Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.
To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coenzyme Q10
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Sciatic Neuropathy | D020426 | 13 associated lipids |
| Proteostasis Deficiencies | D057165 | 5 associated lipids |
| MELAS Syndrome | D017241 | 3 associated lipids |
| Neglected Diseases | D058069 | 3 associated lipids |
| Rare Diseases | D035583 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lankin VZ et al. | [Intensification in vivo of free radical oxidation of low density lipoproteins in plasma from patients with myocardial ischemia treated by HMG-CoA-reductase pravastatin and suppression of lipid peroxidation by ubiquinone Q10]. | 2000 | Biull Eksp Biol Med | pmid:10732240 |
| Brancato R et al. | Prevention of corneal keratocyte apoptosis after argon fluoride excimer laser irradiation with the free radical scavenger ubiquinone Q10. | 2000 Jan-Mar | Eur J Ophthalmol | pmid:10744203 |
| Maulik N et al. | Dietary coenzyme Q(10) supplement renders swine hearts resistant to ischemia-reperfusion injury. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10749701 |
| Mothana RA et al. | Ganomycins A and B, new antimicrobial farnesyl hydroquinones from the basidiomycete Ganoderma pfeifferi. | 2000 | J. Nat. Prod. | pmid:10757736 |
| Khatta M et al. | The effect of coenzyme Q10 in patients with congestive heart failure. | 2000 | Ann. Intern. Med. | pmid:10766682 |
| Werbach MR | Nutritional strategies for treating chronic fatigue syndrome. | 2000 | Altern Med Rev | pmid:10767667 |
| Mattila P et al. | Comparison of in-line connected diode array and electrochemical detectors in the high-performance liquid chromatographic analysis of coenzymes Q(9) and Q(10) in food materials. | 2000 | J. Agric. Food Chem. | pmid:10775376 |
| McCarty MF | Toward a wholly nutritional therapy for type 2 diabetes. | 2000 | Med. Hypotheses | pmid:10783493 |
| Götz ME et al. | Altered redox state of platelet coenzyme Q10 in Parkinson's disease. | 2000 | J Neural Transm | pmid:10809402 |
| Bonetti A et al. | Effect of ubidecarenone oral treatment on aerobic power in middle-aged trained subjects. | 2000 | J Sports Med Phys Fitness | pmid:10822909 |