Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Coenzyme Q10?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

Related references are published most in these journals:

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What genes are associated with Coenzyme Q10?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
pmid:
Kozlov AV et al. Dihydrolipoic acid maintains ubiquinone in the antioxidant active form by two-electron reduction of ubiquinone and one-electron reduction of ubisemiquinone. 1999 Arch. Biochem. Biophys. pmid:10049509
Lönnrot K et al. Coenzyme Q10 supplementation and recovery from ischemia in senescent rat myocardium. 1999 Life Sci. pmid:10072191
Singh RB and Niaz MA Serum concentration of lipoprotein(a) decreases on treatment with hydrosoluble coenzyme Q10 in patients with coronary artery disease: discovery of a new role. 1999 Int. J. Cardiol. pmid:10077397
Complementary treatments highlighted at recent meeting. 1999 Oncology (Williston Park, N.Y.) pmid:10079467
Sinatra ST "Care," cancer and coenzyme Q10. 1999 J. Am. Coll. Cardiol. pmid:10080498
Hara K et al. Oxidative stress in newborn infants with and without asphyxia as measured by plasma antioxidants and free fatty acids. 1999 Biochem. Biophys. Res. Commun. pmid:10092541
Pepping J Coenzyme Q10. 1999 Am J Health Syst Pharm pmid:10192685
Singh RB et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. 1999 J Hum Hypertens pmid:10204818
Yokoyama K et al. Effect of coenzyme Q10 on superoxide production in rats with reperfusion injuries. 1999 Scand J Plast Reconstr Surg Hand Surg pmid:10207958
Barbiroli B et al. Low brain intracellular free magnesium in mitochondrial cytopathies. 1999 J. Cereb. Blood Flow Metab. pmid:10326720
Teranishi Ma et al. Effects of coenzyme Q10 on changes in the membrane potential and rate of generation of reactive oxygen species in hydrazine- and chloramphenicol-treated rat liver mitochondria. 1999 Arch. Biochem. Biophys. pmid:10334876
Miyake Y et al. Effect of treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on serum coenzyme Q10 in diabetic patients. 1999 Arzneimittelforschung pmid:10337451
Wang Q et al. Automated high-performance liquid chromatographic method with precolumn reduction for the determination of ubiquinol and ubiquinone in human plasma. 1999 J. Chromatogr. B Biomed. Sci. Appl. pmid:10348199
De Luca C et al. Blood antioxidant status and urinary levels of catecholamine metabolites in beta-thalassemia. 1999 Free Radic. Res. pmid:10400457
Blatt T et al. [Modulation of oxidative stresses in human aging skin]. 1999 Z Gerontol Geriatr pmid:10408011
Stojkovic M et al. Coenzyme Q(10) in submicron-sized dispersion improves development, hatching, cell proliferation, and adenosine triphosphate content of in vitro-produced bovine embryos. 1999 Biol. Reprod. pmid:10411538
Nakamura T et al. Metabolism of coenzyme Q10: biliary and urinary excretion study in guinea pigs. 1999 Biofactors pmid:10416022
Nohl H et al. Critical aspects of the antioxidant function of coenzyme Q in biomembranes. 1999 Biofactors pmid:10416027
Navarro F et al. Protective role of ubiquinone in vitamin E and selenium-deficient plasma membranes. 1999 Biofactors pmid:10416028
Lass A et al. Mitochondrial coenzyme Q content and aging. 1999 Biofactors pmid:10416032
Thomas SR et al. A role for reduced coenzyme Q in atherosclerosis? 1999 Biofactors pmid:10416033
Tomasetti M et al. Distribution of antioxidants among blood components and lipoproteins: significance of lipids/CoQ10 ratio as a possible marker of increased risk for atherosclerosis. 1999 Biofactors pmid:10416035
Rustin P et al. Quinone analogs prevent enzymes targeted in Friedreich ataxia from iron-induced injury in vitro. 1999 Biofactors pmid:10416037
Barbiroli B et al. Improved brain and muscle mitochondrial respiration with CoQ. An in vivo study by 31P-MR spectroscopy in patients with mitochondrial cytopathies. 1999 Biofactors pmid:10416038
Beal MF Coenzyme Q10 administration and its potential for treatment of neurodegenerative diseases. 1999 Biofactors pmid:10416039
Shults CW et al. A possible role of coenzyme Q10 in the etiology and treatment of Parkinson's disease. 1999 Biofactors pmid:10416040
Langsjoen PH and Langsjoen AM Overview of the use of CoQ10 in cardiovascular disease. 1999 Biofactors pmid:10416041
Munkholm H et al. Coenzyme Q10 treatment in serious heart failure. 1999 Biofactors pmid:10416042
Rosenfeldt FL et al. Coenzyme Q10 improves the tolerance of the senescent myocardium to aerobic and ischemic stress: studies in rats and in human atrial tissue. 1999 Biofactors pmid:10416043
Gvozdjáková A et al. Coenzyme Q10 depletion and mitochondrial energy disturbances in rejection development in patients after heart transplantation. 1999 Biofactors pmid:10416044
Niibori K et al. Bioenergetic effect of liposomal coenzyme Q10 on myocardial ischemia reperfusion injury. 1999 Biofactors pmid:10416045
Eriksson JG et al. The effect of coenzyme Q10 administration on metabolic control in patients with type 2 diabetes mellitus. 1999 Biofactors pmid:10416046
Pedersen HS et al. High serum coenzyme Q10, positively correlated with age, selenium and cholesterol, in Inuit of Greenland. A pilot study. 1999 Biofactors pmid:10416047
Svegliati Baroni S et al. Monounsaturated diet lowers LDL oxidisability in type IIb and type IV dyslipidemia without affecting coenzyme Q10 and vitamin E contents. 1999 Biofactors pmid:10416048
Huertas JR et al. Virgin olive oil and coenzyme Q10 protect heart mitochondria from peroxidative damage during aging. 1999 Biofactors pmid:10416050
Barbieri B et al. Coenzyme Q10 administration increases antibody titer in hepatitis B vaccinated volunteers--a single blind placebo-controlled and randomized clinical study. 1999 Biofactors pmid:10416052
Willis R et al. Clinical implications of the correlation between coenzyme Q10 and vitamin B6 status. 1999 Biofactors pmid:10416053
Hodges S et al. CoQ10: could it have a role in cancer management? 1999 Biofactors pmid:10416054
Hoppe U et al. Coenzyme Q10, a cutaneous antioxidant and energizer. 1999 Biofactors pmid:10416055
Memain N et al. [Greek, but Olympiad impossible]. 1999 Rev Med Interne pmid:10422163
Sacher HL et al. The clinical and hemodynamic effects of coenzyme Q10 in congestive cardiomyopathy. 1997 Feb-Mar Am J Ther pmid:10423594
Kommuru TR et al. Stability and bioequivalence studies of two marketed formulations of coenzyme Q10 in beagle dogs. 1999 Chem. Pharm. Bull. pmid:10434405
Nishimura T beta-Methyl-p-(123I)-iodophenyl pentadecanoic acid single-photon emission computed tomography in cardiomyopathy. 1999 Int J Card Imaging pmid:10453402
I have congestive heart failure. Should I try coenzyme Q-10? 1999 Johns Hopkins Med Lett Health After 50 pmid:10453715
Kucharská J et al. Participation of coenzyme Q10 in the rejection development of the transplanted heart: a clinical study. 1998 Physiol Res pmid:10453746
Zhou Q and Chan E Accuracy of repeated blood sampling in rats: a new technique applied in pharmacokinetic/pharmacodynamic studies of the interaction between warfarin and co-enzyme Q10. 1998 J Pharmacol Toxicol Methods pmid:10465153
Reichenbach J et al. Anti-oxidative capacity in patients with ataxia telangiectasia. 1999 Clin. Exp. Immunol. pmid:10469059
Gvozdjáková A et al. Captopril increased mitochondrial coenzyme Q10 level, improved respiratory chain function and energy production in the left ventricle in rabbits with smoke mitochondrial cardiomyopathy. 1999 Biofactors pmid:10475591
Proceedings of the 1st Conference of the International Coenzyme Q10 Association. Boston, Massachusetts, USA. May 1998. 1999 Biofactors pmid:10484626