Retinal

Retinal is a lipid of Prenol Lipids (PR) class. Retinal is associated with abnormalities such as Retinal Detachment, Uveitis, Endophthalmitis, Infection and LEBER CONGENITAL AMAUROSIS, TYPE II (disorder). The involved functions are known as Pigment, immunoreactivity, Infiltration, Energy Absorption and chromophore. Retinal often locates in Entire visual system, Autosome, Membrane, Basement membrane and Thoracic region (surface region of back). The associated genes with Retinal are isorhodopsin, RPE65 gene, RND1 gene, RPE gene and CASP8AP2 gene. The related lipids are Phosphatidylserines, Membrane Lipids, Fatty Acids, Liposomes and oxidized lipid. The related experimental models are Mouse Model, Knock-out and Genetically Engineered Mouse.

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Introduction

To understand associated biological information of Retinal, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Retinal?

Retinal is suspected in Retinal Degeneration, Retinal Diseases, Retinal Dystrophies, Leber Congenital Amaurosis, Retinitis Pigmentosa, Stargardt's disease and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Retinal

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Retinal?

Related references are published most in these journals:

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What functions are associated with Retinal?


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What lipids are associated with Retinal?

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What genes are associated with Retinal?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Retinal?

Mouse Model

Mouse Model are used in the study 'Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal.' (Maeda A et al., 2006), Mouse Model are used in the study 'Quantitative mapping of ion channel regulation by visual cycle activity in rodent photoreceptors in vivo.' (Berkowitz BA et al., 2009), Mouse Model are used in the study 'Chemistry and biology of vision.' (Palczewski K, 2012) and Mouse Model are used in the study 'Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal.' (Kohno H et al., 2013).

Knock-out

Knock-out are used in the study 'Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice.' (Sahu B et al., 2015), Knock-out are used in the study 'Interpretations of fundus autofluorescence from studies of the bisretinoids of the retina.' (Sparrow JR et al., 2010), Knock-out are used in the study 'Bacterioopsin-mediated regulation of bacterioruberin biosynthesis in Halobacterium salinarum.' (Dummer AM et al., 2011) and Knock-out are used in the study 'RPE65 is essential for the function of cone photoreceptors in NRL-deficient mice.' (Wenzel A et al., 2007).

Genetically Engineered Mouse

Genetically Engineered Mouse are used in the study 'Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina.' (Maeda A et al., 2009) and Genetically Engineered Mouse are used in the study 'Recovery of visual functions in a mouse model of Leber congenital amaurosis.' (Van Hooser JP et al., 2002).

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NCBI Entrez Crosslinks

All references with Retinal

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Authors Title Published Journal PubMed Link
Martinez C et al. Regulation of VIP production and secretion by murine lymphocytes. 1999 J. Neuroimmunol. pmid:10378876
Huang DY et al. Inhibition by retinoids of benzo(A)pyrene metabolism catalyzed by 3-methylcholanthrene-induced rat cytochrome P-450 1A1. 1999 Metab. Clin. Exp. pmid:10381141
Didierjean L et al. Topical 9-cis-retinaldehyde for delivery of 9-cis-retinoic acid in mouse skin. 1999 Exp. Dermatol. pmid:10389637
Bieszke JA et al. The nop-1 gene of Neurospora crassa encodes a seven transmembrane helix retinal-binding protein homologous to archaeal rhodopsins. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10393943
Karlsson T et al. Multiple-quantum relaxation in the magic-angle-spinning NMR of 13C spin pairs. 1999 Solid State Nucl Magn Reson pmid:10408274
ter Laak AM and Kühne R Bacteriorhodopsin in a periodic boundary water-vacuum-water box as an example towards stable molecular dynamics simulations of G-protein coupled receptors. 1999 Recept. Channels pmid:10412722
Weng J et al. Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice. 1999 Cell pmid:10412977
Chon YS et al. Existence of two L photointermediates of halorhodopsin from Halobacterium salinarium, differing in their protein and water FTIR bands. 1999 Biochemistry pmid:10413521
Wingerath T et al. Analysis of cyclic and acyclic analogs of retinol, retinoic acid, and retinal by laser desorption ionization-, matrix-assisted laser desorption ionization-mass spectrometry, and UV/Vis spectroscopy. 1999 Anal. Biochem. pmid:10415093
Imai H et al. Probing for the threshold energy for visual transduction: red-shifted visual pigment analogs from 3-methoxy-3-dehydroretinal and related compounds. 1999 Photochem. Photobiol. pmid:10420849