Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

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What functions are associated with Coenzyme Q10?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

Related references are published most in these journals:

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What genes are associated with Coenzyme Q10?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Sunnetcioglu A et al. Evaluation of Oxidative Damage and Antioxidant Mechanisms in COPD, Lung Cancer, and Obstructive Sleep Apnea Syndrome. 2016 Respir Care pmid:26604330
Sheeran FL and Pepe S Posttranslational modifications and dysfunction of mitochondrial enzymes in human heart failure. 2016 Am. J. Physiol. Endocrinol. Metab. pmid:27406740
Fatima S et al. Combined treatment of epigallocatechin gallate and Coenzyme Q10 attenuates cisplatin-induced nephrotoxicity via suppression of oxidative/nitrosative stress, inflammation and cellular damage. 2016 Food Chem. Toxicol. pmid:27265264
Kesik V et al. Ozone Ameliorates Doxorubicine-Induced Skin Necrosis - results from an animal model. 2016 Int J Low Extrem Wounds pmid:26286933
Astolfi L et al. Coenzyme Q10 plus Multivitamin Treatment Prevents Cisplatin Ototoxicity in Rats. 2016 PLoS ONE pmid:27632426
Sun C et al. Q-Band Electron-Nuclear Double Resonance Reveals Out-of-Plane Hydrogen Bonds Stabilize an Anionic Ubisemiquinone in Cytochrome bo3 from Escherichia coli. 2016 Biochemistry pmid:27622672
Moradi M et al. Effect of Coenzyme Q10 Supplementation on Diabetes Biomarkers: a Systematic Review and Meta-analysis of Randomized Controlled Clinical Trials. 2016 Arch Iran Med pmid:27544369
Latkovskis G et al. Pilot study of safety and efficacy of polyprenols in combination with coenzyme Q10 in patients with statin-induced myopathy. 2016 Medicina (Kaunas) pmid:27496187
Huang CH et al. High plasma coenzyme Q10 concentration is correlated with good left ventricular performance after primary angioplasty in patients with acute myocardial infarction. 2016 Medicine (Baltimore) pmid:27495100
Hyodo F et al. Development of Redox Metabolic Imaging Using Endogenous Molecules. 2016 Yakugaku Zasshi pmid:27477725
Mustafa HN et al. Prophylactic role of coenzyme Q10 and Cynara scolymus L on doxorubicin-induced toxicity in rats: Biochemical and immunohistochemical study. 2015 Nov-Dec Indian J Pharmacol pmid:26729958
Alehagen U et al. Less increase of copeptin and MR-proADM due to intervention with selenium and coenzyme Q10 combined: Results from a 4-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. 2015 Nov-Dec Biofactors pmid:26662217
Knott A et al. Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects. 2015 Nov-Dec Biofactors pmid:26648450
Park S et al. Pseudoseohaeicola caenipelagi gen. nov., sp. nov., isolated from a tidal flat. 2015 Int. J. Syst. Evol. Microbiol. pmid:25754549
El Morsy EM et al. Attenuating effects of coenzyme Q10 and amlodipine in ulcerative colitis model in rats. 2015 Immunopharmacol Immunotoxicol pmid:25753843
Li L et al. Bombella intestini gen. nov., sp. nov., an acetic acid bacterium isolated from bumble bee crop. 2015 Int. J. Syst. Evol. Microbiol. pmid:25336723
Kishita Y et al. Intra-mitochondrial Methylation Deficiency Due to Mutations in SLC25A26. 2015 Am. J. Hum. Genet. pmid:26522469
Alehagen U et al. Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized Double-Blind Placebo-Controlled Trial in Elderly Citizens. 2015 PLoS ONE pmid:26624886
Okeahialam BN Reversal of statin-induced memory dysfunction by co-enzyme Q10: a case report. 2015 Vasc Health Risk Manag pmid:26604775
Yeung CK et al. Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress. 2015 BMC Nephrol pmid:26531095
Kaisar MA et al. Protecting the BBB endothelium against cigarette smoke-induced oxidative stress using popular antioxidants: Are they really beneficial? 2015 Brain Res. pmid:26410779
Alehagen U et al. Levels of sP-selectin and hs-CRP Decrease with Dietary Intervention with Selenium and Coenzyme Q10 Combined: A Secondary Analysis of a Randomized Clinical Trial. 2015 PLoS ONE pmid:26375288
Prusiner SB et al. Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26324905
Grenier-Larouche T et al. Omental adipocyte hypertrophy relates to coenzyme Q10 redox state and lipid peroxidation in obese women. 2015 J. Lipid Res. pmid:26239051
Tarry-Adkins JL et al. Coenzyme Q10 Prevents Insulin Signaling Dysregulation and Inflammation Prior to Development of Insulin Resistance in Male Offspring of a Rat Model of Poor Maternal Nutrition and Accelerated Postnatal Growth. 2015 Endocrinology pmid:26214037
Donnino MW et al. Ubiquinol (reduced Coenzyme Q10) in patients with severe sepsis or septic shock: a randomized, double-blind, placebo-controlled, pilot trial. 2015 Crit Care pmid:26130237
Ben-Meir A et al. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. 2015 Aging Cell pmid:26111777
Ohta Y et al. Effect of Dietary Vitamin E Supplementation on Liver Oxidative Damage in Rats with Water-Immersion Restraint Stress. 2015 J. Nutr. Sci. Vitaminol. pmid:26052141
de la Mata M et al. Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease. 2015 Sci Rep pmid:26045184
Gaul C et al. Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial. 2015 J Headache Pain pmid:25916335
Forester BP et al. Antidepressant effects of open label treatment with coenzyme Q10 in geriatric bipolar depression. 2015 J Clin Psychopharmacol pmid:25874916
Otero-Losada M et al. Functional and morphological changes in endocrine pancreas following cola drink consumption in rats. 2015 PLoS ONE pmid:25790473
Zhang D et al. Coenzyme Q10 inhibits the aging of mesenchymal stem cells induced by D-galactose through Akt/mTOR signaling. 2015 Oxid Med Cell Longev pmid:25789082
Florkowski CM et al. Coenzyme Q10 and congestive heart failure; an evolving evidence base. 2015 Kardiol Pol pmid:25706904
Summitt CB et al. Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria. 2015 Biochem. J. pmid:25697095
Mourier A et al. Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. 2015 J. Cell Biol. pmid:25688136
Domanico D et al. Circulating levels of reactive oxygen species in patients with nonproliferative diabetic retinopathy and the influence of antioxidant supplementation: 6-month follow-up. 2015 Indian J Ophthalmol pmid:25686055
Guevara-Campos J et al. Autism and intellectual disability associated with mitochondrial disease and hyperlactacidemia. 2015 Int J Mol Sci pmid:25679448
Gueven N et al. Border between natural product and drug: comparison of the related benzoquinones idebenone and coenzyme Q10. 2015 Redox Biol pmid:25625583
Desbats MA et al. Primary coenzyme Q10 deficiency presenting as fatal neonatal multiorgan failure. 2015 Eur. J. Hum. Genet. pmid:25564041
Dutta A et al. Hypersensitive response-like lesions 1 codes for AtPPT1 and regulates accumulation of ROS and defense against bacterial pathogen Pseudomonas syringae in Arabidopsis thaliana. 2015 Antioxid. Redox Signal. pmid:25557512
Jing L et al. Coenzyme Q10 protects astrocytes from ROS-induced damage through inhibition of mitochondria-mediated cell death pathway. 2015 Int. J. Biol. Sci. pmid:25552930
Alehagen U and Aaseth J Selenium and coenzyme Q10 interrelationship in cardiovascular diseases--A clinician's point of view. 2015 J Trace Elem Med Biol pmid:25511910
Lo RY et al. Coenzyme Q10 and spinocerebellar ataxias. 2015 Mov. Disord. pmid:25449974
Castro-Marrero J et al. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome? 2015 Antioxid. Redox Signal. pmid:25386668
Iwasaki M et al. Comparison of plasma levels of nutrient-related biomarkers among Japanese populations in Tokyo, Japan, São Paulo, Brazil, and Hawaii, USA. 2015 Eur. J. Cancer Prev. pmid:25633435
Fischer T [Pharmacological therapy of age-related macular degeneration based on etiopathogenesis]. 2015 Orv Hetil pmid:26548469
Fatima S et al. Effect of pre- and post-combined multidoses of epigallocatechin gallate and coenzyme Q10 on cisplatin-induced oxidative stress in rat kidney. 2015 J. Biochem. Mol. Toxicol. pmid:25382014
Nerdal W et al. CoenzymeQ10 localizations in model membranes. A Langmuir monolayer study. 2015 Biophys. Chem. pmid:26408828
Cicero AF and Colletti A Nutraceuticals and Blood Pressure Control: Results from Clinical Trials and Meta-Analyses. 2015 High Blood Press Cardiovasc Prev pmid:25788027