Retinal

Retinal is a lipid of Prenol Lipids (PR) class. Retinal is associated with abnormalities such as Retinal Detachment, Uveitis, Endophthalmitis, Infection and LEBER CONGENITAL AMAUROSIS, TYPE II (disorder). The involved functions are known as Pigment, immunoreactivity, Infiltration, Energy Absorption and chromophore. Retinal often locates in Entire visual system, Autosome, Membrane, Basement membrane and Thoracic region (surface region of back). The associated genes with Retinal are isorhodopsin, RPE65 gene, RND1 gene, RPE gene and CASP8AP2 gene. The related lipids are Phosphatidylserines, Membrane Lipids, Fatty Acids, Liposomes and oxidized lipid. The related experimental models are Mouse Model, Knock-out and Genetically Engineered Mouse.

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Introduction

To understand associated biological information of Retinal, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Retinal?

Retinal is suspected in Retinal Degeneration, Retinal Diseases, Retinal Dystrophies, Leber Congenital Amaurosis, Retinitis Pigmentosa, Stargardt's disease and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Retinal

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Retinal?

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What functions are associated with Retinal?


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What lipids are associated with Retinal?

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What genes are associated with Retinal?

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What common seen animal models are associated with Retinal?

Mouse Model

Mouse Model are used in the study 'Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal.' (Maeda A et al., 2006), Mouse Model are used in the study 'Quantitative mapping of ion channel regulation by visual cycle activity in rodent photoreceptors in vivo.' (Berkowitz BA et al., 2009), Mouse Model are used in the study 'Chemistry and biology of vision.' (Palczewski K, 2012) and Mouse Model are used in the study 'Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal.' (Kohno H et al., 2013).

Knock-out

Knock-out are used in the study 'Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice.' (Sahu B et al., 2015), Knock-out are used in the study 'Interpretations of fundus autofluorescence from studies of the bisretinoids of the retina.' (Sparrow JR et al., 2010), Knock-out are used in the study 'Bacterioopsin-mediated regulation of bacterioruberin biosynthesis in Halobacterium salinarum.' (Dummer AM et al., 2011) and Knock-out are used in the study 'RPE65 is essential for the function of cone photoreceptors in NRL-deficient mice.' (Wenzel A et al., 2007).

Genetically Engineered Mouse

Genetically Engineered Mouse are used in the study 'Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina.' (Maeda A et al., 2009) and Genetically Engineered Mouse are used in the study 'Recovery of visual functions in a mouse model of Leber congenital amaurosis.' (Van Hooser JP et al., 2002).

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NCBI Entrez Crosslinks

All references with Retinal

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Authors Title Published Journal PubMed Link
Griffin RG Dipolar recoupling in MAS spectra of biological solids. 1998 Nat. Struct. Biol. pmid:9665180
Dioumaev AK et al. Partitioning of free energy gain between the photoisomerized retinal and the protein in bacteriorhodopsin. 1998 Biochemistry pmid:9665693
Kluge T et al. Conformational changes in the core structure of bacteriorhodopsin. 1998 Biochemistry pmid:9665736
Gough WH et al. cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids. 1998 J. Biol. Chem. pmid:9677409
Sundaram M et al. Expression, characterization and engineered specificity of rat epididymal retinoic acid-binding protein. 1998 Biochem. J. pmid:9693115
Frydrych M et al. Color recognition with bacteriorhodopsin. 1998 Pac Symp Biocomput pmid:9697209
Heberle J et al. Assessing the functionality of a membrane protein in a three-dimensional crystal. 1998 J. Mol. Biol. pmid:9710532
Bychkova VE et al. Release of retinol and denaturation of its plasma carrier, retinol-binding protein. 1998 Fold Des pmid:9710574
During A et al. Characterization of beta-carotene 15,15'-dioxygenase activity in TC7 clone of human intestinal cell line Caco-2. 1998 Biochem. Biophys. Res. Commun. pmid:9712720
Moltke S et al. Chromophore orientation in bacteriorhodopsin determined from the angular dependence of deuterium nuclear magnetic resonance spectra of oriented purple membranes. 1998 Biochemistry pmid:9718305
Brown LS et al. Connectivity of the retinal Schiff base to Asp85 and Asp96 during the bacteriorhodopsin photocycle: the local-access model. 1998 Biophys. J. pmid:9726947
Hotchandani S and Leblanc RM Spectroscopic behaviour of retinyl polyenes in solid films. 1976 Photochem. Photobiol. pmid:972936
Oesterhelt D The structure and mechanism of the family of retinal proteins from halophilic archaea. 1998 Curr. Opin. Struct. Biol. pmid:9729742
Lin SW et al. Mechanisms of spectral tuning in blue cone visual pigments. Visible and raman spectroscopy of blue-shifted rhodopsin mutants. 1998 J. Biol. Chem. pmid:9733753
Kennedy BN et al. Molecular characterization of the mouse gene encoding cellular retinaldehyde-binding protein. 1998 Mol. Vis. pmid:9736766
Sakamoto M et al. Evidence for the archaebacterial-type conformation about the bond between the beta-ionone ring and the polyene chain of the chromophore retinal in chlamyrhodopsin. 1998 FEBS Lett. pmid:9742950
Humphrey W et al. Three electronic state model of the primary phototransformation of bacteriorhodopsin. 1998 Biophys. J. pmid:9746511
Li T et al. Effect of vitamin A supplementation on rhodopsin mutants threonine-17 --> methionine and proline-347 --> serine in transgenic mice and in cell cultures. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9751768
Max M et al. Light-dependent activation of rod transducin by pineal opsin. 1998 J. Biol. Chem. pmid:9756926
Groebner G et al. Structure and conformation of the retinal chromophore in bovine rhodopsin. 1998 Biochem. Soc. Trans. pmid:9766027
Mata NL and Tsin AT Distribution of 11-cis LRAT, 11-cis RD and 11-cis REH in bovine retinal pigment epithelium membranes. 1998 Biochim. Biophys. Acta pmid:9767084
Edenharder R et al. Effects of beta-carotene, retinal, riboflavin, alpha-tocopherol and vitamins C and K1 on sister-chromatid exchanges induced by 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and cyclophosphamide in human lymphocyte cultures. 1998 Food Chem. Toxicol. pmid:9771550
van der Meer K et al. A new facet in rhodopsin photochemistry. 1976 Photochem. Photobiol. pmid:981341
Seki T et al. The metabolic pathway of visual pigment chromophore formation in Drosophila melanogaster--all-trans (3S)-3-hydroxyretinal is formed from all-trans retinal via (3R)-3-hydroxyretinal in the dark. 1998 Eur. J. Biochem. pmid:9826202
Khitrina LV et al. 13-Demethylbacteriorhodopsin: formation and some properties. 1998 Membr Cell Biol pmid:9829265
Creidi P et al. Profilometric evaluation of photodamage after topical retinaldehyde and retinoic acid treatment. 1998 J. Am. Acad. Dermatol. pmid:9843009
Moore SA et al. Sheep liver cytosolic aldehyde dehydrogenase: the structure reveals the basis for the retinal specificity of class 1 aldehyde dehydrogenases. 1998 Structure pmid:9862807
Wada A et al. Stereoselective synthesis of 11Z-9-demethyl-9-benzyl- and 9-phenyl-retinals and their interaction with bovine opsin. 1998 Bioorg. Med. Chem. Lett. pmid:9871591
Wada A et al. Determination of 6s-trans conformation of retinal chromophore in sensory rhodopsin I and phoborhodopsin. 1998 Bioorg. Med. Chem. Lett. pmid:9871767
Gonzalez-Fernandez F et al. Fourth module of Xenopus interphotoreceptor retinoid-binding protein: activity in retinoid transfer between the retinal pigment epithelium and rod photoreceptors. 1998 Curr. Eye Res. pmid:9872537
Eilers M et al. Magic angle spinning NMR of the protonated retinylidene Schiff base nitrogen in rhodopsin: expression of 15N-lysine- and 13C-glycine-labeled opsin in a stable cell line. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:9892660
Simon A et al. Intracellular localization and membrane topology of 11-cis retinol dehydrogenase in the retinal pigment epithelium suggest a compartmentalized synthesis of 11-cis retinaldehyde. 1999 J. Cell. Sci. pmid:9914166
Wang XD and Krinsky NI The bioconversion of beta-carotene into retinoids. 1998 Subcell. Biochem. pmid:9932514
Carlson A and Bok D Polarity of 11-cis retinal release from cultured retinal pigment epithelium. 1999 Invest. Ophthalmol. Vis. Sci. pmid:9950616