Retinal

Retinal is a lipid of Prenol Lipids (PR) class. Retinal is associated with abnormalities such as Retinal Detachment, Uveitis, Endophthalmitis, Infection and LEBER CONGENITAL AMAUROSIS, TYPE II (disorder). The involved functions are known as Pigment, immunoreactivity, Infiltration, Energy Absorption and chromophore. Retinal often locates in Entire visual system, Autosome, Membrane, Basement membrane and Thoracic region (surface region of back). The associated genes with Retinal are isorhodopsin, RPE65 gene, RND1 gene, RPE gene and CASP8AP2 gene. The related lipids are Phosphatidylserines, Membrane Lipids, Fatty Acids, Liposomes and oxidized lipid. The related experimental models are Mouse Model, Knock-out and Genetically Engineered Mouse.

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Introduction

To understand associated biological information of Retinal, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Retinal?

Retinal is suspected in Retinal Degeneration, Retinal Diseases, Retinal Dystrophies, Leber Congenital Amaurosis, Retinitis Pigmentosa, Stargardt's disease and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Retinal

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Retinal?

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What functions are associated with Retinal?


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What lipids are associated with Retinal?

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What genes are associated with Retinal?

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What common seen animal models are associated with Retinal?

Mouse Model

Mouse Model are used in the study 'Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal.' (Maeda A et al., 2006), Mouse Model are used in the study 'Quantitative mapping of ion channel regulation by visual cycle activity in rodent photoreceptors in vivo.' (Berkowitz BA et al., 2009), Mouse Model are used in the study 'Chemistry and biology of vision.' (Palczewski K, 2012) and Mouse Model are used in the study 'Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal.' (Kohno H et al., 2013).

Knock-out

Knock-out are used in the study 'Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice.' (Sahu B et al., 2015), Knock-out are used in the study 'Interpretations of fundus autofluorescence from studies of the bisretinoids of the retina.' (Sparrow JR et al., 2010), Knock-out are used in the study 'Bacterioopsin-mediated regulation of bacterioruberin biosynthesis in Halobacterium salinarum.' (Dummer AM et al., 2011) and Knock-out are used in the study 'RPE65 is essential for the function of cone photoreceptors in NRL-deficient mice.' (Wenzel A et al., 2007).

Genetically Engineered Mouse

Genetically Engineered Mouse are used in the study 'Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina.' (Maeda A et al., 2009) and Genetically Engineered Mouse are used in the study 'Recovery of visual functions in a mouse model of Leber congenital amaurosis.' (Van Hooser JP et al., 2002).

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NCBI Entrez Crosslinks

All references with Retinal

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Authors Title Published Journal PubMed Link
pmid:
Sumper M and Herrmann G Biosynthesis of purple membrane: control of retinal synthesis by bacterio-opsin. 1976 FEBS Lett. pmid:1001450
Oesterhelt D and Christoffel V Reconstitution of a proton pump. 1976 Biochem. Soc. Trans. pmid:1001723
Penzes P and Napoli JL Holo-cellular retinol-binding protein: distinction of ligand-binding affinity from efficiency as substrate in retinal biosynthesis. 1999 Biochemistry pmid:10026291
Kropf A Is proton transfer the initial photochemical process in vision? 1976 Nature pmid:1004544
Lanyi JK Understanding structure and function in the light-driven proton pump bacteriorhodopsin. 1998 J. Struct. Biol. pmid:10049804
Reeves PJ et al. Structure and function in rhodopsin: kinetic studies of retinal binding to purified opsin mutants in defined phospholipid-detergent mixtures serve as probes of the retinal binding pocket. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10051571
Sass JO et al. Metabolism of retinaldehyde isomers in pregnant rats: 13-cis- and all-trans-retinaldehyde, but not 9-cis-retinaldehyde, yield very similar patterns of retinoid metabolites. 1999 Drug Metab. Dispos. pmid:10064560
Wang Q et al. Binding of lipophilic nutrients to beta-lactoglobulin prepared by bioselective adsorption. 1999 J. Dairy Sci. pmid:10068947
Khalighi M et al. Inhibition of human prenatal biosynthesis of all-trans-retinoic acid by ethanol, ethanol metabolites, and products of lipid peroxidation reactions: a possible role for CYP2E1. 1999 Biochem. Pharmacol. pmid:10075087
Sun H et al. Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease. 1999 J. Biol. Chem. pmid:10075733
Zhang QY Retinoic acid biosynthetic activity and retinoid receptors in the olfactory mucosa of adult mice. 1999 Biochem. Biophys. Res. Commun. pmid:10079186
Yamauchi K et al. Xenopus cytosolic thyroid hormone-binding protein (xCTBP) is aldehyde dehydrogenase catalyzing the formation of retinoic acid. 1999 J. Biol. Chem. pmid:10085078
Herr FM et al. Differential mechanisms of retinoid transfer from cellular retinol binding proteins types I and II to phospholipid membranes. 1999 J. Biol. Chem. pmid:10092641
Baudry J et al. Simulation analysis of the retinal conformational equilibrium in dark-adapted bacteriorhodopsin. 1999 Biophys. J. pmid:10096888
Tanimoto T et al. [Retinol Acetate Reference Standard (Control 971) and Retinol Palmitate Reference Standard (Control 971) of National Institute of Health Sciences]. 1998 Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku pmid:10097532
Burstedt MS et al. Bothnia dystrophy caused by mutations in the cellular retinaldehyde-binding protein gene (RLBP1) on chromosome 15q26. 1999 Invest. Ophthalmol. Vis. Sci. pmid:10102298
Morimura H et al. Recessive mutations in the RLBP1 gene encoding cellular retinaldehyde-binding protein in a form of retinitis punctata albescens. 1999 Invest. Ophthalmol. Vis. Sci. pmid:10102299
Corcoran J and Maden M Nerve growth factor acts via retinoic acid synthesis to stimulate neurite outgrowth. 1999 Nat. Neurosci. pmid:10204534
Li Z et al. Delivery of 9-Cis retinal to photoreceptors from bovine serum albumin. 1999 Photochem. Photobiol. pmid:10212584
Giovannucci DR and Stephenson RS Identification and distribution of dietary precursors of the Drosophila visual pigment chromophore: analysis of carotenoids in wild type and ninaD mutants by HPLC. 1999 Vision Res. pmid:10326132
Duffield GE et al. Anatomical and functional characterisation of a dopaminergic system in the suprachiasmatic nucleus of the neonatal Siberian hamster. 1999 J. Comp. Neurol. pmid:10331581
Renthal R and Alaniz C Conformational change in bacterio-opsin on binding to retinal. 1999 Biophys. Chem. pmid:10343389
Moore SA et al. A structural explanation for the retinal specificity of class 1 ALDH enzymes. 1999 Adv. Exp. Med. Biol. pmid:10352666
Blythe TJ et al. The role of retinoid metabolism by alcohol and aldehyde dehydrogenases in differentiation of cultured neuronal cells. 1999 Adv. Exp. Med. Biol. pmid:10352686
Ambroziak W et al. Metabolism of retinaldehyde by human liver and kidney. 1999 Adv. Exp. Med. Biol. pmid:10352687
Kitson KE and Blythe TJ The hunt for a retinal-specific aldehyde dehydrogenase in sheep liver. 1999 Adv. Exp. Med. Biol. pmid:10352688
Creemers AF et al. Solid state 15N NMR evidence for a complex Schiff base counterion in the visual G-protein-coupled receptor rhodopsin. 1999 Biochemistry pmid:10353830
Datta-Gupta N et al. Categorizing reactivity of bacteriorhodopsin cysteine mutants crosslinking to 4-bromoretinal. 1999 Biochem. Mol. Biol. Int. pmid:10365248
Keys SA and Zimmerman WF Antioxidant activity of retinol, glutathione, and taurine in bovine photoreceptor cell membranes. 1999 Exp. Eye Res. pmid:10375433
Martinez C et al. Regulation of VIP production and secretion by murine lymphocytes. 1999 J. Neuroimmunol. pmid:10378876
Huang DY et al. Inhibition by retinoids of benzo(A)pyrene metabolism catalyzed by 3-methylcholanthrene-induced rat cytochrome P-450 1A1. 1999 Metab. Clin. Exp. pmid:10381141
Didierjean L et al. Topical 9-cis-retinaldehyde for delivery of 9-cis-retinoic acid in mouse skin. 1999 Exp. Dermatol. pmid:10389637
Bieszke JA et al. The nop-1 gene of Neurospora crassa encodes a seven transmembrane helix retinal-binding protein homologous to archaeal rhodopsins. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10393943
Karlsson T et al. Multiple-quantum relaxation in the magic-angle-spinning NMR of 13C spin pairs. 1999 Solid State Nucl Magn Reson pmid:10408274
ter Laak AM and Kühne R Bacteriorhodopsin in a periodic boundary water-vacuum-water box as an example towards stable molecular dynamics simulations of G-protein coupled receptors. 1999 Recept. Channels pmid:10412722
Weng J et al. Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice. 1999 Cell pmid:10412977
Chon YS et al. Existence of two L photointermediates of halorhodopsin from Halobacterium salinarium, differing in their protein and water FTIR bands. 1999 Biochemistry pmid:10413521
Wingerath T et al. Analysis of cyclic and acyclic analogs of retinol, retinoic acid, and retinal by laser desorption ionization-, matrix-assisted laser desorption ionization-mass spectrometry, and UV/Vis spectroscopy. 1999 Anal. Biochem. pmid:10415093
Imai H et al. Probing for the threshold energy for visual transduction: red-shifted visual pigment analogs from 3-methoxy-3-dehydroretinal and related compounds. 1999 Photochem. Photobiol. pmid:10420849
Makino CL et al. Spectral tuning in salamander visual pigments studied with dihydroretinal chromophores. 1999 Biophys. J. pmid:10423447
Tanimura Y et al. Femtochemistry. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10430852
Feng X et al. Rotational resonance NMR of 13C2-labelled retinal: quantitative internuclear distance determination. 1999 Solid State Nucl Magn Reson pmid:10437661
Deshpande A and Sonar S Bacterioopsin-triggered retinal biosynthesis is inhibited by bacteriorhodopsin formation in Halobacterium salinarium. 1999 J. Biol. Chem. pmid:10438533
Luecke H et al. Structure of bacteriorhodopsin at 1.55 A resolution. 1999 J. Mol. Biol. pmid:10452895
Prakash P et al. Subcellular accumulation of beta-carotene and retinoids in growth-inhibited NCI-H69 small cell lung cancer cells. 1999 Nutr Cancer pmid:10453445
Sullivan JM and Shukla P Time-resolved rhodopsin activation currents in a unicellular expression system. 1999 Biophys. J. pmid:10465746
Vought BW et al. Photochemistry of the primary event in short-wavelength visual opsins at low temperature. 1999 Biochemistry pmid:10471278
Peralba JM et al. Structural and enzymatic properties of a gastric NADP(H)- dependent and retinal-active alcohol dehydrogenase. 1999 J. Biol. Chem. pmid:10473548
Sorg O et al. Metabolism of topical retinaldehyde. 1999 Dermatology (Basel) pmid:10473954