Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.
To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coenzyme Q10
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| MELAS Syndrome | D017241 | 3 associated lipids |
| Sciatic Neuropathy | D020426 | 13 associated lipids |
| Rare Diseases | D035583 | 2 associated lipids |
| Proteostasis Deficiencies | D057165 | 5 associated lipids |
| Neglected Diseases | D058069 | 3 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pereira R et al. | Major regulatory mechanisms involved in sperm motility. | 2017 Jan-Feb | Asian J. Androl. | pmid:26680031 |
| Zaki ME et al. | Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects. | 2017 Jan - Feb | J Pediatr (Rio J) | pmid:27770619 |
| Banno H et al. | Analysis of Participant Withdrawal in Huntington Disease Clinical Trials. | 2017 | J Huntingtons Dis | pmid:28671136 |
| Roese E and Bunjes H | Drug release studies from lipid nanoparticles in physiological media by a new DSC method. | 2017 | J Control Release | pmid:28450207 |
| Li HN et al. | Water-Soluble Coenzyme Q10 Reduces Rotenone-Induced Mitochondrial Fission. | 2017 | Neurochem. Res. | pmid:28190227 |
| Guilbot A et al. | A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study. | 2017 | BMC Complement Altern Med | pmid:28854909 |
| Varela-López A et al. | Age-Related Loss in Bone Mineral Density of Rats Fed Lifelong on a Fish Oil-Based Diet Is Avoided by Coenzyme Q10 Addition. | 2017 | Nutrients | pmid:28241421 |
| Zhai J et al. | Effects of Coenzyme Q10 on Markers of Inflammation: A Systematic Review and Meta-Analysis. | 2017 | PLoS ONE | pmid:28125601 |
| Awa H et al. | Effects of Combined Treatment with Branched-Chain Amino Acids, Citric Acid, L-Carnitine, Coenzyme Q10, Zinc, and Various Vitamins in Tumor-Bearing Mice. | 2017 | Biol. Pharm. Bull. | pmid:28123134 |
| Liu HT et al. | Coenzyme Q10 and Oxidative Stress: Inflammation Status in Hepatocellular Carcinoma Patients after Surgery. | 2017 | Nutrients | pmid:28054958 |