Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

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What functions are associated with Coenzyme Q10?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

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What genes are associated with Coenzyme Q10?

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What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Mourier A et al. Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. 2015 J. Cell Biol. pmid:25688136
Staffa P et al. Activity of coenzyme Q 10 (Q-Ter multicomposite) on recovery time in noise-induced hearing loss. 2014 Sep-Oct Noise Health pmid:25209035
Maheshwari RA et al. Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats. 2014 Nov-Dec Indian J Pharmacol pmid:25538335
Ruscica M et al. Nutraceutical approach to moderate cardiometabolic risk: results of a randomized, double-blind and crossover study with Armolipid Plus. 2014 Jan-Feb J Clin Lipidol pmid:24528686
Kosmas CE et al. Statin-mediated low-density lipoprotein lowering in chronic congestive heart failure. 2014 Am. J. Med. Sci. pmid:23154655
Bentinger M et al. Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis. 2014 Biochim. Biophys. Acta pmid:24747199
García Verazaluce JJ et al. [Effect of phlebodium decumanum and coenzyme Q10 on sports performance in professional volleyball players]. 2014 Nutr Hosp pmid:25561135
Yubero D et al. Association between coenzyme Q10 and glucose transporter (GLUT1) deficiency. 2014 BMC Pediatr pmid:25381171
Skarlovnik A et al. Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study. 2014 Med. Sci. Monit. pmid:25375075
Holyoak AL et al. Toxic leukoencephalopathy in the intensive care unit. 2014 Anaesth Intensive Care pmid:25342412
Soleimani M et al. Effects of coenzyme Q10 on the ratio of TH1/TH2 in experimental autoimmune encephalomyelitis model of multiple sclerosis in C57BL/6. 2014 Iran. Biomed. J. pmid:25326018
Agrawal A and Prakash YS Obesity, metabolic syndrome, and airway disease: a bioenergetic problem? 2014 Immunol Allergy Clin North Am pmid:25282291
Durán-Prado M et al. Coenzyme Q10 protects human endothelial cells from β-amyloid uptake and oxidative stress-induced injury. 2014 PLoS ONE pmid:25272163
Shetty RA et al. Coenzyme Q10 and α-tocopherol reversed age-associated functional impairments in mice. 2014 Exp. Gerontol. pmid:25149567
Buján N et al. Characterization of CoQ₁₀ biosynthesis in fibroblasts of patients with primary and secondary CoQ₁₀ deficiency. 2014 J. Inherit. Metab. Dis. pmid:23774949
Nakagawa K et al. Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice. 2014 PLoS ONE pmid:25127365
Oropesa-Ávila M et al. Stabilization of apoptotic cells: generation of zombie cells. 2014 Cell Death Dis pmid:25118929
Ari C et al. Metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in amyotrophic lateral sclerosis (ALS) mouse model. 2014 PLoS ONE pmid:25061944
Ma D et al. Inhibition of stress induced premature senescence in presenilin-1 mutated cells with water soluble Coenzyme Q10. 2014 Mitochondrion pmid:25034304
Matsuzaki M et al. Effects of lifestyle factors on urinary oxidative stress and serum antioxidant markers in pregnant Japanese women: A cohort study. 2014 Biosci Trends pmid:25030853
Onur S et al. Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans. 2014 BMC Res Notes pmid:24996614
Zhou H et al. Novel lipid-free nanoformulation for improving oral bioavailability of coenzyme Q10. 2014 Biomed Res Int pmid:24995328
Chai W et al. Serum coenzyme Q₁₀, α-tocopherol, γ-tocopherol, and C-reactive protein levels and body mass index in adolescent and premenopausal females. 2014 J Am Coll Nutr pmid:24809382
Sikorska M et al. Nanomicellar formulation of coenzyme Q10 (Ubisol-Q10) effectively blocks ongoing neurodegeneration in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model: potential use as an adjuvant treatment in Parkinson's disease. 2014 Neurobiol. Aging pmid:24775711
Zhang K et al. A germline missense mutation in COQ6 is associated with susceptibility to familial schwannomatosis. 2014 Genet. Med. pmid:24763291
Kömürcü E et al. Preventive effects of coenzyme Q10 (CoQ10) on steroid-induced osteonecrosis in rats. 2014 Acta Orthop Traumatol Turc pmid:24747633
Giannubilo SR et al. Amniotic coenzyme Q10: is it related to pregnancy outcomes? 2014 Antioxid. Redox Signal. pmid:24745321
Gironi M et al. Oxidative stress is differentially present in multiple sclerosis courses, early evident, and unrelated to treatment. 2014 J Immunol Res pmid:24741637
Holloway CJ et al. Oral Coenzyme Q10 supplementation does not prevent cardiac alterations during a high altitude trek to everest base cAMP. 2014 High Alt. Med. Biol. pmid:24661196
Amin MM et al. Novel CoQ10 antidiabetic mechanisms underlie its positive effect: modulation of insulin and adiponectine receptors, Tyrosine kinase, PI3K, glucose transporters, sRAGE and visfatin in insulin resistant/diabetic rats. 2014 PLoS ONE pmid:24586567
Chandra A et al. Prospects for neuroprotective therapies in prodromal Huntington's disease. 2014 Mov. Disord. pmid:24573776
Roseiro LC et al. Concentration of antioxidants in two muscles of mature dairy cows from Azores. 2014 Meat Sci. pmid:24211545
Lee D et al. Coenzyme Q10 ameliorates oxidative stress and prevents mitochondrial alteration in ischemic retinal injury. 2014 Apoptosis pmid:24337820
Khorrami A et al. Reduction of coenzyme q10 content: a possible effect of isoproterenol on heart failure and myocardial infarction in rat. 2014 Drug Res (Stuttg) pmid:24026955
Carrasco J et al. The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo-controlled clinical trial. 2014 BJU Int. pmid:24119199
Wang X et al. High selenium impairs hepatic insulin sensitivity through opposite regulation of ROS. 2014 Toxicol. Lett. pmid:24140496
Gutierrez-Mariscal FM et al. Postprandial activation of p53-dependent DNA repair is modified by Mediterranean diet supplemented with coenzyme Q10 in elderly subjects. 2014 J. Gerontol. A Biol. Sci. Med. Sci. pmid:24158762
Murai M et al. Identification of the binding site of the quinone-head group in mitochondrial Coq10 by photoaffinity labeling. 2014 Biochemistry pmid:24870957
Korade Z et al. Antioxidant supplementation ameliorates molecular deficits in Smith-Lemli-Opitz syndrome. 2014 Biol. Psychiatry pmid:23896203
Cordero MD et al. NLRP3 inflammasome is activated in fibromyalgia: the effect of coenzyme Q10. 2014 Antioxid. Redox Signal. pmid:23886272
Allen RM and Vickers KC Coenzyme Q10 increases cholesterol efflux and inhibits atherosclerosis through microRNAs. 2014 Arterioscler. Thromb. Vasc. Biol. pmid:25142877
Doimo M et al. Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency. 2014 Biochim. Biophys. Acta pmid:24140869
Wang D et al. Coenzyme Q10 promotes macrophage cholesterol efflux by regulation of the activator protein-1/miR-378/ATP-binding cassette transporter G1-signaling pathway. 2014 Arterioscler. Thromb. Vasc. Biol. pmid:24675662
Lu W et al. Enhanced production of coenzyme Q10 by self-regulating the engineered MEP pathway in Rhodobacter sphaeroides. 2014 Biotechnol. Bioeng. pmid:24122603
Xu C et al. Light-harvesting chlorophyll pigments enable mammalian mitochondria to capture photonic energy and produce ATP. 2014 J. Cell. Sci. pmid:24198392
Onoue S et al. Biopharmaceutical characterization of nanocrystalline solid dispersion of coenzyme Q10 prepared with cold wet-milling system. 2014 Eur J Pharm Sci pmid:24368114
Contin M et al. The use of coenzyme Q0 as a template in the development of a molecularly imprinted polymer for the selective recognition of coenzyme Q10. 2014 Anal. Chim. Acta pmid:24356222
Garrido-Maraver J et al. Clinical applications of coenzyme Q10. 2014 Front Biosci (Landmark Ed) pmid:24389208
Gvozdjakova A et al. Balneotherapy and coenzyme Q10 in clinical and experimental medicine. 2014 Front Biosci (Schol Ed) pmid:24389258
Sugahara K et al. Coenzyme Q10 protects hair cells against aminoglycoside. 2014 PLoS ONE pmid:25265538
Tobin BD et al. Effect of cooking and in vitro digestion on the stability of co-enzyme Q10 in processed meat products. 2014 Food Chem pmid:24360438
Muthukumaran K et al. Orally delivered water soluble Coenzyme Q10 (Ubisol-Q10) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson's disease. 2014 BMC Neurosci pmid:24483602
Lee D et al. Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma. 2014 Invest. Ophthalmol. Vis. Sci. pmid:24458150
Ginter E Statins, coenzyme Q10 and diabetes type 2. 2014 Bratisl Lek Listy pmid:24601708
Brault M et al. Statin treatment and new-onset diabetes: a review of proposed mechanisms. 2014 Metab. Clin. Exp. pmid:24641882
Kalyan S et al. Nitrogen-bisphosphonate therapy is linked to compromised coenzyme Q10 and vitamin E status in postmenopausal women. 2014 J. Clin. Endocrinol. Metab. pmid:24423355
Jiménez-Santos MA et al. Coenzyme Q10 supplementation improves metabolic parameters, liver function and mitochondrial respiration in rats with high doses of atorvastatin and a cholesterol-rich diet. 2014 Lipids Health Dis pmid:24460631
López-Nicolás JM et al. Cyclodextrins and antioxidants. 2014 Crit Rev Food Sci Nutr pmid:24188271
Schapira AH and Patel S Targeting mitochondria for neuroprotection in Parkinson disease. 2014 JAMA Neurol pmid:24664140
Beal MF et al. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. 2014 JAMA Neurol pmid:24664227
Kobori Y et al. Antioxidant cosupplementation therapy with vitamin C, vitamin E, and coenzyme Q10 in patients with oligoasthenozoospermia. 2014 Arch Ital Urol Androl pmid:24704922
De Gennaro L et al. Statin therapy in heart failure: for good, for bad, or indifferent? 2014 Curr Atheroscler Rep pmid:24277654
Swarnakar NK et al. Enhanced antitumor efficacy and counterfeited cardiotoxicity of combinatorial oral therapy using Doxorubicin- and Coenzyme Q10-liquid crystalline nanoparticles in comparison with intravenous Adriamycin. 2014 Nanomedicine pmid:24637217
Liu YT et al. Autosomal-recessive cerebellar ataxia caused by a novel ADCK3 mutation that elongates the protein: clinical, genetic and biochemical characterisation. 2014 J. Neurol. Neurosurg. Psychiatr. pmid:24218524
Liu J and Wang LN Mitochondrial enhancement for neurodegenerative movement disorders: a systematic review of trials involving creatine, coenzyme Q10, idebenone and mitoquinone. 2014 CNS Drugs pmid:24242074
Cho HT et al. Droplet size and composition of nutraceutical nanoemulsions influences bioavailability of long chain fatty acids and Coenzyme Q10. 2014 Food Chem pmid:24629946
Halm BM et al. In vivo changes in plasma coenzyme Q10, carotenoid, tocopherol, and retinol levels in children after computer tomography. 2014 Arch. Biochem. Biophys. pmid:24583267
Park S et al. Aestuariispira insulae gen. nov., sp. nov., a lipolytic bacterium isolated from a tidal flat. 2014 Int. J. Syst. Evol. Microbiol. pmid:24566829
Brandmeyer EA et al. Using coenzyme Q10 in clinical practice. 2014 Nursing pmid:24531587
Dadabayev AR et al. Apolipoprotein A1 regulates coenzyme Q10 absorption, mitochondrial function, and infarct size in a mouse model of myocardial infarction. 2014 J. Nutr. pmid:24759932
Tompkins R et al. A current approach to statin intolerance. 2014 Clin. Pharmacol. Ther. pmid:24727470
El-Sheikh AA et al. Protective mechanisms of coenzyme-Q10 may involve up-regulation of testicular P-glycoprotein in doxorubicin-induced toxicity. 2014 Environ. Toxicol. Pharmacol. pmid:24632013
Brauner H et al. Markers of innate immune activity in patients with type 1 and type 2 diabetes mellitus and the effect of the anti-oxidant coenzyme Q10 on inflammatory activity. 2014 Clin. Exp. Immunol. pmid:24593795
Alcocer-Gómez E et al. Coenzyme q10 regulates serotonin levels and depressive symptoms in fibromyalgia patients: results of a small clinical trial. 2014 J Clin Psychopharmacol pmid:24525646
Gil-Mohapel J et al. The role of oxidative stress in Huntington's disease: are antioxidants good therapeutic candidates? 2014 Curr Drug Targets pmid:24428525
Phillipson OT Management of the aging risk factor for Parkinson's disease. 2014 Neurobiol. Aging pmid:24246717
Rashid K et al. Kenyan purple tea anthocyanins and coenzyme-Q10 ameliorate post treatment reactive encephalopathy associated with cerebral human African trypanosomiasis in murine model. 2014 Parasitol. Int. pmid:24440762
Liu J et al. Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients. 2014 Free Radic. Biol. Med. pmid:24418157
Nadjarzadeh A et al. Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial. 2014 Andrologia pmid:23289958
Li H et al. Water-soluble coenzyme q10 inhibits nuclear translocation of apoptosis inducing factor and cell death caused by mitochondrial complex I inhibition. 2014 Int J Mol Sci pmid:25089873
Bissoyi A and Pramanik K Effects of non-toxic cryoprotective agents on the viability of cord blood derived MNCs. 2013 Sep-Oct Cryo Letters pmid:24448765
Alcocer-Gómez E et al. Effect of coenzyme Q10 evaluated by 1990 and 2010 ACR Diagnostic Criteria for Fibromyalgia and SCL-90-R: four case reports and literature review. 2013 Nov-Dec Nutrition pmid:24103521
Sawicka E et al. The effects of coenzyme Q10 and baicalin in cisplatin-induced lipid peroxidation and nitrosative stress. 2013 Nov-Dec Acta Pol Pharm pmid:24383321
Takahashi K and Takahashi M Exogenous administration of coenzyme Q10 restores mitochondrial oxygen consumption in the aged mouse brain. 2013 Nov-Dec Mech. Ageing Dev. pmid:24333474
AydoÄŸan F et al. Is there any effect of coenzyme Q10 on prevention of myringosclerosis? Experimental study with rats. 2013 May-Jun Braz J Otorhinolaryngol pmid:23743743
Parker BA et al. A randomized trial of coenzyme Q10 in patients with statin myopathy: rationale and study design. 2013 May-Jun J Clin Lipidol pmid:23725917
Turkowicz MJ and Karpińska J Analytical problems with the determination of coenzyme Q10 in biological samples. 2013 Mar-Apr Biofactors pmid:23303649
Li K et al. Photoionization of oxidized coenzyme Q in microemulsion: laser flash photolysis study in biomembrane-like system. 2013 Jan-Feb Photochem. Photobiol. pmid:22621700
Krim SR et al. Micronutrients in chronic heart failure. 2013 Curr Heart Fail Rep pmid:23070580
Ivanov AV et al. Single intravenous injection of coenzyme Q10 protects the myocardium after irreversible ischemia. 2013 Bull. Exp. Biol. Med. pmid:24288763
Gvozdjakova A et al. Importance of the assessment of coenzyme Q10, alpha-tocopherol and oxidative stress for the diagnosis and therapy of infertility in men. 2013 Bratisl Lek Listy pmid:24236426
Zhu C et al. Biofortification of plants with altered antioxidant content and composition: genetic engineering strategies. 2013 Plant Biotechnol. J. pmid:22970850
Shetty RA et al. Coenzyme Q(10) supplementation reverses age-related impairments in spatial learning and lowers protein oxidation. 2013 Age (Dordr) pmid:23138632
Lafuente R et al. Coenzyme Q10 and male infertility: a meta-analysis. 2013 J. Assist. Reprod. Genet. pmid:23912751
Fash DM et al. Effects of alkyl side chain modification of coenzyme Q10 on mitochondrial respiratory chain function and cytoprotection. 2013 Bioorg. Med. Chem. pmid:23473946
Tani A and Sahin N Methylobacterium haplocladii sp. nov. and Methylobacterium brachythecii sp. nov., isolated from bryophytes. 2013 Int. J. Syst. Evol. Microbiol. pmid:23475343
Larsen S et al. Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance. 2013 J. Am. Coll. Cardiol. pmid:23287371
Fotino AD et al. Effect of coenzyme Q₁₀ supplementation on heart failure: a meta-analysis. 2013 Am. J. Clin. Nutr. pmid:23221577
Mugoni V et al. Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis. 2013 Cell pmid:23374346
Aboul-Fotouh S Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats. 2013 Pharmacol. Biochem. Behav. pmid:23313551