Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Rare Diseases D035583 2 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Neglected Diseases D058069 3 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

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What functions are associated with Coenzyme Q10?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

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What genes are associated with Coenzyme Q10?

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What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
DiNicolantonio JJ CoQ10 and L-carnitine for statin myalgia? 2012 Expert Rev Cardiovasc Ther pmid:23190071
Lee BJ et al. A significant correlation between the plasma levels of coenzyme Q10 and vitamin B-6 and a reduced risk of coronary artery disease. 2012 Nutr Res pmid:23146771
Marotta F et al. Biomarine extracts significantly protect from ultraviolet A-induced skin photoaging: an ex vivo study. 2012 Rejuvenation Res pmid:22533422
Lulli M et al. Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage. 2012 Invest. Ophthalmol. Vis. Sci. pmid:23154463
Ménézo Y et al. [Oxidative stress and fertility: false evidence and bad recipes]. 2012 Gynecol Obstet Fertil pmid:23177978
Mancuso M et al. Fatigue and exercise intolerance in mitochondrial diseases. Literature revision and experience of the Italian Network of mitochondrial diseases. 2012 Neuromuscul. Disord. pmid:23182644
Arias A et al. Analysis of coenzyme Q(10) in lymphocytes by HPLC-MS/MS. 2012 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:23122397
Sun J et al. Effect of particle size on solubility, dissolution rate, and oral bioavailability: evaluation using coenzyme Q₁₀ as naked nanocrystals. 2012 Int J Nanomedicine pmid:23166438
Chang Y et al. Coenzyme Q10 inhibits the release of glutamate in rat cerebrocortical nerve terminals by suppression of voltage-dependent calcium influx and mitogen-activated protein kinase signaling pathway. 2012 J. Agric. Food Chem. pmid:23167655
Park JM et al. Enhancing the production of Rhodobacter sphaeroides-derived physiologically active substances using carbonic anhydrase-immobilized electrospun nanofibers. 2012 Biomacromolecules pmid:22988895
Cluis CP et al. The production of coenzyme Q10 in microorganisms. 2012 Subcell. Biochem. pmid:23080257
Park J et al. Coenzyme Q10 protects neural stem cells against hypoxia by enhancing survival signals. 2012 Brain Res. pmid:23046589
Mikhin VP et al. [Efficacy of the use of coenzyme q10 at the background of traditional therapy of chronic ischemic heart disease]. 2012 Kardiologiia pmid:23098344
Gokce M et al. Antioxidant vitamins C, E and coenzyme Q10 vs dexamethasone: comparisons of their effects in pulmonary contusion model. 2012 J Cardiothorac Surg pmid:23013526
Martin E et al. Hydrogen bonding between the Q(B) site ubisemiquinone and Ser-L223 in the bacterial reaction center: a combined spectroscopic and computational perspective. 2012 Biochemistry pmid:23016832
Vrzhesinskaia OA et al. [The effect of fatty component of diet and coenzyme Q10 on rat sufficiency with vitamins-antioxidans in chronic experiments]. 2012 Vopr Pitan pmid:23530435
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Greenlee H et al. Lack of effect of coenzyme q10 on doxorubicin cytotoxicity in breast cancer cell cultures. 2012 Integr Cancer Ther pmid:22544232
Liu J et al. WITHDRAWN: Coenzyme Q10 for Parkinson's disease. 2012 Cochrane Database Syst Rev pmid:22592726
Bookstaver DA et al. Effect of coenzyme Q10 supplementation on statin-induced myalgias. 2012 Am. J. Cardiol. pmid:22608359
Young JM et al. A randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the metabolic syndrome. 2012 Am. J. Hypertens. pmid:22113168
Aalbers J Coenzyme Q10, an anti-oxidant of value to reduce oxidative stress; also useful to reduce statin-induced myalgia. 2012 Cardiovasc J Afr pmid:22555643
Moreno-Fernández AM et al. Oral treatment with amitriptyline induces coenzyme Q deficiency and oxidative stress in psychiatric patients. 2012 J Psychiatr Res pmid:22118833
Shrader WD et al. Towards a modern definition of vitamin E-evidence for a quinone hypothesis. 2012 Bioorg. Med. Chem. Lett. pmid:22137789
Turi A et al. Coenzyme Q10 content in follicular fluid and its relationship with oocyte fertilization and embryo grading. 2012 Arch. Gynecol. Obstet. pmid:22139446
Tran TP et al. Mitochondria-derived superoxide links to tourniquet-induced apoptosis in mouse skeletal muscle. 2012 PLoS ONE pmid:22912870
Safarinejad MR The effect of coenzyme Q₁₀ supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study. 2012 Int Urol Nephrol pmid:22081410
Binukumar BK et al. Protective efficacy of coenzyme Q10 against DDVP-induced cognitive impairments and neurodegeneration in rats. 2012 Neurotox Res pmid:22083459
Tazato N et al. Gluconacetobacter tumulicola sp. nov. and Gluconacetobacter asukensis sp. nov., isolated from the stone chamber interior of the Kitora Tumulus. 2012 Int. J. Syst. Evol. Microbiol. pmid:22038998
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Horvath R et al. Adult-onset cerebellar ataxia due to mutations in CABC1/ADCK3. 2012 J. Neurol. Neurosurg. Psychiatr. pmid:22036850
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Jung YT et al. Erythrobacter marinus sp. nov., isolated from seawater. 2012 Int. J. Syst. Evol. Microbiol. pmid:22021578
Jung YT et al. Pseudahrensia aquimaris gen. nov., sp. nov., isolated from seawater. 2012 Int. J. Syst. Evol. Microbiol. pmid:22021581
Takahashi M et al. Restoration of the behavioral rates and lifespan in clk-1 mutant nematodes in response to exogenous coenzyme Q(10). 2012 Exp. Gerontol. pmid:22244837
Jin L et al. Kaistia defluvii sp. nov., isolated from river sediment. 2012 Int. J. Syst. Evol. Microbiol. pmid:22247212
Terracciano A et al. The use of muscle biopsy in the diagnosis of undefined ataxia with cerebellar atrophy in children. 2012 Eur. J. Paediatr. Neurol. pmid:21873089
Hirano M et al. CoQ(10) deficiencies and MNGIE: two treatable mitochondrial disorders. 2012 Biochim. Biophys. Acta pmid:22274133
Niharika N et al. Sphingomonas indica sp. nov., isolated from hexachlorocyclohexane (HCH)-contaminated soil. 2012 Int. J. Syst. Evol. Microbiol. pmid:22307515
Persson MF et al. Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes. 2012 Diabetologia pmid:22311417
Felippi CC et al. Safety and efficacy of antioxidants-loaded nanoparticles for an anti-aging application. 2012 J Biomed Nanotechnol pmid:22515083
Zhang M et al. Coenzyme Q(10) enhances dermal elastin expression, inhibits IL-1α production and melanin synthesis in vitro. 2012 Int J Cosmet Sci pmid:22339577
Bravo E et al. Coenzyme Q metabolism is disturbed in high fat diet-induced non-alcoholic fatty liver disease in rats. 2012 Int J Mol Sci pmid:22408414
Lee BJ et al. Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease. 2012 Nutrition pmid:22342390
Cordero MD et al. Coenzyme Q10 in salivary cells correlate with blood cells in Fibromyalgia: improvement in clinical and biochemical parameter after oral treatment. 2012 Clin. Biochem. pmid:22342824
Biglan KM et al. Plasma 8-hydroxy-2'-deoxyguanosine Levels in Huntington Disease and Healthy Controls Treated with Coenzyme Q10. 2012 J Huntingtons Dis pmid:25063191
Moon HJ et al. Antioxidants, like coenzyme Q10, selenite, and curcumin, inhibited osteoclast differentiation by suppressing reactive oxygen species generation. 2012 Biochem. Biophys. Res. Commun. pmid:22252298
Pfeffer G et al. Treatment for mitochondrial disorders. 2012 Cochrane Database Syst Rev pmid:22513923
Rahman S et al. 176th ENMC International Workshop: diagnosis and treatment of coenzyme Q₁₀ deficiency. 2012 Neuromuscul. Disord. pmid:21723727
Fouad AA and Jresat I Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity. 2012 Environ. Toxicol. Pharmacol. pmid:22222558
Qiu L et al. Coenzyme Q(10) production by immobilized Sphingomonas sp. ZUTE03 via a conversion-extraction coupled process in a three-phase fluidized bed reactor. 2012 Enzyme Microb. Technol. pmid:22226200
Young JM et al. Pharmacokinetic comparison of a generic coenzyme Q₁₀ solubilizate and a formulation with soybean phytosterols. 2012 Phytother Res pmid:22228560
García-Rodríguez CE et al. Does consumption of two portions of salmon per week enhance the antioxidant defense system in pregnant women? 2012 Antioxid. Redox Signal. pmid:22229304
Cascella V et al. A new oral otoprotective agent. Part 1: Electrophysiology data from protection against noise-induced hearing loss. 2012 Med. Sci. Monit. pmid:22207104
Sourris KC et al. Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes. 2012 Free Radic. Biol. Med. pmid:22172526
Milano F et al. Enhancing the light harvesting capability of a photosynthetic reaction center by a tailored molecular fluorophore. 2012 Angew. Chem. Int. Ed. Engl. pmid:23011764
Sharma A et al. Design and evaluation of multifunctional nanocarriers for selective delivery of coenzyme Q10 to mitochondria. 2012 Biomacromolecules pmid:22148549
Koziel A et al. The influence of high glucose on the aerobic metabolism of endothelial EA.hy926 cells. 2012 Pflugers Arch. pmid:23053476
Naia L et al. Mitochondrial and metabolic-based protective strategies in Huntington's disease: the case of creatine and coenzyme Q. 2012 Rev Neurosci pmid:22150069
Choi H et al. Coenzyme Q10 protects against amyloid beta-induced neuronal cell death by inhibiting oxidative stress and activating the P13K pathway. 2012 Neurotoxicology pmid:22186599
Hahn SH et al. Assay to measure oxidized and reduced forms of CoQ by LC-MS/MS. 2012 Methods Mol. Biol. pmid:22215547
Horvath R Update on clinical aspects and treatment of selected vitamin-responsive disorders II (riboflavin and CoQ 10). 2012 J. Inherit. Metab. Dis. pmid:22231380
Sica DA Nondrug interventions for the treatment of hypertension: varying effect. 2012 J Clin Hypertens (Greenwich) pmid:22235816
Spindler SR et al. Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation. 2012 PLoS ONE pmid:22737247
Mullin GE The heart speaks II: embracing integrative medicine for heart health. 2012 Nutr Clin Pract pmid:22820900
Okudan N et al. Effects of CoQ10 supplementation and swimming training on exhaustive exercise-induced oxidative stress in rat heart. 2012 Bratisl Lek Listy pmid:22794511
Russo V et al. Early onset "electrical" heart failure in myotonic dystrophy type 1 patient: the role of ICD biventricular pacing. 2012 Anadolu Kardiyol Derg pmid:22728727
Belhaj N et al. Formulation, characterization and pharmacokinetic studies of coenzyme Q₁₀ PUFA's nanoemulsions. 2012 Eur J Pharm Sci pmid:22732255
Takahashi M et al. Reversal of slow growth and heartbeat through the restoration of mitochondrial function in clk-1-deficient mouse embryos by exogenous administration of coenzyme Q10. 2012 Exp. Gerontol. pmid:22465812
Takahashi R et al. Coenzyme Q10 therapy in hereditary motor sensory neuropathy type VI with novel mitofusin 2 mutation. 2012 Intern. Med. pmid:22466841
Forester BP et al. Coenzyme Q10 effects on creatine kinase activity and mood in geriatric bipolar depression. 2012 J Geriatr Psychiatry Neurol pmid:22467846
Okudan N et al. Effects of treatment with coenzyme Q10 on exercised rat aorta. 2012 Acta Physiol Hung pmid:22425807
Onoue S et al. Novel solid self-emulsifying drug delivery system of coenzyme Q₁₀ with improved photochemical and pharmacokinetic behaviors. 2012 Eur J Pharm Sci pmid:22498005
Mehmetoglu I et al. Oxidative stress markers in hemodialysis and peritoneal dialysis patients, including coenzyme Q10 and ischemia-modified albumin. 2012 Int J Artif Organs pmid:22461118
Fetoni AR et al. Efficacy of different routes of administration for Coenzyme Q10 formulation in noise-induced hearing loss: systemic versus transtympanic modality. 2012 Acta Otolaryngol. pmid:22443854
Meng X et al. Characterization and pharmacokinetics of coenzyme Q10 nanoparticles prepared by a rapid expansion of supercritical solution process. 2012 Pharmazie pmid:22512087
Naidoo N et al. Plasma vitamin E and coenzyme Q10 are not associated with a lower risk of acute myocardial infarction in Singapore Chinese adults. 2012 J. Nutr. pmid:22513986
Aziz DM et al. Effects of two homeopathic complexes on bovine sperm mitochondrial activity. 2012 Homeopathy pmid:22487369
Emmanuele V et al. Heterogeneity of coenzyme Q10 deficiency: patient study and literature review. 2012 Arch. Neurol. pmid:22490322
De Luca C et al. Coenzyme Q(10), vitamin E, selenium, and methionine in the treatment of chronic recurrent viral mucocutaneous infections. 2012 Nutrition pmid:22079390
Ostman B et al. Coenzyme Q10 supplementation and exercise-induced oxidative stress in humans. 2012 Nutrition pmid:22079391
Salviati L et al. Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency. 2012 J. Med. Genet. pmid:22368301
Chirapapaisan N et al. The effect of coenzyme Q10 and curcumin on chronic methanol intoxication induced retinopathy in rats. 2012 J Med Assoc Thai pmid:22696856
Matsubara A et al. High-accuracy analysis system for the redox status of coenzyme Q10 by online supercritical fluid extraction-supercritical fluid chromatography/mass spectrometry. 2012 J Chromatogr A pmid:22673808
Damian MS and Hargreaves I Ubiquinone in cardiac arrest: from bathroom to bedside. 2012 Resuscitation pmid:22640977
Galasko DR et al. Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. 2012 Arch. Neurol. pmid:22431837
Yubero-Serrano EM et al. Mediterranean diet supplemented with coenzyme Q10 modifies the expression of proinflammatory and endoplasmic reticulum stress-related genes in elderly men and women. 2012 J. Gerontol. A Biol. Sci. Med. Sci. pmid:22016358
Piepel G et al. Mixture-process variable approach to optimize a microemulsion electrokinetic chromatography method for the quality control of a nutraceutical based on coenzyme Q10. 2012 Talanta pmid:22841049
Wagner AE et al. A combination of lipoic acid plus coenzyme Q10 induces PGC1α, a master switch of energy metabolism, improves stress response, and increases cellular glutathione levels in cultured C2C12 skeletal muscle cells. 2012 Oxid Med Cell Longev pmid:22655115
Vidyashankar S et al. Alcohol depletes coenzyme-Q(10) associated with increased TNF-alpha secretion to induce cytotoxicity in HepG2 cells. 2012 Toxicology pmid:22841563
Lulli M et al. Coenzyme Q10 protects retinal cells from apoptosis induced by radiation in vitro and in vivo. 2012 J. Radiat. Res. pmid:22843363
Lee SK et al. Coenzyme Q10 increases the fatty acid oxidation through AMPK-mediated PPARα induction in 3T3-L1 preadipocytes. 2012 Cell. Signal. pmid:22885103
Gleize B et al. Simple and fast HPLC method for simultaneous determination of retinol, tocopherols, coenzyme Q(10) and carotenoids in complex samples. 2012 Food Chem pmid:22871234
Otocka-Kmiecik A et al. [Prodiabetic effect of statins--do we know the mechanisms of this phenomenon?]. 2012 Postepy Biochem. pmid:23214143
Tsai KL et al. A novel mechanism of coenzyme Q10 protects against human endothelial cells from oxidative stress-induced injury by modulating NO-related pathways. 2012 J. Nutr. Biochem. pmid:21684136
Sharanova NE et al. Effect of coenzyme Q10 on proteomic profile of blood plasma and cytosolic and microsomal fractions of rat hepatocytes during ontogeny. 2012 Bull. Exp. Biol. Med. pmid:23330083
Deichmann RE et al. Impact of coenzyme Q-10 on parameters of cardiorespiratory fitness and muscle performance in older athletes taking statins. 2012 Phys Sportsmed pmid:23306418
Gutierrez-Mariscal FM et al. Mediterranean diet supplemented with coenzyme Q10 induces postprandial changes in p53 in response to oxidative DNA damage in elderly subjects. 2012 Age (Dordr) pmid:21404051
Bergamini C et al. A water soluble CoQ10 formulation improves intracellular distribution and promotes mitochondrial respiration in cultured cells. 2012 PLoS ONE pmid:22432044
Seo MJ et al. Association of colony morphology with coenzyme Q(10) production and its enhancement from Rhizobium radiobacter T6102W by addition of isopentenyl alcohol as a precursor. 2012 J. Microbiol. Biotechnol. pmid:22370354