Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Neglected Diseases D058069 3 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
MELAS Syndrome D017241 3 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

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What functions are associated with Coenzyme Q10?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

Related references are published most in these journals:

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What genes are associated with Coenzyme Q10?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Cordero MD et al. Coenzyme Q(10): a novel therapeutic approach for Fibromyalgia? case series with 5 patients. 2011 Mitochondrion pmid:21496502
Cheng W et al. Coenzyme Q plays opposing roles on bacteria/fungi and viruses in Drosophila innate immunity. 2011 Int. J. Immunogenet. pmid:21518260
Ahmed M et al. Coenzyme q10 and creatine in heart failure: micronutrients, macrobenefit? 2011 Clin Cardiol pmid:21462213
Fumagalli S et al. Coenzyme Q10 terclatrate and creatine in chronic heart failure: a randomized, placebo-controlled, double-blind study. 2011 Clin Cardiol pmid:21462215
Castellotti B et al. Ataxia with oculomotor apraxia type1 (AOA1): novel and recurrent aprataxin mutations, coenzyme Q10 analyses, and clinical findings in Italian patients. 2011 Neurogenetics pmid:21465257
Cooney RV et al. Low plasma coenzyme Q(10) levels and breast cancer risk in Chinese women. 2011 Cancer Epidemiol. Biomarkers Prev. pmid:21467235
Gironi M et al. Oxidative imbalance in different neurodegenerative diseases with memory impairment. 2011 Neurodegener Dis pmid:20838029
Karadas F et al. Changes in broiler chick tissue concentrations of lipid-soluble antioxidants immediately post-hatch. 2011 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:21605692
Garjani A et al. Combined atorvastatin and coenzyme Q10 improve the left ventricular function in isoproterenol-induced heart failure in rat. 2011 Eur. J. Pharmacol. pmid:21570962
Guo J et al. [Effects of milk and coenzyme Q10 on the interference of acrylonitrile on vascular endothelial functions]. 2011 Zhonghua Yi Xue Za Zhi pmid:21609600
Venegas C et al. Determination of coenzyme Q10, coenzyme Q9, and melatonin contents in virgin argan oils: comparison with other edible vegetable oils. 2011 J. Agric. Food Chem. pmid:22007968
Tawfik MK Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoin-induced cognitive impairment and oxidative stress. 2011 Epilepsy Behav pmid:22036465
Tsai KL et al. Coenzyme Q10 suppresses oxLDL-induced endothelial oxidative injuries by the modulation of LOX-1-mediated ROS generation via the AMPK/PKC/NADPH oxidase signaling pathway. 2011 Mol Nutr Food Res pmid:21812107
Gokbel H et al. Coenzyme Q10 and its relation with oxidant and antioxidant system markers in patients with end-stage renal disease. 2011 Ren Fail pmid:21787158
Sharanova NE et al. Effect of coenzyme Q10 on proteomic profile of rat plasma under conditions of metabolic stress. 2011 Bull. Exp. Biol. Med. pmid:22485206
Li HT et al. Differential effects of coenzyme Q10 and α-lipoic acid on two models of in vitro oxidative damage to the rabbit urinary bladder. 2011 Int Urol Nephrol pmid:20533089
Karagodina ZV et al. [Relationship between changes in peroxide oxidation lipoide index, coenzyme Q10 and free fatty acids by of rats depending of fatty acid component in the ration]. 2011 Vopr Pitan pmid:22379857
Jung YT et al. Roseovarius marinus sp. nov., isolated from seawater. 2011 Int. J. Syst. Evol. Microbiol. pmid:20348324
Tiano L et al. Effect of Coenzyme Q10 in mitigating oxidative DNA damage in Down syndrome patients, a double blind randomized controlled trial. 2011 Neurobiol. Aging pmid:20022408
Tran TP et al. Tourniquet-induced acute ischemia-reperfusion injury in mouse skeletal muscles: Involvement of superoxide. 2011 Eur. J. Pharmacol. pmid:21036124
Sagel SD et al. Effect of an antioxidant-rich multivitamin supplement in cystic fibrosis. 2011 J. Cyst. Fibros. pmid:20961818
Esposito M and Carotenuto M Ginkgolide B complex efficacy for brief prophylaxis of migraine in school-aged children: an open-label study. 2011 Neurol. Sci. pmid:20872034
Safarinejad MR Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie's disease: a double-blind, placebo-controlled randomized study. 2010 Sep-Oct Int. J. Impot. Res. pmid:20720560
Fu R et al. Oxidative stress in Niemann-Pick disease, type C. 2010 Oct-Nov Mol. Genet. Metab. pmid:20667755
Ioannou N et al. Bezafibrate induced increase in mitochondrial electron transport chain complex IV activity in human astrocytoma cells: Implications for mitochondrial cytopathies and neurodegenerative diseases. 2010 Nov-Dec Biofactors pmid:20872762
Vargiu R et al. Enhancement of shortening velocity, power, and acto-myosin crossbridge (CB) kinetics following long-term treatment with propionyl-L-carnitine, coenzyme Q10, and omega-3 fatty acids in BIO TO-2 cardiomyopathic Syrian hamsters papillary muscle. 2010 May-Jun Biofactors pmid:20533397
Wynn RL The effects of CoQ10 supplements on patients taking statin drugs. 2010 May-Jun Gen Dent pmid:20478794
Anderson OR An analysis of respiratory activity, Q(10), and microbial community composition of soils from high and low tussock sites at Toolik, Alaska. 2010 Mar-Apr J. Eukaryot. Microbiol. pmid:20021543
Fouad AA et al. Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice. 2010 Jul-Aug Toxicology pmid:20510337
Haruna M et al. Positive correlation between maternal serum coenzyme Q10 levels and infant birth weight. 2010 Jul-Aug Biofactors pmid:20641057
Kern DG et al. Controlling reactive oxygen species in skin at their source to reduce skin aging. 2010 Apr-Jun Rejuvenation Res pmid:19954332
Singh AK et al. Multivitamin and micronutrient treatment improves semen parameters of azoospermic patients with maturation arrest. 2010 Apr-Jun Indian J. Physiol. Pharmacol. pmid:21090533
Tziomalos K et al. Management of statin-intolerant high-risk patients. 2010 Curr Vasc Pharmacol pmid:20507273
Björkhem-Bergman L et al. Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation. 2010 Anticancer Res. pmid:20530415
Brookman RH and St Cyr JA Metabolic supplementation with enhanced external counterpulsation improves myocardial function in acquired cardiomyopathy: a case report. 2010 J Altern Complement Med pmid:20156124
El-Abhar HS Coenzyme Q10: a novel gastroprotective effect via modulation of vascular permeability, prostaglandin Eâ‚‚, nitric oxide and redox status in indomethacin-induced gastric ulcer model. 2010 Eur. J. Pharmacol. pmid:20858483
Cherry CL et al. Ubisol-Aqua: coenzyme Q10 prevents antiretroviral toxic neuropathy in an in vitro model. 2010 Curr. HIV Res. pmid:20158454
Beg S et al. Bioavailability enhancement of coenzyme Q10: an extensive review of patents. 2010 Recent Pat Drug Deliv Formul pmid:20863275
Kien NB et al. Coenzyme Q10 production in a 150-l reactor by a mutant strain of Rhodobacter sphaeroides. 2010 J. Ind. Microbiol. Biotechnol. pmid:20195885
Thomas B and Beal MF Mitochondrial therapies for Parkinson's disease. 2010 Mov. Disord. pmid:20187246
Fu X et al. Antifatigue effect of coenzyme Q10 in mice. 2010 J Med Food pmid:20136457
Gökbel H et al. Effects of coenzyme Q10 supplementation on plasma adiponectin, interleukin-6, and tumor necrosis factor-alpha levels in men. 2010 J Med Food pmid:20136458
Roland L et al. Existence of compensatory defense mechanisms against oxidative stress and hypertension in preeclampsia. 2010 Hypertens Pregnancy pmid:20132021
McMurray JJ et al. Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA (controlled rosuvastatin multinational study in heart failure). 2010 J. Am. Coll. Cardiol. pmid:20883926
Yang X et al. Coenzyme Q10 reduces beta-amyloid plaque in an APP/PS1 transgenic mouse model of Alzheimer's disease. 2010 J. Mol. Neurosci. pmid:19834824
Felker GM Coenzyme Q10 and statins in heart failure: the dog that didn't bark. 2010 J. Am. Coll. Cardiol. pmid:20883927
Boyer FC et al. Post-polio syndrome: Pathophysiological hypotheses, diagnosis criteria, drug therapy. 2010 Ann Phys Rehabil Med pmid:20093102
Takahashi S et al. Development of coenzyme Q10-enriched rice using sugary and shrunken mutants. 2010 Biosci. Biotechnol. Biochem. pmid:20057142
Jain KS et al. Current drug targets for antihyperlipidemic therapy. 2010 Mini Rev Med Chem pmid:20105132
Cordero MD et al. Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease. 2010 Arthritis Res. Ther. pmid:20109177
Busso C et al. Saccharomyces cerevisiae coq10 null mutants are responsive to antimycin A. 2010 FEBS J. pmid:20875086
Zampol MA et al. Over-expression of COQ10 in Saccharomyces cerevisiae inhibits mitochondrial respiration. 2010 Biochem. Biophys. Res. Commun. pmid:20933507
Glover EI et al. A randomized trial of coenzyme Q10 in mitochondrial disorders. 2010 Muscle Nerve pmid:20886510
Chen Y et al. Efficient Lewis acid ionic liquid-catalyzed synthesis of the key intermediate of coenzyme Q10 under microwave irradiation. 2010 Molecules pmid:21178903
Berry EA et al. Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex. 2010 Biochim. Biophys. Acta pmid:20025846
Shcherbakova AG and Sigitova ON [Assessment of quality of life after inclusion of coenzyme Q10 in the scheme of treatment of women with arterial hypertension and elevated risk of cardiovascular complications]. 2010 Kardiologiia pmid:21591387
Yenilmez A et al. Antioxidant effects of melatonin and coenzyme Q10 on oxidative damage caused by single-dose ochratoxin A in rat kidney. 2010 Chin J Physiol pmid:21793342
Yen HW et al. Cultivation of Rhodobacter sphaeroides in the stirred bioreactor with different feeding strategies for CoQ(10) production. 2010 Appl. Biochem. Biotechnol. pmid:19277486
Machado PA et al. Recovery of solanesol from tobacco as a value-added byproduct for alternative applications. 2010 Bioresour. Technol. pmid:19773155
Evans M et al. A randomized, double-blind, crossover study on the pharmacokinetics of a novel formulation of CoQ₁₀ with pyridoxal 5'-phosphate and phosphatidyl choline. 2010 J Diet Suppl pmid:22432561
Ravina B et al. Long term understanding of study information in research participants with Parkinson's disease. 2010 Parkinsonism Relat. Disord. pmid:19501011
Pannuzzo G et al. A galactose-free diet enriched in soy isoflavones and antioxidants results in delayed onset of symptoms of Krabbe disease in twitcher mice. 2010 Mol. Genet. Metab. pmid:20418135
Nonprescription Coenzyme Q10 shown to lower blood pressure. Over-the-counter supplements may also relieve statin-related leg pain. 2010 Heart Advis pmid:22834057
Erol B et al. Coenzyme Q10 treatment reduces lipid peroxidation, inducible and endothelial nitric oxide synthases, and germ cell-specific apoptosis in a rat model of testicular ischemia/reperfusion injury. 2010 Fertil. Steril. pmid:19683231
Gökbel H et al. The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men. 2010 J Strength Cond Res pmid:19644406
Golbidi S and Laher I Antioxidant therapy in human endocrine disorders. 2010 Med. Sci. Monit. pmid:20037503
Ravina B et al. Local institutional review board (IRB) review of a multicenter trial: local costs without local context. 2010 Ann. Neurol. pmid:20225291
Liu CS et al. Atorvastatin increases blood ratios of vitamin E/low-density lipoprotein cholesterol and coenzyme Q10/low-density lipoprotein cholesterol in hypercholesterolemic patients. 2010 Nutr Res pmid:20226997
Gairola CG et al. Dietary coenzyme Q10 does not protect against cigarette smoke-augmented atherosclerosis in apoE-deficient mice. 2010 Free Radic. Biol. Med. pmid:20227489
Arias-Cartin R et al. HYSCORE evidence that endogenous mena- and ubisemiquinone bind at the same Q site (Q(D)) of Escherichia coli nitrate reductase A. 2010 J. Am. Chem. Soc. pmid:20387886
Lam YT et al. The lipophilic antioxidants alpha-tocopherol and coenzyme Q10 reduce the replicative lifespan of Saccharomyces cerevisiae. 2010 Free Radic. Biol. Med. pmid:20403425
Valls-Belles V et al. Effect of beer consumption on levels of complex I and complex IV liver and heart mitochondrial enzymes and coenzymes Q9 and Q10 in adriamycin-treated rats. 2010 Eur J Nutr pmid:19841853
Dimitrova S et al. Synthesis of coenzyme Q10 and beta-carotene by yeasts isolated from antarctic soil and lichen in response to ultraviolet and visible radiations. 2010 Appl. Biochem. Biotechnol. pmid:19924388
Littarru GP and Tiano L Clinical aspects of coenzyme Q10: an update. 2010 Nutrition pmid:19932599
Fato R et al. Coenzyme Q10 vitreous levels after administration of coenzyme Q10 eyedrops in patients undergoing vitrectomy. 2010 Acta Ophthalmol pmid:19799594
Bessero AC and Clarke PG Neuroprotection for optic nerve disorders. 2010 Curr. Opin. Neurol. pmid:19915465
Kurban S and Mehmetoglu I Effects of acetylsalicylic acid on serum paraoxonase activity, Ox-LDL, coenzyme Q10 and other oxidative stress markers in healthy volunteers. 2010 Clin. Biochem. pmid:19891963
López LC et al. Treatment of CoQ(10) deficient fibroblasts with ubiquinone, CoQ analogs, and vitamin C: time- and compound-dependent effects. 2010 PLoS ONE pmid:20689595
Chai W et al. Plasma coenzyme Q10 levels and postmenopausal breast cancer risk: the multiethnic cohort study. 2010 Cancer Epidemiol. Biomarkers Prev. pmid:20668119
Hyson HC et al. Safety and tolerability of high-dosage coenzyme Q10 in Huntington's disease and healthy subjects. 2010 Mov. Disord. pmid:20669312
Martin E et al. Hydrogen bonds between nitrogen donors and the semiquinone in the Q(B) site of bacterial reaction centers. 2010 J. Am. Chem. Soc. pmid:20672818
Schmelzer C et al. Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator-activated receptor-alpha gene expression signature in SAMP1 mice. 2010 Mol Nutr Food Res pmid:19960455
Nepal PR et al. Enhancement of solubility and dissolution of coenzyme Q10 using solid dispersion formulation. 2010 Int J Pharm pmid:19781608
Obeidat WM et al. Preservation of nanostructured lipid carriers (NLC). 2010 Eur J Pharm Biopharm pmid:20452422
Salami A et al. Water-soluble coenzyme Q10 formulation (Q-TER(®)) in the treatment of presbycusis. 2010 Acta Otolaryngol. pmid:20443731
Pinar-Sueiro S et al. Optic neuropathy in methylmalonic acidemia: the role of neuroprotection. 2010 J. Inherit. Metab. Dis. pmid:20449661
Abdul-Rasheed OF et al. Coenzyme Q10 and oxidative stress markers in seminal plasma of Iraqi patients with male infertility. 2010 Saudi Med J pmid:20464038
Yue Y et al. The advantages of a novel CoQ10 delivery system in skin photo-protection. 2010 Int J Pharm pmid:20302925
Xu J et al. Beneficial effects of a Q-ter based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats. 2010 PLoS ONE pmid:20485503
Hauser RA Early pharmacologic treatment in Parkinson's disease. 2010 Am J Manag Care pmid:20297870
Pravst I et al. Coenzyme Q10 contents in foods and fortification strategies. 2010 Crit Rev Food Sci Nutr pmid:20301015
Cordero MD et al. Mitochondrial dysfunction in skin biopsies and blood mononuclear cells from two cases of fibromyalgia patients. 2010 Clin. Biochem. pmid:20599870
Wyman M et al. Coenzyme Q10: a therapy for hypertension and statin-induced myalgia? 2010 Cleve Clin J Med pmid:20601617
Vervelle A et al. [Mouthwash solutions with microencapsuled natural extracts: Efficiency for dental plaque and gingivitis]. 2010 Rev Stomatol Chir Maxillofac pmid:20605180
Harper CR and Jacobson TA Evidence-based management of statin myopathy. 2010 Curr Atheroscler Rep pmid:20628837
Pineda M et al. Coenzyme Q(10)-responsive ataxia: 2-year-treatment follow-up. 2010 Mov. Disord. pmid:20629161
Yuting Tian Y et al. Effects of cell lysis treatments on the yield of coenzyme Q10 following Agrobacterium tumefaciens fermentation. 2010 Food Sci Technol Int pmid:21339135
Beketova NA et al. [Effect of coenzyme Q10 and taurine on the availability of vitamins in the rat experiment]. 2010 Vopr Pitan pmid:21341479
Beketova NA et al. [Effect of dietary fats and supplementary coenzyme Q10 on vitamin provision in animals]. 2010 Vopr Pitan pmid:21395102
Tian Y et al. Tobacco biomass hydrolysate enhances coenzyme Q10 production using photosynthetic Rhodospirillum rubrum. 2010 Bioresour. Technol. pmid:20554198