Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

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What functions are associated with Coenzyme Q10?


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What lipids are associated with Coenzyme Q10?

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What genes are associated with Coenzyme Q10?

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What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Kaikkonen J et al. Determinants of plasma coenzyme Q10 in humans. 1999 FEBS Lett. pmid:9989597
Kagan VE and Tyurina YY Recycling and redox cycling of phenolic antioxidants. 1998 Ann. N. Y. Acad. Sci. pmid:9928449
Linnane AW et al. The universality of bioenergetic disease. Age-associated cellular bioenergetic degradation and amelioration therapy. 1998 Ann. N. Y. Acad. Sci. pmid:9928431
Graves S et al. Analysis of coenzyme Q10 content in human plasma and other biological samples. 1998 Methods Mol. Biol. pmid:9921544
Barbiroli B et al. Aspects of human bioenergetics as studied in vivo by magnetic resonance spectroscopy. 1998 Biochimie pmid:9893943
Freeman LM Interventional nutrition for cardiac disease. 1998 Clin Tech Small Anim Pract pmid:9842116
Sumioka I et al. Mechanisms of protection by S-allylmercaptocysteine against acetaminophen-induced liver injury in mice. 1998 Jpn. J. Pharmacol. pmid:9829623
Singh RB et al. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. 1998 Cardiovasc Drugs Ther pmid:9825179
Andreu AL et al. Missense mutation in the mtDNA cytochrome b gene in a patient with myopathy. 1998 Neurology pmid:9818877
Karpińska J et al. Application of derivative spectrophotometry for determination of coenzyme Q10 in pharmaceuticals and plasma. 1998 J Pharm Biomed Anal pmid:9800653
Chan A et al. Metabolic changes in patients with mitochondrial myopathies and effects of coenzyme Q10 therapy. 1998 J. Neurol. pmid:9776469
Atroshi F et al. Effects of tamoxifen, melatonin, coenzyme Q10, and L-carnitine supplementation on bacterial growth in the presence of mycotoxins. 1998 Pharmacol. Res. pmid:9774492
Niibori K et al. Acute administration of liposomal coenzyme Q10 increases myocardial tissue levels and improves tolerance to ischemia reperfusion injury. 1998 J. Surg. Res. pmid:9758729
Syrkin AL et al. [The use of the antioxidant coenzyme Q10 as a cytoprotection variant in ischemic heart disease]. 1998 Klin Med (Mosk) pmid:9742773
Kaikkonen J et al. Effect of combined coenzyme Q10 and d-alpha-tocopheryl acetate supplementation on exercise-induced lipid peroxidation and muscular damage: a placebo-controlled double-blind study in marathon runners. 1998 Free Radic. Res. pmid:9733025
Lönnrot K et al. Control of arterial tone after long-term coenzyme Q10 supplementation in senescent rats. 1998 Br. J. Pharmacol. pmid:9723964
DiMauro S et al. Mitochondria in neuromuscular disorders. 1998 Biochim. Biophys. Acta pmid:9714805
Makabi-Panzu B et al. Coenzyme Q10 in vesicles composed of archaeal ether lipids or conventional lipids enhances the immuno-adjuvanticity to encapsulated protein. 1998 Vaccine pmid:9711796
Matthews RT et al. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9671775
Noia G et al. Coenzyme Q10 fetal plasma levels. 1998 Mar-Apr Fetal. Diagn. Ther. pmid:9650661
Suzuki S et al. The effects of coenzyme Q10 treatment on maternally inherited diabetes mellitus and deafness, and mitochondrial DNA 3243 (A to G) mutation. 1998 Diabetologia pmid:9628277
Di Bernardo S et al. A high diffusion coefficient for coenzyme Q10 might be related to a folded structure. 1998 FEBS Lett. pmid:9598982
Lönnrot K et al. The effects of lifelong ubiquinone Q10 supplementation on the Q9 and Q10 tissue concentrations and life span of male rats and mice. 1998 Biochem. Mol. Biol. Int. pmid:9584986
Mancini A et al. Relationship between sperm cell ubiquinone and seminal parameters in subjects with and without varicocele. 1998 Feb-Mar Andrologia pmid:9567163
Chopra RK et al. Relative bioavailability of coenzyme Q10 formulations in human subjects. 1998 Int J Vitam Nutr Res pmid:9565826
Boitier E et al. A case of mitochondrial encephalomyopathy associated with a muscle coenzyme Q10 deficiency. 1998 J. Neurol. Sci. pmid:9559985
Costeff H et al. Ineffectiveness of oral coenzyme Q10 supplementation in 3-methylglutaconic aciduria, type 3. 1998 Brain Dev. pmid:9533558
Disch A et al. Mevalonate-derived isopentenyl diphosphate is the biosynthetic precursor of ubiquinone prenyl side chain in tobacco BY-2 cells. 1998 Biochem. J. pmid:9531505
Shults CW et al. Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients. 1998 Neurology pmid:9521279
Shouzu A et al. [Coenzyme Q10]. 1998 Nippon Rinsho pmid:9513406
Sul D and Kaneshiro ES Ubiquinone synthesis by Pneumocystis carinii: incorporation of radiolabeled polyprenyl chain and benzoquinone ring precursors. 1997 Nov-Dec J. Eukaryot. Microbiol. pmid:9508445
Beal MF et al. Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. 1998 Brain Res. pmid:9479058
Hofman-Bang C et al. Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 Study Group. 1995 J. Card. Fail. pmid:9420639
Sinatra ST Coenzyme Q10: a vital therapeutic nutrient for the heart with special application in congestive heart failure. 1997 Conn Med pmid:9419958
Brude IR et al. Peroxidation of LDL from combined-hyperlipidemic male smokers supplied with omega-3 fatty acids and antioxidants. 1997 Arterioscler. Thromb. Vasc. Biol. pmid:9409230
Seki A et al. Mitochondrial encephalomyopathy with 15915 mutation: clinical report. 1997 Pediatr. Neurol. pmid:9367299
Grieb P et al. Oral coenzyme Q10 administration prevents the development of ischemic brain lesions in a rabbit model of symptomatic vasospasm. 1997 Acta Neuropathol. pmid:9341938
Gómez-Díaz C et al. Antioxidant ascorbate is stabilized by NADH-coenzyme Q10 reductase in the plasma membrane. 1997 J. Bioenerg. Biomembr. pmid:9298710
Barbiroli B et al. Coenzyme Q10 improves mitochondrial respiration in patients with mitochondrial cytopathies. An in vivo study on brain and skeletal muscle by phosphorous magnetic resonance spectroscopy. 1997 Cell. Mol. Biol. (Noisy-le-grand) pmid:9298596
Weston SB et al. Does exogenous coenzyme Q10 affect aerobic capacity in endurance athletes? 1997 Int J Sport Nutr pmid:9286743
Levin WM Statin drugs: a double-edged sword? 1997 Hosp Pract (1995) pmid:9275961
Shults CW et al. Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects. 1997 Ann. Neurol. pmid:9266740
Andersen CB et al. The effect of coenzyme Q10 on blood glucose and insulin requirement in patients with insulin dependent diabetes mellitus. 1997 Mol. Aspects Med. pmid:9266541
Sinatra ST Refractory congestive heart failure successfully managed with high dose coenzyme Q10 administration. 1997 Mol. Aspects Med. pmid:9266540
Mizuno M et al. Effects of oral supplementation of coenzyme Q10 on 31P-NMR detected skeletal muscle energy metabolism in middle-aged post-polio subjects and normal volunteers. 1997 Mol. Aspects Med. pmid:9266539
Ylikoski T et al. The effect of coenzyme Q10 on the exercise performance of cross-country skiers. 1997 Mol. Aspects Med. pmid:9266538
Battino M et al. Coenzyme Q homologs and vitamin E in synaptic and non-synaptic occipital cerebral cortex mitochondria in the ageing rat. 1997 Mol. Aspects Med. pmid:9266537
Westermarck T et al. Evaluation of the possible role of coenzyme Q10 and vitamin E in juvenile neuronal ceroid-lipofuscinosis (JNCL). 1997 Mol. Aspects Med. pmid:9266533
Atroshi F et al. T-2 toxin-induced DNA damage in mouse livers: the effect of pretreatment with coenzyme Q10 and alpha-tocopherol. 1997 Mol. Aspects Med. pmid:9266532
Weber C et al. Coenzyme Q10 in the diet--daily intake and relative bioavailability. 1997 Mol. Aspects Med. pmid:9266531
Armeni T et al. Dietary restriction affects antioxidant levels in rat liver mitochondria during ageing. 1997 Mol. Aspects Med. pmid:9266530
Battino M et al. Metabolic and antioxidant markers in the plasma of sportsmen from a Mediterranean town performing non-agonistic activity. 1997 Mol. Aspects Med. pmid:9266529
Strijks E et al. Q10 therapy in patients with idiopathic Parkinson's disease. 1997 Mol. Aspects Med. pmid:9266528
Ramírez-Tortosa MC et al. Rabbit liver mitochondria coenzyme Q10 and hydroperoxide levels: an experimental model of atherosclerosis. 1997 Mol. Aspects Med. pmid:9266527
Huertas JR et al. Lipid peroxidation and antioxidants in newborns. 1997 Mol. Aspects Med. pmid:9266526
Alleva R et al. The protective role of ubiquinol-10 against formation of lipid hydroperoxides in human seminal fluid. 1997 Mol. Aspects Med. pmid:9266525
Lewin A and Lavon H The effect of coenzyme Q10 on sperm motility and function. 1997 Mol. Aspects Med. pmid:9266524
Whitman GJ et al. The mechanisms of coenzyme Q10 as therapy for myocardial ischemia reperfusion injury. 1997 Mol. Aspects Med. pmid:9266522
Serebruany VL et al. Could coenzyme Q10 affect hemostasis by inhibiting platelet vitronectin (CD51/CD61) receptor? 1997 Mol. Aspects Med. pmid:9266521
Suzuki Y et al. Diabetes mellitus associated with 3243 mitochondrial tRNA(Leu(UUR)) mutation: clinical features and coenzyme Q10 treatment. 1997 Mol. Aspects Med. pmid:9266520
Beal MF and Matthews RT Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative diseases. 1997 Mol. Aspects Med. pmid:9266519
Soja AM and Mortensen SA Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials. 1997 Mol. Aspects Med. pmid:9266518
Oda T Recovery of the systolic time intervals by coenzyme Q10 in patients with a load-induced cardiac dysfunction. 1997 Mol. Aspects Med. pmid:9266517
Langsjoen PH et al. Treatment of hypertrophic cardiomyopathy with coenzyme Q10. 1997 Mol. Aspects Med. pmid:9266516
Mortensen SA et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. 1997 Mol. Aspects Med. pmid:9266515
Mataix J et al. Coenzyme Q content depends upon oxidative stress and dietary fat unsaturation. 1997 Mol. Aspects Med. pmid:9266514
Alleva R et al. Oxidation of LDL and their subfractions: kinetic aspects and CoQ10 content. 1997 Mol. Aspects Med. pmid:9266511
Yamamoto Y and Yamashita S Plasma ratio of ubiquinol and ubiquinone as a marker of oxidative stress. 1997 Mol. Aspects Med. pmid:9266509
Wakabayashi T et al. Suppression of the formation of megamitochondria by scavengers for free radicals. 1997 Mol. Aspects Med. pmid:9266506
Ruuge EK et al. The redox state of coenzyme Q10 in mitochondrial respiratory chain and oxygen-derived free radical generation in cardiac cells. 1997 Mol. Aspects Med. pmid:9266505
Lenaz G et al. Coenzyme Q deficiency in mitochondria: kinetic saturation versus physical saturation. 1997 Mol. Aspects Med. pmid:9266503
Cleary J et al. Plasma and LDL levels of major lipophilic antioxidants are similar in patients with advanced atherosclerosis and age-matched controls. 1997 Free Radic. Res. pmid:9257129
Ubiquinone--the everywhere nutrient. 1997 J Am Optom Assoc pmid:9248256
Human JA et al. The effect of Simvastatin on the plasma antioxidant concentrations in patients with hypercholesterolaemia. 1997 Clin. Chim. Acta pmid:9247729
Neuzil J et al. Alpha-tocopheryl hydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low density lipoprotein lipids. 1997 Proc. Natl. Acad. Sci. U.S.A. pmid:9223282
Chen RS et al. Coenzyme Q10 treatment in mitochondrial encephalomyopathies. Short-term double-blind, crossover study. 1997 Eur. Neurol. pmid:9208260
Ren S and Lien EJ Natural products and their derivatives as cancer chemopreventive agents. 1997 Prog Drug Res pmid:9204686
Ozawa S et al. Role of PSII-L protein (psbL gene product) on the electron transfer in photosystem II complex. 1. Over-production of wild-type and mutant versions of PSII-L protein and reconstitution into the PSII core complex. 1997 Plant Mol. Biol. pmid:9177321
Folkers K et al. Activities of vitamin Q10 in animal models and a serious deficiency in patients with cancer. 1997 Biochem. Biophys. Res. Commun. pmid:9177262
Kim Y et al. Therapeutic effect of co-enzyme Q10 on idiopathic dilated cardiomyopathy: assessment by iodine-123 labelled 15-(p-iodophenyl)-3(R,S)-methylpentadecanoic acid myocardial single-photon emission tomography. 1997 Eur J Nucl Med pmid:9169569
Gómez-Díaz C et al. Ascorbate stabilization is stimulated in rho(0)HL-60 cells by CoQ10 increase at the plasma membrane. 1997 Biochem. Biophys. Res. Commun. pmid:9168964
Herschfus JA Prognostic implications of elevated creatine kinase after coronary angioplasty. 1997 JAMA pmid:9168284
Sobreira C et al. Mitochondrial encephalomyopathy with coenzyme Q10 deficiency. 1997 Neurology pmid:9153450
Weber C et al. The coenzyme Q10 content of the average Danish diet. 1997 Int J Vitam Nutr Res pmid:9129255
Fallon J et al. MPP+ produces progressive neuronal degeneration which is mediated by oxidative stress. 1997 Exp. Neurol. pmid:9126170
Rosenthal W and Brumhard M [Coenzyme Q10]. 1997 Dtsch. Med. Wochenschr. pmid:9102295
Kaikkonen J et al. Effect of oral coenzyme Q10 supplementation on the oxidation resistance of human VLDL+LDL fraction: absorption and antioxidative properties of oil and granule-based preparations. 1997 Free Radic. Biol. Med. pmid:9098093
Koroshetz WJ et al. Energy metabolism defects in Huntington's disease and effects of coenzyme Q10. 1997 Ann. Neurol. pmid:9029064
Priemé H et al. No effect of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion in smokers. 1997 Am. J. Clin. Nutr. pmid:9022536
van Belzen R et al. The iron-sulfur clusters 2 and ubisemiquinone radicals of NADH:ubiquinone oxidoreductase are involved in energy coupling in submitochondrial particles. 1997 Biochemistry pmid:9020788
Kucharská J et al. [Coenzyme Q10 and alpha-tocopherol in patients after heart transplantation]. 1996 Bratisl Lek Listy pmid:9019342
de Rijke YB et al. The redox status of coenzyme Q10 in total LDL as an indicator of in vivo oxidative modification. Studies on subjects with familial combined hyperlipidemia. 1997 Arterioscler. Thromb. Vasc. Biol. pmid:9012647
Serebruany VL et al. Dietary coenzyme Q10 supplementation alters platelet size and inhibits human vitronectin (CD51/CD61) receptor expression. 1997 J. Cardiovasc. Pharmacol. pmid:9007665
Ma A et al. Effect of protection and repair of injury of mitochondrial membrane-phospholipid on prognosis in patients with dilated cardiomyopathy. 1996 Blood Press Suppl pmid:8973771
Yamamoto H and Yamamoto F [The effect of coenzyme Q10 and cold cristalloid cardioplegia on hypothermic global ischemia]. 1996 Nihon Kyobu Geka Gakkai Zasshi pmid:8964987
Birnbaum Y et al. The effect of coenzyme Q10 on infarct size in a rabbit model of ischemia/reperfusion. 1996 Cardiovasc. Res. pmid:8944817
Marubayashi S et al. Effect of pretreatment with coenzyme Q10 and monoclonal antibodies to adhesion molecules on ischemic small intestine preservation. 1996 Transplant. Proc. pmid:8907970
Yoshida T et al. Increased myocardial tolerance to ischemia-reperfusion injury by feeding pigs with coenzyme Q10. 1996 Ann. N. Y. Acad. Sci. pmid:8906183
Conget I et al. Coenzyme Q10 and insulin secretion in vitro. 1996 Diabetes Res. Clin. Pract. pmid:8879969
Formiggini G et al. Coenzyme Q depletion in rat plasma after partial hepatectomy. 1996 Biochem. Mol. Biol. Int. pmid:8876966