Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

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What functions are associated with Coenzyme Q10?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

Related references are published most in these journals:

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What genes are associated with Coenzyme Q10?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Rozen TD et al. Open label trial of coenzyme Q10 as a migraine preventive. 2002 Cephalalgia pmid:11972582
Rosenfeldt FL et al. Coenzyme Q10 protects the aging heart against stress: studies in rats, human tissues, and patients. 2002 Ann. N. Y. Acad. Sci. pmid:11976209
Linnane AW et al. Human aging and global function of coenzyme Q10. 2002 Ann. N. Y. Acad. Sci. pmid:11976213
Lamson DW and Plaza SM Mitochondrial factors in the pathogenesis of diabetes: a hypothesis for treatment. 2002 Altern Med Rev pmid:11991790
Imataka G and Yamanouchi H [Coenzyme Q10 deficiency]. 2002 Nippon Rinsho pmid:12013914
Yoneda M [Mitochondrial dysfunction in migraine]. 2002 Nippon Rinsho pmid:12013930
Terada M et al. [Ophthalmoplegia]. 2002 Nippon Rinsho pmid:12013931
Driver C and Georgiou A How to re-energise old mitochondria without shooting yourself in the foot. 2002 Biogerontology pmid:12014827
Linnane AW Cellular coenzyme Q10 redox poise constitutes a major cell metabolic and gene regulatory system. 2002 Biogerontology pmid:12014838
Rosenfeldt FL et al. The effects of ageing on the response to cardiac surgery: protective strategies for the ageing myocardium. 2002 Biogerontology pmid:12014839
Venditti P et al. H2O2 production and response to stress conditions by mitochondrial fractions from rat liver. 2002 J. Bioenerg. Biomembr. pmid:12018888
Mosca F et al. Assay of coenzyme Q(10) in plasma by a single dilution step. 2002 Anal. Biochem. pmid:12018945
Lister RE An open, pilot study to evaluate the potential benefits of coenzyme Q10 combined with Ginkgo biloba extract in fibromyalgia syndrome. 2002 Mar-Apr J. Int. Med. Res. pmid:12025528
Vargiu R et al. Enhancement of muscular performance by a coformulation of propionyl-L-carnitine, coenzyme Q10, nicotinamide, riboflavin and pantothenic acid in the rat. 2002 Physiol. Behav. pmid:12044598
Bräsen JH et al. Comparison of the effects of alpha-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits. 2002 Atherosclerosis pmid:12052471
Nazzal S et al. Optimization of a self-nanoemulsified tablet dosage form of Ubiquinone using response surface methodology: effect of formulation ingredients. 2002 Int J Pharm pmid:12062506
Navas P et al. Ceramide-dependent caspase 3 activation is prevented by coenzyme Q from plasma membrane in serum-deprived cells. 2002 Free Radic. Res. pmid:12069099
Geromel V et al. Coenzyme Q10 depletion is comparatively less detrimental to human cultured skin fibroblasts than respiratory chain complex deficiencies. 2002 Free Radic. Res. pmid:12069100
Kaikkonen J et al. Coenzyme Q10: absorption, antioxidative properties, determinants, and plasma levels. 2002 Free Radic. Res. pmid:12069102
Biondi C et al. Reduction of 1,4-quinone and ubiquinones by hydrogen atom transfer under UVA irradiation. 2002 Free Radic. Res. pmid:12069103
Merlo Pich M et al. Ubiquinol and a coenzyme Q reducing system protect platelet mitochondrial function of transfusional buffy coats from oxidative stress. 2002 Free Radic. Res. pmid:12069107
Linnane AW et al. Cellular redox activity of coenzyme Q10: effect of CoQ10 supplementation on human skeletal muscle. 2002 Free Radic. Res. pmid:12069109
Beal MF Coenzyme Q10 as a possible treatment for neurodegenerative diseases. 2002 Free Radic. Res. pmid:12069110
Lodi R et al. Mitochondrial dysfunction in Friedreich's ataxia: from pathogenesis to treatment perspectives. 2002 Free Radic. Res. pmid:12069111
Battino M et al. Structural damage induced by peroxidation may account for functional impairment of heavy synaptic mitochondria. 2002 Free Radic. Res. pmid:12069114
Jeejeebhoy F et al. Nutritional supplementation with MyoVive repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction. 2002 Am. Heart J. pmid:12075268
Engelsen J et al. Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial. 2002 Thromb. Haemost. pmid:12083489
Wittenstein B et al. Plasma antioxidants in pediatric patients with glycogen storage disease, diabetes mellitus, and hypercholesterolemia. 2002 Free Radic. Biol. Med. pmid:12086688
Sul D and Kaneshiro ES Pneumocystis carinii f. sp. carinii synthesizes de novo four homologs of ubiquinone. 2001 Mar-Apr J. Eukaryot. Microbiol. pmid:12095106
Moyad MA The placebo effect and randomized trials: analysis of alternative medicine. 2002 Urol. Clin. North Am. pmid:12109341
Quiles JL et al. Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. 2002 Arterioscler. Thromb. Vasc. Biol. pmid:12117742
Martín-Romero FJ et al. The NADH oxidase activity of the plasma membrane of synaptosomes is a major source of superoxide anion and is inhibited by peroxynitrite. 2002 J. Neurochem. pmid:12153484
Turunen M et al. beta2-Integrin and lipid modifications indicate a non-antioxidant mechanism for the anti-atherogenic effect of dietary coenzyme Q10. 2002 Biochem. Biophys. Res. Commun. pmid:12163010
Bliznakov EG Diabetes and the role of isoprenoid biosynthesis. 2002 FEBS Lett. pmid:12163182
Gazdík F et al. Decreased levels of coenzyme Q(10) in patients with bronchial asthma. 2002 Allergy pmid:12169177
Magnitsky S et al. EPR characterization of ubisemiquinones and iron-sulfur cluster N2, central components of the energy coupling in the NADH-ubiquinone oxidoreductase (complex I) in situ. 2002 J. Bioenerg. Biomembr. pmid:12171069
Hellwig P et al. Identification of the residues involved in stabilization of the semiquinone radical in the high-affinity ubiquinone binding site in cytochrome bo(3) from Escherichia coli by site-directed mutagenesis and EPR spectroscopy. 2002 Biochemistry pmid:12186553
Muralikrishnan D et al. Effect of MPTP on Dopamine metabolism in Ames dwarf mice. 2002 Neurochem. Res. pmid:12199149
Molina JA et al. Serum levels of coenzyme Q in patients with Lewy body disease. 2002 J Neural Transm pmid:12203046
Kwong LK et al. Effects of coenzyme Q(10) administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. 2002 Free Radic. Biol. Med. pmid:12208349
Venditti P et al. Effect of ischemia-reperfusion on heart mitochondria from hyperthyroid rats. 2002 Cardiovasc. Res. pmid:12237168
Coldiron AD et al. Effects of combined quercetin and coenzyme Q(10) treatment on oxidative stress in normal and diabetic rats. 2002 J. Biochem. Mol. Toxicol. pmid:12242689
Scarlato G and Comi GP Metabolic and drug-induced muscle disorders. 2002 Curr. Opin. Neurol. pmid:12351996
Geromel V et al. Coenzyme Q(10) and idebenone in the therapy of respiratory chain diseases: rationale and comparative benefits. 2002 Sep-Oct Mol. Genet. Metab. pmid:12359126
Ramadan LA et al. Testicular toxicity effects of magnetic field exposure and prophylactic role of coenzyme Q10 and L-carnitine in mice. 2002 Pharmacol. Res. pmid:12361700
Zhou Q and Chowbay B Effect of coenzyme Q10 on the disposition of doxorubicin in rats. 2002 Jul-Sep Eur J Drug Metab Pharmacokinet pmid:12365200
Cammer W Protection of cultured oligodendrocytes against tumor necrosis factor-alpha by the antioxidants coenzyme Q(10) and N-acetyl cysteine. 2002 Brain Res. Bull. pmid:12372563
Rosenberg RN Mitochondrial therapy for Parkinson disease. 2002 Arch. Neurol. pmid:12374488
Shults CW et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. 2002 Arch. Neurol. pmid:12374491
Rabkin SW Lovastatin induces cell death in cardiomyocytes that is not reversible by coenzyme Q 10. 2002 Pharmacol. Toxicol. pmid:12403057