Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Rare Diseases D035583 2 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

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What functions are associated with Coenzyme Q10?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

Related references are published most in these journals:

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What genes are associated with Coenzyme Q10?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Alehagen U et al. Levels of sP-selectin and hs-CRP Decrease with Dietary Intervention with Selenium and Coenzyme Q10 Combined: A Secondary Analysis of a Randomized Clinical Trial. 2015 PLoS ONE pmid:26375288
Staffa P et al. Activity of coenzyme Q 10 (Q-Ter multicomposite) on recovery time in noise-induced hearing loss. 2014 Sep-Oct Noise Health pmid:25209035
Maheshwari RA et al. Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats. 2014 Nov-Dec Indian J Pharmacol pmid:25538335
Ruscica M et al. Nutraceutical approach to moderate cardiometabolic risk: results of a randomized, double-blind and crossover study with Armolipid Plus. 2014 Jan-Feb J Clin Lipidol pmid:24528686
Agrawal A and Prakash YS Obesity, metabolic syndrome, and airway disease: a bioenergetic problem? 2014 Immunol Allergy Clin North Am pmid:25282291
Durán-Prado M et al. Coenzyme Q10 protects human endothelial cells from β-amyloid uptake and oxidative stress-induced injury. 2014 PLoS ONE pmid:25272163
Shetty RA et al. Coenzyme Q10 and α-tocopherol reversed age-associated functional impairments in mice. 2014 Exp. Gerontol. pmid:25149567
Buján N et al. Characterization of CoQ₁₀ biosynthesis in fibroblasts of patients with primary and secondary CoQ₁₀ deficiency. 2014 J. Inherit. Metab. Dis. pmid:23774949
Nakagawa K et al. Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice. 2014 PLoS ONE pmid:25127365
Oropesa-Ávila M et al. Stabilization of apoptotic cells: generation of zombie cells. 2014 Cell Death Dis pmid:25118929
Murai M et al. Identification of the binding site of the quinone-head group in mitochondrial Coq10 by photoaffinity labeling. 2014 Biochemistry pmid:24870957
Korade Z et al. Antioxidant supplementation ameliorates molecular deficits in Smith-Lemli-Opitz syndrome. 2014 Biol. Psychiatry pmid:23896203
Cordero MD et al. NLRP3 inflammasome is activated in fibromyalgia: the effect of coenzyme Q10. 2014 Antioxid. Redox Signal. pmid:23886272
Sugahara K et al. Coenzyme Q10 protects hair cells against aminoglycoside. 2014 PLoS ONE pmid:25265538
Kalyan S et al. Nitrogen-bisphosphonate therapy is linked to compromised coenzyme Q10 and vitamin E status in postmenopausal women. 2014 J. Clin. Endocrinol. Metab. pmid:24423355
Jiménez-Santos MA et al. Coenzyme Q10 supplementation improves metabolic parameters, liver function and mitochondrial respiration in rats with high doses of atorvastatin and a cholesterol-rich diet. 2014 Lipids Health Dis pmid:24460631
Schapira AH and Patel S Targeting mitochondria for neuroprotection in Parkinson disease. 2014 JAMA Neurol pmid:24664140
Beal MF et al. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. 2014 JAMA Neurol pmid:24664227
Cho HT et al. Droplet size and composition of nutraceutical nanoemulsions influences bioavailability of long chain fatty acids and Coenzyme Q10. 2014 Food Chem pmid:24629946
El-Sheikh AA et al. Protective mechanisms of coenzyme-Q10 may involve up-regulation of testicular P-glycoprotein in doxorubicin-induced toxicity. 2014 Environ. Toxicol. Pharmacol. pmid:24632013