Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Rare Diseases D035583 2 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Neglected Diseases D058069 3 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

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What functions are associated with Coenzyme Q10?


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What lipids are associated with Coenzyme Q10?

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What genes are associated with Coenzyme Q10?

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What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Lee J et al. Coenzyme Q10 ameliorates pain and cartilage degradation in a rat model of osteoarthritis by regulating nitric oxide and inflammatory cytokines. 2013 PLoS ONE pmid:23894457
Kandhare AD et al. Elucidation of molecular mechanism involved in neuroprotective effect of Coenzyme Q10 in alcohol-induced neuropathic pain. 2013 Fundam Clin Pharmacol pmid:23057828
Bayir A et al. The effects of ubiquinone (CoQ10) on heart tissue in cardiac toxicity related to organophosphate poisoning. 2013 Hum Exp Toxicol pmid:23060413
Alehagen U et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. 2013 Int. J. Cardiol. pmid:22626835
Kaur J et al. Sphingobium baderi sp. nov., isolated from a hexachlorocyclohexane dump site. 2013 Int. J. Syst. Evol. Microbiol. pmid:22544800
Niharika N et al. Novosphingobium barchaimii sp. nov., isolated from hexachlorocyclohexane-contaminated soil. 2013 Int. J. Syst. Evol. Microbiol. pmid:22544801
Abadi A et al. Supplementation with α-lipoic acid, CoQ10, and vitamin E augments running performance and mitochondrial function in female mice. 2013 PLoS ONE pmid:23565271
Park S et al. Loktanella sediminilitoris sp. nov., isolated from tidal flat sediment. 2013 Int. J. Syst. Evol. Microbiol. pmid:23749279
Yubero-Serrano EM et al. Postprandial antioxidant gene expression is modified by Mediterranean diet supplemented with coenzyme Q(10) in elderly men and women. 2013 Age (Dordr) pmid:22057896
Carvalho TC et al. Development and characterization of phospholipid-stabilized submicron aqueous dispersions of coenzyme Q₁₀ presenting continuous vibrating-mesh nebulization performance. 2013 J Liposome Res pmid:23772691
Ohta Y et al. Vitamin E depletion enhances liver oxidative damage in rats with water-immersion restraint stress. 2013 J. Nutr. Sci. Vitaminol. pmid:23727636
Cornelius N et al. Secondary coenzyme Q10 deficiency and oxidative stress in cultured fibroblasts from patients with riboflavin responsive multiple Acyl-CoA dehydrogenation deficiency. 2013 Hum. Mol. Genet. pmid:23727839
Sheu SY et al. Gemmobacter lanyuensis sp. nov., isolated from a freshwater spring. 2013 Int. J. Syst. Evol. Microbiol. pmid:23728371
Matsushita N et al. Enhanced water dispersibility of coenzyme Q10 by complexation with albumin hydrolysate. 2013 J. Agric. Food Chem. pmid:23731056
Mutations in COQ2 in familial and sporadic multiple-system atrophy. 2013 N. Engl. J. Med. pmid:23758206
Fredericks WJ et al. Ectopic expression of the TERE1 (UBIAD1) protein inhibits growth of renal clear cell carcinoma cells: altered metabolic phenotype associated with reactive oxygen species, nitric oxide and SXR target genes involved in cholesterol and lipid metabolism. 2013 Int. J. Oncol. pmid:23759948
Kuimov AD and Murzina TA [Coenzyme q10 in complex therapy of patients with ischemic heart disease]. 2013 Kardiologiia pmid:24087999
Noh YH et al. Inhibition of oxidative stress by coenzyme Q10 increases mitochondrial mass and improves bioenergetic function in optic nerve head astrocytes. 2013 Cell Death Dis pmid:24091663
Payton S Stones: Coenzyme Q10 protects kidney during ESWL. 2013 Nat Rev Urol pmid:24166344
Ianiro G et al. Effect of an extra-virgin olive oil enriched with probiotics or antioxidants on functional dyspepsia: a pilot study. 2013 Eur Rev Med Pharmacol Sci pmid:23884830
Safarinejad MR et al. Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial. 2013 Br. J. Nutr. pmid:23199523
Jin HJ et al. [Effect of coenzyme Q10 on the expression of tumor necrosis factor-α and interleukin-10 in gingival tissue of experimental periodontitis in rats]. 2013 Zhonghua Kou Qiang Yi Xue Za Zhi pmid:24513070
Carotenuto M and Esposito M Nutraceuticals safety and efficacy in migraine without aura in a population of children affected by neurofibromatosis type I. 2013 Neurol. Sci. pmid:23532548
Korkm E et al. Development and evaluation of coenzyme Q10 loaded solid lipid nanoparticle hydrogel for enhanced dermal delivery. 2013 Acta Pharm pmid:24451076
Dzugkoev SG et al. Effects of endogenous regulators of endothelial NO synthase on nitric oxide homeostasis and blood serum lipoproteins during experimental diabetes mellitus. 2013 Bull. Exp. Biol. Med. pmid:24319749
Gasser DL et al. Focal segmental glomerulosclerosis is associated with a PDSS2 haplotype and, independently, with a decreased content of coenzyme Q10. 2013 Am. J. Physiol. Renal Physiol. pmid:23926186
Ashraf S et al. ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption. 2013 J. Clin. Invest. pmid:24270420
Bhardwaj S et al. Muscular effects of statins in the elderly female: a review. 2013 Clin Interv Aging pmid:23355775
Sharanova NE et al. Effect of coenzyme Q10 on the proteomic profile of the cytosolic and microsomal fractions from rat hepatocytes upon dietary consumption of various lipid components during ontogeny. 2013 Bull. Exp. Biol. Med. pmid:23484191
Kodentsova VM et al. Biochemistry of blood plasma and some parameters of antioxidant status in rats with polyhypovitaminosis of varying severity. 2013 Bull. Exp. Biol. Med. pmid:23486577
Sommerville RB et al. Coenzyme Q10 deficiency in children: frequent type 2C muscle fibers with normal morphology. 2013 Muscle Nerve pmid:23494902
Chen CC et al. Coenzyme Q10 rescues ethanol-induced corneal fibroblast apoptosis through the inhibition of caspase-2 activation. 2013 J. Biol. Chem. pmid:23430247
Cicero AF and Borghi C Evidence of clinically relevant efficacy for dietary supplements and nutraceuticals. 2013 Curr. Hypertens. Rep. pmid:23430658
Niklowitz P et al. Determination of coenzyme Q10 tissue status via high-performance liquid chromatography with electrochemical detection in swine tissues (Sus scrofa domestica). 2013 Anal. Biochem. pmid:23467099
Romanenko LA et al. Devosia submarina sp. nov., isolated from deep-sea surface sediments. 2013 Int. J. Syst. Evol. Microbiol. pmid:23416574
Parkinson MH et al. Co-enzyme Q10 and idebenone use in Friedreich's ataxia. 2013 J. Neurochem. pmid:23859348
Li GW et al. Albimonas pacifica sp. nov., isolated from seawater of the Pacific, and emended description of the genus Albimonas. 2013 Int. J. Syst. Evol. Microbiol. pmid:23606476
Wen B et al. Increased muscle coenzyme Q10 in riboflavin responsive MADD with ETFDH gene mutations due to secondary mitochondrial proliferation. 2013 Mol. Genet. Metab. pmid:23628458
Ivanov AV et al. [Coenzyme Q10 single intravenous infusion protects rat myocardium against subsequent ischemia/reperfusion]. 2013 Eksp Klin Farmakol pmid:23631275
Nanjwade BK et al. Formulation and characterization of nanostructured lipid carrier of ubiquinone (Coenzyme Q10). 2013 J Biomed Nanotechnol pmid:23621001
Zhou H et al. Improvement of the oral bioavailability of coenzyme Q10 with lecithin nanocapsules. 2013 J Nanosci Nanotechnol pmid:23646802
Bohar Topolovec M et al. Endogenous plasma coenzyme Q10 concentration does not correlate with plasma total antioxidant capacity level in healthy untrained horses. 2013 Res. Vet. Sci. pmid:23648076
Luo J et al. A new electrochemically active bacterium phylogenetically related to Tolumonas osonensis and power performance in MFCs. 2013 Bioresour. Technol. pmid:23651598
Yoneda T et al. Anti-aging effects of co-enzyme Q10 on periodontal tissues. 2013 J. Dent. Res. pmid:23694931
Zhang YP et al. Diabetic neuropathic pain development in type 2 diabetic mouse model and the prophylactic and therapeutic effects of coenzyme Q10. 2013 Neurobiol. Dis. pmid:23684663
Miyamae T et al. Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation. 2013 Redox Rep. pmid:23394493
Balta S et al. Serum coenzyme Q10 levels and coronary flow reserve in hemodialysis patients. 2013 Hemodial Int pmid:23347040
Tsuneki H et al. Protective effects of coenzyme Q10 against angiotensin II-induced oxidative stress in human umbilical vein endothelial cells. 2013 Eur. J. Pharmacol. pmid:23348709
Chen SW et al. Detection of suppressed maturation of the human COQ5 protein in the mitochondria following mitochondrial uncoupling by an antibody recognizing both precursor and mature forms of COQ5. 2013 Mitochondrion pmid:23354120
Bibi F et al. Martelella endophytica sp. nov., an antifungal bacterium associated with a halophyte. 2013 Int. J. Syst. Evol. Microbiol. pmid:23355694
Josey BJ et al. Structure-activity relationship study of vitamin k derivatives yields highly potent neuroprotective agents. 2013 J. Med. Chem. pmid:23327468
Zhang YP et al. Prophylactic and antinociceptive effects of coenzyme Q10 on diabetic neuropathic pain in a mouse model of type 1 diabetes. 2013 Anesthesiology pmid:23334664
Bogsrud MP et al. No effect of combined coenzyme Q10 and selenium supplementation on atorvastatin-induced myopathy. 2013 Scand. Cardiovasc. J. pmid:23301875
Gladine C et al. Optimized rapeseed oil enriched with healthy micronutrients: a relevant nutritional approach to prevent cardiovascular diseases. Results of the Optim'Oils randomized intervention trial. 2013 J. Nutr. Biochem. pmid:22784432
Sato T et al. Effect of reduced form of coenzyme Q10 on cyclosporine nephrotoxicity. 2013 Exp Clin Transplant pmid:23194328
Estévez PN et al. Coenzyme Q10 stability in pediatric liquid oral dosage formulations. 2012 Nov-Dec Farm Hosp pmid:23461442
Ahmadvand H et al. Amelioration of altered antioxidant enzymes activity and glomerulosclerosis by coenzyme Q10 in alloxan-induced diabetic rats. 2012 Nov-Dec J. Diabetes Complicat. pmid:22795334
Gardner A Fibromyalgia: unknown pathogenesis and a "chicken or the egg" causality dilemma. 2012 Nov-Dec Nutrition pmid:22898266
Cordero MD et al. Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient. 2012 Nov-Dec Nutrition pmid:22898267
Lance J et al. Coenzyme Q10--a therapeutic agent. 2012 Nov-Dec Medsurg Nurs pmid:23477030
Brugè F et al. Olive oil supplemented with Coenzyme Q(10): effect on plasma and lipoprotein oxidative status. 2012 May-Jun Biofactors pmid:22488910
Yerramilli-Rao P et al. Oral repeated-dose toxicity studies of coenzyme Q10 in beagle dogs. 2012 Jan-Feb Int. J. Toxicol. pmid:22267890
Niklowitz P et al. Coenzyme Q10 concentration in plasma and blood cells of juvenile patients hospitalized for anorexia nervosa. 2012 Jan-Feb Biofactors pmid:22311849
Mikirova N et al. The assessment of the energy metabolism in patients with chronic fatigue syndrome by serum fluorescence emission. 2012 Jan-Feb Altern Ther Health Med pmid:22516851
Ferreiro-Barros CC et al. Determination of a method for extraction of coenzyme Q10 in human plasma: optimization of the use of surfactants and other variables. 2012 Apr-Jun Einstein (Sao Paulo) pmid:23052456
Mikhin VP et al. [Efficacy of the use of coenzyme q10 at the background of traditional therapy of chronic ischemic heart disease]. 2012 Kardiologiia pmid:23098344
Gokce M et al. Antioxidant vitamins C, E and coenzyme Q10 vs dexamethasone: comparisons of their effects in pulmonary contusion model. 2012 J Cardiothorac Surg pmid:23013526
Martin E et al. Hydrogen bonding between the Q(B) site ubisemiquinone and Ser-L223 in the bacterial reaction center: a combined spectroscopic and computational perspective. 2012 Biochemistry pmid:23016832
Gendelman M and Roth Z Incorporation of coenzyme Q10 into bovine oocytes improves mitochondrial features and alleviates the effects of summer thermal stress on developmental competence. 2012 Biol. Reprod. pmid:23018185
Pastore A et al. Pediatric reference intervals for muscle coenzyme Q(10). 2012 Biomarkers pmid:23020092
Stacpoole PW et al. Design and implementation of the first randomized controlled trial of coenzyme CoQ₁₀ in children with primary mitochondrial diseases. 2012 Mitochondrion pmid:23022402
Markley HG CoEnzyme Q10 and riboflavin: the mitochondrial connection. 2012 Headache pmid:23030537
Liu J et al. WITHDRAWN: Coenzyme Q10 for Parkinson's disease. 2012 Cochrane Database Syst Rev pmid:22592726
Bookstaver DA et al. Effect of coenzyme Q10 supplementation on statin-induced myalgias. 2012 Am. J. Cardiol. pmid:22608359
Aalbers J Coenzyme Q10, an anti-oxidant of value to reduce oxidative stress; also useful to reduce statin-induced myalgia. 2012 Cardiovasc J Afr pmid:22555643
Perez-Sanchez C et al. Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q(10) treatment. 2012 Blood pmid:22529290
Cordero MD et al. Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀ effect on clinical improvement. 2012 PLoS ONE pmid:22532869
Marotta F et al. Beneficial modulation from a high-purity caviar-derived homogenate on chronological skin aging. 2012 Rejuvenation Res pmid:22533426
Lin HZ et al. Vision improvement in a Taiwanese (Han Chinese) family with Leber's hereditary optic neuropathy. 2012 Kaohsiung J. Med. Sci. pmid:23217361
Zlatohlavek L et al. The effect of coenzyme Q10 in statin myopathy. 2012 Neuro Endocrinol. Lett. pmid:23183519
Gokce EH et al. A comparative evaluation of coenzyme Q10-loaded liposomes and solid lipid nanoparticles as dermal antioxidant carriers. 2012 Int J Nanomedicine pmid:23055723
Lee BJ et al. Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease. 2012 Nutrition pmid:22342390
Cordero MD et al. Coenzyme Q10 in salivary cells correlate with blood cells in Fibromyalgia: improvement in clinical and biochemical parameter after oral treatment. 2012 Clin. Biochem. pmid:22342824
Biglan KM et al. Plasma 8-hydroxy-2'-deoxyguanosine Levels in Huntington Disease and Healthy Controls Treated with Coenzyme Q10. 2012 J Huntingtons Dis pmid:25063191
Moon HJ et al. Antioxidants, like coenzyme Q10, selenite, and curcumin, inhibited osteoclast differentiation by suppressing reactive oxygen species generation. 2012 Biochem. Biophys. Res. Commun. pmid:22252298
Manya K et al. The use of complementary and alternative medicine among people living with diabetes in Sydney. 2012 BMC Complement Altern Med pmid:22240113
Milano F et al. Enhancing the light harvesting capability of a photosynthetic reaction center by a tailored molecular fluorophore. 2012 Angew. Chem. Int. Ed. Engl. pmid:23011764
Koziel A et al. The influence of high glucose on the aerobic metabolism of endothelial EA.hy926 cells. 2012 Pflugers Arch. pmid:23053476
Russo V et al. Early onset "electrical" heart failure in myotonic dystrophy type 1 patient: the role of ICD biventricular pacing. 2012 Anadolu Kardiyol Derg pmid:22728727
Belhaj N et al. Formulation, characterization and pharmacokinetic studies of coenzyme Q₁₀ PUFA's nanoemulsions. 2012 Eur J Pharm Sci pmid:22732255
Sutachan JJ et al. Cellular and molecular mechanisms of antioxidants in Parkinson's disease. 2012 Nutr Neurosci pmid:22732354
Rasmussen CB et al. Dietary supplements and hypertension: potential benefits and precautions. 2012 J Clin Hypertens (Greenwich) pmid:22747620
Garrido-Maraver J et al. Screening of effective pharmacological treatments for MELAS syndrome using yeasts, fibroblasts and cybrid models of the disease. 2012 Br. J. Pharmacol. pmid:22747838
Matsubara A et al. High-accuracy analysis system for the redox status of coenzyme Q10 by online supercritical fluid extraction-supercritical fluid chromatography/mass spectrometry. 2012 J Chromatogr A pmid:22673808
Damian MS and Hargreaves I Ubiquinone in cardiac arrest: from bathroom to bedside. 2012 Resuscitation pmid:22640977
Lee BJ et al. The relationship between coenzyme Q10, oxidative stress, and antioxidant enzymes activities and coronary artery disease. 2012 ScientificWorldJournal pmid:22645453
Muraki A et al. Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance. 2012 J. Appl. Physiol. pmid:22653988
Deichmann RE et al. Impact of coenzyme Q-10 on parameters of cardiorespiratory fitness and muscle performance in older athletes taking statins. 2012 Phys Sportsmed pmid:23306418
Gutierrez-Mariscal FM et al. Mediterranean diet supplemented with coenzyme Q10 induces postprandial changes in p53 in response to oxidative DNA damage in elderly subjects. 2012 Age (Dordr) pmid:21404051
Seo MJ et al. Association of colony morphology with coenzyme Q(10) production and its enhancement from Rhizobium radiobacter T6102W by addition of isopentenyl alcohol as a precursor. 2012 J. Microbiol. Biotechnol. pmid:22370354