Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

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What functions are associated with Coenzyme Q10?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

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What genes are associated with Coenzyme Q10?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Kandhare AD et al. Elucidation of molecular mechanism involved in neuroprotective effect of Coenzyme Q10 in alcohol-induced neuropathic pain. 2013 Fundam Clin Pharmacol pmid:23057828
Bayir A et al. The effects of ubiquinone (CoQ10) on heart tissue in cardiac toxicity related to organophosphate poisoning. 2013 Hum Exp Toxicol pmid:23060413
Alehagen U et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. 2013 Int. J. Cardiol. pmid:22626835
Kaur J et al. Sphingobium baderi sp. nov., isolated from a hexachlorocyclohexane dump site. 2013 Int. J. Syst. Evol. Microbiol. pmid:22544800
Niharika N et al. Novosphingobium barchaimii sp. nov., isolated from hexachlorocyclohexane-contaminated soil. 2013 Int. J. Syst. Evol. Microbiol. pmid:22544801
Cornelius N et al. Secondary coenzyme Q10 deficiency and oxidative stress in cultured fibroblasts from patients with riboflavin responsive multiple Acyl-CoA dehydrogenation deficiency. 2013 Hum. Mol. Genet. pmid:23727839
Sheu SY et al. Gemmobacter lanyuensis sp. nov., isolated from a freshwater spring. 2013 Int. J. Syst. Evol. Microbiol. pmid:23728371
Matsushita N et al. Enhanced water dispersibility of coenzyme Q10 by complexation with albumin hydrolysate. 2013 J. Agric. Food Chem. pmid:23731056
Mutations in COQ2 in familial and sporadic multiple-system atrophy. 2013 N. Engl. J. Med. pmid:23758206
Fredericks WJ et al. Ectopic expression of the TERE1 (UBIAD1) protein inhibits growth of renal clear cell carcinoma cells: altered metabolic phenotype associated with reactive oxygen species, nitric oxide and SXR target genes involved in cholesterol and lipid metabolism. 2013 Int. J. Oncol. pmid:23759948
Morris G et al. Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications. 2013 Mol. Neurobiol. pmid:23761046
DZugkoev SG et al. [Influence of combined treatment on biochemical and functional characteristics in patients with vascular complications of type 1 diabetes mellitus and different pathways of compensation]. 2013 Klin Med (Mosk) pmid:23718058
Zhang R et al. Thioclava dalianensis sp. nov., isolated from surface seawater. 2013 Int. J. Syst. Evol. Microbiol. pmid:23378112
Noh YH et al. Inhibition of oxidative stress by coenzyme Q10 increases mitochondrial mass and improves bioenergetic function in optic nerve head astrocytes. 2013 Cell Death Dis pmid:24091663
Payton S Stones: Coenzyme Q10 protects kidney during ESWL. 2013 Nat Rev Urol pmid:24166344
Fogagnolo P et al. The effects of topical coenzyme Q10 and vitamin E D-α-tocopheryl polyethylene glycol 1000 succinate after cataract surgery: a clinical and in vivo confocal study. 2013 Ophthalmologica pmid:23011409
Allan CM et al. A conserved START domain coenzyme Q-binding polypeptide is required for efficient Q biosynthesis, respiratory electron transport, and antioxidant function in Saccharomyces cerevisiae. 2013 Biochim. Biophys. Acta pmid:23270816
Safarinejad MR et al. Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial. 2013 Br. J. Nutr. pmid:23199523
Korkm E et al. Development and evaluation of coenzyme Q10 loaded solid lipid nanoparticle hydrogel for enhanced dermal delivery. 2013 Acta Pharm pmid:24451076
Dzugkoev SG et al. Effects of endogenous regulators of endothelial NO synthase on nitric oxide homeostasis and blood serum lipoproteins during experimental diabetes mellitus. 2013 Bull. Exp. Biol. Med. pmid:24319749
Lesser GJ et al. A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer. 2013 J Support Oncol pmid:22682875
Ashraf S et al. ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption. 2013 J. Clin. Invest. pmid:24270420
Sommerville RB et al. Coenzyme Q10 deficiency in children: frequent type 2C muscle fibers with normal morphology. 2013 Muscle Nerve pmid:23494902
Chen CC et al. Coenzyme Q10 rescues ethanol-induced corneal fibroblast apoptosis through the inhibition of caspase-2 activation. 2013 J. Biol. Chem. pmid:23430247
Cicero AF and Borghi C Evidence of clinically relevant efficacy for dietary supplements and nutraceuticals. 2013 Curr. Hypertens. Rep. pmid:23430658
Niklowitz P et al. Determination of coenzyme Q10 tissue status via high-performance liquid chromatography with electrochemical detection in swine tissues (Sus scrofa domestica). 2013 Anal. Biochem. pmid:23467099
Romanenko LA et al. Devosia submarina sp. nov., isolated from deep-sea surface sediments. 2013 Int. J. Syst. Evol. Microbiol. pmid:23416574
Potgieter M et al. Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation. 2013 Nutr. Rev. pmid:23452285
Theuri G et al. Effects of lifestyle on plasma levels of the IGF system and the antioxidants coenzyme Q10 and vitamin E in Kenyan rural and urban populations. 2013 Growth Horm. IGF Res. pmid:23452916
Huynh K et al. Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice. 2013 Free Radic. Biol. Med. pmid:23454064
Abraham WR et al. Prosthecate sphingomonads: proposal of Sphingomonas canadensis sp. nov. 2013 Int. J. Syst. Evol. Microbiol. pmid:23456806
Nanjwade BK et al. Formulation and characterization of nanostructured lipid carrier of ubiquinone (Coenzyme Q10). 2013 J Biomed Nanotechnol pmid:23621001
Zhou H et al. Improvement of the oral bioavailability of coenzyme Q10 with lecithin nanocapsules. 2013 J Nanosci Nanotechnol pmid:23646802
Bohar Topolovec M et al. Endogenous plasma coenzyme Q10 concentration does not correlate with plasma total antioxidant capacity level in healthy untrained horses. 2013 Res. Vet. Sci. pmid:23648076
Luo J et al. A new electrochemically active bacterium phylogenetically related to Tolumonas osonensis and power performance in MFCs. 2013 Bioresour. Technol. pmid:23651598
Yoneda T et al. Anti-aging effects of co-enzyme Q10 on periodontal tissues. 2013 J. Dent. Res. pmid:23694931
Zhang YP et al. Diabetic neuropathic pain development in type 2 diabetic mouse model and the prophylactic and therapeutic effects of coenzyme Q10. 2013 Neurobiol. Dis. pmid:23684663
Duberley KE et al. Coenzyme Q10 quantification in muscle, fibroblasts and cerebrospinal fluid by liquid chromatography/tandem mass spectrometry using a novel deuterated internal standard. 2013 Rapid Commun. Mass Spectrom. pmid:23592193
Castro-Marrero J et al. Could mitochondrial dysfunction be a differentiating marker between chronic fatigue syndrome and fibromyalgia? 2013 Antioxid. Redox Signal. pmid:23600892
Simón-Yarza T et al. Functional benefits of PLGA particulates carrying VEGF and CoQ10 in an animal of myocardial ischemia. 2013 Int J Pharm pmid:23639291
Xue SY et al. Nucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment. 2013 Toxicol. Sci. pmid:23640862
Bibi F et al. Martelella endophytica sp. nov., an antifungal bacterium associated with a halophyte. 2013 Int. J. Syst. Evol. Microbiol. pmid:23355694
Josey BJ et al. Structure-activity relationship study of vitamin k derivatives yields highly potent neuroprotective agents. 2013 J. Med. Chem. pmid:23327468
Zhang YP et al. Prophylactic and antinociceptive effects of coenzyme Q10 on diabetic neuropathic pain in a mouse model of type 1 diabetes. 2013 Anesthesiology pmid:23334664
Bogsrud MP et al. No effect of combined coenzyme Q10 and selenium supplementation on atorvastatin-induced myopathy. 2013 Scand. Cardiovasc. J. pmid:23301875
Kim JW et al. Effects of coenzyme Q10 on bladder dysfunction induced by chronic bladder ischemia in a rat model. 2013 J. Urol. pmid:23306086
Gladine C et al. Optimized rapeseed oil enriched with healthy micronutrients: a relevant nutritional approach to prevent cardiovascular diseases. Results of the Optim'Oils randomized intervention trial. 2013 J. Nutr. Biochem. pmid:22784432
Goldschmidt R et al. Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases. 2013 Bioorg. Med. Chem. pmid:23313093
Sato T et al. Effect of reduced form of coenzyme Q10 on cyclosporine nephrotoxicity. 2013 Exp Clin Transplant pmid:23194328
Veyisoglu A et al. Methylobacterium tarhaniae sp. nov., isolated from arid soil. 2013 Int. J. Syst. Evol. Microbiol. pmid:23315404