Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

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What functions are associated with Coenzyme Q10?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

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What genes are associated with Coenzyme Q10?

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What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Perumal SS et al. Augmented efficacy of tamoxifen in rat breast tumorigenesis when gavaged along with riboflavin, niacin, and CoQ10: effects on lipid peroxidation and antioxidants in mitochondria. 2005 Chem. Biol. Interact. pmid:15766922
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Hoenjet KM et al. Effect of a nutritional supplement containing vitamin E, selenium, vitamin c and coenzyme Q10 on serum PSA in patients with hormonally untreated carcinoma of the prostate: a randomised placebo-controlled study. 2005 Eur. Urol. pmid:15774238
Baker SK Molecular clues into the pathogenesis of statin-mediated muscle toxicity. 2005 Muscle Nerve pmid:15712281
Bentler SE et al. Prospective observational study of treatments for unexplained chronic fatigue. 2005 J Clin Psychiatry pmid:15889950
Bhagavan HN and Chopra RK Potential role of ubiquinone (coenzyme Q10) in pediatric cardiomyopathy. 2005 Clin Nutr pmid:15896419
DÅ‚ugosz A et al. Styrene and ethylene glycol have a synergetic effect on lipid peroxidation that is better protected than repaired by CoQ10. 2005 Toxicol In Vitro pmid:15896551
Ashida Y et al. CoQ10 supplementation elevates the epidermal CoQ10 level in adult hairless mice. 2005 Biofactors pmid:16873943
Blatt T et al. Stimulation of skin's energy metabolism provides multiple benefits for mature human skin. 2005 Biofactors pmid:16873944
Mancini A et al. Coenzyme Q10 evaluation in pituitary-adrenal axis disease: preliminary data. 2005 Biofactors pmid:16873946
Mancini A et al. Relationships between plasma CoQ10 levels and thyroid hormones in chronic obstructive pulmonary disease. 2005 Biofactors pmid:16873947
Sekine K et al. Estimation of plasma and saliva levels of coenzyme Q10 and influence of oral supplementation. 2005 Biofactors pmid:16873948
Battino M et al. Antioxidant status (CoQ10 and Vit. E levels) and immunohistochemical analysis of soft tissues in periodontal diseases. 2005 Biofactors pmid:16873949
Singh RB et al. Effect on absorption and oxidative stress of different oral Coenzyme Q10 dosages and intake strategy in healthy men. 2005 Biofactors pmid:16873950
Moreira PI et al. CoQ10 therapy attenuates amyloid beta-peptide toxicity in brain mitochondria isolated from aged diabetic rats. 2005 Exp. Neurol. pmid:16126199
Ochoa JJ et al. Coenzyme Q10 protects from aging-related oxidative stress and improves mitochondrial function in heart of rats fed a polyunsaturated fatty acid (PUFA)-rich diet. 2005 J. Gerontol. A Biol. Sci. Med. Sci. pmid:16127098
Kremer HP Imaging Huntington's disease (HD) brains--imagine HD trials! 2005 J. Neurol. Neurosurg. Psychiatr. pmid:15834014
Abela D et al. Maternal antioxidant supplementation does not reduce the incidence of phenytoin-induced cleft lip and related malformations in rats. 2005 Birth Defects Res. B Dev. Reprod. Toxicol. pmid:15834897
Forgionne GA Bovine cartilage, coenzyme Q10, and wheat grass therapy for primary peritoneal cancer. 2005 J Altern Complement Med pmid:15750376
Fricker J Heart of the matter. 2004 Nov 3-9 Nurs Stand pmid:15552463
Chung MK Vitamins, supplements, herbal medicines, and arrhythmias. 2004 Mar-Apr Cardiol Rev pmid:14766022
Nutrition and herbs. Cholesterol drug side effects may be linked to low nutrient levels. 2004 Jun-Jul TreatmentUpdate pmid:17219673
Berbel-Garcia A et al. Coenzyme Q 10 improves lactic acidosis, strokelike episodes, and epilepsy in a patient with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes). 2004 Jul-Aug Clin Neuropharmacol pmid:15319706
Jones K et al. Coenzyme Q-10 and cardiovascular health. 2004 Jan-Feb Altern Ther Health Med pmid:14727496
Ebadi M et al. Coenzyme Q10 inhibits mitochondrial complex-1 down-regulation and nuclear factor-kappa B activation. 2004 Apr-Jun J. Cell. Mol. Med. pmid:15256069
Lee CK et al. The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice. 2004 Free Radic. Biol. Med. pmid:15059645
Kong WJ et al. [Protective roles of vitamin E and coenzyme Q10 in the inner ear mitochondrial DNA 4834 bp deletion mutation of rats]. 2004 Zhonghua Er Bi Yan Hou Ke Za Zhi pmid:15813010
Murashima M et al. Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one-week intake of broccoli sprouts. 2004 Biofactors pmid:15630296
Otrocka-Domagała I et al. The effect of coenzyme Q10 and vitamin E on the regeneration of skeletal muscles in pigs. 2004 Pol J Vet Sci pmid:15633790
Ohta H et al. Sphingomonas oligophenolica sp. nov., a halo- and organo-sensitive oligotrophic bacterium from paddy soil that degrades phenolic acids at low concentrations. 2004 Int. J. Syst. Evol. Microbiol. pmid:15545456
Rapoport AM and Bigal ME Preventive migraine therapy: what is new. 2004 Neurol. Sci. pmid:15549532
Ulm G [Differential therapy of advanced Parkinson's disease with special reference to complementary therapeutic approaches]. 2004 Praxis (Bern 1994) pmid:15571302
Glatthaar-Saalmüller B et al. [Influence of homeopathically processed coenzyme q10 on proliferation and redifferentiation of endothelial cells]. 2004 Forsch Komplementarmed Klass Naturheilkd pmid:15572867
Ernst A et al. Antioxidants effectively prevent oxidation-induced protein damage in OLN 93 cells. 2004 Arch. Biochem. Biophys. pmid:14678784
Starkov AA et al. Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. 2004 J. Neurosci. pmid:15356189
Palan PR et al. Lipid-soluble antioxidants and pregnancy: maternal serum levels of coenzyme Q10, alpha-tocopherol and gamma-tocopherol in preeclampsia and normal pregnancy. 2004 Gynecol. Obstet. Invest. pmid:14988604
Palamakula A and Khan MA Evaluation of cytotoxicity of oils used in coenzyme Q10 Self-emulsifying Drug Delivery Systems (SEDDS). 2004 Int J Pharm pmid:15010131
Battino M et al. High-performance liquid chromatography-EC assay of mitochondrial coenzyme Q9, coenzyme Q9H2, coenzyme Q10, coenzyme Q10H2, and vitamin E with a simplified on-line solid-phase extraction. 2004 Meth. Enzymol. pmid:15038966
Chew GT and Watts GF Coenzyme Q10 and diabetic endotheliopathy: oxidative stress and the 'recoupling hypothesis'. 2004 QJM pmid:15256611
Tang PH et al. Measurement of reduced and oxidized coenzyme Q9 and coenzyme Q10 levels in mouse tissues by HPLC with coulometric detection. 2004 Clin. Chim. Acta pmid:14967174
Artuch R et al. A longitudinal study of antioxidant status in phenylketonuric patients. 2004 Clin. Biochem. pmid:14972641
Matsuura K et al. Dioxygen reduction by bo-type quinol oxidase from Escherichia coli studied by submillisecond-resolved freeze-quench EPR spectroscopy. 2004 Biochemistry pmid:14979725
Chow CK Dietary coenzyme Q10 and mitochondrial status. 2004 Meth. Enzymol. pmid:15047099
Beal MF Therapeutic effects of coenzyme Q10 in neurodegenerative diseases. 2004 Meth. Enzymol. pmid:15047118
Sharma S et al. Neuroprotective actions of coenzyme Q10 in Parkinson's disease. 2004 Meth. Enzymol. pmid:15047119
Czap A A patented double dilemma. 2004 Altern Med Rev pmid:15005640
Gironi M et al. Late-onset cerebellar ataxia with hypogonadism and muscle coenzyme Q10 deficiency. 2004 Neurology pmid:15007142
Palamakula A et al. Response surface methodology for optimization and characterization of limonene-based coenzyme Q10 self-nanoemulsified capsule dosage form. 2004 AAPS PharmSciTech pmid:15760063
Ludwig LM et al. Preconditioning by isoflurane is mediated by reactive oxygen species generated from mitochondrial electron transport chain complex III. 2004 Anesth. Analg. pmid:15502022
Mabuchi H et al. Effects of an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase on serum lipoproteins and ubiquinone-10 levels in patients with familial hypercholesterolemia. 1981. 2004 Atheroscler Suppl pmid:15531275
Silver MA et al. Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction. 2004 Am. J. Cardiol. pmid:15541254
Fahn S ALS lessons learned from other neurological diseases. Parkinson's disease. 2004 Amyotroph. Lateral Scler. Other Motor Neuron Disord. pmid:15512865
Shavali S et al. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline, a Parkinsonism-inducing endogenous toxin, increases alpha-synuclein expression and causes nuclear damage in human dopaminergic cells. 2004 J. Neurosci. Res. pmid:15114628
Conklin KA Cancer chemotherapy and antioxidants. 2004 J. Nutr. pmid:15514307
Roffe L et al. Efficacy of coenzyme Q10 for improved tolerability of cancer treatments: a systematic review. 2004 J. Clin. Oncol. pmid:15514384
McCarthy S et al. Paraquat induces oxidative stress and neuronal cell death; neuroprotection by water-soluble Coenzyme Q10. 2004 Toxicol. Appl. Pharmacol. pmid:15519605
Menke T et al. Comparison of coenzyme Q10 plasma levels in obese and normal weight children. 2004 Clin. Chim. Acta pmid:15469864
DÅ‚ugosz A et al. Oxidative stress and coenzyme Q10 supplementation in renal transplant recipients. 2004 Int Urol Nephrol pmid:15368706
Sinatra ST Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study. 2004 Clin Cardiol pmid:15553298
Menke T et al. Plasma levels and redox status of coenzyme Q10 in infants and children. 2004 Biofactors pmid:15665387
Geng A et al. Effects of dietary L-carnitine and coenzyme Q10 supplementation on performance and ascites mortality of broilers. 2004 Arch Anim Nutr pmid:15732580
L'Her E and Sebert P Effects of dichloroacetate and ubiquinone infusions on glycolysis activity and thermal sensitivity during sepsis. 2004 J. Lab. Clin. Med. pmid:15192651
Al-Thakafy HS et al. Alterations of erythrocyte free radical defense system, heart tissue lipid peroxidation, and lipid concentration in streptozotocin-induced diabetic rats under coenzyme Q10 supplementation. 2004 Saudi Med J pmid:15711648
Sato S et al. Changes of plasma coenzyme Q10 levels in early infancy. 2004 Redox Rep. pmid:15606982
Molyneux S et al. The bioavailability of coenzyme Q10 supplements available in New Zealand differs markedly. 2004 N. Z. Med. J. pmid:15477929
Winston GW et al. Antioxidants and total oxyradical scavenging capacity during grass shrimp, Palaemonetes pugio, embryogenesis. 2004 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:15683839
Shults CW et al. Measuring the effects of therapy in Parkinson disease. 2004 JAMA pmid:15161889
Gorelick C et al. Coenzyme Q10 and lipid-related gene induction in HeLa cells. 2004 Am. J. Obstet. Gynecol. pmid:15167860
Berman M et al. Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study. 2004 Clin Cardiol pmid:15188947
Beal MF Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment. 2004 J. Bioenerg. Biomembr. pmid:15377876
Sohmiya M et al. Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease. 2004 J. Neurol. Sci. pmid:15337618
Steele PE et al. Clinical laboratory monitoring of coenzyme Q10 use in neurologic and muscular diseases. 2004 Am. J. Clin. Pathol. pmid:15298157
Miles MV et al. Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adults. 2004 Clin. Chim. Acta pmid:15313151
Jones DL and Greenaway TM Beware the thin, deaf 'type 2' diabetic: maternally inherited diabetes and deafness with systemic (mitochondrial) manifestations. 2004 Intern Med J pmid:15317555
Yalcin A et al. Coenzyme Q10 concentrations in coronary artery disease. 2004 Clin. Biochem. pmid:15302616
Yalcin A et al. Effect of melatonin cotreatment against kainic acid on coenzyme Q10, lipid peroxidation and Trx mRNA in rat hippocampus. 2004 Int. J. Neurosci. pmid:15370175
Wang XL et al. Cosupplementation with vitamin E and coenzyme Q10 reduces circulating markers of inflammation in baboons. 2004 Am. J. Clin. Nutr. pmid:15321805
Kitano M et al. 28-Day repeated dose toxicity study of dried microorganism in rats. 2004 Food Chem. Toxicol. pmid:15350679
Shults CW et al. Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease. 2004 Exp. Neurol. pmid:15246848
Rundek T et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. 2004 Arch. Neurol. pmid:15210526
Compagnoni G et al. CoQ10 plasmatic levels in breast-fed infants compared to formula-fed infants. 2004 Biol. Neonate pmid:15237239
Gille G et al. Oxidative stress to dopaminergic neurons as models of Parkinson's disease. 2004 Ann. N. Y. Acad. Sci. pmid:15240412
Bianchi A et al. Role of magnesium, coenzyme Q10, riboflavin, and vitamin B12 in migraine prophylaxis. 2004 Vitam. Horm. pmid:15196887
Schilling G et al. Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice. 2004 Exp. Neurol. pmid:15081595
Damian MS Neuroprotection becomes reality: changing times for cerebral resuscitation. 2004 Adv. Exp. Med. Biol. pmid:15053432
Marriage BJ et al. Cofactor treatment improves ATP synthetic capacity in patients with oxidative phosphorylation disorders. 2004 Mol. Genet. Metab. pmid:15059613
Winkler-Stuck K et al. Effect of coenzyme Q10 on the mitochondrial function of skin fibroblasts from Parkinson patients. 2004 J. Neurol. Sci. pmid:15140604
Miles MV et al. Coenzyme Q10 changes are associated with metabolic syndrome. 2004 Clin. Chim. Acta pmid:15149886
Artuch R et al. Cerebrospinal fluid concentrations of idebenone in Friedreich ataxia patients. 2004 Neuropediatrics pmid:15127307
Wilburn AJ et al. The natural treatment of hypertension. 2004 J Clin Hypertens (Greenwich) pmid:15133406
Jiang P et al. Analysis of coenzyme Q(10) in human plasma by column-switching liquid chromatography. 2004 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:15135104
Ornato JP Questions & answers. I take a statin to lower my LDL (bad) cholesterol level, but I've heard statins inhibit the production of coenzyme Q10 (CoQ10). Should I take a CoQ10 supplement? 2004 Health News pmid:15088591
Salardi S et al. High glucose levels induce an increase in membrane antioxidants, in terms of vitamin E and coenzyme Q10, in children and adolescents with type 1 diabetes. 2004 Diabetes Care pmid:14747266
Migliore L et al. Evaluation of cytogenetic and DNA damage in mitochondrial disease patients: effects of coenzyme Q10 therapy. 2004 Mutagenesis pmid:14681312
Simko F et al. Effect of simvastatin on remodeling of the left ventricle and aorta in L-NAME-induced hypertension. 2004 Life Sci. pmid:14697405
Schapira AH and Olanow CW Neuroprotection in Parkinson disease: mysteries, myths, and misconceptions. 2004 JAMA pmid:14734599
Hansen G et al. Sensitive and selective analysis of coenzyme Q10 in human serum by negative APCI LC-MS. 2004 Analyst pmid:14737582
Balercia G et al. Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. 2004 Fertil. Steril. pmid:14711549
Karpińska J and Mularczyk B The analysis of the zero-order and the second derivative spectra of retinol acetate, tocopherol acetate and coenzyme Q10 and estimation of their analytical usefulness for their simultaneous determination in synthetic mixtures and pharmaceuticals. 2004 Spectrochim Acta A Mol Biomol Spectrosc pmid:15249004
Rosenfeldt F et al. Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological age. 2004 Ann. N. Y. Acad. Sci. pmid:15246998