Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Coenzyme Q10?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

Related references are published most in these journals:

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What genes are associated with Coenzyme Q10?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Kogan AKh et al. [The antioxidant protection of the heart by coenzyme Q10 in stable stenocardia of effort]. 1999 Oct-Dec Patol Fiziol Eksp Ter pmid:10598457
Bianchi G et al. Oxidative stress and anti-oxidant metabolites in patients with hyperthyroidism: effect of treatment. 1999 Horm. Metab. Res. pmid:10598831
Kaikkonen J et al. Measurement and stability of plasma reduced, oxidized and total coenzyme Q10 in humans. 1999 Scand. J. Clin. Lab. Invest. pmid:10612557
Lass A and Sohal RS Effect of coenzyme Q(10) and alpha-tocopherol content of mitochondria on the production of superoxide anion radicals. 2000 FASEB J. pmid:10627283
Noia G et al. [The antioxidants (coenzyme Q10) in materno-fetal physiopathology]. 1999 Minerva Ginecol pmid:10638164
Wariar R et al. A modular NIRS system for clinical measurement of impaired skeletal muscle oxygenation. 2000 J. Appl. Physiol. pmid:10642395
Ravaglia G et al. Effect of micronutrient status on natural killer cell immune function in healthy free-living subjects aged >/=90 y. 2000 Am. J. Clin. Nutr. pmid:10648276
Singh RB et al. Effect of coenzyme Q10 on experimental atherosclerosis and chemical composition and quality of atheroma in rabbits. 2000 Atherosclerosis pmid:10657562
Atroshi F et al. Fumonisin B1-induced DNA damage in rat liver and spleen: effects of pretreatment with coenzyme Q10, L-carnitine, alpha-tocopherol and selenium. 1999 Pharmacol. Res. pmid:10660942
Portakal O and Inal-Erden M Effects of pentoxifylline and coenzyme Q10 in hepatic ischemia/reperfusion injury. 1999 Clin. Biochem. pmid:10667482
Kagan T et al. Coenzyme Q10 can in some circumstances block apoptosis, and this effect is mediated through mitochondria. 1999 Ann. N. Y. Acad. Sci. pmid:10668462
Lippa S et al. Plasma levels of coenzyme Q(10), vitamin E and lipids in uremic patients on conservative therapy and hemodialysis treatment: some possible biochemical and clinical implications. 2000 Clin. Chim. Acta pmid:10686278
Kendler BS Nutritional strategies in cardiovascular disease control: an update on vitamins and conditionally essential nutrients. 1999 Prog Cardiovasc Nurs pmid:10689723
Czap A When the shark bites. 2000 Altern Med Rev pmid:10696115
Gille L and Nohl H The existence of a lysosomal redox chain and the role of ubiquinone. 2000 Arch. Biochem. Biophys. pmid:10700391
Ostrowski RP Effect of coenzyme Q10 (CoQ10) on superoxide dismutase activity in ET-1 and ET-3 experimental models of cerebral ischemia in the rat. 1999 Folia Neuropathol pmid:10705646
van de Vijver LP et al. Plasma coenzyme Q10 concentrations are not decreased in male patients with coronary atherosclerosis. 1999 Free Radic. Res. pmid:10711786
Veselov AV et al. Q-band ENDOR (electron nuclear double resonance) of the high-affinity ubisemiquinone center in cytochrome bo3 from Escherichia coli. 2000 Biochemistry pmid:10715139
Omri A et al. Influence of coenzyme Q10 on tissue distribution of archaeosomes, and pegylated archaeosomes, administered to mice by oral and intravenous routes. 2000 J Drug Target pmid:10721800
Turunen M et al. Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis. 2000 J. Mol. Biol. pmid:10731415