Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.
To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coenzyme Q10
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| MELAS Syndrome | D017241 | 3 associated lipids |
| Neglected Diseases | D058069 | 3 associated lipids |
| Rare Diseases | D035583 | 2 associated lipids |
| Sciatic Neuropathy | D020426 | 13 associated lipids |
| Proteostasis Deficiencies | D057165 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Barbiroli B et al. | Low brain intracellular free magnesium in mitochondrial cytopathies. | 1999 | J. Cereb. Blood Flow Metab. | pmid:10326720 |
| Teranishi Ma et al. | Effects of coenzyme Q10 on changes in the membrane potential and rate of generation of reactive oxygen species in hydrazine- and chloramphenicol-treated rat liver mitochondria. | 1999 | Arch. Biochem. Biophys. | pmid:10334876 |
| Miyake Y et al. | Effect of treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on serum coenzyme Q10 in diabetic patients. | 1999 | Arzneimittelforschung | pmid:10337451 |
| Wang Q et al. | Automated high-performance liquid chromatographic method with precolumn reduction for the determination of ubiquinol and ubiquinone in human plasma. | 1999 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:10348199 |
| De Luca C et al. | Blood antioxidant status and urinary levels of catecholamine metabolites in beta-thalassemia. | 1999 | Free Radic. Res. | pmid:10400457 |
| Blatt T et al. | [Modulation of oxidative stresses in human aging skin]. | 1999 | Z Gerontol Geriatr | pmid:10408011 |
| Stojkovic M et al. | Coenzyme Q(10) in submicron-sized dispersion improves development, hatching, cell proliferation, and adenosine triphosphate content of in vitro-produced bovine embryos. | 1999 | Biol. Reprod. | pmid:10411538 |
| Nakamura T et al. | Metabolism of coenzyme Q10: biliary and urinary excretion study in guinea pigs. | 1999 | Biofactors | pmid:10416022 |
| Nohl H et al. | Critical aspects of the antioxidant function of coenzyme Q in biomembranes. | 1999 | Biofactors | pmid:10416027 |
| Navarro F et al. | Protective role of ubiquinone in vitamin E and selenium-deficient plasma membranes. | 1999 | Biofactors | pmid:10416028 |