Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

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What functions are associated with Coenzyme Q10?


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What lipids are associated with Coenzyme Q10?

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What genes are associated with Coenzyme Q10?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Rosenthal W and Brumhard M [Coenzyme Q10]. 1997 Dtsch. Med. Wochenschr. pmid:9102295
Fallon J et al. MPP+ produces progressive neuronal degeneration which is mediated by oxidative stress. 1997 Exp. Neurol. pmid:9126170
Weber C et al. The coenzyme Q10 content of the average Danish diet. 1997 Int J Vitam Nutr Res pmid:9129255
Sobreira C et al. Mitochondrial encephalomyopathy with coenzyme Q10 deficiency. 1997 Neurology pmid:9153450
Herschfus JA Prognostic implications of elevated creatine kinase after coronary angioplasty. 1997 JAMA pmid:9168284
Gómez-Díaz C et al. Ascorbate stabilization is stimulated in rho(0)HL-60 cells by CoQ10 increase at the plasma membrane. 1997 Biochem. Biophys. Res. Commun. pmid:9168964
Kim Y et al. Therapeutic effect of co-enzyme Q10 on idiopathic dilated cardiomyopathy: assessment by iodine-123 labelled 15-(p-iodophenyl)-3(R,S)-methylpentadecanoic acid myocardial single-photon emission tomography. 1997 Eur J Nucl Med pmid:9169569
Folkers K et al. Activities of vitamin Q10 in animal models and a serious deficiency in patients with cancer. 1997 Biochem. Biophys. Res. Commun. pmid:9177262
Ozawa S et al. Role of PSII-L protein (psbL gene product) on the electron transfer in photosystem II complex. 1. Over-production of wild-type and mutant versions of PSII-L protein and reconstitution into the PSII core complex. 1997 Plant Mol. Biol. pmid:9177321
Ren S and Lien EJ Natural products and their derivatives as cancer chemopreventive agents. 1997 Prog Drug Res pmid:9204686
Chen RS et al. Coenzyme Q10 treatment in mitochondrial encephalomyopathies. Short-term double-blind, crossover study. 1997 Eur. Neurol. pmid:9208260
Neuzil J et al. Alpha-tocopheryl hydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low density lipoprotein lipids. 1997 Proc. Natl. Acad. Sci. U.S.A. pmid:9223282
Human JA et al. The effect of Simvastatin on the plasma antioxidant concentrations in patients with hypercholesterolaemia. 1997 Clin. Chim. Acta pmid:9247729
Ubiquinone--the everywhere nutrient. 1997 J Am Optom Assoc pmid:9248256
Cleary J et al. Plasma and LDL levels of major lipophilic antioxidants are similar in patients with advanced atherosclerosis and age-matched controls. 1997 Free Radic. Res. pmid:9257129
Lenaz G et al. Coenzyme Q deficiency in mitochondria: kinetic saturation versus physical saturation. 1997 Mol. Aspects Med. pmid:9266503
Ruuge EK et al. The redox state of coenzyme Q10 in mitochondrial respiratory chain and oxygen-derived free radical generation in cardiac cells. 1997 Mol. Aspects Med. pmid:9266505
Wakabayashi T et al. Suppression of the formation of megamitochondria by scavengers for free radicals. 1997 Mol. Aspects Med. pmid:9266506
Yamamoto Y and Yamashita S Plasma ratio of ubiquinol and ubiquinone as a marker of oxidative stress. 1997 Mol. Aspects Med. pmid:9266509
Alleva R et al. Oxidation of LDL and their subfractions: kinetic aspects and CoQ10 content. 1997 Mol. Aspects Med. pmid:9266511