Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.
To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coenzyme Q10
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Sciatic Neuropathy | D020426 | 13 associated lipids |
| Proteostasis Deficiencies | D057165 | 5 associated lipids |
| MELAS Syndrome | D017241 | 3 associated lipids |
| Neglected Diseases | D058069 | 3 associated lipids |
| Rare Diseases | D035583 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sikorska M et al. | Nanomicellar formulation of coenzyme Q10 (Ubisol-Q10) effectively blocks ongoing neurodegeneration in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model: potential use as an adjuvant treatment in Parkinson's disease. | 2014 | Neurobiol. Aging | pmid:24775711 |
| Zhang K et al. | A germline missense mutation in COQ6 is associated with susceptibility to familial schwannomatosis. | 2014 | Genet. Med. | pmid:24763291 |
| Kömürcü E et al. | Preventive effects of coenzyme Q10 (CoQ10) on steroid-induced osteonecrosis in rats. | 2014 | Acta Orthop Traumatol Turc | pmid:24747633 |
| Doimo M et al. | Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency. | 2014 | Biochim. Biophys. Acta | pmid:24140869 |
| Swarnakar NK et al. | Enhanced antitumor efficacy and counterfeited cardiotoxicity of combinatorial oral therapy using Doxorubicin- and Coenzyme Q10-liquid crystalline nanoparticles in comparison with intravenous Adriamycin. | 2014 | Nanomedicine | pmid:24637217 |
| Cho HT et al. | Droplet size and composition of nutraceutical nanoemulsions influences bioavailability of long chain fatty acids and Coenzyme Q10. | 2014 | Food Chem | pmid:24629946 |
| Park S et al. | Aestuariispira insulae gen. nov., sp. nov., a lipolytic bacterium isolated from a tidal flat. | 2014 | Int. J. Syst. Evol. Microbiol. | pmid:24566829 |
| Brandmeyer EA et al. | Using coenzyme Q10 in clinical practice. | 2014 | Nursing | pmid:24531587 |
| El-Sheikh AA et al. | Protective mechanisms of coenzyme-Q10 may involve up-regulation of testicular P-glycoprotein in doxorubicin-induced toxicity. | 2014 | Environ. Toxicol. Pharmacol. | pmid:24632013 |
| Nadjarzadeh A et al. | Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial. | 2014 | Andrologia | pmid:23289958 |