MeSH term | MeSH ID | Detail |
---|---|---|
Lung Neoplasms | D008175 | 171 associated lipids |
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Acne Vulgaris | D000152 | 35 associated lipids |
Lymphoma, Large-Cell, Anaplastic | D017728 | 3 associated lipids |
13-cis-retinoic acid,isotretinoin is a lipid of Prenol Lipids (PR) class. 13-cis-retinoic acid,isotretinoin is associated with abnormalities such as Dermatitis, Phototoxic. The involved functions are known as Regulation, Pigment, chromophore, Light absorption and Pupil constriction. 13-cis-retinoic acid,isotretinoin often locates in Neurosecretory Systems. The associated genes with 13-cis-retinoic acid,Isotretinoin are melanopsin.
To understand associated biological information of 13-cis-retinoic acid,Isotretinoin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
13-cis-retinoic acid,Isotretinoin is suspected in Dermatitis, Phototoxic and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 13-cis-retinoic acid,Isotretinoin
MeSH term | MeSH ID | Detail |
---|---|---|
Lung Neoplasms | D008175 | 171 associated lipids |
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Acne Vulgaris | D000152 | 35 associated lipids |
Lymphoma, Large-Cell, Anaplastic | D017728 | 3 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Zhu J et al. | [3 retinoic acid isomers on proliferation and differentiation properties of APL cell line-NB4]. | 1995 | Zhonghua Yi Xue Za Zhi | pmid:7780822 |
Tang SQ et al. | [Treatment of high-risk neuroblastoma with intensive chemotherapy, autologous peripheral blood stem cell transplantation, and 13-cis-retinoic acid]. | 2004 | Zhonghua Er Ke Za Zhi | pmid:15324562 |
Jiang XG and Xi NZ | [A reversed-phase HPLC method for determining tretinoin]. | 1994 | Zhongguo Yao Li Xue Bao | pmid:7717076 |
Liu CZ et al. | [Randomized control study on the treatment of 26 cases of acne conglobata with encircling acupuncture combined with venesection and cupping]. | 2008 | Zhen Ci Yan Jiu | pmid:19288903 |
Melnik B and Plewig G | [New lipid biochemical aspects in the pathogenesis of a follicular keratinization disorder in acne vulgaris]. | 1988 | Z. Hautkr. | pmid:2973184 |
Mayerhausen W and Riebel B | [Acne fulminans following use of anabolic steroids]. | 1989 | Z. Hautkr. | pmid:2531507 |
Park YK et al. | Pachydermoperiostosis: trial with isotretinoin. | 1988 | Yonsei Med. J. | pmid:3064439 |
Lee SM et al. | A case of suspected isotretinoin-induced malformation in a baby of a mother who became pregnant one month after discontinuation of the drug. | 2009 | Yonsei Med. J. | pmid:19568610 |
Wang QF et al. | [The preparation and kinetic study on enzymatically-controlled drug release of isotretinoin/amylose inclusion complex]. | 2012 | Yao Xue Xue Bao | pmid:23227555 |
Vane FM et al. | Human biliary metabolites of isotretinoin: identification, quantification, synthesis, and biological activity. | 1990 | Xenobiotica | pmid:2333716 |
Kontaxakis VP et al. | Genetic vulnerability and isotretinoin-induced psychiatric adverse events. | 2010 | World J. Biol. Psychiatry | pmid:20109108 |
Ng CH et al. | Acne, isotretinoin treatment and acute depression. | 2001 | World J. Biol. Psychiatry | pmid:12587200 |
Atzpodien J et al. | Biochemotherapy of advanced metastatic renal-cell carcinoma: results of the combination of interleukin-2, alpha-interferon, 5-fluorouracil, vinblastine, and 13-cis-retinoic acid. | 1995 | World J Urol | pmid:7550391 |
Duda-Król W et al. | [A probe using isotretinoin for treatment of poorly differentiated leukemia]. | 1996 | Wiad. Lek. | pmid:9245116 |
Bergler-Czop B and Brzezińska-Wcisło L | [Recurrence in patients diagnosed with acne treated by isotretinoin and other methods]. | 2006 | Wiad. Lek. | pmid:16813256 |
Kaniewski M et al. | [Non-iodine-absorbing metastasis of differentiated thyroid cancer--therapeutic probe with 13-cis retinoic acid]. | 2001 | Wiad. Lek. | pmid:12182038 |
Handkiewicz-Junak D et al. | [Use of 13-cis retinoic acid for treatment of advanced differentiated thyroid cancer]. | 2001 | Wiad. Lek. | pmid:12182039 |
Tallab T et al. | Isotretinoin therapy: any need for laboratory assessment? | 2004 Oct-Dec | West Afr J Med | pmid:15730082 |
Garattini E et al. | Cytodifferentiation by retinoids, a novel therapeutic option in oncology: rational combinations with other therapeutic agents. | 2007 | Vitam. Horm. | pmid:17368321 |
Toma S and Noli C | Isotretinoin in the treatment of multiple benign pilomatrixomas in a mixed-breed dog. | 2005 | Vet. Dermatol. | pmid:16238816 |
MashkilleÄson AL and ZaÄtseva SIu | [Roaccutan in the treatment of severe forms of acneiform eruption]. | 1989 | Vestn Dermatol Venerol | pmid:2532821 |
Gromova SA et al. | [Roaccutan in the therapy of severe manifestations of acne vulgaris and rosacea]. | 1989 | Vestn Dermatol Venerol | pmid:2534455 |
Page DG et al. | An alternative approach to the treatment of oral leukoplakia. | 1995 Apr-Jun | Va Dent J | pmid:9540748 |
Healy B | Pledging for accutane. | 2005 | US News World Rep | pmid:16159042 |
Cardamakis E et al. | Comparative study of systemic interferon alfa-2a plus isotretinoin versus isotretinoin in the treatment of recurrent condyloma acuminatum in men. | 1995 | Urology | pmid:7747375 |
Rossen MH and Roed-Petersen J | [Acne vulgaris]. | 1993 | Ugeskr. Laeg. | pmid:8460427 |
Søderberg U and Thestrup-Pedersen K | [Fulminant acne]. | 1993 | Ugeskr. Laeg. | pmid:8328051 |
Jemec GB | [Treatment of acne]. | 2000 | Ugeskr. Laeg. | pmid:11187138 |
Halkier-Sørensen L and Andresen JH | [Bone changes following long-term isotretinoin (Roaccutane) treatment]. | 1989 | Ugeskr. Laeg. | pmid:2734898 |
Jensen JB | [Isotretinoin (Roaccutan) and depression]. | 1998 | Ugeskr. Laeg. | pmid:9859736 |
Ceviz N et al. | A case of isotretinoin embryopathy with bilateral anotia and Taussig-Bing malformation. | 2000 Jul-Sep | Turk. J. Pediatr. | pmid:11105626 |
Kiliç E et al. | Isotretinoin (13-cis-retinoic acid)-associated premature ventricular contractions. | 2009 Jul-Aug | Turk. J. Pediatr. | pmid:19950851 |
Tankurt E et al. | Esophageal ulcers: a possible adverse effect of isotretinoin. | 2013 | Turk J Gastroenterol | pmid:24623299 |
Vitamin A type drug for Kaposi's sarcoma (KS). | 1995 | Treat Rev | pmid:11363023 | |
Bellman BA et al. | Low dose isotretinoin in the prophylaxis of skin cancer in renal transplant patients. | 1996 | Transplantation | pmid:8560565 |
Kiss E et al. | Isotretinoin ameliorates renal damage in experimental acute renal allograft rejection. | 2003 | Transplantation | pmid:12923432 |
Stinson SF et al. | Atrophy induced in the tubules of the testes of Syrian hamsters by two retinoids. | 1980 | Toxicology | pmid:6938081 |
Kameoka S et al. | A high-throughput screen for teratogens using human pluripotent stem cells. | 2014 | Toxicol. Sci. | pmid:24154490 |
Wang K et al. | Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. | 2006 | Toxicol. Sci. | pmid:16632523 |
Rühl R et al. | Embryonic subcellular distribution of 13-cis- and all-trans-retinoic acid indicates differential cytosolic/nuclear localization. | 2001 | Toxicol. Sci. | pmid:11509747 |
Ferguson SA et al. | Chronic oral treatment with 13-cis-retinoic acid (isotretinoin) or all-trans-retinoic acid does not alter depression-like behaviors in rats. | 2005 | Toxicol. Sci. | pmid:16033993 |
Macejová D et al. | Different mRNA expression profiling of nuclear retinoid, thyroid, estrogen and PPARgamma receptors, their coregulators and selected genes in rat liver and spleen in response to short-term in vivo administration of 13-cis retinoic acid. | 2009 | Toxicol. Lett. | pmid:19041696 |
Ratajewski M et al. | Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. | 2015 | Toxicol. Lett. | pmid:25455453 |
Willhite CC et al. | Distribution, teratogenicity, and embryonic delivered dose of retinoid Ro 23-9223. | 2000 | Toxicol. Appl. Pharmacol. | pmid:10764630 |
Collins MD et al. | Comparative teratology and transplacental pharmacokinetics of all-trans-retinoic acid, 13-cis-retinoic acid, and retinyl palmitate following daily administrations in rats. | 1994 | Toxicol. Appl. Pharmacol. | pmid:8048045 |
Tzimas G et al. | Developmental stage-associated differences in the transplacental distribution of 13-cis- and all-trans-retinoic acid as well as their glucuronides in rats and mice. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7597714 |
Eckhoff C and Willhite CC | Embryonic delivered dose of isotretinoin (13-cis-retinoic acid) and its metabolites in hamsters. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9299599 |
Eckhoff C et al. | Teratogenicity and transplacental pharmacokinetics of 13-cis-retinoic acid in rabbits. | 1994 | Toxicol. Appl. Pharmacol. | pmid:8128493 |
Silva FS et al. | The in vitro and in vivo genotoxicity of isotretinoin assessed by cytokinesis blocked micronucleus assay and comet assay. | 2013 | Toxicol In Vitro | pmid:23318729 |
Rødland O and Helland S | [Hypertrophic granulation tissue as a complication to isotretinoin treatment]. | 1991 | Tidsskr. Nor. Laegeforen. | pmid:1835182 |
Hansen SR et al. | Systemic treatment of acne. | 2011 | Tidsskr. Nor. Laegeforen. | pmid:21267031 |
Berg G et al. | Development of severe thyroid-associated ophthalmopathy in a patient with disseminated thyroid cancer treated with recombinant human thyrotropin/radioiodine and retinoic acid. | 2005 | Thyroid | pmid:16405414 |
Masood MQ and Hakeem H | Isotretinoin associated reversible hypothyroidism. | 2011 | Thyroid | pmid:21834674 |
Coelho SM et al. | Isotretinoin as a diagnostic tool for localization of thyroid tissue in a thyroid cancer patient: a case report. | 2007 | Thyroid | pmid:17956163 |
Wallnöfer AE et al. | Effect of isotretinoin on endogenous tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) in humans. | 1993 | Thromb. Haemost. | pmid:8165591 |
Pernod G et al. | Retinoids induced t-PA synthesis by C6 glioma cells--role in tumoral haemorrhagic necrosis. | 1996 | Thromb. Haemost. | pmid:8815586 |
Veal G et al. | Pharmacokinetics and pharmacogenetics of 13-cis-retinoic acid in the treatment of neuroblastoma. | 2007 Mar-Apr | Therapie | pmid:17582307 |
Choquet-Kastylevsky G et al. | [Recurrent subcutaneous edema induced by isotretinoin]. | 1999 Mar-Apr | Therapie | pmid:10394267 |
Rouzès A and Jonville-Béra AP | [Exposure to isotretinoin during pregnancy in France: 25 years of follow-up]. | 2014 Jan-Feb | Therapie | pmid:24698189 |
Amalfitano G et al. | [Risk of intracerebral hematoma and profibrinolytic activity of isotretinoin]. | 1995 Sep-Oct | Therapie | pmid:8571296 |
Taillan B et al. | [Paroxysmal nocturnal hemoglobinuria and hemolysis induced by isotretinoin]. | 1994 Sep-Oct | Therapie | pmid:7855773 |
Gerny H | [Current therapy of acne vulgaris]. | 1989 | Ther Umsch | pmid:2522686 |
Lübbe J and Harms M | [Therapy of acne vulgaris]. | 1998 | Ther Umsch | pmid:9757813 |
Ortolon K | A pox on your practice. iPLEDGE program scars dermatologists. | 2006 | Tex Med | pmid:17115578 |
Lynberg MC et al. | Sensitivity, specificity, and positive predictive value of multiple malformations in isotretinoin embryopathy surveillance. | 1990 | Teratology | pmid:2278026 |
Honein MA et al. | Continued occurrence of Accutane-exposed pregnancies. | 2001 | Teratology | pmid:11514944 |
Kassis I et al. | Isotretinoin (Accutane) and pregnancy. | 1985 | Teratology | pmid:3862261 |
Hart RC et al. | Avian model for 13-cis-retinoic acid embryopathy: morphological characterization of ventricular septal defects. | 1992 | Teratology | pmid:1290153 |
Werler MM et al. | Maternal vitamin A supplementation in relation to selected birth defects. | 1990 | Teratology | pmid:2278025 |
Lee QP et al. | Microinjection of cultured rat embryos: studies with retinol, 13-cis- and all-trans-retinoic acid. | 1991 | Teratology | pmid:1948766 |
Recommendations for isotretinoin use in women of childbearing potential. | 1991 | Teratology | pmid:1957255 | |
Sulik KK and Dehart DB | Retinoic-acid-induced limb malformations resulting from apical ectodermal ridge cell death. | 1988 | Teratology | pmid:3165225 |
Burk DT and Willhite CC | Inner ear malformations induced by isotretinoin in hamster fetuses. | 1992 | Teratology | pmid:1440418 |
Ritchie H and Webster WS | Parameters determining isotretinoin teratogenicity in rat embryo culture. | 1991 | Teratology | pmid:2006473 |
Rosa FW et al. | Teratogen update: vitamin A congeners. | 1986 | Teratology | pmid:3461576 |
Robertson JA et al. | Accutane cases: a teratogen information service's approach. | 2002 | Teratology | pmid:12115772 |
Irving DW et al. | Morphogenesis of isotretinoin-induced microcephaly and micrognathia studied by scanning electron microscopy. | 1986 | Teratology | pmid:3465061 |
Kubow S | Inhibition of isotretinoin teratogenicity by acetylsalicylic acid pretreatment in mice. | 1992 | Teratology | pmid:1731396 |
Korte R et al. | Importance of early exposure to 13-cis retinoic acid to induce teratogenicity in the cynomolgus monkey. | 1993 | Teratology | pmid:8475456 |
Källén B | Restriction of the use of drugs with teratogenic properties: Swedish experiences with isotretinoin. | 1999 | Teratology | pmid:10440771 |
Therapeutic Teratology: the 1996 Teratology Society Public Affairs Symposium. | 1996 | Teratology | pmid:9098924 | |
Rizzo R et al. | Limb reduction defects in humans associated with prenatal isotretinoin exposure. | 1991 | Teratology | pmid:1805430 |
Kwasigroch TE and Bullen M | Effects of isotretinoin (13-cis-retinoic acid) on the development of mouse limbs in vivo and in vitro. | 1991 | Teratology | pmid:1805431 |
Kochhar DM and Penner JD | Developmental effects of isotretinoin and 4-oxo-isotretinoin: the role of metabolism in teratogenicity. | 1987 | Teratology | pmid:3478842 |
Hummler H et al. | Maternal toxicokinetics, metabolism, and embryo exposure following a teratogenic dosing regimen with 13-cis-retinoic acid (isotretinoin) in the cynomolgus monkey. | 1994 | Teratology | pmid:7871482 |
Makori N et al. | 13-cis-retinoic acid causes patterning defects in the early embryonic rostral hindbrain and abnormal development of the cerebellum in the macaque. | 2001 | Teratology | pmid:11241428 |
Hummler H et al. | Induction of malformations in the cynomolgus monkey with 13-cis retinoic acid. | 1990 | Teratology | pmid:2274892 |
Kochhar DM et al. | Placental transfer and developmental effects of 9-cis retinoic acid in mice. | 1995 | Teratology | pmid:7570368 |
Tzimas G et al. | Retinoid metabolism and transplacental pharmacokinetics in the cynomolgus monkey following a nonteratogenic dosing regimen with all-trans-retinoic acid. | 1996 | Teratology | pmid:9035347 |
Creech Kraft J et al. | Isotretinoin (13-cis-retinoic acid) metabolism, cis-trans isomerization, glucuronidation, and transfer to the mouse embryo: consequences for teratogenicity. | 1991 | Teratog., Carcinog. Mutagen. | pmid:1677495 |
Torabi B and Shemirani F | A new approach to highly sensitive determination of retinoic acid isomers by preconcentration with CdSe quantum dots. | 2014 | Talanta | pmid:24468339 |
Browning DJ and Proia AD | Ocular rosacea. | 1986 Nov-Dec | Surv Ophthalmol | pmid:2433782 |
Louryan S et al. | Induced and genetic mouse middle ear ossicular malformations: a model for human malformative ossicular diseases and a tool for clarifying their normal ontogenesis. | 1992 | Surg Radiol Anat | pmid:1440187 |
Dunst J et al. | A 2-week pretreatment with 13-cis-retinoic acid + interferon-alpha-2a prior to definitive radiation improves tumor tissue oxygenation in cervical cancers. | 1998 | Strahlenther Onkol | pmid:9830438 |
Bläse M et al. | 13-cis retinoic acid in combination with interferon-alpha enhances radiation sensitivity of human squamous cell carcinoma cells of the oral cavity. | 1999 | Strahlenther Onkol | pmid:10584127 |
Jones G and Rocke DM | Multivariate survival analysis with doubly-censored data: application to the assessment of Accutane treatment for fibrodysplasia ossificans progressiva. | 2002 | Stat Med | pmid:12205698 |
Shih WJ et al. | Analysis of pilot and early phase studies with small sample sizes. | 2004 | Stat Med | pmid:15195318 |
Varghese SJ et al. | In vitro interaction study of retinoic acid isomers with telmisartan and amlodipine by equilibrium dialysis method using UV spectroscopy. | 2011 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:21489865 |
Wooten J | Adverse drug reactions. | 2006 | South. Med. J. | pmid:17004521 |
Millan SB et al. | Isotretinoin. | 1987 | South. Med. J. | pmid:2951855 |