Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.
To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coenzyme Q10
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Sciatic Neuropathy | D020426 | 13 associated lipids |
| Proteostasis Deficiencies | D057165 | 5 associated lipids |
| MELAS Syndrome | D017241 | 3 associated lipids |
| Neglected Diseases | D058069 | 3 associated lipids |
| Rare Diseases | D035583 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lass A et al. | Mitochondrial coenzyme Q content and aging. | 1999 | Biofactors | pmid:10416032 |
| Thomas SR et al. | A role for reduced coenzyme Q in atherosclerosis? | 1999 | Biofactors | pmid:10416033 |
| Tomasetti M et al. | Distribution of antioxidants among blood components and lipoproteins: significance of lipids/CoQ10 ratio as a possible marker of increased risk for atherosclerosis. | 1999 | Biofactors | pmid:10416035 |
| Rustin P et al. | Quinone analogs prevent enzymes targeted in Friedreich ataxia from iron-induced injury in vitro. | 1999 | Biofactors | pmid:10416037 |
| Barbiroli B et al. | Improved brain and muscle mitochondrial respiration with CoQ. An in vivo study by 31P-MR spectroscopy in patients with mitochondrial cytopathies. | 1999 | Biofactors | pmid:10416038 |
| Beal MF | Coenzyme Q10 administration and its potential for treatment of neurodegenerative diseases. | 1999 | Biofactors | pmid:10416039 |
| Shults CW et al. | A possible role of coenzyme Q10 in the etiology and treatment of Parkinson's disease. | 1999 | Biofactors | pmid:10416040 |
| Langsjoen PH and Langsjoen AM | Overview of the use of CoQ10 in cardiovascular disease. | 1999 | Biofactors | pmid:10416041 |
| Munkholm H et al. | Coenzyme Q10 treatment in serious heart failure. | 1999 | Biofactors | pmid:10416042 |
| Rosenfeldt FL et al. | Coenzyme Q10 improves the tolerance of the senescent myocardium to aerobic and ischemic stress: studies in rats and in human atrial tissue. | 1999 | Biofactors | pmid:10416043 |