Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

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What functions are associated with Coenzyme Q10?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

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What genes are associated with Coenzyme Q10?

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What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Rosenfeldt FL et al. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. 2007 J Hum Hypertens pmid:17287847
Liao P et al. [Effects of coenzyme Q10 supplementation on liver mitochondrial function and aerobic capacity in adolescent athletes]. 2007 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21180141
Diomedi-Camassei F et al. COQ2 nephropathy: a newly described inherited mitochondriopathy with primary renal involvement. 2007 J. Am. Soc. Nephrol. pmid:17855635
Schmelzer C et al. Influence of Coenzyme Q_{10} on release of pro-inflammatory chemokines in the human monocytic cell line THP-1. 2007 Biofactors pmid:18997284
Schmelzer C et al. Effects of Coenzyme Q10 on TNF-alpha secretion in human and murine monocytic cell lines. 2007 Biofactors pmid:18806307
Littarru GP and Tiano L Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. 2007 Mol. Biotechnol. pmid:17914161
Young JM et al. Effect of coenzyme Q(10) supplementation on simvastatin-induced myalgia. 2007 Am. J. Cardiol. pmid:17950797
Molfino A et al. Statins, coenzyme Q10, and cachexia: what's the link? 2007 Am. J. Cardiol. pmid:17950821
Brown RS One doctor's opinion of new age concepts. 2007 Dent Today pmid:17955857
Witort EJ et al. Autologous lipofilling: coenzyme Q10 can rescue adipocytes from stress-induced apoptotic death. 2007 Plast. Reconstr. Surg. pmid:17496590
Cluis CP et al. Current prospects for the production of coenzyme Q10 in microbes. 2007 Trends Biotechnol. pmid:17935805
Sahach VF et al. [Inhibition of mitochondrial permeability transition pore is one of the mechanisms of cardioprotective effect of coenzyme Q10]. 2007 Fiziol Zh pmid:17902369
Constantinescu R et al. A randomized study of the bioavailability of different formulations of coenzyme Q(10) (ubiquinone). 2007 J Clin Pharmacol pmid:17925590
Mollet J et al. Prenyldiphosphate synthase, subunit 1 (PDSS1) and OH-benzoate polyprenyltransferase (COQ2) mutations in ubiquinone deficiency and oxidative phosphorylation disorders. 2007 J. Clin. Invest. pmid:17332895
Shah SA et al. Electrocardiographic and hemodynamic effects of coenzyme Q10 in healthy individuals: a double-blind, randomized controlled trial. 2007 Ann Pharmacother pmid:17341532
Xia S et al. Effect of coenzyme Q(10) incorporation on the characteristics of nanoliposomes. 2007 J Phys Chem B pmid:17288474
Wu KL et al. Impairment of the mitochondrial respiratory enzyme activity triggers sequential activation of apoptosis-inducing factor-dependent and caspase-dependent signaling pathways to induce apoptosis after spinal cord injury. 2007 J. Neurochem. pmid:17298387
Hargreaves IP et al. Inhibition of mitochondrial complex IV leads to secondary loss complex II-III activity: implications for the pathogenesis and treatment of mitochondrial encephalomyopathies. 2007 Mitochondrion pmid:17395552
Hyun DH et al. Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria. 2007 J. Neurochem. pmid:17250676
López-Martín JM et al. Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis. 2007 Hum. Mol. Genet. pmid:17374725
van Dalen EC et al. Prevention of anthracycline-induced cardiotoxicity in children: the evidence. 2007 Eur. J. Cancer pmid:17383867
Since my heart attack two years ago I have been taking a stain and my cholesterol numbers are excellent. My chiropractor suggests I also should be taking CoQ10 for even better cholesterol health. Does that make sense? 2007 Duke Med Health News pmid:17299892
Hershey AD et al. Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. 2007 Headache pmid:17355497
Zhu J et al. Simultaneous reduction of iron-sulfur protein and cytochrome b(L) during ubiquinol oxidation in cytochrome bc(1) complex. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17360398
Geng A et al. Effects of dietary L-carnitine and coenzyme Q10 at different supplemental ages on growth performance and some immune response in ascites-susceptible broilers. 2007 Arch Anim Nutr pmid:17361948
Hasan SM et al. Oxidative stress alters physiological and morphological neuronal properties. 2007 Neurochem. Res. pmid:17390220
Kaufmann P et al. Excellent inter-rater, intra-rater, and telephone-administered reliability of the ALSFRS-R in a multicenter clinical trial. 2007 Amyotroph Lateral Scler pmid:17364435
Ohno K and Ohashi T [Diagnosis and treatment of hereditary neurological disorders during childhood]. 2007 No To Hattatsu pmid:17370634
de Lau LM et al. Serum cholesterol, use of lipid-lowering drugs, and risk of Parkinson disease. 2007 Mov. Disord. pmid:17557354
Cadoni G et al. Coenzyme Q 10 and cardiovascular risk factors in idiopathic sudden sensorineural hearing loss patients. 2007 Otol. Neurotol. pmid:17558340
Bolcal C et al. Do N-acetylcystein, beta-glucan, and coenzyme Q10 mollify myocardial ischemia-reperfusion injury? 2007 Heart Surg Forum pmid:17599896
Bhandari KH et al. Preparation, characterization and evaluation of coenzyme Q10 binary solid dispersions for enhanced solubility and dissolution. 2007 Biol. Pharm. Bull. pmid:17541177
Rahman S and Hargreaves IP Allogeneic stem cell transplantation corrects biochemical derangements in MNGIE. 2007 Neurology pmid:17515557
Premkumar VG et al. Serum cytokine levels of interleukin-1beta, -6, -8, tumour necrosis factor-alpha and vascular endothelial growth factor in breast cancer patients treated with tamoxifen and supplemented with co-enzyme Q(10), riboflavin and niacin. 2007 Basic Clin. Pharmacol. Toxicol. pmid:17516992
Morré DJ et al. ECTO-NOX target for the anticancer isoflavene phenoxodiol. 2007 Oncol. Res. pmid:17518268
de Luca C et al. Beneficial effects of pro-/antioxidant-based nutraceuticals in the skin rejuvenation techniques. 2007 Cell. Mol. Biol. (Noisy-le-grand) pmid:17519117
Rusciani L et al. Recombinant interferon alpha-2b and coenzyme Q10 as a postsurgical adjuvant therapy for melanoma: a 3-year trial with recombinant interferon-alpha and 5-year follow-up. 2007 Melanoma Res. pmid:17505263
Rötig A et al. Infantile and pediatric quinone deficiency diseases. 2007 Mitochondrion pmid:17442627
Hargreaves IP Coenzyme Q10 in phenylketonuria and mevalonic aciduria. 2007 Mitochondrion pmid:17442628
Miles MV The uptake and distribution of coenzyme Q10. 2007 Mitochondrion pmid:17446143
Kalenikova EI et al. Chronic administration of coenzyme Q10 limits postinfarct myocardial remodeling in rats. 2007 Biochemistry Mosc. pmid:17447888
Littarru GP and Langsjoen P Coenzyme Q10 and statins: biochemical and clinical implications. 2007 Mitochondrion pmid:17482884
Bhagavan HN and Chopra RK Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. 2007 Mitochondrion pmid:17482886
Linnane AW et al. Coenzyme Q(10)--its role as a prooxidant in the formation of superoxide anion/hydrogen peroxide and the regulation of the metabolome. 2007 Mitochondrion pmid:17482887
Pepe S et al. Coenzyme Q10 in cardiovascular disease. 2007 Mitochondrion pmid:17485243
Cooper JM and Schapira AH Friedreich's ataxia: coenzyme Q10 and vitamin E therapy. 2007 Mitochondrion pmid:17485244
Haas RH The evidence basis for coenzyme Q therapy in oxidative phosphorylation disease. 2007 Mitochondrion pmid:17485245
Barshop BA and Gangoiti JA Analysis of coenzyme Q in human blood and tissues. 2007 Mitochondrion pmid:17485249
Carrozzo R et al. Infantile mitochondrial disorders. 2007 Biosci. Rep. pmid:17486440
Martin SF et al. Coenzyme Q and protein/lipid oxidation in a BSE-infected transgenic mouse model. 2007 Free Radic. Biol. Med. pmid:17462540
Yuvaraj S et al. Ameliorating effect of coenzyme Q10, riboflavin and niacin in tamoxifen-treated postmenopausal breast cancer patients with special reference to lipids and lipoproteins. 2007 Clin. Biochem. pmid:17425952
Ankola DD et al. Development of potent oral nanoparticulate formulation of coenzyme Q10 for treatment of hypertension: can the simple nutritional supplements be used as first line therapeutic agents for prophylaxis/therapy? 2007 Eur J Pharm Biopharm pmid:17452099
Caso G et al. Effect of coenzyme q10 on myopathic symptoms in patients treated with statins. 2007 Am. J. Cardiol. pmid:17493470
Rodriguez MC et al. Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders. 2007 Muscle Nerve pmid:17080429
Storch A et al. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease. 2007 Arch. Neurol. pmid:17502459
Bolcal C et al. Protective effects of antioxidant medications on limb ischemia reperfusion injury. 2007 J. Surg. Res. pmid:17349658
Cosmeceuticals. A reality check on anti-wrinkle products. 2007 Mayo Clin Womens Healthsource pmid:17476178
Niklowitz P et al. Enrichment of coenzyme Q10 in plasma and blood cells: defense against oxidative damage. 2007 Int. J. Biol. Sci. pmid:17479158
Ha SJ et al. Controlling the sucrose concentration increases Coenzyme Q10 production in fed-batch culture of Agrobacterium tumefaciens. 2007 Appl. Microbiol. Biotechnol. pmid:17479258
van der Merwe J et al. Antioxidant therapy for severe cardiac failure induced by iron overload secondary to dyserythropoietic anaemia. 2007 Heart Lung Circ pmid:17314073
Gempel K et al. The myopathic form of coenzyme Q10 deficiency is caused by mutations in the electron-transferring-flavoprotein dehydrogenase (ETFDH) gene. 2007 Brain pmid:17412732
Hellsten Y et al. Antioxidant supplementation enhances the exercise-induced increase in mitochondrial uncoupling protein 3 and endothelial nitric oxide synthase mRNA content in human skeletal muscle. 2007 Free Radic. Biol. Med. pmid:17602951
Coenzyme Q10. Monograph. 2007 Altern Med Rev pmid:17604461
Singh U et al. Coenzyme Q10 supplementation and heart failure. 2007 Nutr. Rev. pmid:17605305
Houston MC Treatment of hypertension with nutraceuticals, vitamins, antioxidants and minerals. 2007 Expert Rev Cardiovasc Ther pmid:17605647
Wada H et al. Redox status of coenzyme Q10 is associated with chronological age. 2007 J Am Geriatr Soc pmid:17608895
Tavintharan S et al. Reduced mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: a possible role in statin-induced hepatotoxicity? 2007 Toxicol. Appl. Pharmacol. pmid:17610923
Nukui K et al. Comparison of uptake between PureSorb-Q40 and regular hydrophobic coenzyme Q10 in rats and humans after single oral intake. 2007 J. Nutr. Sci. Vitaminol. pmid:17616008
Nakanishi M et al. Images in cardiovascular medicine. Mitochondrial cardiomyopathy evaluated with cardiac magnetic resonance. 2007 Circulation pmid:17620516
Ochiai A et al. Improvement in intestinal coenzyme q10 absorption by food intake. 2007 Yakugaku Zasshi pmid:17666877
Galili N et al. Clinical response of myelodysplastic syndromes patients to treatment with coenzyme Q10. 2007 Leuk. Res. pmid:17064768
Ha SJ et al. Optimization of culture conditions and scale-up to pilot and plant scales for coenzyme Q10 production by Agrobacterium tumefaciens. 2007 Appl. Microbiol. Biotechnol. pmid:17124579
Niklowitz P et al. Coenzyme Q10 concentration in the plasma of children suffering from acute lymphoblastic leukaemia before and during induction treatment. 2007 Biofactors pmid:17673825
Mikashinovich ZI et al. [Effect of biologically active food supplement coenzyme Q10 on metabolic processes in the myocardium of rats kept in different temperature conditions]. 2007 Vopr Pitan pmid:17674515
Tiano L et al. Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study. 2007 Eur. Heart J. pmid:17644511
Bhagavan HN et al. Assessment of coenzyme Q10 absorption using an in vitro digestion-Caco-2 cell model. 2007 Int J Pharm pmid:17092667
Vladutiu G Statin-induced adverse effects and malignant hyperthermia susceptibility: comment on the article by Guis et al. 2007 Arthritis Rheum. pmid:17266123
Lankin VZ et al. Mechanisms of oxidative modification of low density lipoproteins under conditions of oxidative and carbonyl stress. 2007 Biochemistry Mosc. pmid:18021066
Ono K and Yamada M Vitamin A potently destabilizes preformed alpha-synuclein fibrils in vitro: implications for Lewy body diseases. 2007 Neurobiol. Dis. pmid:17169566
Miles MV et al. Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21. 2007 Pediatr. Neurol. pmid:18021919
Bunaciu AA et al. FT-IR spectrophotometric analysis of coenzyme Q10 (CoQ10) and its pharmaceutical formulations. 2007 Prep. Biochem. Biotechnol. pmid:17134983
Ochoa JJ et al. Effect of lifelong coenzyme Q10 supplementation on age-related oxidative stress and mitochondrial function in liver and skeletal muscle of rats fed on a polyunsaturated fatty acid (PUFA)-rich diet. 2007 J. Gerontol. A Biol. Sci. Med. Sci. pmid:18000140
Seo MJ et al. Increase of CoQ10 production level by the coexpression of decaprenyl Diphosphate synthase and 1-deoxy-D-xylulose 5-phosphate synthase isolated from Rhizobium radiobacter ATCC 4718 in recombinant Escherichia coli. 2007 J. Microbiol. Biotechnol. pmid:18050926
Haleng J et al. [Oxidative stress]. 2007 Rev Med Liege pmid:18069575
Khan M et al. Coenzyme Q10 does not protect cochlear hair cells from death in the ischemic organotypic culture. 2007 Otolaryngol Head Neck Surg pmid:18036427
Fehér J et al. [Metabolic therapy for early treatment of age-related macular degeneration]. 2007 Orv Hetil pmid:18039616
Zhipeng W et al. Toxicity of coenzyme Q(10): a report of 90-day repeated dose toxicity study in rats. 2007 J Toxicol Sci pmid:18198482
Kon M et al. Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats. 2007 Exerc Immunol Rev pmid:18198662
Schapira AH Future directions in the treatment of Parkinson's disease. 2007 Mov. Disord. pmid:18175401
Nuku K et al. Safety assessment of PureSorb-Q40 in healthy subjects and serum coenzyme Q10 level in excessive dosing. 2007 J. Nutr. Sci. Vitaminol. pmid:17874823
Schmelzer C et al. Functional connections and pathways of coenzyme Q10-inducible genes: an in-silico study. 2007 IUBMB Life pmid:17852568
Aeby A et al. Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency. 2007 J. Inherit. Metab. Dis. pmid:17703371
Lipshutz BH et al. Enhancing regiocontrol in carboaluminations of terminal alkynes. Application to the one-pot synthesis of coenzyme Q10. 2007 Org. Lett. pmid:17705500
Rákóczi K et al. [Statin drugs decrease the plasma level of coenzyme Q10 (ubiquinone) in the organism]. 2007 Ideggyogy Sz pmid:17713110
Shalansky S et al. Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with complementary and alternative medicine: a longitudinal analysis. 2007 Pharmacotherapy pmid:17723077
Lu J and Frank EL Measurement of coenzyme Q10 in clinical practice. 2007 Clin. Chim. Acta pmid:17689513
Kucharská J et al. Simvastatin decreased coenzyme Q in the left ventricle and skeletal muscle but not in the brain and liver in L-NAME-induced hypertension. 2007 Physiol Res pmid:17824807
Tsuneki H et al. Coenzyme Q10 prevents high glucose-induced oxidative stress in human umbilical vein endothelial cells. 2007 Eur. J. Pharmacol. pmid:17434478
Oztay F et al. Effects of coenzyme Q10 on the heart ultrastructure and nitric oxide synthase during hyperthyroidism. 2007 Chin J Physiol pmid:18274157
Le Ber I et al. Muscle coenzyme Q10 deficiencies in ataxia with oculomotor apraxia 1. 2007 Neurology pmid:17242337