotenoid intake and adipose tissue carotenoid levels in relation to prostate cancer aggressiveness among African-American and European-American men in the North Carolina-Louisiana prostate cancer project (PCaP). | 2016 | Prostate | pmid:27271547 |
| Pandurangaiah S et al. | Differential expression of carotenoid biosynthetic pathway genes in two contrasting tomato genotypes for lycopene content. | 2016 | J. Biosci. | pmid:27240986 |
| Aizawa K et al. | Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation. | 2016 | Int. J. Cancer | pmid:27116542 |
| Mohan V et al. | Neofunctionalization of Chromoplast Specific Lycopene Beta Cyclase Gene (CYC-B) in Tomato Clade. | 2016 | PLoS ONE | pmid:27070417 |
| Feng C et al. | Lycopene protects human SH‑SY5Y neuroblastoma cells against hydrogen peroxide‑induced death via inhibition of oxidative stress and mitochondria‑associated apoptotic pathways. | 2016 | Mol Med Rep | pmid:27035331 |
| BaÅŸ H and Pandir D | Protective Effects of Lycopene on Furan-treated Diabetic and Non-diabetic Rat Lung. | 2016 | Biomed. Environ. Sci. | pmid:27003172 |
| Tong C et al. | Intravenous Administration of Lycopene, a Tomato Extract, Protects against Myocardial Ischemia-Reperfusion Injury. | 2016 | Nutrients | pmid:26950150 |
| Hackshaw-McGeagh L et al. | Prostate cancer - evidence of exercise and nutrition trial (PrEvENT): study protocol for a randomised controlled feasibility trial. | 2016 | Trials | pmid:26948468 |
| Kataria Y et al. | Retinoid and carotenoid status in serum and liver among patients at high-risk for liver cancer. | 2016 | BMC Gastroenterol | pmid:26927700 |
| van Die MD et al. | Phytotherapeutic interventions in the management of biochemically recurrent prostate cancer: a systematic review of randomised trials. | 2016 | BJU Int. | pmid:26898239 |
| Petyaev IM | Lycopene Deficiency in Ageing and Cardiovascular Disease. | 2016 | Oxid Med Cell Longev | pmid:26881023 |
| Sharma A et al. | Potential biological efficacy of Pinus plant species against oxidative, inflammatory and microbial disorders. | 2016 | BMC Complement Altern Med | pmid:26822870 |
| Graff RE et al. | Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression. | 2016 | Am. J. Clin. Nutr. | pmid:26817504 |
| Ascenso A et al. | The Effect of Lycopene Preexposure on UV-B-Irradiated Human Keratinocytes. | 2016 | Oxid Med Cell Longev | pmid:26664697 |
| Nordström T et al. | Associations between circulating carotenoids, genomic instability and the risk of high-grade prostate cancer. | 2016 | Prostate | pmid:26585352 |
| Liu TY and Chen SB | Sarcandra glabra combined with lycopene protect rats from lipopolysaccharide induced acute lung injury via reducing inflammatory response. | 2016 | Biomed. Pharmacother. | pmid:27631138 |
| Godsey J and Grundmann O | Review of Various Herbal Supplements as Complementary Treatments for Oral Cancer. | 2016 | J Diet Suppl | pmid:26863913 |
| Boehm F et al. | A dramatic effect of oxygen on protection of human cells against γ-radiation by lycopene. | 2016 | FEBS Lett. | pmid:26991327 |
| Janse VAN Rensburg A and Wenhold F | Validity and Reliability of Field Resonance Raman Spectroscopy for Assessing Carotenoid Status. | 2016 | J. Nutr. Sci. Vitaminol. | pmid:27928118 |
| Stuetz W et al. | Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35-74 Years) General Population: A Cross-Sectional Study in Six European Countries. | 2016 | Nutrients | pmid:27706032 |
| GÅ‚Ä…bska D et al. | Lycopene, Lutein and Zeaxanthin May Reduce Faecal Blood, Mucus and Pus but not Abdominal Pain in Individuals with Ulcerative Colitis. | 2016 | Nutrients | pmid:27706028 |
| Mumford SL et al. | Serum Antioxidants Are Associated with Serum Reproductive Hormones and Ovulation among Healthy Women. | 2016 | J. Nutr. | pmid:26581679 |
| Cunja V et al. | Fresh from the Ornamental Garden: Hips of Selected Rose Cultivars Rich in Phytonutrients. | 2016 | J. Food Sci. | pmid:26773854 |
| Piña-Zentella RM et al. | Lycopene Improves Diet-Mediated Recuperation in Rat Model of Nonalcoholic Fatty Liver Disease. | 2016 | J Med Food | pmid:27214602 |
| Moran NE et al. | Absorption and Distribution Kinetics of the 13C-Labeled Tomato Carotenoid Phytoene in Healthy Adults. | 2016 | J. Nutr. | pmid:26674763 |