Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

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What functions are associated with Coenzyme Q10?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

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What genes are associated with Coenzyme Q10?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Pereira R et al. Major regulatory mechanisms involved in sperm motility. 2017 Jan-Feb Asian J. Androl. pmid:26680031
Zaki ME et al. Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects. 2017 Jan - Feb J Pediatr (Rio J) pmid:27770619
Banno H et al. Analysis of Participant Withdrawal in Huntington Disease Clinical Trials. 2017 J Huntingtons Dis pmid:28671136
Chen PY et al. Protective effect of Co-enzyme Q10 On doxorubicin-induced cardiomyopathy of rat hearts. 2017 Environ. Toxicol. pmid:27087047
Roese E and Bunjes H Drug release studies from lipid nanoparticles in physiological media by a new DSC method. 2017 J Control Release pmid:28450207
Li HN et al. Water-Soluble Coenzyme Q10 Reduces Rotenone-Induced Mitochondrial Fission. 2017 Neurochem. Res. pmid:28190227
Sheu SJ et al. Differential autophagic effects of vital dyes in retinal pigment epithelial ARPE-19 and photoreceptor 661W cells. 2017 PLoS ONE pmid:28358857
Jain S et al. α-Tocopherol as functional excipient for resveratrol and coenzyme Q10-loaded SNEDDS for improved bioavailability and prophylaxis of breast cancer. 2017 J Drug Target pmid:28274130
Guilbot A et al. A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study. 2017 BMC Complement Altern Med pmid:28854909
Alehagen U et al. Increase in insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 after supplementation with selenium and coenzyme Q10. A prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. 2017 PLoS ONE pmid:28609475
Alehagen U et al. Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. 2017 PLoS ONE pmid:28448590
Ulla A et al. Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats. 2017 BMC Pharmacol Toxicol pmid:28427467
Ki Y et al. Effect of Coenzyme Q10 on Radiation Nephropathy in Rats. 2017 J. Korean Med. Sci. pmid:28378548
Garg S et al. CoQ10 selective miscibility and penetration into lipid monolayers with lower lateral packing density. 2017 Biochim. Biophys. Acta pmid:28366515
Lee SQ et al. Cellular factories for coenzyme Q10 production. 2017 Microb. Cell Fact. pmid:28253886
Varela-López A et al. Age-Related Loss in Bone Mineral Density of Rats Fed Lifelong on a Fish Oil-Based Diet Is Avoided by Coenzyme Q10 Addition. 2017 Nutrients pmid:28241421
Zhai J et al. Effects of Coenzyme Q10 on Markers of Inflammation: A Systematic Review and Meta-Analysis. 2017 PLoS ONE pmid:28125601
Awa H et al. Effects of Combined Treatment with Branched-Chain Amino Acids, Citric Acid, L-Carnitine, Coenzyme Q10, Zinc, and Various Vitamins in Tumor-Bearing Mice. 2017 Biol. Pharm. Bull. pmid:28123134
Liu HT et al. Coenzyme Q10 and Oxidative Stress: Inflammation Status in Hepatocellular Carcinoma Patients after Surgery. 2017 Nutrients pmid:28054958
Mustafa HN et al. Protective role of CoQ10 or L-carnitine on the integrity of the myocardium in doxorubicin induced toxicity. 2017 Tissue Cell pmid:28410798
Mao Z et al. Additive enhancement of wound healing in diabetic mice by low level light and topical CoQ10. 2016 Sci Rep pmid:26830658
Zhang YP et al. Acute Hypoglycemia Induces Painful Neuropathy and the Treatment of Coenzyme Q10. 2016 J Diabetes Res pmid:26824041
Barca E et al. Cerebellar ataxia and severe muscle CoQ10 deficiency in a patient with a novel mutation in ADCK3. 2016 Clin. Genet. pmid:26818466
Kasai T et al. Serum Levels of Coenzyme Q10 in Patients with Multiple System Atrophy. 2016 PLoS ONE pmid:26812605
Emma F et al. Mitochondrial dysfunction in inherited renal disease and acute kidney injury. 2016 Nat Rev Nephrol pmid:26804019
Fragaki K et al. Coenzyme Q10 defects may be associated with a deficiency of Q10-independent mitochondrial respiratory chain complexes. 2016 Biol. Res. pmid:26742794
Murad HA L-Carnitine, but not coenzyme Q10, enhances the anti-osteoporotic effect of atorvastatin in ovariectomized rats. 2016 J Zhejiang Univ Sci B pmid:26739525
Tarry-Adkins JL et al. Coenzyme Q10 prevents hepatic fibrosis, inflammation, and oxidative stress in a male rat model of poor maternal nutrition and accelerated postnatal growth. 2016 Am. J. Clin. Nutr. pmid:26718412
Tsai HY et al. Coenzyme Q10 Attenuates High Glucose-Induced Endothelial Progenitor Cell Dysfunction through AMP-Activated Protein Kinase Pathways. 2016 J Diabetes Res pmid:26682233
Sunnetcioglu A et al. Evaluation of Oxidative Damage and Antioxidant Mechanisms in COPD, Lung Cancer, and Obstructive Sleep Apnea Syndrome. 2016 Respir Care pmid:26604330
Claessens AJ et al. Rapid and sensitive analysis of reduced and oxidized coenzyme Q10 in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and application to studies in healthy human subjects. 2016 Ann. Clin. Biochem. pmid:26056391
Sheeran FL and Pepe S Posttranslational modifications and dysfunction of mitochondrial enzymes in human heart failure. 2016 Am. J. Physiol. Endocrinol. Metab. pmid:27406740
Asencio C et al. Severe encephalopathy associated to pyruvate dehydrogenase mutations and unbalanced coenzyme Q10 content. 2016 Eur. J. Hum. Genet. pmid:26014431
Takekawa Y et al. An Approach to Improve Intestinal Absorption of Poorly Absorbed Water-Insoluble Components via Niemann-Pick C1-Like 1. 2016 Biol. Pharm. Bull. pmid:26934923
Fišar Z et al. Effect of Simvastatin, Coenzyme Q10, Resveratrol, Acetylcysteine and Acetylcarnitine on Mitochondrial Respiration. 2016 Folia Biol. (Praha) pmid:27187037
Kim MK et al. Fluviicoccus keumensis gen. nov., sp. nov., isolated from freshwater. 2016 Int. J. Syst. Evol. Microbiol. pmid:26498187
Fatima S et al. Combined treatment of epigallocatechin gallate and Coenzyme Q10 attenuates cisplatin-induced nephrotoxicity via suppression of oxidative/nitrosative stress, inflammation and cellular damage. 2016 Food Chem. Toxicol. pmid:27265264
Kesik V et al. Ozone Ameliorates Doxorubicine-Induced Skin Necrosis - results from an animal model. 2016 Int J Low Extrem Wounds pmid:26286933
Da Y et al. Successful treatment of periodic paralysis with coenzyme Q10: two case reports. 2016 Acta Myol pmid:28344441
Lipovac M et al. Comparison of the effect of a combination of eight micronutrients versus a standard mono preparation on sperm parameters. 2016 Reprod. Biol. Endocrinol. pmid:27938385
Fischer A et al. Coenzyme Q10 Status as a Determinant of Muscular Strength in Two Independent Cohorts. 2016 PLoS ONE pmid:27907044
Lopes-Ramos CM et al. Lithium carbonate and coenzyme Q10 reduce cell death in a cell model of Machado-Joseph disease. 2016 Braz. J. Med. Biol. Res. pmid:27878228
Liu HT et al. Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial. 2016 Nutr J pmid:27716246
Astolfi L et al. Coenzyme Q10 plus Multivitamin Treatment Prevents Cisplatin Ototoxicity in Rats. 2016 PLoS ONE pmid:27632426
Sun C et al. Q-Band Electron-Nuclear Double Resonance Reveals Out-of-Plane Hydrogen Bonds Stabilize an Anionic Ubisemiquinone in Cytochrome bo3 from Escherichia coli. 2016 Biochemistry pmid:27622672
Moradi M et al. Effect of Coenzyme Q10 Supplementation on Diabetes Biomarkers: a Systematic Review and Meta-analysis of Randomized Controlled Clinical Trials. 2016 Arch Iran Med pmid:27544369
Latkovskis G et al. Pilot study of safety and efficacy of polyprenols in combination with coenzyme Q10 in patients with statin-induced myopathy. 2016 Medicina (Kaunas) pmid:27496187
Huang CH et al. High plasma coenzyme Q10 concentration is correlated with good left ventricular performance after primary angioplasty in patients with acute myocardial infarction. 2016 Medicine (Baltimore) pmid:27495100
Hyodo F et al. Development of Redox Metabolic Imaging Using Endogenous Molecules. 2016 Yakugaku Zasshi pmid:27477725
Alehagen U et al. Supplementation with Selenium and Coenzyme Q10 Reduces Cardiovascular Mortality in Elderly with Low Selenium Status. A Secondary Analysis of a Randomised Clinical Trial. 2016 PLoS ONE pmid:27367855
Morrison JT et al. Effect of rosuvastatin on plasma coenzyme Q10 in HIV-infected individuals on antiretroviral therapy. 2016 HIV Clin Trials pmid:27294339
Özcan P et al. Can Coenzyme Q10 supplementation protect the ovarian reserve against oxidative damage? 2016 J. Assist. Reprod. Genet. pmid:27255570
Barca E et al. Decreased Coenzyme Q10 Levels in Multiple System Atrophy Cerebellum. 2016 J. Neuropathol. Exp. Neurol. pmid:27235405
Kumari S et al. Ubisol-Q10 Prevents Glutamate-Induced Cell Death by Blocking Mitochondrial Fragmentation and Permeability Transition Pore Opening. 2016 Int. J. Biol. Sci. pmid:27194946
Mirmalek SA et al. Antioxidant and Anti-Inflammatory Effects of Coenzyme Q10 on L-Arginine-Induced Acute Pancreatitis in Rat. 2016 Oxid Med Cell Longev pmid:27190575
Jenkins BJ et al. Characterization of a Plasmodium falciparum Orthologue of the Yeast Ubiquinone-Binding Protein, Coq10p. 2016 PLoS ONE pmid:27015086
Sharma A et al. Coenzyme Q10 and Heart Failure: A State-of-the-Art Review. 2016 Circ Heart Fail pmid:27012265
Barden A et al. n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease. 2016 Nutrients pmid:27007392
Cullen JK et al. AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation. 2016 PLoS ONE pmid:26866375
Higashi T et al. Improvement of Pharmaceutical Properties of Isoprenoid Compounds through the Formation of Cyclodextrin Pseudorotaxane-Like Supramolecules. 2016 Chem. Pharm. Bull. pmid:26852798
Mustafa HN et al. Prophylactic role of coenzyme Q10 and Cynara scolymus L on doxorubicin-induced toxicity in rats: Biochemical and immunohistochemical study. 2015 Nov-Dec Indian J Pharmacol pmid:26729958
Alehagen U et al. Less increase of copeptin and MR-proADM due to intervention with selenium and coenzyme Q10 combined: Results from a 4-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. 2015 Nov-Dec Biofactors pmid:26662217
Knott A et al. Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects. 2015 Nov-Dec Biofactors pmid:26648450
Park S et al. Pseudoseohaeicola caenipelagi gen. nov., sp. nov., isolated from a tidal flat. 2015 Int. J. Syst. Evol. Microbiol. pmid:25754549
El Morsy EM et al. Attenuating effects of coenzyme Q10 and amlodipine in ulcerative colitis model in rats. 2015 Immunopharmacol Immunotoxicol pmid:25753843
Li L et al. Bombella intestini gen. nov., sp. nov., an acetic acid bacterium isolated from bumble bee crop. 2015 Int. J. Syst. Evol. Microbiol. pmid:25336723
Kishita Y et al. Intra-mitochondrial Methylation Deficiency Due to Mutations in SLC25A26. 2015 Am. J. Hum. Genet. pmid:26522469
Alehagen U et al. Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized Double-Blind Placebo-Controlled Trial in Elderly Citizens. 2015 PLoS ONE pmid:26624886
Okeahialam BN Reversal of statin-induced memory dysfunction by co-enzyme Q10: a case report. 2015 Vasc Health Risk Manag pmid:26604775
Yeung CK et al. Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress. 2015 BMC Nephrol pmid:26531095
Hyung S et al. Coculture of Primary Motor Neurons and Schwann Cells as a Model for In Vitro Myelination. 2015 Sci Rep pmid:26456300
Kaisar MA et al. Protecting the BBB endothelium against cigarette smoke-induced oxidative stress using popular antioxidants: Are they really beneficial? 2015 Brain Res. pmid:26410779
Alehagen U et al. Levels of sP-selectin and hs-CRP Decrease with Dietary Intervention with Selenium and Coenzyme Q10 Combined: A Secondary Analysis of a Randomized Clinical Trial. 2015 PLoS ONE pmid:26375288
Prusiner SB et al. Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26324905
Grenier-Larouche T et al. Omental adipocyte hypertrophy relates to coenzyme Q10 redox state and lipid peroxidation in obese women. 2015 J. Lipid Res. pmid:26239051
Tarry-Adkins JL et al. Coenzyme Q10 Prevents Insulin Signaling Dysregulation and Inflammation Prior to Development of Insulin Resistance in Male Offspring of a Rat Model of Poor Maternal Nutrition and Accelerated Postnatal Growth. 2015 Endocrinology pmid:26214037
Donnino MW et al. Ubiquinol (reduced Coenzyme Q10) in patients with severe sepsis or septic shock: a randomized, double-blind, placebo-controlled, pilot trial. 2015 Crit Care pmid:26130237
Ben-Meir A et al. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. 2015 Aging Cell pmid:26111777
Ohta Y et al. Effect of Dietary Vitamin E Supplementation on Liver Oxidative Damage in Rats with Water-Immersion Restraint Stress. 2015 J. Nutr. Sci. Vitaminol. pmid:26052141
de la Mata M et al. Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease. 2015 Sci Rep pmid:26045184
Gaul C et al. Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial. 2015 J Headache Pain pmid:25916335
Forester BP et al. Antidepressant effects of open label treatment with coenzyme Q10 in geriatric bipolar depression. 2015 J Clin Psychopharmacol pmid:25874916
Zhang D et al. Coenzyme Q10 inhibits the aging of mesenchymal stem cells induced by D-galactose through Akt/mTOR signaling. 2015 Oxid Med Cell Longev pmid:25789082
Florkowski CM et al. Coenzyme Q10 and congestive heart failure; an evolving evidence base. 2015 Kardiol Pol pmid:25706904
Summitt CB et al. Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria. 2015 Biochem. J. pmid:25697095
Mourier A et al. Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. 2015 J. Cell Biol. pmid:25688136
Domanico D et al. Circulating levels of reactive oxygen species in patients with nonproliferative diabetic retinopathy and the influence of antioxidant supplementation: 6-month follow-up. 2015 Indian J Ophthalmol pmid:25686055
Guevara-Campos J et al. Autism and intellectual disability associated with mitochondrial disease and hyperlactacidemia. 2015 Int J Mol Sci pmid:25679448
Gueven N et al. Border between natural product and drug: comparison of the related benzoquinones idebenone and coenzyme Q10. 2015 Redox Biol pmid:25625583
Desbats MA et al. Primary coenzyme Q10 deficiency presenting as fatal neonatal multiorgan failure. 2015 Eur. J. Hum. Genet. pmid:25564041
Dutta A et al. Hypersensitive response-like lesions 1 codes for AtPPT1 and regulates accumulation of ROS and defense against bacterial pathogen Pseudomonas syringae in Arabidopsis thaliana. 2015 Antioxid. Redox Signal. pmid:25557512
Jing L et al. Coenzyme Q10 protects astrocytes from ROS-induced damage through inhibition of mitochondria-mediated cell death pathway. 2015 Int. J. Biol. Sci. pmid:25552930
Alehagen U and Aaseth J Selenium and coenzyme Q10 interrelationship in cardiovascular diseases--A clinician's point of view. 2015 J Trace Elem Med Biol pmid:25511910
Lo RY et al. Coenzyme Q10 and spinocerebellar ataxias. 2015 Mov. Disord. pmid:25449974
Castro-Marrero J et al. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome? 2015 Antioxid. Redox Signal. pmid:25386668
Iwasaki M et al. Comparison of plasma levels of nutrient-related biomarkers among Japanese populations in Tokyo, Japan, São Paulo, Brazil, and Hawaii, USA. 2015 Eur. J. Cancer Prev. pmid:25633435
Fischer T [Pharmacological therapy of age-related macular degeneration based on etiopathogenesis]. 2015 Orv Hetil pmid:26548469
Fatima S et al. Effect of pre- and post-combined multidoses of epigallocatechin gallate and coenzyme Q10 on cisplatin-induced oxidative stress in rat kidney. 2015 J. Biochem. Mol. Toxicol. pmid:25382014
Nerdal W et al. CoenzymeQ10 localizations in model membranes. A Langmuir monolayer study. 2015 Biophys. Chem. pmid:26408828
Cicero AF and Colletti A Nutraceuticals and Blood Pressure Control: Results from Clinical Trials and Meta-Analyses. 2015 High Blood Press Cardiovasc Prev pmid:25788027